Patents by Inventor David A. Goldstein

David A. Goldstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazo-substituted compounds as P38 kinase inhibitors
    Publication number: 20060252784
    Abstract: The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.
    Type: Application
    Filed: July 13, 2006
    Publication date: November 9, 2006
    Inventors: David Goldstein, Ronald Hawley, Alfred Lui, Eric Sjogren
  • Decision support method and system
    Publication number: 20060235707
    Abstract: In accordance with the invention, there is a decision support method comprising collecting data about a set of components of an asset, wherein the data comprises information about the status of each component in the set of components. The method also comprises comparing the data to a set of requirements for a use of the asset and estimating a remaining life for each of the components in the set of components based on the status of each of the components and the set of requirements for an intended use of the asset.
    Type: Application
    Filed: April 19, 2005
    Publication date: October 19, 2006
    Inventors: David Goldstein, Darryl Busch
  • Interactive hand held apparatus with stylus
    Publication number: 20060188861
    Abstract: An interactive, handheld apparatus is provided. The apparatus includes a housing, a display screen on the housing, an electronic position location system, a stylus for selecting images on the display screen, a directional control pad on the housing and a memory device. The electronic position location system includes a processor that is capable of determining a location of a selected region of the display screen. The memory device includes computer code for an educational game and is operatively coupled to the processor.
    Type: Application
    Filed: April 13, 2006
    Publication date: August 24, 2006
    Applicant: LeapFrog Enterprises, Inc.
    Inventors: Michael Wood, Alice Vordan, David Goldstein, Mark Flowers, Joseph Miller, Michelle Fitts, Curtis Cole, Rick Adolf, Antonia Kohl, Carol Thies
  • Interactive handheld apparatus with stylus
    Patent number: 7083420
    Abstract: An interactive, handheld apparatus is provided. The apparatus includes a housing, a display screen on the housing, an electronic position location system, a stylus for selecting images on the display screen, a directional control pad on the housing and a memory device. The electronic position location system includes a processor that is capable of determining a location of a selected region of the display screen. The memory device includes computer code for an educational game and is operatively coupled to the processor.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: August 1, 2006
    Assignee: LeapFrog Enterprises, Inc.
    Inventors: Michael C. Wood, Alice Chen, David Goldstein, Mark Flowers, Joseph B. Miller, III, Michelle Fitts, Curtis Cole, Rick Adolf, Antonia Kohl, Carol Thies
  • Combined treatment with interferon-alpha and an epidermal growth factor receptor kinase inhibitor
    Publication number: 20060134064
    Abstract: The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of an EGFR kinase inhibitor and IFN? combination, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of an EGFR kinase inhibitor and IFN? combination in combination with a pharmaceutically acceptable carrier. A preferred example of an EGFR kinase inhibitor that can be used in practicing this invention is the compound erlotinib HCl (also known as TARCEVA®).
    Type: Application
    Filed: December 16, 2005
    Publication date: June 22, 2006
    Inventors: David Goldstein, Xian-Jun Qu, Pamela Russell, Jia-Lin Yang
  • Treatment of gastrointestinal disorders with duloxetine
    Publication number: 20050272805
    Abstract: The present invention belongs to the fields of medicinal and pharmaceutical chemistry, and provides a new method of treating gastrointestinal disorders by the administration of duloxetine.
    Type: Application
    Filed: November 18, 2003
    Publication date: December 8, 2005
    Inventors: Michael Detke, David Goldstein, Smriti Iyengar
  • Indazole derivatives and methods for using the same
    Publication number: 20050215595
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, k, B, R1, R2 and R3 are those defined herein, and compositions comprising the same. Also provided are methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a patient.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 29, 2005
    Inventors: Nidhi Arora, Tobias Gabriel, David Goldstein, Teresa Trejo-Martin
  • 6-Alkoxy-pyrido-pyrimidines
    Publication number: 20050203300
    Abstract: The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(?O), Z is N or CH; and R2 and R3are as defined herein, pharmaceutical compositions comprising same, and methods for their use.
    Type: Application
    Filed: May 4, 2005
    Publication date: September 15, 2005
    Inventors: David Goldstein, Julie Lim
  • Heteroaryl-fused pyrazolo derivatives and methods for using the same
    Publication number: 20050203091
    Abstract: Compounds of the formula I: where A, B, X, Y, Z, k, R1, R2 and R3 are those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a patient.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 15, 2005
    Inventors: Nidhi Arora, Roland Billedeau, Nolan Dewdney, Tobias Gabriel, David Goldstein, Kristen McCaleb, Michael Soth, Teresa Trejo-Martin
  • Fused-pyrazolo pyrimidine and pyrazolo pyrimidinone derivatives and methods for using the same
    Publication number: 20050197340
    Abstract: Compounds of the formula Ia or Ib: wherein A, B, X, Y, Z, W, k, R1, R2, R3, R4 and R5 are those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a subject.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 8, 2005
    Inventors: Nidhi Arora, Roland Billedeau, Nolan Dewdney, Tobias Gabriel, David Goldstein, Counde O'Yang, Michael Soth
  • Imidazo-substituted compounds as p38 kinase inhibitors
    Publication number: 20050197352
    Abstract: The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.
    Type: Application
    Filed: May 4, 2005
    Publication date: September 8, 2005
    Inventors: David Goldstein, Ronald Hawley, Alfred Lui, Eric Sjogren
  • Methods and apparatus for orthopedic surgical navigation and alignment
    Publication number: 20050149040
    Abstract: Methods and apparatus for orthopedic surgical navigation and alignment techniques and instruments.
    Type: Application
    Filed: October 23, 2004
    Publication date: July 7, 2005
    Inventors: Timothy Haines, David Goldstein
  • Methods and apparatus for orthopedic implants
    Publication number: 20050149039
    Abstract: Methods and apparatus for orthopedic implants.
    Type: Application
    Filed: October 29, 2004
    Publication date: July 7, 2005
    Inventors: Timothy Haines, David Goldstein
  • Methods and apparatus for orthopedic implant preparation systems
    Publication number: 20050149038
    Abstract: Methods and apparatus for systems for preparing musculoskeletal structures to receive an orthopedic implant.
    Type: Application
    Filed: October 4, 2004
    Publication date: July 7, 2005
    Inventors: Timothy Haines, David Goldstein
  • Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
    Publication number: 20050107408
    Abstract: Compounds of the Formula: where X1, Ar1, R1, and R2 are as defined herein, and compositions comprising the same. Also provided are methods for using compounds of Formula I in treating p38 mediated disorders in a patient.
    Type: Application
    Filed: November 12, 2004
    Publication date: May 19, 2005
    Inventor: David Goldstein
  • Interactive hand held apparatus with stylus
    Publication number: 20050037327
    Abstract: An interactive, handheld apparatus is provided. The apparatus includes a housing, a display screen on the housing, an electronic position location system, a stylus for selecting images on the display screen, a directional control pad on the housing and a memory device. The electronic position location system includes a processor that is capable of determining a location of a selected region of the display screen. The memory device includes computer code for an educational game and is operatively coupled to the processor. A light is associated with the stylus. The light is illuminated to indicate that the stylus is available for use during operation of the educational game.
    Type: Application
    Filed: February 9, 2004
    Publication date: February 17, 2005
    Applicant: LepFrog Enterprises,Inc.
    Inventors: Michael Wood, Alice Chen Jordan, David Goldstein, Mark Flowers, Joseph Miller, Michelle Fitts, Robert Cole, Rick Adolf, Antonia Kohl, Carol Thies
  • Interactive handheld apparatus with stylus
    Publication number: 20040224775
    Abstract: An interactive, handheld apparatus is provided. The apparatus includes a housing, a display screen on the housing, an electronic position location system, a stylus for selecting images on the display screen, a directional control pad on the housing and a memory device. The electronic position location system includes a processor that is capable of determining a location of a selected region of the display screen. The memory device includes computer code for an educational game and is operatively coupled to the processor.
    Type: Application
    Filed: February 9, 2004
    Publication date: November 11, 2004
    Applicant: LeapFrog Enterprises, Inc.
    Inventors: Michael C. Wood, Alice Chen, David Goldstein, Mark Flowers, Joseph B. Miller, Michelle Fitts, Curtis Cole, Rick Adolf, Antonia Kohl, Carol Thies
  • Non-welded shape memory alloy rings produced from roll flattened wire
    Patent number: 6780260
    Abstract: A method for producing a non-welded shape memory alloy ring, such as Nitinol, includes a wire segment. The alloy ring may be used in a venting mechanism for rocket motors or as a coupling device, such as for fitting piping.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: August 24, 2004
    Assignee: The United Sates of America as represented by the Secretary of the Navy
    Inventors: David Goldstein, Steven S. Kim
  • Orbit transfer vehicle with support services
    Publication number: 20030132350
    Abstract: The excess space and weight capacity of a conventional launch vehicle for a high-energy orbit, such as GEO, is used to deploy satellites to a low-energy orbit, such as LEO. In a preferred embodiment, an orbit-transfer vehicle provides the navigation, propulsion, and control systems required to transport a payload satellite from a high-energy-transfer orbit, such as GTO, to a predetermined low-energy orbit. Upon entering the low-energy orbit, the payload satellite is released from the orbit-transfer vehicle. To reduce the fuel requirements for this deployment via the orbit-transfer vehicle, a preferred embodiment includes aerobraking to bring the satellite into a low-earth orbit.
    Type: Application
    Filed: January 21, 2003
    Publication date: July 17, 2003
    Inventors: David Goldstein, Scott A. McDermott, Paul Gloyer, Richard Fleeter
  • Electric bellows system
    Patent number: 6571788
    Abstract: An electric bellows system for stimulating and igniting a fire includes a funnel. The funnel has a central axis with a circular intake end of a larger diameter and a circular exhaust of a smaller diameter and a tapered region therebetween. The first region is tapered in a convex fashion. The second region diminishes in a concave fashion. A screen covers the intake end of the base region of the funnel. A battery housing comprises a cylindrical tube with a short longitudinal slit therethrough. An axial fan has a central base with an axial bore. The axial fan also has a plurality of blades coupled to the base. A switch is coupled to the tube of the battery housing adjacent the slit.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: June 3, 2003
    Inventor: David Goldstein