Abstract: A torque converter includes a cover, a piston plate, a first damper, a pendulum plate, and a drive plate. The cover forms at least a portion of a housing for the torque converter. The piston plate includes a friction surface for clutching engagement with the cover. The first damper includes a first elastic member and a first flange drivingly engaged with the first elastic member. The pendulum plate is axially disposed between the piston plate and the first flange and includes first slots arranged for supporting a pendulum mass. The drive plate includes a first portion fixed to the piston plate and an axial tab extending through the pendulum plate to engage the first flange.

Abstract: A method and assembly for protecting a device connected to a wiring harness is disclosed. The assembly includes a protective shield having a bore for receiving the device and a positioning device. An elongated wiring harness extends from the device being protected and through the bore of the protective shield. The positioning device is formed having a band that surrounds a central space. At least one flexible, resilient finger extends radially inwardly from the band into the central space. At least one of the fingers forcibly engages the harness sleeve to maintain the positioning device and the protective shield in a predetermined protection position along the harness sleeve at least partially surrounding the device being protected.

Abstract: An apparatus and method for controlling the orientation, geometry, shape or length of an inserted catheter is provided to optimize it's position during procedures for treating cardiac arrhythmia by ablation based on functions derived from one or more parameters including the temporal relationship between intracardiac signals, patient anatomy, cardiac tissue electrical properties, imaging data, and other criteria that may include previously stored data collected from one or more patients who have had successful therapy delivered.

Abstract: Apparatus and methods facilitate analysis of events associated with network and computer systems. Event data, such as security threats, are comparison matched with event rules of event rule sets associated with each network or computer system to determine whether the items are potentially significant. Additionally, the system-event data may be scored where the score is used for prioritizing system-event data as to their significance. Associated with the comparison matching are various analytics that further analyze event data for measuring and analyzing the system-event data according to various algorithms.

Abstract: The invention provides compositions and methods for treatment of neurodegenerative diseases or disorders, particularly neurodegenerative diseases and disorders associated with protein aggregation. The present invention is based on the discovery of binding regions on the surface of PrPc, referred to as PrPc Binding Domains (PBD). In particular, the inventors have identified six different binding regions on PrPc, referred to herein as PrP-binding domain-1 (PBD-1), PrP-binding domain-2 (PBD-2), PrP-binding domain-3 (PBD-3), PrP-binding domain-4 (PBD-4), PrP-binding domain-5 (PBD-5), and PrP-binding domain-6 (PBD-6), herein. The PBD-1 to PBD-6 are each defined by a cluster of amino acids located in the globular domain of the protein, e.g., in the C-terminal half of the protein (i.e., in residues 120-230). One embodiment uses residues 127-226.

Abstract: An embodiment of a communication system includes a client device adapted to receive a location object that includes tracer information, and to perform one or more location object-based actions using the location object. The client device stores the tracer information and location object usage information, which describes the one or more location object-based actions that have been performed using the location object. The client device also sends the stored information to a server. The system also includes the server, which is adapted to receive the location object usage information and the tracer information reported by the client device. In an embodiment, the system also includes a service provider adapted to initiate a billing event, which may include generation and transmission of a bill to a sponsor entity based on an evaluation of the location object usage information and the tracer information reported by the client device.

Abstract: A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

Abstract: Dry powder inhalers and methods are provided that facilitate deagglomeration of powdered medicament during inspiration. A dry powder inhaler includes a dry powder medicament container assembly, and an elongated dry powder delivery tube having an inlet at one end that communicates with a dose container, and an outlet or inhalation port that extends from the inhaler housing at an opposite end. The delivery tube includes one or more apertures adjacent the inlet that cause cyclonic or turbulent airflow through the delivery tube. The inner surface of the delivery tube has a polygonal configuration and the cyclonic air stream bounces off the polygonal inner surface numerous times as the air stream flows through the delivery tube. Another dry powder inhaler includes a deagglomeration chamber with a polygonal inner surface. An air stream containing dry powder medicament is directed into the deagglomeration chamber and impacts the polygonal inner surface numerous times.

Abstract: The present application provides novel compositions comprising posaconazole and a polymer wherein the composition has a glass transition temperature temperature (Tg) of less than about 110° C. The application also describes compositions comprising posaconazole and a polymer having a bulk density of greater than about 0.4 mg/mL. The application also describes compositions comprising posaconazole and a polymer which provide an exposure (AUCtf) of at least about 10,000 ng·hr/mL when administered to a patient in a fasted state. The application also describes a novel process for preparing these compositions.

Abstract: Various embodiments of payout systems and methods are disclosed. One embodiment, among others, comprises providing a defined payout amount and a party adjustable payout volatility for a video gaming device, and responsive to party input, modifying the payout volatility while maintaining the defined payout amount.

Abstract: A multilayer textile sleeve and method of construction thereof is provided. The sleeve has an outer layer constructed at least in part from a first warp yarn extending along a length direction of the sleeve and a weft yarn extending transversely to the length direction. The sleeve further includes an inner layer constructed at least in part from a second warp yarn extending along the length direction and a weft yarn extending transversely to the length direction, with the second warp yarn being a different type of yarn than the first warp yarn. The outer layer and inner layer are connected to one another by interlinking the weft yarn of the outer layer with at least some of the second warp yarns of the inner layer and by interlinking the weft yarn of the inner layer with at least some of the first warp yarns of the outer layer.

Abstract: A wrappable textile sleeve and method of reducing cracking in a foil layer of a wrappable textile sleeve are provided. The sleeve includes an elongate wall extending along a longitudinal axis between opposite ends with lengthwise extending edges extending along the longitudinal axis between the opposite ends. The wall includes a textile layer, a polymeric film layer fixed to the inner textile layer and a metal foil layer fixed to the polymeric film layer. The polymeric film layer has a first thickness and the metal foil layer has a second thickness, wherein the second thickness is greater than the first thickness.

Abstract: Dry powder inhalers are described with an inhaler body defining an enclosed cavity space and at least one of (a) an endless strip having opposing primary surfaces, the strip comprising a plurality of spaced apart blisters or dose containers holding dry powder medicament. The inhaler also has an inhalation exit flow path in the inhaler body in communication with at least one blister or at least one dose container held by the strip in a dispensing position and a piercer configured to release dry powder medicament from the blister or dose container in the dispensing position.

Abstract: Various embodiments are described herein for methods and systems that can be used for generating a planogram data file by: receiving, at a remote computing device, recorded position data for one or more items located on first and second fixtures of a display segment, and generating, using the remote computing device, a planogram data file. The planogram data file may be generated by: writing product data for the one or more items, and fixture location data for the first fixture; writing, based on the recorded position data, position data for the items located on the first fixture to the planogram data file, determining a first maximum item height for the one or more items on the first fixture, and writing, based on the first maximum item height, fixture location data for the second fixture to the planogram data file.

Abstract: A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

Abstract: A training urinal attachment mountable to the bowl of a toilet. The attachment includes a resiliently collapsible shell having an intake opening that receives a flow of urine from a standing child and a discharge opening that directs the flow into a collection area of the bowl. The shell is mounted on the rim of the bowl in an area that is covered by the seat of the toilet when lowered. When the seat is lowered, the shell compresses to a collapsed configuration in the area between the seat and the rim. When the seat is raised, the shell expands to an erected configuration in which the intake opening extends above the rim to receive the flow of urine. The discharge opening is visible through the intake opening to provide the child with a target to aid in training.

Abstract: The present invention relates to a load management controller for a household electrical installation comprising a pair of electricity supplies, a grid supply and a micro-generator supply, providing electricity to a plurality if sub-circuits. The household electrical installation has means to monitor the amount of electricity being supplied by the micro-generator supply and the amount of electricity being consumed in the household. The load management controller has means to access and use that information to control the supply of electricity to an energy storage sub-circuit to route surplus electricity supplied by the micro-generator to the energy storage sub-circuit. Furthermore, the load management controller can communicate with a remote electricity supplier to control the loads in the household to achieve better grid management and efficiency.

Abstract: A method and apparatus for alerting a user of topical negative pressure therapy apparatus to a full waste canister condition are described, the apparatus comprising a device having vacuum pump means and a waste canister connected to the device and the waste canister operably connected to a wound dressing by aspiration conduit means for aspirating fluid from the wound, the aspiration conduit means, the waste canister and the device providing a fluid flow path therethrough and the vacuum pump means providing fluid flow through the apparatus, the apparatus further comprising fluid flow restriction means in the fluid flow path of said vacuum pump and fluid pressure sensing means upstream and downstream of said fluid flow restriction means.

Abstract: A digital transmitter with sample rate digital predistortion is disclosed. The transmitter includes a digital radio frequency (RF) signal generator configured to receive a baseband digital signal and transform the baseband digital signal to a digital RF signal. The digital transmitter further includes a sample rate predistorter configured to predistort the digital RF signal so as to compensate for distortion associated with the transmitter that is generated subsequent to an output of the sample rate predistorter, and resulting in a digital predistorted RF signal. The digital transmitter further includes a digital to analog converter configured to convert the digital predistorted RF signal to analog, resulting in an analog predistorted RF signal.

Abstract: For optimizing resources for a parallel data integration job, a job request is received, which specifies a parallel data integration job to deploy in a grid. Grid resource utilizations are predicted for hypothetical runs of the specified job on respective hypothetical grid resource configurations. This includes automatically predicting grid resource utilizations by a resource optimizer module responsive to a model based on a plurality of actual runs of previous jobs. A grid resource configuration is selected for running the parallel data integration job, which includes the optimizer module automatically selecting a grid resource configuration responsive to the predicted grid resource utilizations and an optimization criterion.