Abstract: A system for interfacing predetermined services to a user at a fixed location includes a processing platform running an operating system. The system further includes a data store for storing configuration information for enabling the operating system to interface with available physical system resources through the physical system resource interface associated therewith. A communication resource for interfacing with the operating system allows communication of the operating system with a central office for downloading configuration information to selectively enable ones of the available physical system resources to interface with the operating system through associated ones of the physical system resource interfaces in accordance with the configuration information and the predetermined service selected by a user. A plurality of configurations is stored in the data store, and each is associated with a predetermined service and one or more of the available physical system resources.

Abstract: Methods for reducing the progression of ER+breast cancer in a patient are provided, the methods comprising administering to the patient an effective amount of lasofoxifene or a pharmaceutically acceptable salt thereof and an effective amount of a CDK4/6 inhibitor (CDK4/6i), wherein the breast cancer: (i) is estrogen receptor positive (ER+); (ii) has at least one gain of function missense mutation within the ligand binding domain (LBD) of the Estrogen Receptor 1 (ESR1) gene; and (iii) has progressed during prior CDK4/6 inhibitor therapy and/or has an oncogenic mutation in a gene other than ESR1.

Abstract: An apparatus, comprising a camera, a motion sensor, a receiving section, gas tanks, a screen, and a computing device. The computing device is configured to control the camera to take electronic images, determine a type of food placed in a particular container, determine an amount of gas and a type of gas to fill the particular container, generate an electronic message to request placement of the particular container onto the receiving section, and inject gas into the particular container when the particular container is placed onto the receiving section. The injected gas is used to preserve food inside the container.

Abstract: A cardiac mapping method includes determining locations of contacts between a catheter and heart surfaces of a patient's heart using a localization system, selecting a three-dimensional (3D) heart model representative of the patient's heart based on the determined locations; using the localization system to detect locations of electrocardiogram (ECG) electrodes disposed on the patient to generate ECG electrode location data; collecting ECG data from the patient using the ECG electrodes; and generating an activation map of the heart based on the 3D model, the ECG data, and the location data. Embodiments also include ECG electrodes and intracardiac catheters that include an element configured to support localization by the localization system.

Abstract: The disclosure provides an approach for certificate management for cryptographic agility. Embodiments include receiving, by a cryptographic agility system, a cryptographic request related to an application. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique based on contextual information associated with the cryptographic request. Embodiments include determining, by the cryptographic agility system, based on the cryptographic request, a certificate for authenticating a key related to the cryptographic technique. Embodiments include providing, by the cryptographic agility system, the certificate to an endpoint related to the cryptographic request for use in authenticating the key.

Abstract: The disclosure provides an approach for cryptographic agility. Embodiments include establishing, by a proxy component associated with a cryptographic agility system, a first secure connection with an application. Embodiments include receiving, by the proxy component, via the first secure connection, a communication from the application directed to an endpoint. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique based on contextual information related to the communication. Embodiments include establishing, by the proxy component, a second secure connection with the endpoint based on the cryptographic technique. Embodiments include transmitting, by the proxy component, a secure communication to the endpoint via the second secure connection based on the communication.

Abstract: A distributed transaction system for enabling users to conduct transactions using services from third party service providers includes a central processing center with one or more communications interfaces to facilitate transactions initiated by users at a plurality of kiosks wherein each of the kiosks includes a user interface enabling a user to access a user selected service and a data store for storing configurations associated with services provided by the third party service providers, whereby a user interfaces with one or more of physical system resources of the kiosk to open a user identity session such that the kiosk is operative to facilitate at least one first user action with the physical resources to initiate a financial transaction and the central processing center is operative to execute at least a second action to facilitate the transaction and to communicate with a financial institution.

Abstract: Various embodiments include a vessel clamping pressure device that is configured to receive suture threads extending from the closure of a vascular vessel of a patient, and maintaining tension on suture threads between the patient and the vessel clamping pressure device to apply pressure to the patient so as to apply a clamping pressure to the vascular vessel to facilitate clotting.

Abstract: Various embodiments include a vessel clamping pressure device that is configured to receive suture threads extending from the closure of a vascular vessel of a patient, and maintaining tension on suture threads between the patient and the vessel clamping pressure device to apply pressure to the patient so as to apply a clamping pressure to the vascular vessel to facilitate clotting. In some embodiments, a pressure applying surface may include a cushioning material configured to cushion application of the pressure applying surface the patient.

Abstract: Various embodiments include a vessel clamping pressure device that is configured to receive suture threads extending from the closure of a vascular vessel of a patient, and maintaining tension on suture threads between the patient and the vessel clamping pressure device to apply pressure to the patient so as to apply a clamping pressure to the vascular vessel to facilitate clotting. In some embodiments, a pressure applying surface may include a pressure sensitive film configured to change color in response to pressure applied to the patient by the pressure applying surface the patient.

Abstract: The present invention provides methods of administering certain PD-1 binding agents to patients having cancer. Dosage regimens for compositions comprising a PD-1 binding agent are also explicitly provided.

Abstract: Various embodiments include methods and diagnostic systems implementing the methods for determining a prognostic prediction of a likelihood of success or a likelihood of complications of an electrophysiology procedure at the identified area of electrophysiological interest.

Abstract: An oil field chemical-carrying material comprising polymeric particles and a process for making the same are disclosed. An oil field chemical is integrally incorporated into the granulated particle. The oil field chemical is in particular a tracer and the particle is in particular a proppant for use in hydraulic fracturing of a subterranean formation. Methods of delivering oil field chemicals, methods of monitoring subterranean formations, methods of tracing flow of fluid from hydrocarbon reservoirs and methods of hydraulic fracturing subterranean formations are also disclosed.

Abstract: The present invention provides methods of administering certain PD-1 binding agents to patients having cancer. Dosage regimens for compositions comprising a PD-1 binding agent are also explicitly provided.

Abstract: The disclosure provides antibody agents that bind to a Lymphocyte Activation Gene-3 (LAG-3) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using anti-LAG-3 antibody agents to treat a disorder or disease that is responsive to LAG-3 inhibition, such as, for example, cancer or an infectious disease.

Abstract: An oil field chemical-carrying material comprising polymeric particles and a process for making the same are disclosed. An oil field chemical is integrally incorporated into the granulated particle. The oil field chemical is in particular a tracer and the particle is in particular a proppant for use in hydraulic fracturing of a subterranean formation. Methods of delivering oil field chemicals, methods of monitoring subterranean formations, methods of tracing flow of fluid from hydrocarbon reservoirs and methods of hydraulic fracturing subterranean formations are also disclosed.

Abstract: A charged particle detector is provided. The charged particle detector includes a flexible semiconductor wafer, the semiconductor wafer being doped to form a p-n junction, and an amplifier coupled to the semiconductor wafer and configured to amplify a current or voltage across the p-n junction.

Abstract: The present invention relates to a method and apparatus for detecting radioactivity. In particular, but not exclusively, the present invention relates to the detection of radioactivity in a target fluid in a fluid communication passageway using a region of scintillator material (130) to provide light responsive to the presence of radioactive material and at least one silicon photomultiplier (SiPM) (150) for providing an output signal responsive to the light provided by the scintillator material.

Abstract: A method of operating a content management includes collecting or receiving data which relates to a user's behavior when using a digital content catalogue, and prior to the consumption of a content item. This collected or received data is processed and analyzed to create a data table which may be used to demonstrate to a content manager which items in the digital content catalogue are most difficult to discover in order that the catalogue be re-ordered appropriately. In this way, user behavior may be used to optimize digital content management systems. Once it is known, for a given digital content item, how discoverable, or indeed undiscoverable it is based on a user's behavior prior to consuming the content item, that item may be promoted to a more prominent location in the catalogue, or relocated to a different location so as to allow a user to more easily locate it.

Abstract: Various embodiments include a catheter positioning device that may include a sled member, a sled base, an active damping system, a sensor, and a control system. The sled member may be configured to accept a handle of a catheter. The sled base may be configured to move the sled member along a length of the sled base for positioning the catheter within a patient. The active damping system may be configured to apply a force to the sled base to resist movement of the sled base in response to a control signal. The sensor may be configured to generate signals in response to a movement of the sled base. The control system may be configured to receive sensor signals from the sensor and transmit control signals to cause the active damping system to apply the force to resist movement of the sled base indicated in the received sensor signals.