Abstract: The disclosure provides an approach for cryptographic agility. Embodiments include receiving, by a cryptographic agility system associated with an application, a request to establish a secure communication session. Embodiments include, prior to establishing the secure communication session, selecting, by the cryptographic agility system, a first cryptographic technique and a second cryptographic technique for the secure communication session. Embodiments include, during the secure communication session, utilizing the first encryption technique for securely communicating a first set of data. Embodiments include determining that a condition has been met for switching from the first encryption technique to the second encryption technique. Embodiments include, based on the determining that the condition has been met, utilizing the second encryption technique for securely communication a second set of data.

Abstract: The disclosure provides an approach for certificate management for cryptographic agility. Embodiments include receiving, by a cryptographic agility system, a cryptographic request related to an application. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique based on contextual information associated with the cryptographic request. Embodiments include determining, by the cryptographic agility system, based on the cryptographic request, a certificate for authenticating a key related to the cryptographic technique. Embodiments include providing, by the cryptographic agility system, the certificate to an endpoint related to the cryptographic request for use in authenticating the key.

Abstract: The disclosure provides an approach for auditable cryptographic agility. Embodiments include receiving, by a cryptographic agility system, a request to perform a cryptographic operation related to an application. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique for performing the cryptographic operation based on contextual information associated with the request. Embodiments include performing, by the cryptographic agility system, the cryptographic operation using the cryptographic technique. Embodiments include writing, by the cryptographic agility system, data related to selecting the cryptographic technique to a secure digital ledger.

Abstract: The disclosure provides an approach for cryptographic agility. Embodiments include establishing, by a proxy component associated with a cryptographic agility system, a first secure connection with an application. Embodiments include receiving, by the proxy component, via the first secure connection, a communication from the application directed to an endpoint. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique based on contextual information related to the communication. Embodiments include establishing, by the proxy component, a second secure connection with the endpoint based on the cryptographic technique. Embodiments include transmitting, by the proxy component, a secure communication to the endpoint via the second secure connection based on the communication.

Abstract: The disclosure provides an approach for cryptographic agility. Embodiments include receiving a request from an application for a cryptographic operation, wherein the request is associated with a computing device. Embodiments include determining one or more resource constraints related to the computing device. Embodiments include selecting, based on the one or more resource constraints, a cryptographic technique from a plurality of cryptographic techniques associated with indications of resource requirements. Embodiments include performing the cryptographic operation using the cryptographic technique. Embodiments include providing a response to the application based on performing the cryptographic operation.

Abstract: Disclosed are methods of treating a disorder or disease associated with myotonic dystrophy. Methods of treating a CNS dysfunction and/or cognitive impairment associated with myotonic dystrophy in a subject comprising administering a therapeutically effective amount of a GABAA receptor antagonist or inverse agonist to the subject are disclosed. Methods of treating a myotonic dystrophy associated disease or disorder caused by mis-splicing of GABRG2 in a subject comprising administering a therapeutically effective amount of a GABAA receptor antagonist or inverse agonist to the subject are disclosed. Methods of improving cognitive function or alertness in a subject having myotonic dystrophy comprising administering a therapeutically effective amount of a GABAA receptor antagonist or inverse agonist to the subject are disclosed.

Abstract: Various embodiments include methods and diagnostic systems implementing the methods for determining a prognostic prediction of a likelihood of success or a likelihood of complications of an electrophysiology procedure at the identified area of electrophysiological interest.

Abstract: Methods of determining a final space reservation for a new aircraft are disclosed. The methods include using parametric definitions of potential payloads to generate a population of representative payloads for use in creating an initial space reservation. The methods include accounting for and applying a variety of margins on each potential payload and taking the union of potential payloads. Alternatively, the union can be taken first and then the margins applied. A homogenous space reservation can be determined based upon a variety of differently shaped or sized payloads, including a margin build-up to mitigate risk of unknowns associated with future changes in specific payload shapes and sizes, build tolerances, environmental conditions, and/or loading and unloading motions and clearances. Once this space reservation is known, it is possible to design an external shape of a carrying vehicle by staying outside of this space reservation.

Abstract: Described herein are modified fibroblast growth factor (FGF) polypeptides, pharmaceutical compositions and medicaments that include such modified FGF polypeptides, and methods of using such modified FGF polypeptides to treat or prevent conditions that benefit from administration of FGFs.

Abstract: Methods and systems are provided for electrical power distribution. In one example, a system includes plurality of electric consumers comprising one or more operating modes with different levels of power consumption, an energy storage and an electric machine arranged in the vehicle and configured to provide energy to the energy storage device or power to the electric consumers and torque to wheels of the vehicle, a power allocating device coupled to the energy storage device and the plurality of electric consumers, and a controller configured to maintain two indices for allocating power to the plurality of electric consumers, wherein a first index comprises a first power allocation strategy based on power from only the energy storage device and a second index comprises a second power allocation strategy based on power from the energy storage device and the electric machine.

Abstract: The present disclosure is directed to examples of a single modular heat spreader piece. In one example, the single modular heat spreader piece includes a body portion, wherein the body portion comprises a curved outer surface and a flange member coupled to a first side of the body portion, wherein the flange member has a curved outer edge, a connection member coupled to a second side of the body portion, wherein the second side of the body portion is opposite the first side, and a heat spreader member coupled to the second side of the body portion and on an opposite end of the body portion from the connection member.

Abstract: An oil field chemical-carrying material comprising polymeric particles and a process for making the same are disclosed. An oil field chemical is integrally incorporated into the granulated particle. The oil field chemical is in particular a tracer and the particle is in particular a proppant for use in hydraulic fracturing of a subterranean formation. Methods of delivering oil field chemicals, methods of monitoring subterranean formations, methods of tracing flow of fluid from hydrocarbon reservoirs and methods of hydraulic fracturing subterranean formations are also disclosed.

Abstract: The present invention provides methods of administering certain PD-1 binding agents to patients having cancer. Dosage regimens for compositions comprising a PD-1 binding agent are also explicitly provided.

Abstract: Methods of determining a final space reservation for a new aircraft are disclosed. The methods include using parametric definitions of potential payloads to generate a population of representative payloads for use in creating an initial space reservation. The methods include accounting for and applying a variety of margins on each potential payload and taking the union of potential payloads. Alternatively, the union can be taken first and then the margins applied. A homogenous space reservation can be determined based upon a variety of differently shaped or sized payloads, including a margin build-up to mitigate risk of unknowns associated with future changes in specific payload shapes and sizes, build tolerances, environmental conditions, and/or loading and unloading motions and clearances. Once this space reservation is known, it is possible to design an external shape of a carrying vehicle by staying outside of this space reservation.

Abstract: The disclosure provides antibody agents that bind to a Lymphocyte Activation Gene-3 (LAG-3) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using anti-LAG-3 antibody agents to treat a disorder or disease that is responsive to LAG-3 inhibition, such as, for example, cancer or an infectious disease.

Abstract: An oil field chemical-carrying material comprising polymeric particles and a process for making the same are disclosed. An oil field chemical is integrally incorporated into the granulated particle. The oil field chemical is in particular a tracer and the particle is in particular a proppant for use in hydraulic fracturing of a subterranean formation. Methods of delivering oil field chemicals, methods of monitoring subterranean formations, methods of tracing flow of fluid from hydrocarbon reservoirs and methods of hydraulic fracturing subterranean formations are also disclosed.

Abstract: A charged particle detector is provided. The charged particle detector includes a flexible semiconductor wafer, the semiconductor wafer being doped to form a p-n junction, and an amplifier coupled to the semiconductor wafer and configured to amplify a current or voltage across the p-n junction.

Abstract: The present invention relates to a method and apparatus for detecting radioactivity. In particular, but not exclusively, the present invention relates to the detection of radioactivity in a target fluid in a fluid communication passageway using a region of scintillator material (130) to provide light responsive to the presence of radioactive material and at least one silicon photomultiplier (SiPM) (150) for providing an output signal responsive to the light provided by the scintillator material.

Abstract: A method of operating a content management includes collecting or receiving data which relates to a user's behavior when using a digital content catalogue, and prior to the consumption of a content item. This collected or received data is processed and analyzed to create a data table which may be used to demonstrate to a content manager which items in the digital content catalogue are most difficult to discover in order that the catalogue be re-ordered appropriately. In this way, user behavior may be used to optimize digital content management systems. Once it is known, for a given digital content item, how discoverable, or indeed undiscoverable it is based on a user's behavior prior to consuming the content item, that item may be promoted to a more prominent location in the catalogue, or relocated to a different location so as to allow a user to more easily locate it.

Abstract: Various embodiments include a catheter positioning device that may include a sled member, a sled base, an active damping system, a sensor, and a control system. The sled member may be configured to accept a handle of a catheter. The sled base may be configured to move the sled member along a length of the sled base for positioning the catheter within a patient. The active damping system may be configured to apply a force to the sled base to resist movement of the sled base in response to a control signal. The sensor may be configured to generate signals in response to a movement of the sled base. The control system may be configured to receive sensor signals from the sensor and transmit control signals to cause the active damping system to apply the force to resist movement of the sled base indicated in the received sensor signals.