Abstract: Various embodiments include a catheter positioning device that may include a sled member, a sled base, an active damping system, a sensor, and a control system. The sled member may be configured to accept a handle of a catheter. The sled base may be configured to move the sled member along a length of the sled base for positioning the catheter within a patient. The active damping system may be configured to apply a force to the sled base to resist movement of the sled base in response to a control signal. The sensor may be configured to generate signals in response to a movement of the sled base. The control system may be configured to receive sensor signals from the sensor and transmit control signals to cause the active damping system to apply the force to resist movement of the sled base indicated in the received sensor signals.

Abstract: Various embodiments enable an introducer for a catheter to be rotated around an axis and/or traversed backward and/or forward along the axis. In various embodiments, positioning of an introducer may be enabled by an introducer support configured to be rotated around an axis and/or extended or retracted along the axis. The introducer may be manually operated and/or operated by motors in a nose cone of a catheter positioning system. In various embodiments, a portion of the introducer support may be configured to flex. In other embodiment, positioning of an introducer may be enabled by an adjustable nose cone of a catheter positioning system.

Abstract: The present invention provides methods of administering certain PD-1 binding agents to patients having cancer. Dosage regimens for compositions comprising a PD-1 binding agent are also explicitly provided.

Abstract: An imaging system is provided with an ultrasound catheter and a controller coupled to the ultrasound catheter. The catheter includes a localizer sensor configured to generate positional information for the ultrasound catheter, and an imaging ultrasound sensor having a restricted field of view. The controller co-registers images from the imaging ultrasound sensor with positional information from the localizer sensor.

Abstract: A process for cross-linking siloxane and organic polymers comprising reacting (a) a silyl hydride with (b) an unsaturated polymeric compound in the presence of (d) a platinum diene compound with a chelating dianionic ligand.

Abstract: The present disclosure relates to antibodies or fragments thereof that target at least one conformational epitope of a Notch 3 or mutant Notch 3 receptor; and compositions and methods of use thereof.

Abstract: The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: Method and apparatus of a network configuration configured to permit a dense wavelength division multiplexing (“DWDM”) element to connect to a storage server, an Internet Protocol (“IP”) router, and DWDM network are disclosed. The configuration includes the DWDM network, storage area network (“SAN”) server, IP router, and optical transport network (“OTN”) switch. While the DWDM network transports information via optical fibers, the DWDM switch is coupled to the DWDM network for transporting optical signals. The SAN server is coupled to a port of the DWDM switch and is configured to store data at a remote location. The IP router which is coupled to the DWDM switch facilitates IP traffic between a user and the DWDM network. The OTN switch, coupled to the first DWDM switch, is capable of processing at least a portion of the optical signals.

Abstract: A charged particle detector is provided. The charged particle detector includes a flexible semiconductor wafer, the semiconductor wafer being doped to form a p-n junction, and an amplifier coupled to the semiconductor wafer and configured to amplify a current or voltage across the p-n junction.

Abstract: The present invention relates to a method and apparatus for detecting radioactivity. In particular, but not exclusively, the present invention relates to the detection of radioactivity in a target fluid in a fluid communication passageway using a region of scintillator material (130) to provide light responsive to the presence of radioactive material and at least one silicon photomultiplier (SiPM) (150) for providing an output signal responsive to the light provided by the scintillator material.

Abstract: Method and apparatus of a network configuration configured to permit a dense wavelength division multiplexing (“DWDM”) element to connect to a storage server, an Internet Protocol (“IP”) router, and DWDM network are disclosed. The configuration includes the DWDM network, storage area network (“SAN”) server, IP router, and optical transport network (“OTN”) switch. While the DWDM network transports information via optical fibers, the DWDM switch is coupled to the DWDM network for transporting optical signals. The SAN server is coupled to a port of the DWDM switch and is configured to store data at a remote location. The IP router which is coupled to the DWDM switch facilitates IP traffic between a user and the DWDM network. The OTN switch, coupled to the first DWDM switch, is capable of processing at least a portion of the optical signals.

Abstract: Method and apparatus of a network configuration configured to permit a dense wavelength division multiplexing (“DWDM”) element to connect to a storage server, an Internet Protocol (“IP”) router, and DWDM network are disclosed. The configuration includes the DWDM network, storage area network (“SAN”) server, IP router, and optical transport network (“OTN”) switch. While the DWDM network transports information via optical fibers, the DWDM switch is coupled to the DWDM network for transporting optical signals. The SAN server is coupled to a port of the DWDM switch and is configured to store data at a remote location. The IP router which is coupled to the DWDM switch facilitates IP traffic between a user and the DWDM network. The OTN switch, coupled to the first DWDM switch, is capable of processing at least a portion of the optical signals.

Abstract: Various embodiments enable an introducer for a catheter to be rotated around an axis and/or traversed backward and/or forward along the axis. In various embodiments, positioning of an introducer may be enabled by an introducer support configured to be rotated around an axis and/or extended or retracted along the axis. The introducer may be manually operated and/or operated by motors in a nose cone of a catheter positioning system. In various embodiments, a portion of the introducer support may be configured to flex. In other embodiment, positioning of an introducer may be enabled by an adjustable nose cone of a catheter positioning system.

Abstract: A process for the hydrosilylation of an unsaturated compound comprising reacting (a) a silyl hydride with (b) an unsaturated compound in the presence of (c) a platinum based hydrosilylation catalyst comprising a platinum-diene complex with chelating anions. The use of the present catalysts in the process provides silylated products in good yields and allows for using lower platinum loadings than conventional catalysts, reduced cycle times, and may reduce yellowing in the product.

Abstract: Various embodiments enable an introducer for a catheter to be rotated around an axis and/or traversed backward and/or forward along the axis. In various embodiments, positioning of an introducer may be enabled by an introducer support configured to be rotated around an axis and/or extended or retracted along the axis. The introducer may be manually operated and/or operated by motors in a nose cone of a catheter positioning system. In various embodiments, a portion of the introducer support may be configured to flex. In other embodiment, positioning of an introducer may be enabled by an adjustable nose cone of a catheter positioning system.

Abstract: Various embodiments provide a catheter positioning device with components for controlling actuators of the catheter in multiple axes. A catheter may be attached to a sled member by a modular plate with one or more actuator interfaces that may couple with the actuators of a catheter handle. One or more motors or drives in the sled member may move the actuator interfaces of the modular plate to control one or more actuators on the catheter in different axes. In various embodiments the sled member may have a clam shell design in which two or more sides of the sled member close around the catheter handle. In further embodiments, the sled member may include adjustable faces that can fit different types of modular plates and thereby control actuators on different types of the catheter.

Abstract: A method according to an embodiment may be used to make a carbonated protein beverage composition for large quantity mass production purposes. The method includes flowing a liquid protein concentrate and water, and mixing them to form a beverage composition pre-mix. The temperature of the pre-mix is sensed, and the water temperature of the water prior to mixing with the flowing protein concentrate is controlled to maintain a substantially constant temperature of the beverage composition pre-mix. Carbonation is added to the temperature controlled pre-mix to form the carbonated protein beverage composition, which is then containerized.

Abstract: An emergency vision apparatus for providing an operator visual access to information during a smoke emergency, comprises an enclosure made of airtight material having spaced apart front and rear panels, the front panel being transparent, the front panel including fasteners for attachment to an instrument panel; an image capture device attached to said rear panel, the image capture device being oriented to view the instrument panel through the transparent front panel; an image viewing device for being disposed in front of one of the operator's eyes, the image viewing device being operably associated with the image capture device; and a support structure to support said viewing lens in front of one of the operator's eyes.

Abstract: The present invention provides curable compositions comprising non-tin metal accelerators that accelerate the condensation curing of moisture-curable silicones/non-silicones. In particular, the present invention provides an accelerator comprising amino acid compounds that are suitable as replacements for organotin in sealant and RTV formulations.

Abstract: The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit.