Abstract: A casing for a turbomachine is disclosed. The casing includes a casing body including an interior surface and an exterior surface. At least one sensor is coupled relative to the interior surface of the body, the at least one sensor at most only partially extending through the body. A communications lead is operatively coupled to the at least one sensor, and extends circumferentially along the interior surface of the body.

Abstract: The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitor enantiomers of formula (I), (Ia), (Ib), (II), (IIa), or (IIb), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, with high enantiomeric excess (% ee). The disclosure also relates to method of using the compound of formula (I), (Ia), (Ib), (II), (IIa), or (IIb), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

Abstract: The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

Abstract: A substrate for a reservoir having an aerosol former stored therein, the substrate comprising: a property modifying agent disposed on the substrate, wherein the substrate is configured to be received in the reservoir to contact the aerosol former, so as to facilitate a release of the property modifying agent from the substrate to the aerosol former, and wherein the substrate is insoluble in the aerosol former.

Abstract: A recyclable packaging film comprising a coextruded web having a high degree of optical clarity and a high level of moisture barrier. The coextruded web comprises a skin layer comprising polyethylene having a high degree of optical clarity and a heat sealant layer which forms an innermost layer of the packaging film, the heat sealant layer comprising a polyolefin polymer. The coextruded web also includes a moisture barrier layer which is disposed intermediate the skin layer and the heat sealant layer. An energy-cured coating is disposed on the skin layer of the coextruded web, wherein the energy-cured coating has a coating weight which is effective to impart a property in the packaging film selected from reduced susceptibility to melting, reduced susceptibility to stretching, or both.

Abstract: The present invention relates to a dispenser for dispensing a liquid, comprising: a reservoir for storing a liquid to be dispensed; a manually operative pump arrangement disposed at a first end region of the reservoir; a conduit extending from the pump arrangement to a second end region of the reservoir distal the first end region, the conduit configured for communicating reservoir contents from the second end region to the pump arrangement; a dispense conduit extending from the pump arrangement and comprising a dispense aperture at an end region thereof, the dispense aperture in liquid communication with the pump arrangement; and an open ended tube extending in a direction away from the pump arrangement and configured to surround the dispense conduit, wherein the open ended tube extends to a position such that the open end thereof is at least coterminous with an dispense aperture end of the dispense conduit and actuation of the pump arrangement causes transfer of reservoir contents from the reservoir to the

Abstract: Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-associated disorder or disease and methods of diagnosing a KIT-associated disorder or disease using the antibodies described herein.

Abstract: Composite transparent conductors are described, which comprise a primary conductive medium based on metal nanowires and a secondary conductive medium based on a continuous conductive film.

Abstract: This disclosure is directed to allocation of one or more radio bands to a user equipment (UE) for establishing a radio link with a radio node (e.g., eNodeB or gNodeB). The radio bands may include a shared band, such as citizens band radio service (CBRS), a primary licensed band, such as the B66 band, and/or an unlicensed band, such as B46 band. A radio communications system may consider a variety of parameters associated with the distance of a UE from a radio node, signal strength of a signal from the UE, the services requested by the UE, and/or spectral availability of the each of the radio bands to determine which radio band(s) to allocate to the UE. In some cases, the radio band allocated to a UE may be dynamically changed by the radio communications system as conditions related to the UE and/or the mobile network change.

Abstract: Systems, methods, and software are disclosed herein for facilitating enhanced canvas presentation environments. In an implementation, a user interacts with a touch-enabled display system capable of displaying items on a canvas. In response to a gesture made by the user with respect to an item being displayed, a format-specific interaction model is identified based on a format associated with the item. A response to the gesture may then be determined using the interaction model and the response rendered for display.

Abstract: The present invention relates to a system and assembly for refilling a reservoir with liquid dispensed from a dispenser, in particular, but not exclusively, to a system and assembly for the substantially leak-free refilling of the reservoir of a smoking-substitute device with a liquid comprising nicotine from a refill dispenser. The assembly is configured to provide a gas communication pathway through the assembly and physically separate from the liquid communication pathway for venting gas from an end of the assembly proximal the first aperture to an exterior of the assembly responsive to the movement of the assembly to the secured and open configuration, the assembly configured to close the gas communication pathway in the unsecured and closed configuration.

Abstract: The invention provides methods of making microparticle and nanoparticle ocular implants from a compositions comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent.

Abstract: Techniques for warm cloning of computing nodes are provided. A request to clone a first computing node is received. Upon determining that a first transaction of a plurality of transactions is ongoing, a first moment in time when data associated with the first transaction was coherent on the first computing node is identified. Tracking data related to the first transaction is collected, beginning at the first moment in time. Further, a first storage associated with the first computing node is copied to a second storage associated with a second computing node, where the first transaction continues during the copying. The tracking data related to the first transaction is then transmitted to the second computing node.

Abstract: A recyclable, laminated polyolefin-based film structure comprises two or more film plies laminated to each other. Each of the laminated film plies comprises one or more polyolefin-based films. The film structure has an energy-cured coating layer disposed on the outermost outward facing surface of the film structure and a printed ink layer on an interior surface of one of the polyolefin-based polyolefin layers. In certain embodiments, the outermost surface of the laminated polyolefin-based film structure has a melting temperature which is at least 100 degrees Celsius, and more preferably 180 degrees Celsius, higher than a melting temperature of the innermost surface of the laminated polyolefin-based film structure.

Abstract: A method for forming a weapon accessory mounting device to attach to a projectile firing weapon is disclosed. A flexure for receiving a body of the weapon accessory is formed. A pivot portion is formed at a first end of the flexure to attach the flexure to the weapon at a first attachment region. A second attachment portion is formed at a second end of the flexure to attach the flexure to the weapon at a second attachment region. A first aperture is formed in the pivot portion configured to receive a pivot pin. A second aperture in the weapon accessory body receives the pivot pin at a weapon accessory body first end to attach the weapon accessory body first end to the pivot portion. The pivot portion is configured to convert at least a portion of energy of a weapon shock recoil from translational energy to rotational energy.

Abstract: Embodiments of the present invention provide techniques, systems, and methods for remote, agent-less enterprise computer threat data collection, malicious threat analysis, and identification and reporting of potential and real threats present on an enterprise computer system. Specifically, embodiments are directed to a system that securely identifies and maps sensitive information from computers across the enterprise. Secure and sensitive information may be internally encrypted and analyzed for indicators of compromise, threatening behavior, and known vulnerabilities. The remote, agent-less collection, analysis, and identification process can be repeated periodically to detect and map additional sensitive information over time, and may delete itself after completion to avoid detection.

Abstract: A mounting system for a tool for machining a half-shell casing of a turbomachine is disclosed. The mounting system includes a base frame including a mounting element configured to fixedly mount the base frame to the half-shell casing, wherein the base frame spans at least a portion of the half-shell casing. A tool mount includes a first end pivotally coupled to the base frame to pivot about a pivot axis that is substantially parallel relative to an axis of the half-shell casing, and a second end configured to couple to and position the tool for machining the half-shell casing.

Abstract: The present application relates to the control and management of an energy system in coordination with a fluctuating energy market and, in one form provides a method for managing supply of energy to a number of energy consuming devices connected to a power distribution system of an energy supply system. The method may include the steps of: (1) monitoring one or more parameters affecting energy usage, (2) acquiring a first set of values based on the parameters, (3) calculating a set of predicted future values based on the first set of values, (4) identifying a context related to the first set of values, and (5) presenting control actions to increase efficiency of energy supply in response to the context.

Abstract: In embodiments, the ability to have two separate Db2 Mirror pair environments, each providing HA, which have the capability to switch application spaces between the Db2 Mirror pairs, is presented. At least one IASP is registered to a first node of a first pair of nodes at a first HA mirroring environment at a first location. The at least one IASP is replicated to a second HA mirroring environment, the second HA mirroring environment including a second pair of nodes at a second location, the second location different than the first location. The at least one IASP is registered with one node of the pair of nodes of the second mirroring environment, the at least one IASP is switched offline at the first pair of nodes of the first mirroring environment, and subsequently switched online at the second pair of nodes of the second mirroring environment.