Abstract: Gasket assemblies and related system and methods. An apparatus includes a system, a flow cell, and a plurality of gasket assemblies. The system includes a flow cell interface and the flow cell has one or more channels. Each channel has a first channel opening and a second channel opening. The first channel openings are positioned at a first end of the flow cell and the second channel openings are positioned at a second end of the flow cell. A gasket assembly coupled at each second channel opening. Each gasket assembly includes an adhesive stack and a gasket. The adhesive stack includes a first side bonded to the gasket and a second side bonded to the flow cell. The flow cell interface is engagable with the corresponding gaskets to establish a fluidic coupling between system and the flow cell.

Abstract: Provided are systems and methods for predicting a travel range of a vehicle. The method comprises receiving, using at least one processor, travel information associated with the vehicle, receiving, using the at least one processor, a weather forecast and a traffic forecast associated with the travel information, and predicting, using the at least one processor, the predicted travel range based at least in part on a battery charge level of the vehicle, the weather forecast, and the traffic forecast. In embodiments, the predicted travel range may be based on current and historical battery charge levels, current and/or historical battery discharge rates, weather forecast data, and traffic forecast data.

Abstract: A processing system includes a processor core for processing instructions and a memory that stores a page table set including an extended page table having an extended page table entry storing extended page table attributes associated with a physical memory page. The system receives a virtual address and translates the virtual address to a physical address for the physical memory page. One or more extended page attributes associated with the physical memory page are retrieved from the extended page table entry based on the virtual address.

Abstract: A processor implements a simultaneous multithreading (SMT) protection mode that, when enabled, prevents execution of particular software (e.g., a virtual machine) at a processor core when a thread associated with different software (e.g., a different virtual machine or a hypervisor) is currently executing at the processor core. By preventing execution of the software, data, software execution patterns, and other potentially sensitive information is kept protected from unauthorized access or detection. Further, in at least some embodiments the SMT protection mode is implemented on a per-software basis, so that different software can choose whether to implement the protection mode, thereby allowing the processor to be employed in a wide variety of computing environments.

Abstract: A computing system may implement a split random number generator that may use a random number generator to generate and store seed values in a memory for retrieval and use by one or more core processors to generate random numbers for secure processes within each core processor.

Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind ILT3, including human ILT3, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.

Abstract: Gasket assemblies and related system and methods. An apparatus includes a system, a flow cell, and a plurality of gasket assemblies. The system includes a flow cell interface and the flow cell has one or more channels. Each channel has a first channel opening and a second channel opening. The first channel openings are positioned at a first end of the flow cell and the second channel openings are positioned at a second end of the flow cell. A gasket assembly coupled at each second channel opening. Each gasket assembly includes an adhesive stack and a gasket. The adhesive stack includes a first side bonded to the gasket and a second side bonded to the flow cell. The flow cell interface is engagable with the corresponding gaskets to establish a fluidic coupling between system and the flow cell.

Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind ILT2, ILT4, or both ILT2 and ILT4, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.

Abstract: Restricting peripheral device protocols in confidential compute architectures, the method including: receiving a first address translation request from a peripheral device supporting a first protocol, wherein the first protocol supports cache coherency between the peripheral device and a processor cache; determining that a confidential compute architecture is enabled; and providing, in response to the first address translation request, a response including an indication to the peripheral device to not use the first protocol.

Abstract: A method for generating three dimensional indicators for the visually impaired. The method includes selecting one or more pre-designed symbols from a plurality of pre-designed symbols. The pre-designed symbols represent standard building layout features and are sized to be readable via a physical touch. The method further includes inserting the one or more selected symbols into a two dimensional digital layout, and generating one or more of an orientation object and a legend object into the two dimensional digital layout. The method further includes converting the two dimensional digital layout into a three dimensional digital model, and generating an output file including the three dimensional model in a format compatible with a three dimensional printing device.

Abstract: A virtualized computing environment is protected from a malicious hypervisor by restricting the hypervisor's access to one or more portions of an event (interrupt or exception) handling pathway of a guest virtual machine, wherein the guest virtual machine includes both a secure layer to manage security for the guest and one or more non-secure layers to handle event processing. The hypervisor is restricted from providing normal exception information to the guest virtual machine (referred to simply as a “guest” herein), and instead is only permitted to provide an event signal to the secure layer of the guest. In response to the event signal, the secure layer of the guest accesses a specified region of memory for the event information, reviews the information, and provides the information to another, non-secure, layer of the guest for processing only if the event information complies with specified security protocols.

Abstract: A load/store unit includes a first queue including a first entry for a store operation and a second queue including a second entry for a load operation that includes a return instruction that redirects a program flow to a location indicated by the return instruction. The load/store unit also includes a processor to determine that the store operation matches the load operation and selectively perform store-to-load forwarding (STLF) of a return address for the return instruction from the first entry to the second entry based on whether the store operation is associated with a call instruction. The load/store unit forwards the return address to the second entry in response to the store operation being associated with the call instruction. The load/store unit blocks forwarding until the store operation retires in response to the store operation not being associated with the call instruction.

Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind ILT2, ILT4, or both ILT2 and ILT4, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.

Abstract: A processing system includes a branch prediction structure storing information used to predict the outcome of a branch instruction. The processing system also includes a register storing a first identifier of a first process in response to the processing system changing from a first mode that allows the first process to modify the branch prediction structure to a second mode in which the branch prediction structure is not modifiable. The processing system further includes a processor core that selectively flushes the branch prediction structure based on a comparison of a second identifier of a second process and the first identifier stored in the register. The comparison is performed in response to the second process causing a change from the second mode to the first mode.

Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind ILT3, including human ILT3, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.

Abstract: The present invention provides animal cells that have been engineered to express one or more viral antigens. The engineered cells can be formulated into cultured meat products that can be used as edible vaccines.

Abstract: A processor core executes a first process. The first process is associated with a first context tag that is generated based on context information controlled by an operating system or hypervisor of the processing system. A branch prediction structure selectively provides the processor core with access to an entry in the branch prediction structure based on the first context tag and a second context tag associated with the entry. The branch prediction structure selectively provides the processor core with access to the entry in response to the first process executing a branch instruction. Tagging entries in the branch prediction structure reduces, or eliminates, aliasing between information used to predict branches taken by different processes at a branch instruction.

Abstract: Restricting peripheral device protocols in confidential compute architectures, the method including: receiving a first address translation request from a peripheral device supporting a first protocol, wherein the first protocol supports cache coherency between the peripheral device and a processor cache; determining that a confidential compute architecture is enabled; and providing, in response to the first address translation request, a response including an indication to the peripheral device to not use the first protocol.

Abstract: The present disclosure provides binding agents that modulate the interaction between liver-expressed antimicrobial peptide 2 (LEAP2) and growth hormone secretagogue receptor (GHSR). Specifically, the present disclosure provides binding agents, such as LEAP2 peptides that bind GHSR and methods of their use to treat or ameliorate a neuroendocrine and/or metabolic disease or disorder such as obesity, diabetes, acromegaly, gigantism and/or Prader-Willi syndrome. The present disclosure also provides binding agents, such as antibodies, that bind LEAP2, and methods of their use to, e.g., treat or ameliorate a neuroendocrine and/or metabolic disease or disorder such as cachexia, anorexia, or other wasting syndromes, increase growth hormone levels, or increase GHSR activity.

Abstract: Gasket assemblies and related system and methods. An apparatus includes a system, a flow cell, and a plurality of gasket assemblies. The system includes a flow cell interface and the flow cell has one or more channels. Each channel has a first channel opening and a second channel opening. The first channel openings are positioned at a first end of the flow cell and the second channel openings are positioned at a second end of the flow cell. A gasket assembly coupled at each second channel opening. Each gasket assembly includes an adhesive stack and a gasket. The adhesive stack includes a first side bonded to the gasket and a second side bonded to the flow cell. The flow cell interface is engagable with the corresponding gaskets to establish a fluidic coupling between system and the flow cell.