Abstract: The present application discloses a compound which is which activates Wnt/?-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

Abstract: A closed suction system module is provided. In one embodiment, the closed suction system module includes a coupling member configured to couple to a suction port of a multi-port manifold or endotracheal tube adapter (e.g., dual-port or tri-port adapter). In one embodiment, the closed suction system module includes a suction catheter configured to clean the interior surfaces of body-inserted tubes or artificial airways (alone or in addition to suctioning natural airways or portions of the respiratory tract or other body lumens). The suction catheter may include a cleaning portion at a distal portion of the suction catheter (e.g., near the distal end or tip of the suction catheter). In some embodiments, the cleaning portion includes at least one expandable cleaning member (e.g., balloon, sleeve, wiper).

Abstract: An endotracheal tube stabilizer comprising a stabilization bar; and a tube cradle comprising a first component having a concave portion, the first component coupled to the stabilization bar; a second component having a concave portion; and a securing element adapted to selectively maintain the first component at a fixed location relative to the second component, wherein the first and second components are adapted to translate toward one another in a linear direction transverse to the concave portions.

Abstract: A respiratory mask assembly includes a frame having a channel and a cushioning element including a clip portion adapted for interference seal and retention in the channel. The cushioning element includes an interfacing portion constructed from foam and having a wider width than the clip portion.

Abstract: A novel and useful acknowledgement and adaptive frequency hopping mechanism for use in wireless communication systems such as IO-Link Wireless. One or two additional acknowledgement bits are added to packet transmissions. One is a current acknowledgment bit which indicates whether a packet was successfully received anytime during the current cycle. The second bit is a previous acknowledgment bit which indicates whether packets were received successfully anytime during the previous cycle. An adaptive hopping table is constructed using a greedy algorithm which chooses frequencies with the best PER for transmission of higher priority packets, while equalizing the PER products across cycles. A last resort frequency mechanism further improves transmission success by switching to a better performing channel for the last subcycle when previous attempts to transmit a high priority packet have failed.

Abstract: Methods for loading a module on a plurality of device types without modification includes initializing an application native to the client device, the application including a web browser; determining a module to be loaded on the application, the module written in a web-based format and having a set of dependencies indicated within a code thereof; and loading the determined module on the web browser for recognition by the application native to the client device. The loading the determined module on the web browser includes loading the set of dependencies of the module.

Abstract: A system for installing replacement plungers in plunger pumps used in the hydrocarbon industry includes an elongated, cylindrical plunger body with an elongated circular tube disposed around the cylindrical plunger body. An end wall having an aperture encloses one end of the tube with an axially movable plate adjacent the end wall between the end wall and an end of the plunger body. A removable cap is mounted to the opposite end of the tube to enclose the plunger body within the tube. The outer diameter of the tube fits in the plunger bore of a pump. To install the replacement plunger, the cap is removed and the tube is inserted into the plunger bore until the tube abuts packing within the tube. Once positioned, an axial force is applied to the movable plate to urge the plunger body from the tube and into engagement with the packing.

Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.

Abstract: Indazole compounds for treating various diseases and pathologies are provided. More particularly, the use of an indazole compound or analogs thereof, in the treatment of inflammatory diseases or disorders is provided.

Abstract: Provided are compositions and methods for treating osteoarthritis including intra-articular administration of a compound of Formula (I) including amorphous and polymorph forms thereof.

Abstract: An absorbent article selected from a sanitary napkin, an incontinence pad and a pantyliner, comprising a topsheet layer a backsheet layer a fastening adhesive applied on the backsheet garment facing surface, wherein at least a portion of said fastening adhesive (PFA) is applied in a pattern and wherein said backsheet layer is a plastic film having a basis weight of less than 20 gsm.

Abstract: Systems and methods for magnetic field-dependent relaxometry using magnetic resonance imaging (“MRI”) are provided. Relaxation parameters, including longitudinal relaxation time (“T1”) and transverse relaxation time (“T2”), are estimated from magnetic resonance signal data acquired at multiple different magnetic field strengths using the same MRI system. By measuring these relaxation parameters as a function of magnetic field strength, T1 dispersion data, T2 dispersion data, or both, are generated. Based on this dispersion data, quantitative physiological parameters can be estimated. As one example, iron content can be estimated from T2 dispersion data.

Abstract: A valve assembly having a valve body, a hardened insert, a sealing insert, and a carrier. The hardened insert is cylindrical and comprises a primary sealing surface. The sealing insert is cylindrical and comprises an initial sealing surface. The carrier has an inside surface. The hardened insert and the sealing insert are coupled to the carrier. In a closed configuration of the valve assembly, the valve body contacts the primary sealing surface of the hardened insert and the initial sealing surface of the sealing insert to prevent fluid flow through the valve assembly, and in an open configuration, the valve body is separated from the primary sealing surface of the hardened insert and the initial sealing surface of the sealing insert to allow fluid flow through the valve assembly.

Abstract: A system may include a first network device configured to communicate via an encrypted session, and a second network device configured to communicate with the first network device via the encrypted session, where the second network device may be configured to perform operations to facilitate communication via the encrypted session. The operations may include receive a first set of data from a device other than the first network device, where the first set of data is used to communicate via the encrypted session. The operations may also include combine peer-to-peer information to be used by the first network device to communicate via the encrypted session to an encrypted packet, where the peer-to-peer information is combined with the encrypted packet in an unencrypted form. The operations may additionally include send the encrypted packet with the peer-to-peer information to the first network device.

Abstract: Methods, systems, and media for providing media guidance with contextual controls are provided. In some embodiments, the method comprises: causing a user interface to be presented that includes media interface elements, wherein each of the media interface elements is a selectable object that represents at least one media content item; determining that a media interface element from the media interface elements has been selected; in response to determining that the media interface element has been selected, causing the at least one media content item corresponding to the selected media interface element to be presented in a portion of the user interface; and concurrently with causing the at least one media content item to be presented, causing a control interface to be presented that is associated with the selected media interface element.

Abstract: Aspects of the present disclosure involve a system comprising a computer-readable storage medium storing at least one program and a method for navigating an avatar based on time zones. A global event is identified that begins at a particular time on a given date; a sequential list of time zones associated with a plurality of geographical locations is retrieved; and a current time at a first time zone of the sequential list of time zones is determined to have reached the particular time on the given date. In response, an avatar is generated for display on a map at a first of the plurality of geographical locations associated with the first time zone and is navigated to a second geographical location when a current time at a second time zone, associated with the second geographical location, reaches the particular time on the given date.

Abstract: A respiratory mask assembly includes a frame having a channel and a cushioning element including a clip portion adapted for interference seal and removable retention in the channel. The cushioning element includes an interfacing portion constructed from foam and adapted to contact the patient's face in use. The interfacing portion may have a wider width than the clip portion.

Abstract: A method for providing notifications to a patient associated with a mobile device is provided. The method includes receiving and storing information related to a scheduled visit to the healthcare services facility, determining a first notification based upon the information related to the scheduled visit, and outputting the first notification to the mobile device. The first notification is further based upon the medical history of the patient, the insurance network of the patient, where the patient lives and works, the price information of the healthcare service being performed for the patient, preferences of the patient, the knowledge and skill and self-confidence of the patient to manage healthcare, and the location of the healthcare services facility and patient and a geofenced area indicating that the patient is in close proximity to the healthcare services facility when entered into by the mobile device associated with the patient.

Abstract: A valve assembly having a valve body, a hardened insert, a sealing insert, and a carrier. The hardened insert is cylindrical and comprises a primary sealing surface. The sealing insert is cylindrical and comprises an initial sealing surface. The carrier has an inside surface. The hardened insert and the sealing insert are coupled to the carrier. In a closed configuration of the valve assembly, the valve body contacts the primary sealing surface of the hardened insert and the initial sealing surface of the sealing insert to prevent fluid flow through the valve assembly, and in an open configuration, the valve body is separated from the primary sealing surface of the hardened insert and the initial sealing surface of the sealing insert to allow fluid flow through the valve assembly.

Abstract: A laser-welded assembly of opposing sheets of ceramic and glass, ceramic, or glass-ceramic compositions comprises an intervening bonding layer having a thickness dimension that separates the opposing sheets by less than about 1000 nm. Each of the opposing sheets has a thickness dimension at least about 20 times the thickness dimension of the intervening bonding layer. The intervening bonding layer has a melting point greater than that of one or both of the opposing sheets. The ceramic sheet is a pass-through sheet with a composite T/R spectrum comprising a portion that lies below about 30% across a target irradiation band residing at or above about 1400 nm and at or below about 4500 nm wavelength. The intervening bonding layer has an absorption spectrum comprising a portion that lies above about 80% across the target irradiation band. The assembly comprises a weld bonding the opposing surfaces of the opposing sheets.