Abstract: A fluid injector system for delivering a multi-phase fluid injection to a patient and methods of fluid delivery is disclosed. Methods of creating and using a multi-aspect fluid path impedance model of the injector system are used. Modeling and adjustment of factors that affect impedance and prevent or reduce backflow, reduce the likelihood of fluid flow rate spikes and provide more accurate flow rates and mixing ratios of fluids may be repeated or happen essentially continuously during an injection. The adjustments may be determined before the injection or determined and/or adjusted during the injection. The determination may include sensor feedback commonly used in injectors such as pressure and position feedback as well as other sensors. In all cases, the user can be notified of adjustments through on-screen notices and/or through the recordation of the injection data by a control device of the injector at the conclusion of the injection.

Abstract: The present invention relates to treatments of hereditary angioedema (HAE). In particular, the present invention provides on-demand treatments of hereditary angioedema (HAE) by orally administering a plasma kallikrein inhibitor to a patient in need thereof on-demand.

Abstract: An electronic gaming device including a display device, a memory device storing instructions, and a processor in communication with the display device and the memory device is described. The instructions, when executed by the processor, cause the processor to cause display of a plurality of symbols, present an output amount, determine that the plurality of symbols includes a plurality of consolidating symbols, cause display of the plurality of consolidating symbols consolidating into a consolidated symbol, fill any vacant symbol positions with new symbols, determine a second output amount, and present the second output amount. The instructions also cause the processor to cause display of a third plurality of symbols, the third plurality of symbols and the consolidated symbol defining a fourth plurality of symbols, determine a third output amount based upon the fourth plurality of symbols, and present the third output amount.

Abstract: Disclosed are video slot games, including Class II and III gaming machines and systems, comprising a five reel video (5RV) arrangement that includes metamorphic symbols that incrementally expand, enlarge, balloon, widen, lengthen, or grow, e.g., when the metamorphic symbol lands on a predetermined position, or a winning payline, and that communicate the effect to the player of the incremental growth or increase in size by providing an enhanced user interface with information about the player's progress toward a potential special awards or status. The metamorphic symbols may incrementally expand, enlarge, balloon, widen, lengthen, or grow with each successive winning land, and may, in some examples, ultimately snap, crack, pop, deflate, or explode, while optionally deforming adjacent presentations to provide various award enhancements.

Abstract: An electronic gaming machine includes a processor configured to control at least one display device to display at least one of a matrix of symbol positions and a plurality of multipliers, and to evaluate a bingo card to determine a bingo game outcome. The processor is also configured to evaluate a bingo card to determine a bingo game outcome, and to determine whether the bingo game outcome is a winning outcome. If the bingo game outcome is a winning outcome, the processor is also configured to determine an award value associated with the winning outcome, and to obtain an award quotient based at least in part on the award value and a value of at least one multiplier of the plurality of multipliers. In addition, the processor is configured to determine a winning reel outcome associated with the award quotient, where the winning reel outcome includes a winning plurality of symbols.

Abstract: An electronic gaming device includes a display device and a game controller in communication with the display device. The game controller includes a processor and a memory storing instructions, which when executed by the processor, cause the game controller to: cause display of a base game including a plurality of reels; control the plurality of reels to display a combination of symbols corresponding to a primary game outcome; determine that the primary game outcome satisfies a bonus game condition and an enhancement condition to trigger a bonus game having at least one enhanced characteristic; identify outcomes for one or more free spins of the bonus game having the at least one enhanced characteristic; randomly select an outcome for each free spin from the identified outcomes; and initiate the bonus reel game that includes display of the randomly selected outcome for each of the one or more free spins.

Abstract: A mass spectrometer comprising: a vacuum housing comprising a first vacuum chamber having a first gas exhaust port; a gas pump (1700) having a first gas inlet port connected to the first gas exhaust port (H1) by a first gas conduit for evacuating the first vacuum chamber, and a first apertured cover (2010) arranged over the first gas exhaust port (H1) or first gas inlet port, or in the first gas conduit therebetween.

Abstract: A slot type game with one or more dynamic paylines and/or dynamic payline modifiers includes a grid or matrix of symbols for which one or more symbol outcomes may be determined and presented. In embodiments with a dynamic payline, the slot type game also includes a payline determination for which a payline outcome may be determined and presented. The payline outcome may correspond to positions of symbols in the grid or matrix and may determine whether or not the corresponding symbols in the grid or matrix are winners. In embodiments with a dynamic payline modifier, the slot type game also includes a payline modifier for which a payline modifier outcome may be determined and presented. The payline modifier outcome may correspond to positions of symbols in one or more paylines and may determine whether or not the one or more paylines and/or symbols are modified.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: Embodiments of the disclosure provide an electronic gaming machine, systems and methods with a wheel feature mode dependent on base game outcomes. Specifically, a gaming machine comprises a user interface, a display device, and a game controller. The wheel feature mode is triggered during a base game based on wheel feature mode trigger conditions. The wheel feature mode animates a graphical user interface to present a spinning feature wheel that provides credit value awards, dependent on base game outcomes (e.g., one or more base game bingo pattern outcomes), through a sequence of player-initiated feature wheel spins. If one or more winning base game outcomes remain in the base game, the wheel feature mode continues with each wheel slice value reset, such that the minimum wheel slice value is equal to or greater than the previous spinning feature wheel credit value award which continues until no winning base game outcomes remain.

Abstract: An electronic gaming machine includes a game controller configured to execute instructions stored in a tangible, non-transitory, computer-readable storage medium, which, when executed by the game controller, cause the game controller to at least: (i) simulate spinning and stopping a first plurality of reels to display a first plurality of symbols from each reel of the first plurality of reels, wherein, while the first plurality of reels are spinning, a second plurality of reels are held stationary; (ii) determine whether the first plurality of symbols include at least one trigger symbol; and (iii) simulate spinning and stopping, in response to the at least one trigger symbol, the second plurality of reels to display a second plurality of symbols from each reel of the second plurality of reels, wherein, while the second plurality of reels are spinning, the first plurality of reels are held stationary.

Abstract: Wagering gaming systems, devices, and methods are presented. A gaming device includes a credit input mechanism, a player interface mechanism, a display, and a controller. The credit input mechanism receives a physical item representing a monetary value and increases a credit balance of a credit meter based on the monetary value of the received physical item. The display includes symbol positions arranged in an array of rows and columns. During game play, the controller is further configured to display symbols selected from the set of symbols on the array. The symbol set includes a plurality of image segments that form a contiguous image when they are displayed in a predetermined arrangement on the array of symbol positions. The controller makes an award or triggers an event, such as a bonus game, if the displayed symbols include the plurality of image segments arranged to display the contiguous image. Numerous additional aspects are disclosed.

Abstract: A composite drug delivery material may be injected into an eye of a human being or mammal to provide sustained delivery of the drug. A composite drug delivery material may include a plurality of microparticles dispersed in a media composition. The microparticles may contain a drug and a coating comprising a bioerodible material or a biodegradable material, and the media composition includes the drug dispersed in a depot-forming material. The media composition may gel or solidify upon injection into the eye.

Abstract: Embodiments of the disclosure provide an electronic gaming machine, systems and methods with a wheel feature mode dependent on base game outcomes. Specifically, a gaming machine comprises a user interface, a display device, and a game controller. The wheel feature mode is triggered during a base game based on wheel feature mode trigger conditions. The wheel feature mode animates a graphical user interface to present a spinning feature wheel that provides credit value awards, dependent on base game outcomes (e.g., one or more base game bingo pattern outcomes), through a sequence of player-initiated feature wheel spins. If one or more winning base game outcomes remain in the base game, the wheel feature mode continues with each wheel slice value reset, such that the minimum wheel slice value is equal to or greater than the previous spinning feature wheel credit value award which continues until no winning base game outcomes remain.

Abstract: An electronic gaming machine includes a game controller configured to execute instructions stored in a tangible, non-transitory, computer-readable storage medium, which, when executed by the game controller, cause the game controller to at least: (i) simulate spinning and stopping a first plurality of reels to display a first plurality of symbols from each reel of the first plurality of reels, wherein, while the first plurality of reels are spinning, a second plurality of reels are held stationary; (ii) determine whether the first plurality of symbols include at least one trigger symbol; and (iii) simulate spinning and stopping, in response to the at least one trigger symbol, the second plurality of reels to display a second plurality of symbols from each reel of the second plurality of reels, wherein, while the second plurality of reels are spinning, the first plurality of reels are held stationary.

Abstract: Wagering gaming systems, devices, and methods are presented. A gaming device includes a credit input mechanism, a player interface mechanism, a display, and a controller. The credit input mechanism receives a physical item representing a monetary value and increases a credit balance of a credit meter based on the monetary value of the received physical item. The display includes symbol positions arranged in an array of rows and columns. During game play, the controller is further configured to display symbols selected from the set of symbols on the array. The symbol set includes a plurality of image segments that form a contiguous image when they are displayed in a predetermined arrangement on the array of symbol positions. The controller makes an award or triggers an event, such as a bonus game, if the displayed symbols include the plurality of image segments arranged to display the contiguous image. Numerous additional aspects are disclosed.

Abstract: An electronic gaming device including a display device, a memory device, and a game controller including a processor is described. The processor is configured to determine a total output amount for an electronic game, determine a display sequence of a plurality of display sequences stored in the memory device and associated with the output amount, and control display of the base display pattern in a first display area on the display device. The processor is also configured to control display of a first feature display pattern of the plurality of feature display patterns in a second display area on the display device, and control sequential display of each remaining feature display pattern in the second display area, wherein each at least one symbol in each subsequent feature display pattern is associated with an output amount greater than or equal to any currently displayed at least one symbol.

Abstract: An electronic gaming machine includes a display, a credit input mechanism, and a processor configured to perform operations comprising: (i) initiating a free play bonus game; (ii) awarding, during the free play bonus game, a plurality of free spins of a plurality of reels; (iii) displaying, on the display, a plurality of numerical indicia, the plurality of numerical indicia displayed one at a time and increasing from an initial numerical indicium associated with an initial free spin to a final numerical indicium associated with a final free spin; and (iv) providing a game award in conjunction with the final free spin.

Abstract: A free spin count-up bonus game and a subsequent banked free spin count-down secondary bonus game are described herein. The free spin count-up game may be triggered during play of a base game. A numerical indicium may be provided. During the free spin count-up bonus game, the indicium may count up from an initial value to a final value. When the indicium reaches a maximum or final value, the value may be regarded as indicating a number of “banked” free spins. The number of banked free spins may be compared to one or more threshold values. If the number of banked dree spins is greater than or equal to one or more threshold values and there is a successful outcome on a random determination, a secondary bonus game may be initiated, during which the indicium is decremented from the final value back down toward the initial value.

Abstract: An electronic gaming device includes a display device and a processor configured to execute instructions stored in a memory device. When executed, the instructions cause the processor to at least initiate a primary bonus game in response to a free play trigger condition being satisfied during a base game and determine a number of free spins of a plurality of reels for use during the primary bonus game. The instructions further cause the processor to control the display device to simulate spinning and stopping the plurality of reels in conjunction with sequentially counting up from an initial numerical indicium to a final numerical indicium in association with spinning the plurality of reels according to the determined number of free spins and initiate a secondary bonus game that includes a free spin count-down from the final numerical indicium to the initial numerical indicium.