Patents by Inventor David A. Mills

David A. Mills has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODUCTION OF BIOACTIVE OLIGOSACCHARIDES
    Publication number: 20220042057
    Abstract: Methods of generating oligosaccharides are provided.
    Type: Application
    Filed: June 21, 2021
    Publication date: February 10, 2022
    Inventors: Matthew J. AMICUCCI, Dayoung PARK, Ace Gita GALERMO, David A. MILLS, John Bruce GERMAN, Carlito B. LEBRILLA
  • ENZYMES AND METHODS FOR CLEAVING N-GLYCANS FROM GLYCOPROTEINS
    Publication number: 20210308235
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: April 16, 2021
    Publication date: October 7, 2021
    Inventors: Daniel GARRIDO, J. Bruce GERMAN, Carlito B. LEBRILLA, David A. MILLS
  • Production of bioactive oligosaccharides
    Patent number: 11066684
    Abstract: Methods of generating oligosaccharides are provided.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: July 20, 2021
    Assignee: The Regents of the University of California
    Inventors: Matthew J. Amicucci, Dayoung Park, Ace Gita Galermo, David A. Mills, John Bruce German, Carlito B. Lebrilla
  • Enzymes and methods for cleaving n-glycans from glycoproteins
    Patent number: 11000576
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: May 11, 2021
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Garlito B. Lebrilla, David A. Mills
  • HIGH-FREQUENCY RECIPROCAL TRANSDUCER CALIBRATION
    Publication number: 20210096018
    Abstract: A high-frequency dynamic pressure transducer calibration system and method is provided. The method directs a source onto a diaphragm of a dynamic pressure transducer. An oscillating voltage at a target frequency (or range of frequencies) is generated. The oscillating voltage is coupled to an electrical connector of the dynamic pressure transducer. A deflection pattern of the diaphragm is recorded. The dynamic pressure transducer is calibrated by correlating magnitude of the deflection pattern with the oscillating voltage as a function of the target frequency (or range of frequencies).
    Type: Application
    Filed: September 29, 2020
    Publication date: April 1, 2021
    Inventors: Mark Sheplak, David A. Mills
  • Compositions and methods relating to the treatment of cancer, autoimmune disease, and neurodegenerative disease
    Patent number: 10927075
    Abstract: Described herein are methods and compositions relating to the treatment of e.g., cancer, autoimmune disease, immune deficiency, and/or neurodegenerative disease. In some embodiments, the methods of treatment relate to administering a compound as described herein. In some embodiments, the subject treated according to the methods described herein is a subject determined to have an increased level of DNA damage.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: February 23, 2021
    Assignee: THE JACKSON LABORATORY
    Inventors: Kevin David Mills, Muneer Gulamhusein Hasham
  • Bovine milk oligosaccharides
    Patent number: 10918653
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: February 16, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • REDUCTION OF MILK GLYCANS AND THEIR DEGRADATION PRODUCTS IN THE NEONATE GUT
    Publication number: 20200405788
    Abstract: Methods of reducing milk glycans, and thus enteric pathogens that use such glycans as carbon sources, in the gut of nursing mammals.
    Type: Application
    Filed: August 18, 2020
    Publication date: December 31, 2020
    Inventors: David A. MILLS, Steven A. FRESE
  • ACTIVATED BIFIDOBACTERIA AND METHODS OF USE THEREOF
    Publication number: 20200397837
    Abstract: Some embodiments of the invention include a composition and method for treating dysbiosis in infants. The composition may include a mixture of activated bifidobacteria and a complex oligosaccharide wherein the complex oligosaccharide may be derived from a human or non-human source.
    Type: Application
    Filed: June 8, 2020
    Publication date: December 24, 2020
    Inventors: David KYLE, David MILLS, Samara FREEMAN-SHARKY
  • ENZYMES AND METHODS FOR CLEAVING N-GLYCANS FROM GLYCOPROTEINS
    Publication number: 20200345818
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: May 11, 2020
    Publication date: November 5, 2020
    Inventors: Daniel GARRIDO, J. Bruce GERMAN, Carlito B. LEBRILLA, David A. MILLS
  • Reduction of milk glycans and their degradation products in the neonate gut
    Patent number: 10780136
    Abstract: Methods of reducing milk glycans, and thus enteric pathogens that use such glycans as carbon sources, in the gut of nursing mammals.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: September 22, 2020
    Assignee: The Regents of the University of California
    Inventors: David A. Mills, Steven A. Frese
  • COMPOSITIONS THAT METABOLIZE OR SEQUESTER FREE SUGAR MONOMERS AND USES THEREOF
    Publication number: 20200237836
    Abstract: Compositions comprising at least two non-pathogenic microbes are described herein. The non-pathogenic microbes may be from a first species capable of internalizing and/or metabolizing dietary glycans and/or from a second species capable of consuming and metabolizing free sugar monomers. Methods of making and use in treating and/or preventing the overgrowth of pathogenic bacteria in mammals are also described herein.
    Type: Application
    Filed: November 6, 2019
    Publication date: July 30, 2020
    Inventors: David KYLE, David Mills, Carlito Lebrilla, Samara Freeman-sharkey, Steven Frese
  • Activated bifidobacteria and methods of use thereof
    Patent number: 10716816
    Abstract: Some embodiments of the invention include a composition and method for treating dysbiosis in infants. The composition may include a mixture of activated bifidobacteria and a complex oligosaccharide wherein the complex oligosaccharide may be derived from a human or non-human source.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: July 21, 2020
    Assignee: EVOLVE BIOSYSTEMS INC.
    Inventors: David Kyle, David Mills, Samara Freeman-Sharkey
  • Enzymes and methods for cleaving N-glycans from glycoproteins
    Patent number: 10688160
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: June 23, 2020
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • Enzymes and methods for cleaving N-glycans from glycoproteins
    Patent number: 10639357
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: May 5, 2020
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • BOVINE MILK OLIGOSACCHARIDES
    Publication number: 20200078384
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Application
    Filed: October 29, 2019
    Publication date: March 12, 2020
    Inventors: J. Bruce GERMAN, David MILLS, Carlito B. LEBRILLA, Daniela BARILE, Riccardo LoCASCIO
  • TECHNIQUES FOR NEUROMODULATION
    Publication number: 20200054228
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell.
    Type: Application
    Filed: October 31, 2017
    Publication date: February 20, 2020
    Inventors: Christopher Michael Puleo, Victoria Cotero, Ying Fan, Tzu-Jen Kao, David Mills, Jeffrey Ashe, Sireesha KAANUMALLE, Kirk Dennis WALLACE, Kenneth Wayne RIGBY, Ileana HANCU, James ROTHMAN
  • NON-INVASIVE METHOD FOR PRESSURE MEASUREMENT
    Publication number: 20200046313
    Abstract: The present invention relates to the use of contrast-enhanced ultrasound using microbubble-based ultrasound contrast agents to accomplish noninvasive subharmonic aided pressure estimation (SHAPE) in a region of interest (ROI) of a subject. The method of the invention provides a non-invasive, direct, and accurate method for pressure estimation.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 13, 2020
    Applicants: THOMAS JEFFERSON UNIVERSITY, GE HEALTHCARE LIMITED
    Inventors: Flemming Forsberg, David Mills, John R. Eisenbrey, Kirk Wallace, Ipshita Gupta
  • REDUCTION OF MILK GLYCANS AND THEIR DEGRADATION PRODUCTS IN THE NEONATE GUT
    Publication number: 20200046783
    Abstract: Methods of reducing milk glycans, and thus enteric pathogens that use such glycans as carbon sources, in the gut of nursing mammals.
    Type: Application
    Filed: May 22, 2019
    Publication date: February 13, 2020
    Inventors: David A. MILLS, Steven A. FRESE
  • ENZYMES AND METHODS FOR CLEAVING N-GLYCANS FROM GLYCOPROTEINS
    Publication number: 20200030418
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: September 3, 2019
    Publication date: January 30, 2020
    Inventors: Daniel GARRIDO, J. Bruce GERMAN, Carlito B. LEBRILLA, David A. MILLS