Patents by Inventor David A. Nobles
David A. Nobles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6091981Abstract: This invention concerns performing clinical tissue examination with a device that includes sensors which produces signals in response to pressure imposed on the sensors as the sensors are pressed against the tissue. The sensors generate signals in response to pressure imposed on the sensors when pressed against a selected region of tissue. That pressure varies in accordance with properties of underlying tissue structures. An image of the region of tissue is generated based on the signals generated by the sensors. The image is then displayed. The image represents the pressure imposed on the sensors. The image that is displayed may be a three dimensional image of the region of tissue. The signals produced by the sensors can also be processed to detect an underlying tissue structure in the region of tissue. A location or a map of the detected underlying tissue structure relative to a reference point is generated and displayed. The results of a current examination are compared to those of a previous examination.Type: GrantFiled: September 16, 1997Date of Patent: July 18, 2000Assignee: Assurance Medical Inc.Inventors: Michael Anthony Cundari, Alan Irving West, Brian David Noble, Troy William Roberts, David Raymond Widder
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Patent number: 6039507Abstract: A method for assembling a cluster platform in a body of water, by embedding a plurality of conductors in soil underlying the body of water; wet welding in the body of water at least one bracing element between the plurality of conductors, wherein the bracing element is wet welded to at least a first conductor of the plurality of conductors at a first elevation and wet welded to at least a second conductor of the plurality of conductors at a second elevation different from the first elevation; securing a deck atop the plurality of conductors.Type: GrantFiled: June 26, 1998Date of Patent: March 21, 2000Assignee: Atlantic Richfield CompanyInventors: Kevin Kennelly, Ian Gardiner, David Noble, Achmad R. Muliadiredja
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Patent number: 5866759Abstract: The provision of cell lines from virtually any cell type of the animal body is greatly facilitated by transgenic non-human eukaryotic animals of the invention in which at least some cells have (i) a differentiation inhibiting sequence chromosomally incorporated under the control of a non-constitutive promotor and/or (ii) a differentiation inhibiting sequence which is itself conditionally active. Said genes are chromosomally incorporated under the control of a promotor such that expression of said sequence is normally held below an effective level, thus allowing normal cell development. However, cells taken from said animal may be prevented from completing differentiation to a non-dividing state in tissue culture by activating expression of said sequence.Type: GrantFiled: July 2, 1997Date of Patent: February 2, 1999Assignee: Ludwig Institute For Cancer ResearchInventors: Parmjit Singh Jat, Dimitris Kioussis, Mark David Noble
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Patent number: 5766873Abstract: The invention is directed to therapeutic methods for treating diseases associated with tumour necrosis factor-alpha (TNF-.alpha.) induced cell toxicity and/or complement induced cell toxicity, and improved methods for treating diseases whose therapy comprises the administration of n-acetylcysteine.Type: GrantFiled: January 31, 1994Date of Patent: June 16, 1998Assignee: Lugwig Institute for Cancer ResearchInventors: Mark David Noble, Margot Mayer
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Patent number: 5762922Abstract: The invention is directed to therapeutic methods for treating diseases associated with tumor necrosis factor-alpha (TNF-.alpha.) induced cell toxicity and/or complement induced cell toxicity, improved methods for treating diseases whose therapy comprises the administration of at least one growth factor, and improved methods for preventing cell death associated with acute tissue injury.Type: GrantFiled: July 1, 1994Date of Patent: June 9, 1998Assignee: Ludwig Institute for Cancer ResearchInventors: Mark David Noble, Margot Mayer
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Patent number: 5688692Abstract: The provision of cell lines from virtually any cell type of the animal body is greatly facilitated by transgenic non-human eukaryotic animals of the invention in which at least some cells have (i) a differentiation inhibiting sequence chromosomally incorporated under the control of a non-constitutive promotor and/or (ii) a differentiation inhibiting sequence which is itself conditionally active. Said genes are chromosomally incorporated under the control of a promotor such that expression of said sequence is normally held below an effective level, thus allowing normal cell development. However, cells taken from said animal may be prevented from completing differentiation to a non-dividing state in tissue culture by activating expression of said sequence.Type: GrantFiled: February 11, 1993Date of Patent: November 18, 1997Assignee: Ludwig Institute for Cancer ResearchInventors: Parmjit Singh Jat, Dimitris Kioussis, Mark David Noble
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Patent number: 5409950Abstract: Compounds are described of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a hydroxyl group or a group selected from --OCOCH.dbd.CHCH(CH.sub.3)(CH.sub.2).sub.3 CH.sub.3, --OCOCH.dbd.CHC(CH.sub.3).dbd.CHCH(CH.sub.3)--CH.sub.2 CH.sub.3, or --OCO--X--CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 [where X is --CH.dbd.CHCH(CH.sub.3)--, --CH.sub.2 CH(OH)CH(CH.sub.3)--, --CH.dbd.CHC(OH)(CH.sub.3)--, --CH.sub.2 CH(OH)CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH(CH.sub.3)--)];R.sub.2 represents a hydrogen atom or a hydroxyl group;R.sub.3 represents a group selected from --C(.dbd.CH.sub.2)CH(OR.sub.7)CH(CH.sub.3)CH.sub.2 Ph (where R.sub.7 is a hydrogen atom or an acetyl group), --C(CH.sub.3).dbd.CHCH(CH.sub.2 R.sub.8)CH.sub.2 Ph (where R.sub.8 is a hydrogen or a hydroxyl group), --C(CH.sub.2 OH).dbd.CHCH(CH.sub.3)CH.sub.2 Ph, --C(.dbd.CH.sub.2)CH(OH)CH(CH.sub.2 OH)CH.sub.2 Ph, --C(.dbd.CH.sub.2)CH(NHCOCH.sub.3)CH(CH.sub.3)CH.sub.2 Ph, --C(CH.sub.2 NHCOCH.sub.3).dbd.CHCH(CH.sub.3)CH.sub.2 Ph or ##STR2## R.sub.4, R.Type: GrantFiled: October 26, 1993Date of Patent: April 25, 1995Assignee: Glaxo Group LimitedInventors: Michael J. Dawson, Allan Baxter, Robert M. Tait, Nigel S. Watson, David Noble, Alan Shuttleworth, Howard G. Wildman, Michael V. Hayes
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Patent number: 5336789Abstract: Compounds of formula (I) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 is a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 is a hydrogen atom, or (when R.sup.2 is a hydrogen atom) a bromine atom; or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.O or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group >C.dbd.NOR.sup.5 is in the E configuration); andY represents an oxygen atom or a group NOR.sup.5 (where R.sup.5 is as defined above); with the proviso that when Y is an oxygen atom and R.sup.1 is an isopropyl group, then R.sup.2 is other than hydroxyl group.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: August 27, 1992Date of Patent: August 9, 1994Assignee: American Cyanamid CompanyInventors: Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Brian M. Bain
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Patent number: 5278067Abstract: The invention is directed to a biologically pure culture of the microorganism Phoma sp. IMI 332962 or a mutant thereof.Type: GrantFiled: January 8, 1992Date of Patent: January 11, 1994Assignee: Glaxo Group LimitedInventors: Michael J. Dawson, Allan Baxter, Robert M. Tait, Nigel S. Watson, David Noble, Alan Shuttleworth, Howard G. Wildman, Michael V. Hayes
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Patent number: 5185456Abstract: Compounds of formula (I) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 is a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 is a hydrogen atom, or (when R.sup.2 is a hydrogen atom) a bromine atom; or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.0 or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group >C.dbd.NOR.sup.5 is in the E configuration); andY represents an oxygen atom or a group NOR.sup.5 (where R.sup.5 is as defined above); with the proviso that when Y is an oxygen atom and R.sup.1 is an isopropyl group, then R.sup.2 is other than hydroxyl group.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: March 18, 1991Date of Patent: February 9, 1993Assignee: American Cyanamid CompanyInventors: Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Brian M. Bain
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Patent number: 5182207Abstract: Compounds as described having the partial formula ##STR1## These compounds may have a 5-OH or --OMe group and at the 25- position an isopropylene group substituted by methyl, ethyl or isopropyl.The compounds may be used in agriculture or medicine as antiparasitics, and may be prepared by culturing certain Streptomyces strains, in particular Streptomyces thermoarchaensis NC1B 12015.Type: GrantFiled: February 14, 1990Date of Patent: January 26, 1993Assignee: American Cyanamid CompanyInventors: John B. Ward, Hazel M. Noble, Neil Porter, Richard A. Fletton, David Noble
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Patent number: 5116968Abstract: Compounds of formula (1) ##STR1## wherein R represents a sugar residue or an acylated derivative thereof;R.sup.1 represents a methyl, ethyl or isopropyl group;Y.sup.1 is --CH.sub.2, Y.sup.2 is --CH-- and X represents ##STR2## [wherein R.sup.2 represents a hydrogen atom or a group OR.sup.6 (where OR.sup.6 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.0, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.7 (where R.sup.7 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group) and the group >C.dbd.NOR.sup.7 is in the E configuration] or --Y.sup.1 --X--Y.sup.2 -- represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--; andR.sup.4 represents a group OR.sup.6 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which the are attached represent >C.dbd.0 or >C.Type: GrantFiled: December 20, 1990Date of Patent: May 26, 1992Assignee: American Cyanamid CompanyInventors: Gordon C. Lawrence, Michael J. Dawson, David Noble, Michael V. J. Ramsay, Richard Bell, Derek R. Sutherland, Edward P. Tiley
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Patent number: 5108992Abstract: Compounds of formula (1) ##STR1## and their salts, wherein R.sup.1 is a methyl, ethyl or isopropyl group each substituted by a hydroxyl group or R.sup.1 is a group --(CH.sub.2).sub.n R7 or a group --CH(CH.sub.3)R.sup.7 (where n is zero or 1 and R.sup.7 l is CHO or CO.sub.2 H);Y.sup.1 is --CH.sub.2 --, Y.sup.2 is --CH-- and X represents ##STR2## [where R.sup.2 is a hydrogen atom or a group OR.sup.8 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 is a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >.dbd.O, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.9 (where R.sup.9 is a hydrogen atom or a C.sub.1-8 alkyl or C.sub.3-8 alkenyl group) and the group >C.dbd.NOR.sup.9 is in the E configuration] or --Y.sup.1 --X--Y.sup.2 -- represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--;R.sup.4 is a group OR.sup.8 as defined above and R.sup.5 is a hydrogen atom, or R.sup.4 and R.sup.Type: GrantFiled: December 20, 1990Date of Patent: April 28, 1992Assignee: American Cyanamid CompanyInventors: Gordon C. Lawrence, Michael J. Dawson, David Noble, Richard A. Fletton, Stephen J. Lane
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Patent number: 5104871Abstract: Compounds of formula (I) ##STR1## and salts thereof, wherein R is a C.sub.1-4 alkyl group, R.sup.1 is a methyl, ethyl or isopropyl group; and OR.sup.2 is a hydroxyl or substituted hydroxyl group having up to 25 carbon atoms.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: September 9, 1988Date of Patent: April 14, 1992Assignee: American Cyanamid CompanyInventors: Richard Bell, Michael V. J. Ramsay, Hazel M. Noble, David Noble, Neil Porter, John B. Ward, Richard A. Fletton
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Patent number: 5057536Abstract: Compounds of formula (1) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;Y.sup.1 is --CH.sub.2 --, Y.sup.2 is --CH-- and X represents ##STR2## where R.sup.2 represents a hydrogen atom or a group OR.sup.8 (where OR.sup.8 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.O, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.9 (where R.sup.9 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group) and the group >C.dbd.NOR.sup.9 is in the E configuration] or --Y.sup.1 --X--Y.sup.2 -- represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--;R.sup.4 represents a group OR.sup.8 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached represent >C.dbd.O or >C.dbd.NOR.sup.9a (where R.sup.Type: GrantFiled: May 9, 1989Date of Patent: October 15, 1991Assignee: American Cyanamid CompanyInventors: Michael J. Dawson, David Noble, Gordon C. Lawrence, Richard A. Fletton, Stephen J. Lane, Michael V. J. Ramsay, Oswy Z. Pereira, Derek R. Sutherland, Edward P. Tiley
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Patent number: 5034542Abstract: A process for the preparation of a compound of formula (I) ##STR1## (in which R.sup.1 is methyl, ethyl or isopropyl) by hydrogenation of a corresponding compound having a double bond at the 22,23-position, for example in the presence of a rhodium catalyst.Type: GrantFiled: June 9, 1989Date of Patent: July 23, 1991Assignee: American Cyanamid CompanyInventors: Michael V. J. Ramsay, Derek R. Sutherland, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble
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Patent number: 5001145Abstract: Compounds are described of formula (1) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 represents a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.O or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom or a C.sub.1-8 alkyl group and the group >C.dbd.NOR.sup.5 is in the E configuration).These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: January 27, 1989Date of Patent: March 19, 1991Assignee: American Cyanamid CompanyInventors: Michael V. J. Ramsay, Derek N. Evans, Derek R. Sutherland, Edward P. Tiley, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble
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Patent number: 4996228Abstract: Compounds are described of formula (I) ##STR1## and salts therof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;R.sup.2 is alkyl; alkyl substituted by a carboxy or alkoxycarbonyl; alkenyl; phenyl or phenalkyl;R.sup.3 is --OH;OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: March 11, 1987Date of Patent: February 26, 1991Assignee: American Cyanamid CompanyInventors: Derek R. Sutherland, Michael V. J. Ramsay, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble
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Patent number: 4978675Abstract: Compounds are described of formula (II) ##STR1## and salts thereof, wherein R.sup.1 reprsents a methyl, ethyl or isopropyl group;R.sup.2 represents a hydrogen atom or a group OR.sup.5 (where OR.sup.5 is a hydroxy group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent a >C.dbd.0 group; andOR.sup.4 represnts a group OR.sup.5 as defined above;with the proviso that when R.sup.2 represents a hydroxy group OR.sup.4 represents a substituted hydroxy group other than a methoxy group.These compounds may be used for controlling insect, acarine, nematide or other pests.Type: GrantFiled: November 10, 1987Date of Patent: December 18, 1990Assignee: American Cyanamid CompanyInventors: John B. Ward, Hazel M. Noble, Neil Porter, Richard A. Fletton, David Noble, Derek R. Sutherland, Michael V. J. Ramsay
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Patent number: 4950683Abstract: Compounds are described of formula (I) ##STR1## and salts thereof, wherein OR is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms, R.sup.1 represents a methyl, ethyl or isopropyl group and the broken line represents a double bond at the 22,23-position or at the 23,24-position.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: November 10, 1987Date of Patent: August 21, 1990Assignee: American Cyanamid CompanyInventors: John B. Ward, Hazel M. Noble, Neil Porter, Richard A. Fletton, David Noble, Derek R. Sutherland, Michael V. J. Ramsay