Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.

Abstract: A remote control and monitoring apparatus for heat-treatment equipment, including heating elements installed on a workpiece at a work site to perform a heat-treatment operation, has a data acquisition and control unit, a heat-treatment unit, a communication bridge, and a control center, to permit the heat-treatment equipment installed at the work site to be controlled and monitored at a distant control facility.

Abstract: The invention relates to devices and methods of characterising a single unknown pulse signal. They create multiple replica of the original that may be more reliably measured, by dividing the signal through nodes and using different signal pathways that may apply a temporal delay. The device and methods have multiple fields of application, most notably with the internal confinement fusion industry.

Abstract: Embodiments of the present disclosure provide methods, systems, apparatuses, and computer program products for auto-adjustment signal quality. A method may include determining one or more cable modem devices configured to communicate with a device via a network. The method may include sending poll requests to the one or more cable modem devices to determine a signal power level associated with each of the one or more cable modem devices. The method may include receiving a first poll response from a first cable modem device. The method may include determining, based on the first poll response, a first signal strength associated with the first cable modem device. The method may include determining that the first signal strength deviates from a signal strength threshold. The method may include determining, based on the determination that the first signal strength deviates from the signal strength threshold, a first adjustment to an output power of the device for the first cable modem device.

Abstract: A compound of formula (I), wherein Ar1, R21, R23, R24, R25, R26, R27, A, X, Y and W are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: A grid power configuration may provide a reliable, efficient, inexpensive and environmentally conscious power source to a site, for example, a remote site such as a well services environment. Grid power may be provided for one or more operations at the site by coupling a main breaker to a switchgear unit coupled to one or more loads. The switchgear unit may be coupled to the main breaker via a main power distribution unit and may also be coupled to one or more loads. At least one of a grid power unit and a switchgear unit may be coupled to the main breaker via the main power distribution unit and may also be coupled to one or more additional loads. A control center may be communicatively coupled to the main breaker or any one or more other components to control one or more operations of the grid power configuration.

Abstract: This disclosure describes systems, methods, and devices related to resetting observable channel knockouts. A device may transmit a poll request frame to a cable modem to solicit information associated with the cable modem. The device may receive a response frame from the cable modem, wherein the response frame includes information indicating the cable modem is in a partial operation state. The device may store at least a portion of the information in the memory. The device may determine a command configured to cause the cable modem to transition from the partial operation state. The device may transmit the command to the cable modem.

Abstract: A compound of formula (I) wherein R1, R2, R3, R4, X, Y, and A are as defined herein. The compounds of the present invention are inhibitors of hematopoletic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: A grid power configuration may provide a reliable, efficient, inexpensive and environmentally conscious power source to a site, for example, a remote site such as a well services environment. Grid power may be provided for one or more operations at the site by coupling a main breaker to a switchgear unit coupled to one or more loads. The switchgear unit may be coupled to the main breaker via a main power distribution unit and may also be coupled to one or more loads. At least one of a grid power unit and a switchgear unit may be coupled to the main breaker via the main power distribution unit and may also be coupled to one or more additional loads. A control center may be communicatively coupled to the main breaker or any one or more other components to control one or more operations of the grid power configuration.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for a biometric authentication system. In one aspect, a method includes broadcasting, through a transceiver, a signal that includes a kiosk identifier; receiving, from a server system, a reference image of the user based on a mobile computing device associated with the user having received the signal and providing the kiosk identifier to the server system; capturing, with a camera, an image of the user; and authenticating the user based on a comparison of the captured image of the user to the reference image of the user based on a comparison of the captured image of the user to the reference image of the user.

Abstract: The present invention relates to compounds of Formula (XI): wherein R1a, R2a, R3a, R4a, R5a, R6a, and Aa are as defined herein, and pharmaceutically acceptable salts thereof. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) inhibitors and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: A compound of formula (I) wherein R1, R2, R3, R4, X, Y, and A are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: This disclosure describes systems, methods, and devices related to resetting observable channel knockouts. A device may transmit a poll request frame to a cable modem to solicit information associated with the cable modem. The device may receive a response frame from the cable modem, wherein the response frame includes information indicating the cable modem is in a partial operation state. The device may store at least a portion of the information in the memory. The device may determine a command configured to cause the cable modem to transition from the partial operation state. The device may transmit the command to the cable modem.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for a biometric authentication system. In one aspect, a method includes broadcasting, through a transceiver, a signal that includes a kiosk identifier; receiving, from a server system, a reference image of the user based on a mobile computing device associated with the user having received the signal and providing the kiosk identifier to the server system; capturing, with a camera, an image of the user; and authenticating the user based on a comparison of the captured image of the user to the reference image of the user based on a comparison of the captured image of the user to the reference image of the user.

Abstract: A grid power configuration may provide a reliable, efficient, inexpensive and environmentally conscious power source to a site, for example, a remote site such as a well services environment. Grid power may be provided for one or more operations at the site by coupling a main breaker to a switchgear unit coupled to one or more loads. The switchgear unit may be coupled to the main breaker via a main power distribution unit and may also be coupled to one or more loads. At least one of a grid power unit and a switchgear unit may be coupled to the main breaker via the main power distribution unit and may also be coupled to one or more additional loads. A control center may be communicatively coupled to the main breaker or any one or more other components to control one or more operations of the grid power configuration.

Abstract: Methods and systems for facilitating group payment are disclosed. In one embodiment, a group payment system is configured to execute instructions to perform operations that include receiving, from a first computing device, a request to create a group payment event and, in response, providing to the first computing device a first interface associated with the group payment event. The operations further include receiving, from a second computing device, a request to join the group payment event and, in response, providing a second interface to the second computing device. The operations further include receiving, from the first and/or second computing devices, messages associated with the group payment event and modifying the first and second interfaces to display the messages. The operations further include receiving, from the first and/or second computing devices, financial contributions for the group payment event and modifying the first and second interfaces to display the financial contributions.

Abstract: A vehicle exhaust system is provided. The exhaust system may include a muffler including a casing, an inlet tube extending therethrough, and an outlet pipe partially disposed therein. The exhaust system may also include an orifice tube that may have a tapered body inserted within an end of the outlet pipe that is disposed between a baffle and a wall of the casing. The orifice tube may also include an inlet portion flared from the tapered body configured to attenuate noise of exhaust gas funneling into the outlet pipe.

Abstract: Systems and methods for mixing and/or reconstituting drugs are presented. A system may include an injection device, a vial, a needle, and a base station. The device has a chamber containing a first material. The vial has a chamber containing a second material. A drive unit of the base station moves the vial and/or the housing of the device relative to each other into an activated position. In the activated position, the needle is fluidly connected with the vial's chamber, and the drive unit is connected to a driver that moves the plunger in the axial direction of the device such that during fluid connection of the needle with the vial's chamber the first material is expelled from the device's chamber into the vial's chamber or the second material is expelled from the vial's chamber into the device's chamber.

Abstract: A mixing and/or reconstitution system reduces the possibility of user error and provides a well mixed and/or reconstituted drug in a short time. The system comprises a device containing a first material within a first chamber, a housing, and a plunger, the plunger comprising a second chamber containing a second material, wherein one of the first and the second material is a fluid, and a movable element with an electric, magnetic, or paramagnetic characteristic, wherein the second chamber is initially closed; and a base unit comprising a recess for accommodation of the device, a control unit, and an electromagnetic unit which is adapted to produce an electromagnetic field penetrating the recess, wherein the control unit can electrically operate the electromagnetic unit such that the element contained in the second chamber moves in a direction of the device determined by the electromagnetic field and fluidly communicates the first and second chambers.