Abstract: Conductimetric assay devices that have both low end and high end sensitivity are described. The geometric shape and/or arrangement of the capture zones make it possible for the assay devices to have both low end and high end sensitivity. Also described is a conductimetric assay device having a pre-capture zone to capture unbound analyte. The assay device overcomes the problem of flooding by the analyte.

Abstract: A MEMS fuze having a moveable slider with a microdetonator at an end for positioning adjacent an initiator. A setback activated lock and a spin activated lock prevent movement of the slider until respective axial and centrifugal acceleration levels have been achieved. Once these acceleration levels are achieved, the slider is moved by a V-beam shaped actuator arrangement to position the microdetonator relative to a secondary lead to start an explosive train in a munitions round.

Abstract: A reactor for hydrolytic splitting of cellulose under high pressure and heat has an inlet and outlet each with a cross-sectional area smaller than the cross-sectional area of the reactor. The pressure and heat in the reactor forms a cellulose plug within the inlet and the outlet. The inlet plug stops cellulose from escaping out the inlet. Cellulose begins to breakdown under heat, pressure, and if required an acid or a lubricant. The outlet plug slows downstream movement of cooking cellulose. Cellulose may be pre-treated by the addition of water, a weak acid, a lubricant, or a combination of the foregoing. The outer surface of the plug cooks faster than the inner core of the plug, becomes a liquefied slurry, and slides faster towards the outlet than the inner core.

Abstract: The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.

Abstract: Disclosed are automated processes and systems for the assembly of composite doors, and doors made using such processes and systems. The automated process may comprise a continuous series of steps allowing individual doors to be made in tandem, rather than in batch. The process may allow for the automation of individual steps such that the need for coordinating separate assembly steps may be substantially reduced.

Abstract: Disclosed are automated processes and systems for the assembly of composite doors, and doors made using such processes and systems. The automated process may comprise a continuous series of steps allowing individual doors to be made in tandem, rather than in batch. The process may allow for the automation of individual steps such that the need for coordinating separate assembly steps may be substantially reduced.

Abstract: The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.

Abstract: A MEMS apparatus having a substrate layer, a device layer and an intermediate oxide layer joining them. A slider is formed in the device layer and includes an enlarged end portion. A walled chamber having a hollow interior in which is positioned a microdetonator is formed in the substrate layer beneath the enlarged end portion and is secured to it by the oxide layer. A drive is operable to move the slider, and with it, the walled chamber, from an initial position to a final position. When in the final position an initiator is operable to initiate the microdetonator.

Abstract: New nonwoven fibrous webs are taught which comprise a collected mass of a) directly formed fibers disposed within the web in a C-shaped cross-sectional configuration and b) staple fibers having a crimp of at least 15% dispersed among the directly formed fibers in an amount of at least 5% the weight of the directly formed fibers. The web is lofty but free of macrovoids. Preferably, the web has a filling ratio of at least 50 and a light transmittance variation of about 2% or less. Typically, fibers within the web are bonded together at points of fiber intersection, preferably with autogenous bonds, to provide a compression-resistant matrix. The webs are especially useful as acoustic and thermal insulation.

Abstract: The present invention relates to a fluid treatment system comprising: an inlet; an outlet; and a fluid treatment zone disposed between the inlet and the outlet. The fluid treatment zone has disposed therein: (i) an elongate first radiation source assembly having a first longitudinal axis, and (ii) an elongate second radiation source assembly having a second longitudinal axis. The first longitudinal axis and the second longitudinal axis are non-parallel to each other and to a direction of fluid flow through the fluid treatment zone. The present fluid treatment system has a number of advantages including: it can treat large volumes of fluid (e.g.

Abstract: Multilayer articles having acoustical absorbance properties are disclosed. Methods of making and using the multilayer articles are also disclosed.

Abstract: The flow cytometer user interface of the preferred embodiment comprises the steps of (1) running the sample and saving all collected data, (2) viewing the raw (or “unmodified”) data, (3) modifying the raw data (e.g., scaling and/or culling the raw data), (4) reviewing and saving the modified settings, and (5) exporting the saved data. Once the sample has been run and all collected data have been saved, the user can repeat the steps of modifying the raw data, saving the modified settings, and exporting the saved data as many times as necessary and/or desirable without the need to run an additional sample.

Abstract: The present invention relates to a fluid treatment system comprising: an inlet; an outlet; and a fluid treatment zone disposed between the inlet and the outlet. The fluid treatment zone has disposed therein: (i) an elongate first radiation source assembly having a first longitudinal axis, and (ii) an elongate second radiation source assembly having a second longitudinal axis. The first longitudinal axis and the second longitudinal axis are non-parallel to each other and to a direction of fluid flow through the fluid treatment zone. The present fluid treatment system has a number of advantages including: it can treat large volumes of fluid (e.g.

Abstract: A system, method and program product for determining parallelism of an ion beam using a refraction method, are disclosed. One embodiment includes determining a first test position of the ion beam while not exposing the ion beam to an acceleration/deceleration electrical field, determining a second test position of the ion beam while exposing the ion beam to an acceleration/deceleration electrical field, and determining the parallelism of the ion beam based on the first test position and the second test position. The acceleration/deceleration electrical field acts to refract the ion beam between the two positions when the beam is not parallel, hence magnifying any non-parallelism. The amount of refraction, or lateral shift, can be used to determine the amount of non-parallelism of the ion beam. An ion implanter system and adjustments of the ion implanter system based on the parallelism determination are also disclosed.

Abstract: The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.

Abstract: The output current of a fixed-frequency DC to DC converter is sensed, creating a voltage representative of the load current. This voltage is then compared to one or more threshold voltages using a plurality of comparators, creating a plurality of logic signals indicative of which of a plurality of ranges the output current falls within. These logic signals are coupled to a multiplexer which decodes the logical inputs to one-of-n and selects one gate drive voltage from a plurality of such voltages, each optimized for its corresponding current range. The selected gate drive voltage is then used as the gate drive in a known art DC to DC converter, thereby increasing efficiency over a wide range of output current.

Abstract: The reactor pump for hydrolytic splitting of cellulose is configured to pump cellulose, under high pressure, with low availability of sugar into a reactor. The reactor has an upstream transition segment connected to a downstream reaction chamber. The transition segment has an inlet that is smaller than the outlet. The inner walls taper outward. The chamber has an inlet that is larger than the discharge outlet. The inner walls taper inward. The transition segment outlet has an area that is substantially the same as the area of the chamber inlet. Back pressure in the chamber forms a cellulose plug within the inlet of the transition segment. The plug stops cellulose from escaping out the inlet. High pressure pumping forms a cellulose plug within the discharge outlet of the chamber. The plug slows downstream movement of the cooking cellulose giving the cellulose time to cook. Cooking cellulose begins to breakdown under heat and the injection of acid, if required.

Abstract: Presently described are microstructured articles such as a brightness enhancing film or optical turning film. The microstructured articles comprise a brightness enhancing polymerized structure comprising the reaction product of a composition comprising an organic component having at least one oligomeric urethane (meth)acrylate and surface modified silica nanoparticles.

Abstract: Polymerizable compositions comprising nanopartilces particularly useful for brightness enhancing films.

Abstract: In general, the invention is directed to a patient programmer for an implantable medical device. The patient programmer may include one or more of a variety of features that may enhance performance, support mobility and compactness, or promote patient convenience.