Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of some sarcomas, preferably in the treatment and/or prevention of osteosarcoma, Ewing sarcoma, rhabdomyosarcoma or lung metastasis associated thereof.

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

Abstract: A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.

Abstract: This invention relates to a breath indicator that is receivable by a part of a breathing assistance apparatus that supplies gas to a patient. The indicator comprises an elongate body having a gas sampling end and an attachment end. The attachment end is adapted to attach to a part of a breathing assistance apparatus and for locating the gas sampling end. The gas sampling end is to be located in a region where gas from the patient is to be exhaled. The gas sampling end being in communication with a sensor comprising a detector material changeable between a first visual indicator state relating to an inhalation phase of the patient, and a second visual indicator state relating to an exhalation phase of the patient. The detector material is capable of changing between the visual indicator states at a sufficient rate to substantially correspond with the inhalation and exhalation phases of the patient.

Abstract: Devices, systems, and methods are provided for performing volume and intensity-based activity evaluations. A method may include determining, by a device, a heart rate. The method may include determining, based on the heart rate, a motion threshold amount for a time period. The method may include determining motion data. The method may include comparing the motion data to the motion threshold for the time period. The method may include determining, based on the comparison of the motion data to the motion threshold for the time period, an activity intensity level associated with the heart rate and the motion data. The method may include determining, based on the activity intensity level, an activity score. The method may include sending data indicating the activity score for presentation at a second device.

Abstract: The present invention relates to compositions, such as filled and coated papers, comprising microfibrillated cellulose and inorganic particulate material.

Abstract: An immersive virtual reality experience is provided. A plurality of areas within a virtual environment are determined. The plurality of areas includes at least a first area and a second area. A plurality of videos associated with the virtual environment are presented. The plurality of videos include a first video associated with the first area and a second video associated with the second area. The first video has a first quality, and the second video has a second quality lower than the first quality. A three-dimensional model of a first object is overlaid in the virtual environment.

Abstract: Exemplary embodiments provide wear spreading among die regions (i.e., one or more circuits) in an integrated circuit or among dies by using operating condition data in addition to or instead of environmental data such as temperature data, from each of a plurality of die regions. Control logic produces a cumulative amount of time each of the plurality of die regions has spent at an operating condition based on operating condition data wherein the operating condition data is based on at least one of the following operating characteristics: frequency of operation of the plurality of die regions, an operating voltage of the plurality of die regions, an activity level of the plurality of die regions, a timing margin of the plurality of die regions, and a number of detected faults of the plurality of die regions. The method and apparatus spreads wear among the plurality of same type of die regions by controlling task execution among the plurality of die regions using the die wear-out data.

Abstract: A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

Abstract: Exemplary embodiments provide thermal wear spreading among a plurality of thermal die regions in an integrated circuit or among dies by using die region wear-out data that represents a cumulative amount of time each of a number of thermal die regions in one or more dies has spent at a particular temperature level. In one example, die region wear-out data is stored in persistent memory and is accrued over a life of each respective thermal region so that a long term monitoring of temperature levels in the various die regions is used to spread thermal wear among the thermal die regions. In one example, spreading thermal wear is done by controlling task execution such as thread execution among one or more processing cores, dies and/or data access operations for a memory.

Abstract: A support apparatus 1 for supporting a user in an elevated working position above a ground surface G comprises a frame 60 for supporting a floor portion 20 of the support apparatus and a plurality of leg members 40a, 40b mounted to the frame 60 for supporting the frame above the ground surface G. Each leg member has a foot portion 42 for engaging the ground surface G. Each leg member is rotatably mounted to the frame for rotation about a rotational axis which is substantially perpendicular to the width and the length of the frame and each leg member extends from the frame in a radial direction of the rotational axis, whereby the foot portion is offset from the rotational axis.

Abstract: The present disclosure provides scalable nanotube fabrics and methods for controlling or otherwise adjusting the nanotube length distribution of a nanotube application solution in order to realize scalable nanotube fabrics. In one aspect of the present disclosure, one or more filtering operations are used to remove relatively long nanotube elements from a nanotube solution until nanotube length distribution of the nanotube solution conforms to a preselected or desired nanotube length distribution profile. In another aspect of the present disclosure, a sono-chemical cutting process is used to break up relatively long nanotube elements within a nanotube application solution into relatively short nanotube elements to realize a pre-selected or desired nanotube length distribution profile.

Abstract: A method of limiting the chemical degradation of hydrocarbonaceous liquids due to nitrogen dioxide contamination at elevated temperature comprises the addition thereto of an ionic liquid composed of a cation and a boron- and halogen-free, multi-functional aromatic anion, the ionic liquid serving to inhibit the nitration of hydrocarbonaceous liquid components that initiates degradation.

Abstract: A method for manufacturing microfibrillated cellulose, a particulate grinding medium suitable for use in said method, a material which wears rough, and a method for making said particulate grinding medium.

Abstract: An ionic liquid composed of nitrogen-free cations and aromatic halogen- and boron-free anions is useful as an additive to prolong the service life of hydrocarbonaceous liquids exposed to nitrogen dioxide contamination, and to provide friction and wear reduction.

Abstract: An additive composition for limiting the chemical degradation of hydrocarbonaceous liquids due to nitrogen dioxide contamination at elevated temperature comprises the combination of an ionic liquid composed of a cation and a boron- and halogen-free, multi-functional anion and a detergent additive, the combination of ionic liquid and detergent serving to inhibit the nitration of hydrocarbonaceous liquid components that initiates degradation.

Abstract: Systems and methods described herein enforce access controls for network slices via proxy in a secure enclave of a user equipment (UE) device. A UE device executes, in a rich execution environment (REE), a function or application designated for using one or more secure network slices of a telecommunications network. The UE device executes, in a trusted execution environment (TEE), a slice admission control proxy (SACP) to perform admission control for the one or more secure network slices, and forces network traffic for the function or application through the SACP.

Abstract: A lid assembly for a processing chamber in a substrate processing system includes a dielectric window. The dielectric window includes an upper portion having flat upper and lower surfaces. The lower surface is a plasma-facing surface of the dielectric window. A lower portion of the dielectric window is cylindrical and extends downward from the lower surface and an outer diameter of the lower portion at least one of is aligned with a gap between inner and outer coils arranged above the dielectric window and overlaps one of the inner and outer coils.

Abstract: Methods for delivering a replacement heart valve include advancing a delivery system through a femoral vein and into the atrium of a heart, wherein the delivery system includes an outer sheath assembly, a mid shaft assembly and an inner assembly. The outer sheath assembly and the mid shaft assembly are adapted to retain the replacement heart valve in a radially compacted state over the inner assembly. The outer sheath assembly is retracted to allow a plurality of distal anchors to self-expand while a portion of the replacement heart valve remains retained in a compacted state by the mid shaft assembly. The distal anchors are positioned to engage one or more native leaflets and the retained portion of the replacement heart valve is then released and allowed to fully expand for implanting the replacement heart valve within the native valve.

Abstract: Systems, apparatuses, and methods for more effectively preparing for and responding to cybersecurity threats directed at people or at groups of people. A segmentation process is described that evaluates multiple characteristics of a person that may make them a potential target or that may make a cybersecurity attack on that person more likely to be successful. Based on the segmentation, a security analyst can apply an appropriate risk reduction or security protocol to each person or group of similarly situated people to reduce the likelihood of an attack and/or the likelihood of a successful attack.