Abstract: A method and apparatus physically partitions clean and dirty cache lines into separate memory partitions, such as one or more banks, so that during low power operation, a cache memory controller reduces power consumption of the cache memory containing the clean only data. The cache memory controller controls refresh operation so that data refresh does not occur for clean data only banks or the refresh rate is reduced for clean data only banks. Partitions that store dirty data can also store clean data, however other partitions are designated for storing only clean data so that the partitions can have their refresh rate reduced or refresh stopped for periods of time. When multiple DRAM dies or packages are employed, the partition can occur on a die or package level as opposed to a bank level within a die.

Abstract: A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided.

Abstract: A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

Abstract: A method of monitoring a patient's foot forms a thermogram of the sole of at least one foot of the patient, and determines whether the thermogram presents at least one of a plurality of prescribed patterns. The method also compares the thermogram against a prior thermogram of the same foot, and produces output information indicating the emergence of an ulcer on a given portion on the at least one foot as a function of 1) whether the thermogram is determined to present the at least one pattern, and 2) the comparison with the prior thermogram, which shows non-ulcerated tissue at the given location.

Abstract: Apparatuses and methods for adaptive control of memory are disclosed. One example apparatus includes a memory translation unit configured to receive a memory access request including a requested address and to determine a mapping state of a region of a memory associated with the requested address. The memory translation unit further configured to provide a mapped address to the memory. The mapped address is selected from one of the requested address or a translated requested address based on the state of the region of the memory associated with the requested address.

Abstract: A flying theater motion base is implemented using one or more rows of seats pivotably connected to an end of a pivot structure about respective pitch axes, which is in turn pivotably supported over an underlying surface by a support structure about a pivot axis. One or more pivot drives are operable to pivot the pivot structure about the pivot axis to both move the rows of seats between a load/unload position adjacent the underlying surface and a show position elevated in front of a viewing area, and, while in the show position, simulate a heave motion by further pivoting the pivot structure about the pivot axis. One or more pitch drives adjust the pitch of the rows or seats about the pitch axes. The rows include canopies pivotably connected thereabove.

Abstract: The description is directed broadly to a locking differential, comprising; a pair of rotating bevel gears engaged with one another via at least one pinion gear rotatably supported within a carrier; a locking member disposed within the carrier and engagable with each of the bevel gears, the locking member being movable between a locked configuration and an unlocked configuration, such that in the unlocked configuration the locking member allows free rotation of the bevel gears in engagement with the at least one pinion gear to equalise torque between a first bevel gear and a second bevel gear of the pair, and in the locked configuration the locking member locks the first bevel gear to the carrier and locks the second bevel gear to the carrier, simultaneously, to prevent relative movement therebetween.

Abstract: A method and system for presence and vitals detection of a living subject is disclosed herein. The system comprises a device that monitors and is an interface. The device comprises an RGB/IR imaging sensor, a radar, a processor, and a first communication module. The processor is configured to run an algorithm to perform digital signal processing on data provided by the radar and the RGB/IR imaging sensor to generate presence and vitals information for the living subject for communication to the device.

Abstract: A method and system for non-invasive detection of a living subject's blood oxygen saturation is disclosed herein. A system, method, and apparatus utilizes an imaging RGB/infrared sensor and an active two-color light source for detecting blood oxygen saturation (SpO2) of a living subject in a non-contact manner. The system comprises a non-contact light source comprising red light or infrared light; an imaging sensor; a processor; and a user interface.

Abstract: The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.

Abstract: Introduced here is an artificial intelligence system designed for machine learning. The system may be based on a neuromorphic computational model that learns spatial patterns in inputs using data structures called Sparse Distributed Representations (SDRs) to represent the inputs. Moreover, the system can generate signatures for these SDRs, and these signatures may be used to create definitions of classes or subclasses for classification purposes.

Abstract: An implantable medical device includes a first component including a first material, a second component including a second material, and a fiber matrix including a plurality of fibers. The fiber matrix joins the first component to the second component. The fiber matrix includes a first a first portion connected to the first component, and a second portion connected to the second component. The first portion of the fiber matrix is interpenetrated with, and mechanically fixed to, the first material. The first portion of the fiber matrix directly contacts the first material.

Abstract: A method and an apparatus for characterising a sample comprising particles is disclosed. The method comprises performing a first measurement on the sample using a first particle characterisation technique; flowing the sample from the first particle characterisation technique to a particle separating device; separating the sample with the particle separating device; and performing a second measurement on the separated sample. The apparatus is configured to perform the method, and comprises a measurement system for performing measurements according to a first particle characterisation technique and a particle separating device for separating samples comprising particles.

Abstract: The present disclosure provides communication systems and devices for use in noise environments, such as during magnetic resonance imaging (MRI). In some embodiments, a communication headrest is provided that consists of a headrest that supports a patients' head, an optional bone conduction microphone, and one or more vibration actuators. The headset makes contact with noise-isolating earplugs worn by the subject such that vibrations generated by the vibration actuators are transferred through the earplug, via acoustic conduction, to enable the patient to hear audio content while the earplugs provide passive noise protection by occluding the ear canal.

Abstract: Systems and methods for energy storage system are provided. The system includes a particle regeneration subsystem for applying electrical energy to regenerate metallic particulate fuel; a fuel storage subsystem for storing metallic particulate fuel, the fuel storage subsystem in fluid communication with the particle regeneration subsystem; and a power generation subsystem for producing electrical energy from the metallic particulate fuel, the power generation subsystem in fluid communication with the fuel storage subsystem; a bearer electrolyte for transporting the metallic particulate fuel through the particle regeneration subsystem, the fuel storage subsystem and the power generation subsystem; and a control unit configured to independently control flow of the bearer electrolyte between the particle regeneration subsystem and the fuel storage subsystem, and the fuel storage subsystem and the power generation subsystem.

Abstract: An electronic gaming machine includes a display, a credit input mechanism, and a processor programmed to perform operations comprising: (i) determining, during a wagering game initiated in response to receiving a credit wager, that a replay trigger condition is satisfied, the wagering game including a plurality of reels; (ii) initiating, in response to the replay trigger condition, a replay bonus game; (iii) determining a number of replays for use in the replay bonus game; (iv) generating a set of symbols for the plurality of reels for each of the number of replays including an award amount associated with the set of symbols; (v) serially displaying, on the display each of the sets of symbols for each of the number of replays; and (vi) awarding a total award amount including the sum of each award amount for each of the sets of symbols.

Abstract: An adaptor for a respiratory assistance system delivers aerosols to a patient. The adaptor is lightweight with a small footprint to increase patient comfort. The adaptor has a nozzle and a sealing mechanism to maintain pressure therein regardless of whether the nozzle is inserted into the adaptor. The adaptor is configured to connect to medical tubing and a medicament delivery device.

Abstract: Described are antibodies that specifically bind to the Axl protein and inhibit the interaction between Axl and the Axl-ligand, Gas6. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

Abstract: Disclosed are improved methods for manufacturing large-scale populations of robust, highly pure, and functional T regulatory cells (Tregs). Also disclosed are expanded Treg populations, cryopreserved Treg populations and methods and uses of these cells in compositions formulated for treating one or more mammalian diseases, including, for example, treatment, prophylaxis, and/or amelioration of one or more symptoms of a human neurodegenerative disorder. In particular, the compositions and methods provided herein find clinical use in the treatment and amelioration of one or more symptoms of amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and other neurological diseases and disorders.