Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design and manufacture of physical structures include, in at least one aspect, a method including: obtaining a design space for a modeled object, load cases for physical simulation, and design criteria, wherein the modeled object includes specified geometry with which generatively designed geometry will connect, and wherein the load cases include at least one in-use load case for the physical structure and at least one subtractive-manufacturing load case associated with the specified geometry and with a subtractive manufacturing system; producing the generatively designed geometry in the design space for the modelled object in accordance with the load cases for physical simulation of the modelled object and the design criteria for the modeled object; and providing the modeled object with the generatively designed geometry for use in manufacturing the physical structure.

Abstract: A method for processing user orders for products may include receiving an order for an order quantity of the product from a user computing device, determining that the order management system cannot communicate with the inventory management system to reserve the order quantity of the product, retrieving a last known inventory quantity of the product, retrieving an offline demand quantity for the product, transmitting a confirmation of the order to the user computing device when the sum of the order quantity and the offline demand quantity of the product is less than or equal to the last known inventory quantity of the product, and transmitting a denial of the order to the user computing device when the sum of the order quantity and the offline demand quantity of the product is greater than the last known inventory quantity of the product.

Abstract: The invention relates to compositions comprising Candidatus Liberibacter. The invention includes growth mediums, microbial cultures, methods, assays, and kits related to the compositions comprising Candidatus Liberibacter.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design and manufacture of physical structures include, in at least one aspect, a method including: obtaining a design space for a modeled object, load cases for physical simulation, and design criteria, wherein the modeled object includes specified geometry with which generatively designed geometry will connect, and wherein the load cases include at least one in-use load case for the physical structure and at least one subtractive-manufacturing load case associated with the specified geometry and with a subtractive manufacturing system; producing the generatively designed geometry in the design space for the modelled object in accordance with the load cases for physical simulation of the modelled object and the design criteria for the modeled object; and providing the modeled object with the generatively designed geometry for use in manufacturing the physical structure.

Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

Abstract: Compounds of Formula I, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) are provided. Methods and uses of these compounds for the treatment or prevention of disorders requiring a reduction of second messenger responses mediated by cyclic 3?,5?-adenosine monophosphate (cAMP) are also described.

Abstract: A headborne attachment platform includes multiple rigid plates and straps of connecting material connecting the rigid plates in an assembly at independently selectable and pre-set distances apart from each other. The assembly of rigid plates is shaped and connected to sit adjacent to, and surround, the bone regions of a wearer's skull, and define an overall headgear shape and contour. The straps are more flexible than the rigid plates in directions perpendicular to the thickness of the straps, and the straps are inelastic in a direction of a length thereof. A tightening mechanism is configured to adjust a circumference of a headband region, and the rigid plates have mounting features configured to mount an outer helmet shell and/or a headborne device. The rigid plates are sufficiently rigid to support and maintain their three-dimensional shape when subjected to forces exerted upon them by the outer helmet shell or headborne device.

Abstract: Systems, methods, and software are disclosed herein for enhancing the content capture experience on computing devices. In an implementation, a combined user input comprises a voice signal and a touch gesture sustained at least partially coincident with the voice signal. An occurrence of the combined user input triggers the identification of an associated content object which may then be associated with a captured version of the voice signal. Such an advance provides users with a new framework for interacting with their devices, applications, and surroundings.

Abstract: In one embodiment, a personal flotation device that can be worn by a user includes an inflation system including an inflatable bladder, a gas-generating component configured to generate gas using a chemical reaction and inject the generated gas into the bladder to inflate it, and an actuator configured to activate the gas-generating component; a sensor configured to sense one or more physiological parameters of the user; and an inflation control system configured to receive physiological parameter data from the sensor, to determine whether or not the user is experiencing a medical event that places the user at risk of drowning, and, if the user is experiencing such a medical event, to signal the actuator to activate the gas-generating component so as to provide floatation to the user.

Abstract: A rapid diagnostic testing device for testing of a biological sample is provided. The device comprises a channeled construct, at least one lateral flow unit, and a cassette housing. The channeled construct is configured to receive a biological sample to form at least partially purified biological sample. The lateral flow unit is at least partially disposed in the cassette housing. The lateral flow unit comprises: a sample receiving zone, a conjugate zone and a detection zone. The sample receiving zone is operatively coupled to the channeled construct for receiving the partially purified biological sample comprising at least one analyte. The conjugate zone comprising a conjugate particle to bind the analyte is disposed adjacent to the first side of the sample receiving zone. The detection zone is disposed adjacent to the second side of the sample receiving zone and comprises at least one binding agent for detecting the analyte.

Abstract: A soldering tool, comprising nozzle shaped soldering tip and a hot gas feed channel that runs in the soldering tip, wherein the hot gas feed channel includes openings that provide a hot gas exhaust, and wherein the soldering tip as well as a portion of a soldering environment is heatable by the hot gas, characterized in that the soldering tip includes one or plural contact surfaces that have a surface structure which corresponds to a surface structure of a soldering object so that the soldering object is thermally contactable by the soldering tip with a minimum heat resistance, wherein a hot gas jet that passes through the openings is forced to perform at least one directional reversal or directional deflection by placement of the soldering tip and contacting the soldering object.

Abstract: This invention relates to novel opioid derivatives of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R3, R4 and Z are as defined herein in the disclosure. The invention also relates to the use of such compounds for the treatment or prevention of, for example, pain.

Abstract: An apparatus for measuring lesion volume, for example, in laboratory animals, provides a mirror box allowing a camera to simultaneously acquire profiles of the lesion along at least two crossing axes from which accurate volume may be approximated at low cost.

Abstract: A rapid detection method of a target biomolecule comprising an antigenic moiety is provided. The method includes providing a source biological sample comprising the target biomolecule; contacting the source biological sample to an ion-exchange medium; eluting the captured-target biomolecule from the ion-exchange medium as an eluate, and loading the eluate to a rapid diagnostic testing device comprising an antibody. The eluate comprises a concentrated form of the biomolecule in a solution having a salt concentration greater than 150 mM. A concentration of the target biomolecule in the eluate is in a range from about 2× to 25× compared to a concentration of the biomolecule in the source biological sample. The target biomolecule binds to the antibody under the salt concentration of greater than 150 mM. A device for rapid detection of target biomolecule is also provided.

Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.

Abstract: The present invention relates to compounds as defined herein, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) and to therapies using these activators. In particular, the invention relates to these activator compounds for use in a method for the treatment or prevention of disorders requiring a reduction of second messenger responses mediated by cyclic 3?,5?-adenosine monophosphate (cAMP).

Abstract: A ferro-magnetic material recovery system includes a drum rotating within a magnet housing. An array of magnets mounted within the magnet housing have corresponding magnetic fields which decrease in strength in the direction of rotation of the drum to extract the material from a slurry flowing through the drum. Flow deflectors may be mounted in the drum. The array of magnets may form a magnetic core having magnetic fields that are radially aligned.

Abstract: A rapid detection method of a target biomolecule comprising an antigenic moiety is provided. The method includes providing a source biological sample comprising the target biomolecule; contacting the source biological sample to an ion-exchange medium; eluting the captured-target biomolecule from the ion-exchange medium as an eluate, and loading the eluate to a rapid diagnostic testing device comprising an antibody. The eluate comprises a concentrated form of the biomolecule in a solution having a salt concentration greater than 150 mM. A concentration of the target biomolecule in the eluate is in a range from about 2× to 25× compared to a concentration of the biomolecule in the source biological sample. The target biomolecule binds to the antibody under the salt concentration of greater than 150 mM. A device for rapid detection of target biomolecule is also provided.

Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.