Abstract: G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound GDP for GTP in the G? subunit of the heterotrimeric G-protein. The G? subunit dissociates from the ?/? subunits and both proceed to affect downstream signaling targets. The signal terminates by the hydrolysis of GTP to GDP and is regulated by Regulators of G-protein Signaling (RGS) proteins that act as GTPase Activating Proteins (GAPs). This makes RGS proteins potentially desirable targets for “tuning” the effects of current therapies as well as developing novel pharmacotherapies. The present invention provides a convenient assay for identifying modulators of RGS proteins that can be adapted for high throughput screening utilizing the colorimetric dye, malachite green, to detect free phosphate in the presence of a test compound.

Abstract: Devices, systems and methods are disclosed for the mapping of electrical signals and the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be transformed from a compact, linear configuration to a helical configuration, such as to map and ablate pulmonary vein ostia.

Abstract: A wheelchair assembly for propelling a wheelchair is provided. The wheelchair has front wheels and rear wheels and a pair of armrests. The wheelchair assembly comprises a first gear wheel secured to each rear wheel and a second gear wheel secured to each armrest. The second gear wheel is positioned directly over the first gear wheel with the second gear wheel being completely encased by a cover. A chain is secured over and between the first and second gear wheels and extends from an opening in the cover. Rotatable handles are attached to each armrest with each having a grasping portion extending Upward. A control linkage extends between the handles and the second gear wheels and mounted to and under the armrest such that rotation of the handles also rotates the second gear wheels with the control linkage being perpendicular to the line formed between the first and second gear wheels.

Abstract: Devices, systems and methods are disclosed for the mapping of electrical signals and the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be transformed from a compact, linear configuration to a helical configuration, such as to map and ablate pulmonary vein ostia.

Abstract: Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition. The carrier assembly includes multiple electrodes that are configured to ablate tissue at low power. Systems include an interface unit with a visual display that provides a visual representation of the geometry of the ablation elements and/or provides selection means for selecting an icon provided on the display.

Abstract: A shredder feeder has a first receiving post configured to receive a roll of first material, second and third receiving posts respectively configured to receive first and second rolls of second material, and a pair of guideposts that form an outlet of the shredder feeder therebetween. The respective guideposts are positioned to respectively direct the second material from the first and second rolls toward the first material from the roll of first material so that the first material is interposed between the second material from the first roll of second material and the second material from the second roll of second material when the first material and the second materials from the first and second rolls of second material pass concurrently through the outlet.

Abstract: Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition. The carrier assembly includes multiple electrodes that are configured to ablate tissue at low power. Systems include an interface unit with a visual display that provides a visual representation of the geometry of the ablation elements and/or provides selection means for selecting an icon provided on the display.

Abstract: A photovoltaic connector assembly includes a housing that has a mating end and a cable end. The housing has a securing feature that is configured to secure the housing to another photovoltaic connector assembly. The housing has a cavity that extends between the mating end and the cable end. A terminal is received in the cavity. The terminal is configured to be mated to a corresponding terminal of the other photovoltaic connector assembly. The terminal is configured to be terminated to a cable. A cable locator is configured to be coupled to the cable rearward of the terminal. The cable locator has wings that extend from opposite sides of the cable locator. The cable locator is received in the cavity. The wings engage the housing to position the cable locator within the cavity.

Abstract: A junction box for electrically connecting a photovoltaic (PV) module to a power distribution system having a mating conductor. The junction box includes a housing configured to be mounted on the PV module, the housing comprising a mating interface and an opening formed in the housing for engaging foil of the PV module. The housing is configured to mate with a mating conductor of the power distribution system at the mating interface. Engagement features positioned in the housing to secure a component form an electrical connection between foil of the PV module and the mating conductor.

Abstract: A shredder feeder has a first receiving post configured to receive a roll of first material, second and third receiving posts respectively configured to receive first and second rolls of second material, and a pair of guideposts that form an outlet of the shredder feeder therebetween. The respective guideposts are positioned to respectively direct the second material from the first and second rolls toward the first material from the roll of first material so that the first material is interposed between the second material from the first roll of second material and the second material from the second roll of second material when the first material and the second materials from the first and second rolls of second material pass concurrently through the outlet.

Abstract: Devices, systems and methods are disclosed for the mapping of electrical signals and the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be transformed from a compact, linear configuration to a helical configuration, such as to map and ablate pulmonary vein ostia.

Abstract: A photovoltaic connector assembly includes a housing that has a mating end and a cable end. The housing has a securing feature that is configured to secure the housing to another photovoltaic connector assembly. The housing has a cavity that extends between the mating end and the cable end. A terminal is received in the cavity. The terminal is configured to be mated to a corresponding terminal of the other photovoltaic connector assembly. The terminal is configured to be terminated to a cable. A cable locator is configured to be coupled to the cable rearward of the terminal. The cable locator has wings that extend from opposite sides of the cable locator. The cable locator is received in the cavity. The wings engage the housing to position the cable locator within the cavity.

Abstract: Apparatus and methods of fixating bone include repairing or remodeling a hard tissue defect with a composite bone structure. The composite bone structure includes at least two hard tissues or bones and a scaffold material fixed together by an adhesive component. The apparatus and methods include positioning the hard tissues/bones, conforming the scaffold material to at least a portion of a surface of the hard tissues/bones, contacting the adhesive component with the hard tissues/bones and the scaffold material, and changing the material state of the adhesive component to another material state at which the adhesive component fixes together the hard tissues/bones and the scaffold material, thereby forming a composite bone structure having a desired rigidity.

Abstract: A shredder feeder has a first receiving post configured to receive a roll of first material, second and third receiving posts respectively configured to receive first and second rolls of second material, and a pair of guideposts that form an outlet of the shredder feeder therebetween. The respective guideposts are positioned to respectively direct the second material from the first and second rolls toward the first material from the roll of first material so that the first material is interposed between the second material from the first roll of second material and the second material from the second roll of second material when the first material and the second materials from the first and second rolls of second material pass concurrently through the outlet.

Abstract: Devices, systems and methods are disclosed for the mapping of electrical signals and the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be transformed from a compact, linear configuration to a helical configuration, such as to map and ablate pulmonary vein ostia.

Abstract: An angioplasty balloon catheter and method of making and using the same. The balloon catheter may include a catheter shaft and a balloon coupled to the shaft. The balloon may include one or more cutting edges or member and may include a plurality of chambers defined therein.

Abstract: A drink mixing glass which is graduated in a manner uniquely adapted to provide a prescribed volume of a drink mixture while compensating for the presence of water in the mixture attributable to the melting of ice which normally occurs during the drink mixing process. In an exemplary embodiment of the present invention, the graduations included on the mixing glass are adapted to facilitate the pouring of one or more martinis which are each of a volume of approximately seven ounces, inclusive of the presence of water from ice which melts during the drink mixing process.

Abstract: Devices, systems and methods are disclosed for the mapping of electrical signals and the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be transformed from a compact, linear configuration to a helical configuration, such as to map and ablate pulmonary vein ostia.

Abstract: An angioplasty balloon catheter and method of making and using the same. The balloon catheter may include a catheter shaft and a balloon coupled to the shaft. The balloon may include one or more cutting edges coupled thereto. The shaft may include one or more inflation lumens and a plurality of openings defined therein that are in fluid communication with the inflation lumen or lumens.

Abstract: An angioplasty balloon catheter and method of making and using the same. The balloon catheter may include a catheter shaft and a balloon coupled to the shaft. The balloon may include one or more cutting edges or member and may include one or more wings. The wings may include an undulating surface.