Abstract: Methods, systems, apparatuses, and computer program products are provided for enabling access to a resource in a secured manner. A token request from an application executing in a first computing environment may be received in a second computing environment. The second computing environment may assign a trust level to the received token request that indicates that the first computing environment may not be trusted. The token request, along with the trust level, may be provided to an authorization server to generate an authorization token that includes a trust indication indicative of the trust level of the second computing environment. When the application executing in the second computing environment transmits the authorization token to a resource manager to access a resource, the resource manager may be configured to perform a precautionary action to protect the resource prior to providing access, such as creating a backup of the resource.

Abstract: The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.

Abstract: This application describes methods, systems, and apparatus for allowing a user to easily determine whether the user and/or other user(s) have viewed content. For example, a program guide may display one or more graphics associated with the content (e.g., a movie poster), and in response to determining whether the user has viewed the content, the program guide may include an indication of whether the user has viewed the content. The program guide may include indications associated with multiple users (e.g., different colors, icons, graphics, or text). The program guide may filter the content based on whether the user has viewed the content (e.g., only display content the user has not viewed). A computing device storing the content may manage recording of the content based on whether the user has viewed the content (e.g., delete the recording if the user has viewed the content). A viewing history of the user may be maintained.

Abstract: A method includes receiving, at a security platform, a plurality of threat indicators associated with current intrusive activities with respect to computing resources of a first entity and receiving, at the security platform, a plurality of threat datasets associated with prior intrusive activities with respect to computing resources associated with one or more entities including the first entity. The method further includes receiving, at the security platform, a plurality of environmental datasets associated with the computing resources of the first entity and determining an alert level associated with a first threat indicator of the plurality of threat indicators based on the plurality of threat datasets and the plurality of environmental datasets. The method further includes generating, responsive to the alert level satisfying an alert threshold criterion, an alert associated with the first threat indicator for one or more users of the first entity.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: Systems and techniques for determining a sideslip vector for a vehicle that may have a direction that is different from that of a heading vector for the vehicle. The sideslip vector in a current vehicle state and sideslip vectors in predicted vehicles states may be used to determine paths for a vehicle through an environment and trajectories for controlling the vehicle through the environment. The sideslip vector may be based on a vehicle position that is the center point of the wheelbase of the vehicle and may include lateral velocity, facilitating the control of four-wheel steered vehicle while maintaining the ability to control two-wheel steered vehicles.

Abstract: The disclosure relates to generation of an occupant settings profile for an occupant in a vehicle. A corresponding method for providing a control instruction for controlling at least one occupant setting for a seat location in a vehicle can comprise receiving, by a system comprising a processor, audio data based on speech of an occupant inside the vehicle, identifying, by the system, a seat location of the occupant inside the vehicle based on the received audio data, identifying, by the system, an occupant settings profile indicative of one or more occupant settings of the occupant based on a comparison of the received audio data with stored audio data associated with different occupant settings profiles, and providing, by the system, the control instruction for controlling the at least one occupant setting for the identified seat location of the occupant based on the identified occupant settings profile.

Abstract: Mechanisms are provided for organizing food items within a refrigerator system. The mechanisms detect the presence of a food item within a refrigerator system. The mechanisms retrieve a food item profile for the food item and determine, based on application of one or more rulesets to parameters of the food item specified in the food item profile, a placement for the food item at a goal location within a compartment of the refrigerator system. The goal location comprises a specification of a shelf in the refrigerator compartment and a location on the shelf. The mechanisms control mechanical movement mechanisms of the refrigerator system to move the food item from a current position within the refrigerator system to the goal location.

Abstract: The instant disclosure provides reagent compounds, and antibody and oligonucleotide reagents, for use in a variety of assays, including immunoassays and nucleic acid hybridizations. The reagent compounds comprise a bridging antigen or bridging oligonucleotide and a latent crosslinker moiety, such as a tyramide moiety. The bridging antigens are recognizable by the antibody of a corresponding antibody reagent with high affinity, and the bridging oligonucleotides are complementary to the oligonucleotide of a corresponding oligonucleotide reagent. The antibody reagents and oligonucleotide reagents also comprise a crosslinker activation agent, such as a peroxidase enzyme. Reaction of the reagent compounds with the crosslinker activation agent results in the amplification of signal in assays for target cellular markers, including cellular antigens and nucleic acids.

Abstract: The present disclosure provides reagent compounds, reactive biopolymeric compounds, and methods of making and using these materials for the rapid and efficient synthesis and purification of biopolymeric compounds at low cost. The materials and methods yield highly pure synthetic biopolymeric compounds, including synthetic oligonucleotides and polypeptides, and reduce or eliminate the need for toxic solvents in the synthetic process.

Abstract: An incorrect transmission, of a record of data to a distributed ledger system, can be prevented. A first signal can be received. The first signal can include a first instruction to cause the record to be transmitted to the system. One or more items of information in the record can be determined. A delay of time to be elapsed, before a transmission of the record to the system, can be set in response to a receipt of the first signal and a determination of the one or more items. The transmission of the record to the system can be caused to occur after the delay has elapsed. The transmission of the record to the system can be prevented in response to a receipt of a second signal before the delay has elapsed. The second signal can include a second instruction that supersedes the first instruction.

Abstract: A method of screening a test compound, e.g., a fibrosis or IPF inhibitor, for induction of an unjammed-to-jammed transition (UJT) in fibrotic primary human bronchial epithelial cells (HBECs) isolated from a subject with a fibrotic lung disease includes culturing the fibrotic primary HBECs at an air-liquid interface for a time sufficient to provide a differentiated pseudostratified epithelium contacting the cultured cells with the test compound; and monitoring the motility of the cultured cells to identify the cultured cells as moving or stationary; wherein stationary cultured cells indicate that the test compound induces the UJT. Also included are methods of identifying lung fibrosis biomarkers.

Abstract: The instant disclosure provides reagent compounds, and antibody and oligonucleotide reagents, for use in a variety of assays, including immunoassays and nucleic acid hybridizations. The reagent compounds comprise a bridging antigen or bridging oligonucleotide and a latent crosslinker moiety, such as a tyramide moiety. The bridging antigens are recognizable by the antibody of a corresponding antibody reagent with high affinity, and the bridging oligonucleotides are complementary to the oligonucleotide of a corresponding oligonucleotide reagent. The antibody reagents and oligonucleotide reagents also comprise a crosslinker activation agent, such as a peroxidase enzyme. Reaction of the reagent compounds with the crosslinker activation agent results in the amplification of signal in assays for target cellular markers, including cellular antigens and nucleic acids.

Abstract: A website building system (WBS) includes an experiment management system to provide experiment management services to at least two tenancies where a single tenancy conducts at least one experiment independently without interfering with experiments conducted by other tenancies, the experiment management system includes an experiment creator to receive an experiment specification with source material from an external source and to create an experiment definition based on inspection and analysis of the source material; an experiment integrator to integrate the experiment definition as an experiment into the experiment management system; an experiment configurer to configure a variant and population selection criteria for the experiment; and an experiment manager to manage experiment conflicts between concurrently running experiments for the at least two tenancies at runtime according to the variant and population selection.

Abstract: An erroneous transmission, of a record of data, to a distributed ledger system can be prevented. A first operation can confirm that a format of a content within the record of data is correct. A second operation can confirm that formats of elements of a set of information, about authorizations used to cause the record of data to be communicated via the distributed ledger system, are correct. A third operation can confirm that subject matters of the elements and a subject matter of the record of data are the same. A fourth operation can retrieve credentials associated with entities that produced the elements. A fifth operation, using the credentials, can confirm that the entities that produced the elements were authorized to produce them. A sixth operation can confirm that the set of information is sufficient to authorize causing the record of data to be communicated via the distributed ledger system.

Abstract: Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.

Abstract: A system to detect and resolve conflicts between different experiments running on a website building system (WBS). The system includes at least one processor, a conflict resolver to check for interactions and conflicts between an experiment and at least one other existing experiment from a set of existing experiments in the WBS, when the experiment is set-up or integrated into the set of existing experiments. The conflict resolver either resolves the interactions and conflicts, or allows the interactions and conflicts to remain. The system also includes an experiment manager running on the at least one processor to manage and coordinate the experiment and the at least one other existing experiment when the experiment is running concurrently with the at least one other existing experiment, after set-up or integration of the experiment.

Abstract: Exemplary embodiments of the present disclosure can provide for a transparent panel that can have a featured image which can be surrounded by a pattern of repeating designs on a first side of the panel. A vinyl layer can be provided on the entire first side of the panel to assist in the featured image and repeating designs to be viewable on the second side of the panel (opposite of the first side). On the second opposite side of the panel, an area of the panel where the pattern of designs is visible is provided with a series of lens that can overly the repeating designs. In some exemplary embodiments, the lenses can project enlarged representations of the underlying repeating designs that appear to the eye as occupying a different plane than the featured image, creating a sense of depth within the image.

Abstract: Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.

Abstract: Various embodiments are directed to a docking station for the mechanical alignment of an autonomous robotic platform. A correlator may receive the wheels of a moving autonomous robotic platform. A first set of rollers in the correlator may align the wheels, in a substantially linear direction, into a space created by a second set of rollers attached to a frame of a backstop. The second set of rollers may continue to align the wheels of the moving autonomous robotic platform until the wheels come in contact with a stopping roller coupled to the backstop. The stopping roller may be vertically oriented at a height above a wheel radius of the autonomous robotic platform. The stopping roller provides a force to prevent further forward travel. Upon being stopped by the stopping roller, the autonomous robotic platform is positioned for mating with charging contacts in the docking station.