Abstract: A wrench includes a wrench head mounted on an end of a handle. A handle of the wrench includes a fixed portion and a rotatable portion. Rotation of the rotatable portion of the handle causes movement of at least one contact surface of the wrench head. In one embodiment, rotation of the rotatable portion provides adjustment or movement of one of the jaws of the wrench head relative to another jaw of the wrench head. In another embodiment, rotation of the rotatable portion provides rotation of the wrench head. The rotatable portion of the handle is slidably mounted within the fixed portion of the handle, such that rotatable portion can be selectively extended to provide additional leverage on the wrench.

Abstract: Disclosed herein is an LED-based light for replacing a fluorescent bulb in a conventional fluorescent light fixture. The LED-based light includes a housing having a first end opposing a second end, a circuit board disposed within the housing and extending along a longitudinal axis of the housing, at least one LED mounted to the circuit board, at least one end cap disposed on one of the first and second ends of the housing, the end cap including a switch and at least one electrically conductive pin configured for physical and electrical connection to the light fixture; and circuitry configured to provide a current path between the at least one LED and the at least one electrically conductive pin, wherein the switch is configured to selectively disconnect the current path.

Abstract: The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.

Abstract: A method and apparatus for registering physical space to image space is disclosed. The system allows for determining fiducial markers as pixels or voxels in image data. The system can correlate and register the determined fiducial points with fiducial markers in physical space.

Abstract: An impedance tomography apparatus is disclosed for the measuring of the electrical activity of excitable tissue. The apparatus comprises a plurality of signal transfer devices adapted for transferring an input signal to a body and receiving an output signal from a body. An input signal generator is adapted to generate an electrical input signal and apply it to at least one of the signal transfer devices. A measurement device is arranged to measure the output signal from the body at least one or more of the remaining signal transfer devices, wherein the input signal generator is adapted to generate an input signal of frequency greater than 100 Hz and less that 5 kHz. This allows the depolarisation of nervous or muscle tissue to be imaged.

Abstract: A method and apparatus to perform a procedure that can include a processor assisted surgical procedure. During the procedure patient space and image space can be registered to allow for tracking of various tracking sensors. An instrument can be placed relative to patient space based upon a plan.

Abstract: The invention provides a functionalised compound of formula (II), which functionalised compound comprises n carbene precursor groups which are the same or different, wherein n is an integer equal to or greater than 3: wherein x is 1, E is a group which is capable of being converted into a carbene reactive intermediate group, Q is a core moiety, a polymer or a dendrimer, and each of the [R]x-E-L- groups, which are the same or different, is independently selected from a group of formula (Ie) and a group of formula (Ia): wherein L is a single bond or a linker group as defined herein, R is a terminal group as defined herein, and R1 is as defined herein. Further provided is the use of the functionalised compound as an agent for producing a chemically-bound three-dimensional network on or within a substrate.

Abstract: The invention relates to a method of assessing the proliferation or differentiation behavior of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at least one time point t, wherein said proliferation characteristic is the clone size distribution; [b] comparing the clone size distribution measured in [a] to a reference clone size distribution at a corresponding time point t predicted or described by the equation; wherein a difference between the measured clone size distribution of [a] and the predicted or described clone size distribution of [b] indicates an altered proliferation or differentiation behavior of said cells. The invention further relates to methods involving assessing the scaling form of the above behaviors, values of the parameters, and inferring effects on cell proliferation and/or differentiation therefrom.

Abstract: An LED light tube and method of manufacturing an LED light tube includes the steps of forming an LED light tube housing of a first housing segment joined to a first end cap. One end of a circuit board is inserted through the one housing segment into contact with the first end cap. One or more additional housing segments are slid over the circuit board into engagement with ends of previously mounted housing segments. A second end cap is joined to the engaged ends of the multiple housing segments are fixed together to complete a unitary housing.

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: A mobile retail store structure transportable to a plurality of different locations includes a trailer construction configured both exteriorly and interiorly for housing a plurality of storage bins wherein products and/or parts can be stored. Each trailer is a self-sufficient module which includes doors at one end of the trailer unit for entry and exit thereto, portable stairs for providing access to the entry doors, opposed side doors and associated walkways for allowing coupling to additional similarly constructed trailers, extendable canopies for providing a secure passageway between the respective coupled trailers, and a generator/HVAC system for providing heating, cooling and electrical power to each trailer unit. In one embodiment, a terminal is provided to allow a user to either browse electronically various items for selection and/or sale, or access a self-service check-out station to complete a transaction.

Abstract: A compound of formula (I), or a pharmaceutical acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p38-mediated disease, disorder, or condition, in particular the allergic and non-allergic airways diseases, more particularly obstructive or inflammatory airways diseases, preferably chronic obstructive pulmonary disease.

Abstract: The invention relates to a method of assessing the proliferation or differentiation behaviour of a population of target cells in a biological system, said method comprising the steps of; [a] measuring the value of at least one proliferation characteristic of said cells at least one time point t, wherein said proliferation characteristic is the clone size distribution; [b] comparing the clone size distribution measured in [a] to a reference clone size distribution at a corresponding time point t predicted or described by the predicted or described clone size distribution of [b] indicates an altered proliferation or differentiation behaviour of said cells. The invention further relates to methods involving assessing the scaling form of the above behaviours, values of the parameters, and inferring effects on cell proliferation and/or differentiation therefrom.

Abstract: Digital x-ray images taken before a surgical procedure by a fluoroscopic C-arm imager are displayed by a computer and overlaid with graphical representations of instruments being used in the operating room. The graphical representations are updated in real-time to correspond to movement of the instruments in the operating room. A number of different techniques are described that aid the physician in planning and carrying out the surgical procedure.

Abstract: A system for performing a medical procedure on a patient is provided. The system can include an imaging head defining a field of view relative to the patient. The imaging head can include at least one transmitter that emits at least one signal in the field of view, and at least one receiver that receives at least one reflected signal from the field of view. The at least one reflected signal received can be based on at least one electrical property of at least one material in the field of view. The system can further include a workstation, which can determine, based on the at least one reflected signal received by the at least one receiver, a location of at least one boundary of the material within the field of view. The system can include a display that displays an image of the location of the at least one boundary.

Abstract: There is provided a device comprising a body structure having one or more surfaces wherein at least one of the surfaces comprises a pH sensitive layer comprising a linear polymer, wherein the water solubility of the linear polymer increases from a first water solubility to a second water solubility at a pH trigger. A method of forming a device, and a method of preventing or mitigating infection is also described.

Abstract: A service node (520) for filtering in a wireless communication network short messages sent by a communication party (510) to a mobile device (530), said service node being arranged to intercept a first short message sent by the communication entity to the mobile equipment, find, upon determining that the intercepted short message is a data update short message comprising a data update for the mobile equipment, if the first short message comprises an indication that the communication party is requesting a proof of receipt message issued by said mobile equipment in reply to the reception of said first short message, in the same byte format as the first short message, provided the indication is found, modify the subsequent transmission of the first short message to the mobile device when said communication party matches a predefined criterion.

Abstract: A mobile device (301) for use in a wireless communication network, said mobile device comprising a processor (335) arranged to send a short message delivery receipt to a communication party, after normal receipt by the communication device of a first short message sent by said communication party, said first short message delivery receipt being in a byte format different than the received first short message, Send mobile originated (MO) short messages, of the same byte format as the received first short message, transfer the received first short message to an identification module (350) of the mobile device when said first short message is identified as a data update message comprising a data update for said identification module, the processor being further arranged, upon determination by the authentication module that the communication party requested from said authentication module that proof of receipt (PoR) data for the data update be inserted in a new MO short message serving as a PoR message to said co

Abstract: A mobile device (301) for use in a wireless communication network, said mobile device comprising a processor (335) arranged to send a short message delivery receipt to a communication party, after normal receipt by the communication device of a first short message sent by said communication party, said first short message delivery receipt being in a byte format different than the received first short message, send mobile originated (MO) short messages, of the same byte format as the received first short message, transfer the received first short message to an identification module (350) of the mobile device when said first short message is identified as a data update message comprising a data update for said identification module, either one of the processor and the authentication module being further arranged, upon determination by the authentication module that the communication party requested that proof of receipt (PoR) data for the data update be inserted in a new MO short message serving as a PoR messag