Abstract: A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

Abstract: One or more markers or sensors are positioned in the vasculature of a patient to facilitate determining the location, configuration, and/or orientation of a vessel or certain aspects thereof (e.g., a branch vessel), determining the location, configuration and/or orientation of a endovascular devices prior to and during prosthesis deployment as well as the relative position of portions of the vasculature and devices, generating an image of a virtual model of a portion of one or more vessels (e.g., branch vessels) or devices, and/or formation of one or more openings in a tubular prosthesis in situ to allow branch vessel perfusion when the prosthesis is placed over one or more branch vessels in a patient (e.g., when an aortic abdominal artery stent-graft is fixed to the aorta superior to the renal artery ostia).

Abstract: A method and circuit is disclosed for a laser system wherein the power of the laser signal is kept at a constant near optimum value and a portion of an frequency doubled output signal is monitored and detected so that noise within the frequency doubled output signal can be minimized. A feedback signal is used to dither the temperature of a frequency doubled crystal so as to minimize the noise in the frequency doubled output signal.

Abstract: One or more localization markers are implanted in a patient's vessel to provide a virtual image of a portion of the vessel, provide a target for deploying a prosthesis, and/or facilitate post operative surveillance of a deployed prosthesis (e.g., to measure prosthesis migration and/or aneurysm elongation). In the case of providing a target or facilitating surveillance, one or more localization markers also can be provided on the prosthesis (e.g., the proximal end portion of the prosthesis) and the position of the prosthesis marker(s) monitored relative to the implanted marker(s). In another embodiment, one or more localization markers are provided adjacent to one opening of a tubular prosthesis to assist with cannulation of the opening. In one example, one or more localization markers are provided on the contralateral stump of a modular bifurcated stent-graft (e.g., to assist a surgeon with inserting a contralateral stent-graft into the contralateral stump of a modular bifurcated stent-graft).

Abstract: A branch vessel in a human patient is located or mapped using in vivo tracked field sensors where in one variation the sensor positions can be located by determining the positions of the sensors relative to a plurality of magnetic field sources of known location. This approach is used, for example, in locating the opening in a renal artery and positioning the proximal end of the AAA stent-graft adjacent to the opening. In another example, the sensors are tracked along the inner wall of an aneurysm and the acquired sensor location data processed to map the contour of the aneurysm to size a prostheses for spanning the aneurysm. The portions of the vessel adjacent the aneurysm also can be mapped. In a further embodiment, an in vivo sensor is positioned in a deployed prosthesis to create a reference for a prosthetic member having a sensor to track to during cannulation of the deployed prosthesis with the prosthetic member.

Abstract: A branch vessel in a human patient is located using in vivo tracked field sensors where in one variation the sensor positions can be located by determining the positions of the sensors relative to a plurality of magnetic field sources of known location. This approach is used, for example, in locating the opening in a renal artery and positioning the proximal end of the AAA stent-graft adjacent to the opening. According to another embodiment, field sensors in combination with signal generators are placed in vivo to locate vasculature aspects. In a further embodiment, an in vivo sensor is positioned in a deployed prosthesis to create a reference for a prosthetic member having a sensor to track to during cannulation of the deployed prosthesis with the prosthetic member.

Abstract: A method and apparatus for optimizing a computer assisted procedure is provided. A method and apparatus for performing a procedure is also provided. Data can be accessed and processed to optimize and perform a procedure. The data can be augmented or supplemented with patient specific data.

Abstract: Embodiments of the invention provide a substrate with a device layer having different crystal orientations in different portions or areas. One layer of material having one crystal orientation may be bonded to a substrate having another crystal orientation. Then, a portion of the layer may be amorphized and annealed to be re-crystallized to the crystal orientation of the substrate. N- and P-type devices, such as tri-gate devices, may both be formed on the substrate, with each type of device having the proper crystal orientation along the top and side surfaces of the claimed region for optimum performance. For instance, a substrate may have a portion with a <100> crystal orientation along a top and sidewalls of an NMOS tri-gate transistor and another portion having a <110> crystal orientation along parallel top and sidewall surfaces of a PMOS tri-gate transistor.

Abstract: A control pedal disabling device includes a housing having a side opening or notch for receiving a pedal assembly component. The opening has a forward surface for bearing against the underside of a pedal assembly component. A rod is slidably mounted to the housing. The rod is movable across the opening to trap the pedal assembly component in the opening. The rod is also movable forwardly from the housing to bear against a vehicle floor, thereby preventing movement of the pedal assembly component toward the vehicle floor.

Abstract: End-to-end authentication capability based on public-key certificates is combined with the Session Initiation Protocol (SIP) to allow a SIP node that receives a SIP request message to authenticate the sender of request. The SIP request message is sent with a digital signature generated with a private key of the sender and may include a certificate of the sender. The SIP request message my also be encrypted with a public key of the recipient. After receiving the SIP request, the receiving SIP node obtains a certificate of the sender and authenticates the sender based on the digital signature. The digital signature may be included in an Authorization header of the SIP request, or in a multipart message body constructed according to the S/MIME standard.

Abstract: A method and system for configuring a client computer for real-time communication is provided, in which configuration settings are sent to the computer in the form of a configuration document, such as mark-up language document, that is readable by the client computer. The client computer may request the configuration document on an as-needed basis, or may request to be notified whenever new configuration settings are needed.

Abstract: A bird toy providing activity for a pet bird such as a parrot including an enclosure receiving a slide in which treats can be placed. The slide is retracted into the enclosure to prevent access to the treats and cannot be pulled out until the pet bird rotates one or more predetermined orientations whereat the slide can be pulled out to access the treats. Appendages are provided to enable gripping of the slide and enclosure to allow rotation and pull out of the slide.

Abstract: A method and apparatus to perform a procedure that can include a processor assisted surgical procedure. During the procedure patient space and image space can be registered to allow for tracking of various tracking sensors. An instrument can be placed relative to patient space based upon a plan.

Abstract: A system and method allowing engineers to create large scale, consumer oriented, distributed applications that utilize peer to peer messaging patterns and service oriented architectures. Applications built using the method produce operational cost curves typical of successful peer to peer systems. The system includes mechanisms to deal with reliably and securely sending messages over consumer grade networks that are inherently unreliable and insecure while still permitting direct, consumer-to-consumer messaging by virtue of an extensible Network Address Translation traversal strategy. The system and method allows for the creation of consumer applications by facilitating the identification, location and assembly of services running in a network on a plurality of devices. While the application of the system and method to the distribution of large digital media is readily apparent, the system and method is, in no way, limited to this domain.

Abstract: A device, a software product, and a method for obtaining content in a peer-to-peer (P2P) network are provided. A request is received for content from a device. For example, using a browser, a user at the device selects a hyperlink indicating content that can be obtained by the user. The content may include an application and a media file. For example, the content may be a movie, a song, a picture, a game, a software application, etc. The request includes information associated with the device. The information associated with the device is added to a collection, which is a group of devices connected in a P2P network that have received the selected content. A file is sent to the device using the P2P network. The file includes the content and programmed instructions to instantiate a management application at the device and to execute the first content at the device.

Abstract: A method of presenting an advertisement to a user executing content at a device is provided. A request for content is sent to a device in a peer-to-peer (P2P) network. A file is received from the P2P network. The file includes the content requested and a campaign file. The campaign file includes information identifying when and which advertisements are presented to a user during execution of the requested content. The received file is installed and the requested content is executed. A time is determined for presenting an advertisement based on information read from the campaign file. At the determined time, the advertisement is requested and presented. The advertisement itself is delivered either in-advance of a request or on demand in response to a request as determined by the campaign file. The advertisement is delivered from either the content-requesting device, a peer or server in the P2P network, or a third party Internet delivery service.

Abstract: A control pedal disabling device includes a housing having a side opening or notch for receiving a pedal assembly component. The opening has a forward surface for bearing against the underside of a pedal assembly component. A rod is slidably mounted to the housing. The rod is movable across the opening to trap the pedal assembly component in the opening. The rod is also movable forwardly from the housing to bear against a vehicle floor, thereby preventing movement of the pedal assembly component toward the vehicle floor.

Abstract: The present invention relates to a method for a media-on-demand server of handling streaming of media based on media requests received from user operated clients, wherein said server receives media requests from a user operated client and streams said media to said user operated client, wherein the handling of streaming comprises using a presence service adapted for determining the presence status of said user operating said client and only streaming user requested media if said user has a predefined presence status. Thereby it is possible at the server to check the presence status of the user before streaming media requested by the user, and it can e.g.

Abstract: Method and apparatus for testing a milk for mastitis wherein the milk sample is admixed with a detergent under condition that increase the viscosity of the milk sample; the increased viscosity mixture is subjected to a further procedure for further increasing its viscosity; and the further increased viscosity mixture is then tested for an attribute of somatic cells, such as DNA. This determination is then used to establish if the cow from whom the milk came has mastitis.

Abstract: The invention relates to a system of apparatuses for receiving content items, e.g. television sets, a method of controlling the apparatuses for receiving content items and a remote control unit for communicating with the apparatus for receiving content items. The system comprises selection control means (120, 130, 140) for controlling the apparatuses to select automatically the same content items for users having substantially the same user preferences. The selection control means may be located at the head-end of a cable network. The selection control means may comprise a selection control circuit (120), a user profiling unit (130) and/or an operator interface (140). Selection control data may be generated for transmission to the receivers, for example, by using a collaborative user profile for users with the same user preferences and EPG data.