Abstract: Disclosed herein are compositions, uses, and methods for treatment of ovarian cancers. In one aspect, provided herein is a composition or medical preparation comprising at least one RNA, wherein the at least one RNA encodes the following amino acid sequences: (i) an amino acid sequence comprising claudin 6 (CLDN6), an immunogenic variant thereof, or an immunogenic fragment of the CLDN6 or the immunogenic variant thereof; (ii) an amino acid sequence comprising p53, an immunogenic variant thereof, or an immunogenic fragment of the p53 or the immunogenic variant thereof; and (iii) an amino acid sequence comprising Preferentially Expressed Antigen In Melanoma (PRAME), an immunogenic variant thereof, or an immunogenic fragment of the PRAME or the immunogenic variant thereof.

Abstract: A computer-implemented method for controlling a vehicle system of a host vehicle merging into a lane. The method includes determining an actual distance between the host vehicle and the one or more remote vehicles. The actual distance is a longitudinal distance between the host vehicle and the one or more remote vehicles. The method includes determining a safe distance for merging into the lane based on a relative position of the host vehicle to the one or more remote vehicles, a speed of the host vehicle, and a speed of the one or more remote vehicles. The safe distance is a second longitudinal distance between the host vehicle and the one or more remote vehicles. The method includes controlling the vehicle system of the host vehicle to assist a merge maneuver by the host vehicle according to the actual distance and the safe distance.

Abstract: An acceleration transducer defines a rectangular coordinate system with two orthogonal horizontal axes that are both normal to a vertical axis and includes a main body defining tangential side faces arranged tangentially to the vertical axis, and normal side faces arranged normally to the vertical axis. The transducer includes exactly three piezoelectric elements and three seismic masses. Exactly one piezoelectric element is secured to each of the three tangential side faces, and exactly one seismic mass is secured to each of the three piezoelectric elements. Each piezoelectric element has a high sensitivity for a shear force exerted by the attached seismic mass along a principal tangential axis that is another one of the three axes for each of the three piezoelectric elements.

Abstract: An acceleration transducer defines a rectangular coordinate system with two orthogonal horizontal axes that are both normal to a vertical axis and includes a main body defining tangential side faces arranged tangentially to the vertical axis, and normal side faces arranged normally to the vertical axis. The transducer includes a converter unit, exactly three piezoelectric elements and three seismic masses. Each piezoelectric element generates piezoelectric charges transmitted to the converter unit, which is only and directly arranged on a normal side face of the main body or only on a support that is attached to a normal side face of the main body. Exactly one piezoelectric element is secured to each of the three tangential side faces, and exactly one seismic mass is secured to each of the three piezoelectric elements.

Abstract: An acceleration transducer defines a rectangular coordinate system with two orthogonal horizontal axes that are both normal to a vertical axis and includes a main body disposed within a housing and defining tangential side faces arranged tangentially to the vertical axis, and a normal side face arranged normally to the vertical axis. A piezoelectric element is secured to one of the tangential side faces, and a seismic mass secured to the piezoelectric element. A signal output is attached to the housing and includes a signal conductor spaced apart by an assembly gap from a tangential side face that is not attached to the piezoelectric element. The assembly gap extends perpendicularly to the vertical axis. The normal side face includes main body output conductors spanning the assembly gap in a direction perpendicular to the vertical axis and directly contacting the signal conductor.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: Techniques and apparatuses are described that enable radar attenuation mitigation. To improve radar performance, characteristics of an attenuator and/or properties of a radar signal are determined to reduce attenuation of the radar signal due to the attenuator and enable a radar system to detect a target located on an opposite side of the attenuator. These techniques are beneficial in situations in which the attenuator is unavoidably located between the radar system and a target, either due to integration within other electronic devices or due to an operating environment. These techniques save power and cost by reducing the attenuation without increasing transmit power or changing material properties of the attenuator.

Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.

Abstract: A technique is described for the application of three-dimensional (3D) relief to a substrate such as a ceramic tile using digital inkjet technology. In an example embodiment, the introduced technique includes application of binder ink to a portion of the surface of a substrate using a digital inkjet process. This binder ink forms a barrier layer which protects the portion of the surface of the substrate. Next, a brushing process is applied to remove unprotected portions of the substrate, thereby forming the 3D relief in the substrate.

Abstract: The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool.

Abstract: A system for an electro magnetic oscillator tube with enhanced isotopes is disclosed herein having at least one magnetron layer. Each layer has a first magnet, a conduction block, and a second magnet of opposite polarity. The conduction block is disposed in a plane about an emitter of isotopic particles, where an opposite electrical polarity relative to the emitter forms between the emitter and the conduction block. The conduction block has an RF port, an interaction space in its inner periphery, and a polar array of resonant cavities forming along its outer periphery, and a diamond or similar material coating the conduction block surfaces. The system also has a connection between selected groups of resonant cavities at locations of like electrical polarity, wherein the connections have conductive strapping elements within the conduction block.

Abstract: A technique is described for the application of three-dimensional (3D) relief to a substrate such as a ceramic tile using digital inkjet technology. In an example embodiment, the introduced technique includes application of binder ink to a portion of the surface of a substrate using a digital inkjet process. This binder ink forms a barrier layer which protects the portion of the surface of the substrate. Next, a brushing process is applied to remove unprotected portions of the substrate, thereby forming the 3D relief in the substrate.

Abstract: Techniques and apparatuses are described that enable radar attenuation mitigation. To improve radar performance, characteristics of an attenuator and/or properties of a radar signal are determined to reduce attenuation of the radar signal due to the attenuator and enable a radar system to detect a target located on an opposite side of the attenuator. These techniques are beneficial in situations in which the attenuator is unavoidably located between the radar system and a target, either due to integration within other electronic devices or due to an operating environment. These techniques save power and cost by reducing the attenuation without increasing transmit power or changing material properties of the attenuator.

Abstract: The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool.

Abstract: Techniques and apparatuses are described that enable radar attenuation mitigation. To improve radar performance, characteristics of an attenuator and/or properties of a radar signal are determined to reduce attenuation of the radar signal due to the attenuator and enable a radar system to detect a target located on an opposite side of the attenuator. These techniques are beneficial in situations in which the attenuator is unavoidably located between the radar system and a target, either due to integration within other electronic devices or due to an operating environment. These techniques save power and cost by reducing the attenuation without increasing transmit power or changing material properties of the attenuator.

Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.

Abstract: A cooling assembly includes a cooling chamber disposed inside of a turbine assembly. The cooling chamber directs cooling air inside an airfoil of the turbine assembly. The cooling assembly includes a metered channel fluidly coupled with the cooling chamber. The metered channel directs at least some of the cooling air out of the cooling chamber outside of a rail surface of the airfoil. The metered channel is elongated along and encompasses an axis. The metered channel has an interior surface with a distance between opposing first portions of the interior surface. The distance between the opposing first portions decreases at increasing distances along the axis from the cooling chamber toward the rail surface.

Abstract: A technique is described for the application of three-dimensional (3D) relief to a substrate such as a ceramic tile using digital inkjet technology. In an example embodiment, the introduced technique includes application of binder ink to a portion of the surface of a substrate using a digital inkjet process. This binder ink forms a barrier layer which protects the portion of the surface of the substrate. Next, a brushing process is applied to remove unprotected portions of the substrate, thereby forming the 3D relief in the substrate.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: Disclosed are compositions, such as inkjet inks, for jetting onto a ceramic substrate, and associated methods and systems. The compositions comprise a pigment compound that is configured to be jetted on a ceramic substrate during a ceramic inkjet process to impart a color effect to the ceramic substrate, and a reduction agent which, when exposed to a firing temperature, reacts with the pigment compound to cause a reduction reaction. In some embodiments, the pigment compound comprises jettable copper particles, which can cause the fired composition to take on a red or oxblood color, which can be used for decoration.