Abstract: Embodiments of the present disclosure generally relate to methods for forming a waveguide. Methods may include measuring a waveguide substrate, the waveguide having a substrate thickness distribution; and depositing an index-matched layer onto a surface of the waveguide, the index-matched layer having a first surface disposed on the waveguide substrate and a second surface opposing the first surface, wherein the index-matched layer is disposed only over a portion of the waveguide substrate, and a device slope of a second surface of the index-matched layer is substantially the same as the waveguide slope of the first surface of the waveguide.

Abstract: A surfboard multitool has a handle with a fin key or screwdriver inserted into one end for storage, and the other end terminating in a brush on the front side and a fin removal tool on the back side. The fin removal tool has two fin grippers that are placed around a surfboard fin in use, and pivoted to remove the fin from its fin box. A fin key or screwdriver is stored in the end of the handle. Between the fin removal tool, brush, and removable fin key or screwdriver, an all-in-one multitool for the most regular tasks in surfboard maintenance is provided.

Abstract: Disclosed are embodiments of microstrip and substrate integrated waveguide circulators/isolators which can be integrated with a substrate. This composite structure can serve as a platform for other components, allowing for improved miniaturization of components. Embodiments of the disclosure can be particular advantageous in the high frequency ranges, such as above 1.8 GHz or above 3 GHz, which allows devices to be used in the 5G space.

Abstract: A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein A1 and A2 are independently O or S; X is selected from CH2, CD2, NR3, O, and S, where R3 is selected from hydrogen, C1-C4 linear or branched chain alkyl, halo(C1-C4)linear or branched chain alkyl, and hydroxyl(C1-C4)linear or branched chain alkyl; Y and Z are selected from C and N, where when Y is C, then Z is N, and when Y is N, then Z is C; R1 and R2 are independently selected from hydrogen, deuterium, C1-C4 linear or branched chain alkyl, etc.; or a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring; or taken together to form a C3-C6 cycloalkyl ring; or where X is CH2 or CD2, then R1 and R2 are independently selected from hydrogen, deuterium, halogen, hydroxyl, C1-C4 linear or branched chain alkyl, etc.; R4 is selected from hydrogen, deuterium, cyano, halogen, (C1-C3) alkoxy, etc.; R5 is selected from hydrogen, deuterium, halogen, C1-C3 alkoxy, amino, (C1-C4 linear or branched chain alkyl)amino, etc.

Abstract: Embodiments of the present disclosure generally relate to methods of forming a substrate having a target thickness distribution at one or more eyepiece areas across a substrate. The substrate includes eyepiece areas corresponding to areas where optical device eyepieces are to be formed on the substrate. Each eyepiece area includes a target thickness distribution. A base substrate thickness distribution of a base substrate is measured such that a target thickness change can be determined. The methods described herein are utilized along with the target thickness change to form a substrate with the target thickness distribution.

Abstract: A separable tool including a mill section, a mill face disposed on the mill section and having a bore therethrough that is offset from a longitudinal axis of the mill section, a tool adapter section, and a release configuration releasably securing the mill section to the tool adapter section with the mill face disposed between the mill section and the tool adapter section. A method for operating a wellbore system including in a single run, setting a plug in the wellbore system, releasing the plug, pumping cement, dressing the cement, and testing the cement.

Abstract: In one embodiment, a coupler includes a glass tube having a refractive index n3 and a passageway, a first optical waveguide and a second optical waveguide positioned within the passageway, each of the first optical waveguide and the second optical waveguide comprising a core surrounded by a cladding. The glass tube further includes a tapered region having a taper length. A coupling region is present between the first optical waveguide and the second optical waveguide within the tapered region. A refractive index of the cladding is less than a refractive index of the core, and a lowest refractive index of the cladding of the first optical waveguide and the second optical waveguide is n2. Additionally, n3 is lower than n2 such that a value of ?2-3 is 0.07%??2-3?0.125, where ?2-3 equals (n22?n32)/2n22.

Abstract: A data migration and integration system is disclosed. In various embodiments, the system includes a memory configured to store a mapping from a source schema to a target schema; and a processor coupled to the memory and configured to migrate to a target schema an instance of source data organized according to the source schema, including by using a chase engine to perform an ordered sequence of steps comprising adding a bounded layer of new elements to a current canonical chase state associated with migrating the source data to the target schema; adding coincidences associated with one or more of the target schema data integrity constraints and a mapping from the source schema to the target schema; and merging equal elements based on the coincidences; and repeat the preceding ordered sequence of steps iteratively until an end condition is met.

Abstract: Physical layouts of Majorana-based qubits for implementations of pentagonal tilings are described. An example quantum device comprises a set of tetrons for enabling Majorana-based qubits. The set of tetrons is arranged in a lattice to allow pentagonal tilings associated with the set of tetrons. The vertices of the pentagonal tilings relate to the qubits and single qubit operations, and the edges of the pentagonal tilings (connecting different vertices) relate to 2-qubit operations acting on a pair of qubits connected by a given edge. As an example, the 1-qubit Pauli measurements relate to the operations performed on the vertices associated with the pentagonal tilings and the 2-qubit measurements relate to the operations performed along the edges of the pentagonal tilings.

Abstract: An interface for positive pressure respiratory therapy includes a mask assembly having a mask seal and a mask shell. The mask assembly is positioned lower than and exposes a bridge of the user's nose. The mask seal includes first and second portions on respective first and second sides of a nasal region that contact opposing sides of the user's nose. The first and second portions each include supports that help maintain a shape of the mask seal. A pair of covers can be supported relative to the mask assembly and adjacent a respective one of the first and second portions of the mask seal. The covers limit expansion of the first and second portions of the mask seal in response to pressurized air within the mask seal. The supports of the first and second portions can transfer load from the mask seal to the covers.

Abstract: This invention concerns a sole element for a cleated article of footwear, in particular for a football shoe. The sole element includes a composite element with an anisotropic bending property. The sole element further includes a polymer element, and the polymer element at least partially covers the composite element of the sole element.

Abstract: Method and apparatuses for diffuse optical tomography (DOT) are disclosed herein. A DOT device includes a substrate, one or more radiation sources, a plurality of detectors, and structures disposed over the second surface of the plurality of detectors. The one or more radiation sources are disposed over or under a surface of the substrate. Each detector of the plurality of detectors has a first surface and a second surface. The first surface is opposite the second surface. The first surface of the plurality of detectors disposed over or under the surface of the substrate. The method of DOT method of includes emitting and scattering radiation from one or more sources of a DOT device; detecting scattered radiation with a plurality of detectors of the DOT device; and translating the scattered radiation that is detected into data.

Abstract: Aspects of the invention include methods, systems, and computer program products for integrated circuit development using cross-hierarchy antenna condition verification. A method includes obtaining a design of a hierarchical macro distributed between multiple files for an integrated circuit and analyzing, by a design verification tool, a route between at least one child macro and at least one pin of the hierarchical macro as defined in the files. The method further includes determining, by the design verification tool, a plurality of connection characteristics of the at least one child macro and the at least one pin forming the route and calculating, by the design verification tool, an antenna condition for the route based on the connection characteristics. The design of the hierarchical macro is adjusted to remove a violation of an antenna rule based on determining that the antenna condition of the route violates the antenna rule.

Abstract: A system for cooling a hermetic motor includes a motor cooling refrigerant flow path configured to direct refrigerant from a condenser disposed along a refrigerant loop to a hermetic motor, and from the hermetic motor back to the refrigerant loop, and a housing of the hermetic motor disposed along the motor cooling refrigerant flow path and configured to receive the refrigerant from the condenser, wherein the housing of the hermetic motor comprises an annulus surrounding at least a portion of a stator of the hermetic motor, and wherein the annulus comprises a plurality of openings configured to direct refrigerant toward the stator and into a cavity of the housing of the hermetic motor.

Abstract: A system and method for displaying images of internal anatomy includes an image processing device configured to provide high resolution images of the surgical field from low resolution scans during the procedure. The image processing device digitally manipulates a previously-obtained high resolution baseline image to produce many representative images based on permutations of movement of the baseline image. During the procedure a representative image is selected having an acceptable degree of correlation to the new low resolution image. The selected representative image and the new image are merged to provide a higher resolution image of the surgical field. The image processing device is also configured to provide interactive movement of the displayed image based on movement of the imaging device, and to permit placement of annotations on the displayed image to facilitate communication between the radiology technician and the surgeon.

Abstract: Provided herein are compounds binding to KRAS protein or a mutant thereof, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Abstract: A drug delivery system for injecting a medicament includes a housing, a container configured to receive a medicament including a stopper configured to move within the container and a closure, a needle in fluid communication with the container, a spacer configured to be engaged with the stopper, a first plunger, a first spring configured to bias the first plunger in an axial direction, second plunger disposed about the first plunger, a second spring configured to bias the second plunger in an axial direction. The first plunger is configured to move the spacer and the container relative to the housing via the first spring to establish fluid communication between the container and the patient needle, and the second plunger is configured to move the spacer and the stopper relative to the container via the second spring.

Abstract: A system for detecting external leaks in a cabin of a vehicle includes sensors and onboard vehicle controls disposed on the vehicle. Control modules of the system have processors, memory, and input/output (I/O) ports. The I/O ports communicate with the sensors and onboard vehicle controls. The control modules execute program code portions stored memory. The program code portions include first and second algorithm portions. The first algorithm portion receives data from the sensors and controls and determines that the data from the sensors and controls meets initialization threshold values. When the data from the sensors and controls meets the threshold values, the second algorithm portion generates a cabin leak detection output including: a first output, a second output, or a third output. The first output indicates a large leak, the second output indicates no leak, and the third output indicates that a small leak has been detected.

Abstract: Navigation and simulation systems and methods for minimally invasive therapy in which the navigation system imports a planning method using patient specific preoperative images. The navigation system uses intraoperative imaging during the medical procedure to update the preoperative images and provides images of tracked surgical tools along the surgical path prepared from the preoperative images.

Abstract: Methods and systems for delivering well stimulation materials to a wellbore using a high-pressure delivery manifold are provided. In some embodiments, the methods of the present disclosure include: providing a pressurizable delivery manifold at a well site, wherein the pressurizable delivery manifold is continuously equalized with a piping system; providing a pressurized treatment fluid to the pressurizable delivery manifold; releasing one or more well stimulation materials into the pressurized treatment fluid to create a payload delivery treatment fluid; and injecting the payload delivery treatment fluid into at least a portion of a subterranean formation.