Abstract: Pharmaceutical compositions and methods are disclosed for the treatment of menstrual pain, primary and secondary dysmenorrhea, and premenstrual symptoms. The compositions comprise, in a unit dose: (a) acetaminophen in an analgesic-effective amount; (b) pyrilamine maleate in an antihistaminic and smooth-muscle-relaxant amount; and (c) paraxanthine in a sub-stimulant adjuvant analgesic-enhancing amount of from about 25 mg to about 200 mg per unit dose, preferably about 75 mg. The sub-stimulant paraxanthine dose potentiates the analgesic efficacy of acetaminophen via competitive antagonism of adenosine A1 and A2A receptors and offsets the mild sedation of pyrilamine, while avoiding the peripheral vasoconstriction, anxiogenesis, and rebound fatigue that characterize the caffeine component of existing OTC menstrual analgesic products.

Abstract: The present disclosure relates to ruthenium promoter catalyst compositions. The ruthenium promoter catalyst compositions comprise ruthenium metal species, an oxide support material, and a promoter species independently selected from the group consisting of La, Rb, Y, Yb, K, Cs, and Ba, or hydroxides, nitrates or oxides thereof. The present disclosure also relates to various methods, processes, systems, membranes and/or reactors, which can utilise the ruthenium promoter catalyst compositions, for example in ammonia synthesis.

Abstract: A casing exit assembly, including a whipstock, a mill releasably attached to the whipstock, the mill including an initiation sensor and a drive, and an anchor attached to the whipstock, the anchor including a housing with a ramp, a slip disposed to move radially of the housing upon axially transitioning on the ramp, and an interlock operably attached to the driver. A method for managing a casing exit, including running the casing exit assembly to a target location in a borehole, sensing a pressure within or around the assembly, imposing a tensile load on the interlock, releasing the interlock, moving the slip with a drive plate of the interlock, and setting the slip. A borehole system, including a borehole in a subsurface formation, a string disposed in the borehole, and a casing exit assembly, disposed within or as a part of the string.

Abstract: A mill, whipstock, and anchor assembly, including a mill, a whipstock attached to the mill, an anchor attached to the whipstock, the anchor having a kinetic energy releaser, the releaser including an energetic material, and a sensor in the assembly, the sensor configured to respond to a selected parameter by sending a first signal. A method for setting an anchor of the assembly, the method including causing a condition to exist at the sensor that at least reaches a threshold for the sensor to generate the first signal, igniting the energetic material, disappearing the releaser, and applying kinetic energy to a slip to set the anchor. A borehole system, including a borehole in a subsurface formation, a string disposed in the borehole, and the mill, whipstock, and anchor assembly disposed within or as a part of the string.

Abstract: A mill, whipstock, and anchor assembly, including a mill, a whipstock attached to the mill, an anchor attached to the whipstock, the anchor having a kinetic energy releaser, the releaser including an energetic material, and a sensor in the assembly, the sensor configured to respond to a selected parameter by sending a first signal. A method for setting an anchor of the assembly, the method including causing a condition to exist at the sensor that at least reaches a threshold for the sensor to generate the first signal, igniting the energetic material, disappearing the releaser, and applying kinetic energy to a slip to set the anchor. A borehole system, including a borehole in a subsurface formation, a string disposed in the borehole, and the mill, whipstock, and anchor assembly disposed within or as a part of the string.

Abstract: A casing exit assembly, including a whipstock, a mill releasably attached to the whipstock, the mill including an initiation sensor and a drive, and an anchor attached to the whipstock, the anchor including a housing with a ramp, a slip disposed to move radially of the housing upon axially transitioning on the ramp, and an interlock operably attached to the driver. A method for managing a casing exit, including running the casing exit assembly to a target location in a borehole, sensing a pressure within or around the assembly, imposing a tensile load on the interlock, releasing the interlock, moving the slip with a drive plate of the interlock, and setting the slip. A borehole system, including a borehole in a subsurface formation, a string disposed in the borehole, and a casing exit assembly, disposed within or as a part of the string.

Abstract: A milling tool, including an outer housing having a first end and a second end, a blade shifter mandrel movably disposed within the outer housing, a biaser disposed at the first end to bias the shifter mandrel toward the second end, a piston that in response to reverse circulation moves the shifter mandrel toward the first end to compress the biaser, and a blade mounted to the outer housing and in operable contact with the blade shifter mandrel. A method for operating a milling tool, the method including running the milling tool to a target location of a borehole, reverse circulating a fluid in the borehole, biasing the piston with the reverse circulating fluid to deploy the blade. A borehole system, including a borehole in a subsurface formation, a string disposed within the borehole, and a milling tool disposed within or as a part of the string.

Abstract: A separable tool including a mill section, a mill face disposed on the mill section and having a bore therethrough that is offset from a longitudinal axis of the mill section, a tool adapter section, and a release configuration releasably securing the mill section to the tool adapter section with the mill face disposed between the mill section and the tool adapter section. A method for operating a wellbore system including in a single run, setting a plug in the wellbore system, releasing the plug, pumping cement, dressing the cement, and testing the cement.

Abstract: A method for pulling casing includes disposing a casing modification and pulling tool having an element therein that includes a profile, causing the element to move radially outwardly into contact with a casing disposed radially outwardly of the tool, deforming the casing with the element, applying a load to the casing, and failing the casing at the deformation. A system for pulling casing includes a casing modification tool having an element radially displaceable into a casing disposed radially outwardly thereof, the element configured to deform the casing, a casing spear operably connected to the casing modification tool, the spear configured to apply a load to the casing to fail the casing at the deformation. A borehole system includes a borehole in a subsurface formation, a casing disposed in the borehole, and a casing modification and pulling tool disposed in the casing.

Abstract: An object carrier including a housing having a bore with a diametrically larger portion and a diametrically smaller portion, an object keeper having a first and a second end, the first end being initially disposed in the diametrically smaller portion, an actuator assembly configured to move the first end of the object keeper from the diametrically smaller portion to the diametrically larger portion responsive to selected application of pressure, and an object disposed within the object keeper and secured within the object keeper while the first end of the object keeper is in the diametrically smaller portion, the object being released from the object keeper upon the first end of the object keeper moving to the diametrically larger portion. A method for managing an object-based operation downhole of a restriction including pressuring up on the object carrier, withdrawing the first end from the diametrically smaller portion, and releasing the object.

Abstract: A section milling tool includes an electrically operated section mill configured to mill without conveying swarf to surface, an electric motor operably connected to the section mill, an electric stroker operably connected to the motor, and an electric anchor operably connected to the stroker. A method for section milling a downhole structure without conveying swarf to surface includes running a bottom hole assembly (BHA) on a wireline, deploying an anchor, rotating a section mill, and stroking the section mill with a stroker. A method for reducing emissions during a section milling operation includes running a tool on wireline, and milling a tubular structure in the borehole. A method for plugging and abandonment of a well includes running a tool on wireline, milling a tubular structure in the borehole, and plugging the well at the milled tubular structure.

Abstract: A separable tool including a mill section, a mill face disposed on the mill section and having a bore therethrough that is offset from a longitudinal axis of the mill section, a tool adapter section, and a release configuration releasably securing the mill section to the tool adapter section with the mill face disposed between the mill section and the tool adapter section. A method for operating a wellbore system including in a single run, setting a plug in the wellbore system, releasing the plug, pumping cement, dressing the cement, and testing the cement.

Abstract: A casing mill including a first milling configuration having a first blade for milling a first casing section, and a second milling configuration having a second blade, the second blade being an ultra-high expansion blade for milling a second casing section. A wellbore system including a borehole in a subsurface formation, two nested casings disposed within the borehole, a string disposed within the casings, a casing mill disposed within or as a part of the string and including a first milling configuration having a first blade for milling a first casing section, and a second milling configuration having a second blade, the second blade being an ultra-high expansion blade for milling a second casing section, the second casing section being radially outwardly disposed of the first casing section, and a stroking tool disposed between the first milling configuration and the second milling configuration.

Abstract: In some embodiments, techniques for creating a fabricable segmented design for a physical device are provided. A computing system receives a design specification. The computing system generates a proposed segmented design based on the design specification. The computing system determines one or more fabricable segmented designs based on the proposed segmented design. The computing system determines an overall fabrication loss value based on the one or more fabricable segmented designs. The computing system backpropagates a gradient of the overall fabrication loss value to create an updated design specification.

Abstract: An object carrier including a housing having a bore with a diametrically larger portion and a diametrically smaller portion, an object keeper having a first and a second end, the first end being initially disposed in the diametrically smaller portion, an actuator assembly configured to move the first end of the object keeper from the diametrically smaller portion to the diametrically larger portion responsive to selected application of pressure, and an object disposed within the object keeper and secured within the object keeper while the first end of the object keeper is in the diametrically smaller portion, the object being released from the object keeper upon the first end of the object keeper moving to the diametrically larger portion. A method for managing an object-based operation downhole of a restriction including pressuring up on the object carrier, withdrawing the first end from the diametrically smaller portion, and releasing the object.

Abstract: A casing mill including a first milling configuration having a first blade for milling a first casing section, and a second milling configuration having a second blade, the second blade being an ultra-high expansion blade for milling a second casing section. A wellbore system including a borehole in a subsurface formation, two nested casings disposed within the borehole, a string disposed within the casings, a casing mill disposed within or as a part of the string and including a first milling configuration having a first blade for milling a first casing section, and a second milling configuration having a second blade, the second blade being an ultra-high expansion blade for milling a second casing section, the second casing section being radially outwardly disposed of the first casing section, and a stroking tool disposed between the first milling configuration and the second milling configuration.

Abstract: A mill for a single casing string including a housing, a first blade section having a blade of a first profile disposed in the housing and positionable to axially mill the single casing string, a second blade section having a blade of a second profile disposed in the housing and positionable to axially mill the single casing string, the first and second blades deployable simultaneously, the second blade configured to ride on an inside diameter surface of the single casing string while the second blade in the deployed position.

Abstract: A stump cutter includes a mainframe and a cutter wheel supported by a boom and rotatable about a cutter wheel axis spaced from the mainframe. A two-axis gimbal set supports the boom from the mainframe, the two-axis gimbal set supporting the boom for sweep movements of the cutter wheel about a vertical cutter wheel sweep axis and for tilt movements of the cutter wheel about a horizontal cutter wheel tilt axis. A prime mover on the mainframe is configured to drive the cutter wheel about the cutter wheel axis. A mechanical driveline is configured to provide power transmission from the prime mover to the cutter wheel, the mechanical driveline including a constant velocity joint.