Abstract: A method is provided for non-intrusively determining deposits of a fluidic channel. The method includes creating a pressure pulse in a fluidic channel. The method also includes sensing, by one or more sensors, reflections of the pressure pulse; and obtaining, from the one or more sensors, a measured pressure profile based on the sensed reflections of the pressure pulse. A processor then can determine one or more properties of the deposit in the fluidic channel based on the measured pressure profile.

Abstract: An aircraft includes a fuselage module and at least two vertical lift rotor modules supporting at least four rotor assemblies. Each rotor assembly is supported by a rotor boom having at least one boom free end and a boom mounting portion. Each rotor assembly has at least one vertical lift rotor mounted on the boom free end. Each boom mounting portion is removably couplable to the fuselage module. The vertical lift rotor modules are configured such that when coupled to the fuselage module, a pair of the rotor assemblies are located on each of laterally opposite sides of the fuselage module, and the rotor assemblies of each pair are respectively located forward of and aft of a wing center portion. A pair of wings are configured to be removably couplable to the wing center portion. The aircraft includes a forward thrust module removably couplable to the fuselage body.

Abstract: The invention provides systems and method for the removal of diseased cells during surgery.

Abstract: Non-visible objects which differ in their physical properties from their surroundings by association with a variable strength magnetic field may be detected by a suitable array of sensors which can be moved relative to the object in question. By analyzing the signals from the plurality of the sensors in the array, the position of the object can be deduced relative to the array and the array moved to enable a machining guide thereon to be aligned with the non-visible object. The system is of particular value in locating apertures in wing spars when attempting to fix the skin of the wing on to them where it is important to be able to locate the correct point at which to drill a hole through the skin to coincide with the hole in the spar. By defining a magnetic field in the vicinity of the hole to identify the hole magnetically and using an array of magnetic field sensors in a base with an aperture, it is possible to shift the array so that the aperture is precisely aligned with the non-visible hole.

Abstract: Provided herein are systems, methods, and software for facilitating message sessions. In one implementation, a method for building a type-based reporting model associated with an industrial automation environment includes interrogating a system control to acquire a data structure programmed therein, wherein the data structure includes properties of a component of the industrial automation environment. The method also includes correlating the data structure to a type package object, and generating a model object based on the correlation of the data structure to the type package object, the model object configured to visually display the properties of the component on a report.

Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

Abstract: The invention relates to a method for optimizing an MR imaging sequence with a plurality of sequence blocks where gradient requirements of logical gradients switched along axes including a read, slice, and phase axis are determined. Based on the requirements, a reference gradient is determined among the logical gradients having a longest minimum duration relative to remaining logical gradients within the sequence block during which the reference gradient is switched on. A scaling factor is determined for each of the logical gradients. The scaling factors for the logical gradient factors are updated taking into account the determined stretch ratios, and optimized amplitudes are determined for the logical gradients based on the updated scaling factors.

Abstract: A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial thickness or gland lumen roundness of the tissue, wherein an increase in epithelial thickness or a decrease in gland lumen roundness indicates the presence of prostate cancer or a prostate cancer field defect.

Abstract: Methods, non-transitory machine readable media, and computing devices that accelerate storage operations are disclosed. With this technology, computational storage devices are assigned by a NIC processor of a computational network interface controller (NIC) to storage locations corresponding to respective partitions of an n-dimensional space. One of the storage locations to which a data location in the n-dimensional space maps is then identified by the NIC processor. The data location is determined based on a hash for data associated with a received storage operation. The NIC processor subsequently communicates via a system bus with a storage processor of one of the computational storage device to service the storage operation. The storage processor is coupled directly to flash media of the one of the computational storage device that is assigned to the one of the storage locations and maintains a key/value store comprising the data.

Abstract: Provided are nylon fibers having fire-retardant agents dispersed therein and methods for manufacturing such fibers. The fire-retardant agents may comprise Tris(tribromophenyl) triazine and/or antimony trioxide. Fabrics made from such fibers are also provided.

Abstract: Hierarchical stalling strategies are disclosed. An indication is received of a stalling event caused by a requested resource being inaccessible. In response to receiving the indication of the stalling event, a set of cost functions usable to determine how to handle the stalling event is selected based at least in part on a type of the stalling event. The stalling event is handled based at least in part on an evaluation of the set of cost functions selected based at least in part on the type of the stalling event.

Abstract: In one embodiment, a device classification service obtains telemetry data for a plurality of devices in a network. The device classification service repeatedly assigns the devices to device clusters by applying clustering to the obtained telemetry data. The device classification service determines a measure of stability loss associated with the cluster assignments. The measure of stability loss is based in part on whether a device is repeatedly assigned to the same device cluster. The device classification service determines, based on the measure of stability loss, that the cluster assignments have stabilized. The device classification service obtains device type labels for the device clusters, after determining that the cluster assignments have stabilized.

Abstract: Systems and methods are disclosed for periodic real-time reporting of in-flight turbulence experienced by aircraft using the existing Automatic Dependent Surveillance-Broadcast (ADS-B) messaging system. The invention includes both broadcast to and reception from other aircraft and ground stations using the ADS-B system. Systems and methods for displaying the received turbulence reports on a cockpit display system are also disclosed. The disclosed systems and methods accomplish the objectives of the invention on a non-interference basis with existing ADS-B system functionality by utilizing currently reserved message types and/or unused data fields for the turbulence reporting. The invention is applicable to both 1090ES and 978 UAT ADS-B systems.

Abstract: The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.

Abstract: A radio frequency identification (RFID) tag includes an antenna, an analog front end, a processing circuit, and memory. The analog front end includes a power circuit, a tuning circuit, a transmitter, and a receiver. The power circuit is operably coupled to convert a radio frequency (RF) signal into a power supply voltage. The tuning circuit, when enabled, adjusts an RF characteristic of the analog front end to tune power harvesting from the RF signal. The transmitter is operably coupled to transmit a response signal to the RFID reader via the antenna. The receiver is operably coupled to receive a command signal from the RFID reader, wherein the command signal is contained within a portion of the RF signal. The processing circuit is operable to interpret the command signal and generate the response signal.

Abstract: A device for altering vergence of light to improve human vision of an electronic display. The change in vergence is received at the pupil of the wearer. The altered light effectively recreates the rays emitted by a pixel such that they reach a presbyopic eye as though they were being viewed at a distance (i.e., the rays are substantially parallel). As such, the emmetropic presbyopic eye produces a sharp image of the electronic display. The device comprises: a refractive element that refracts rays, emitted from a pixel of an electronic display, at a predetermined vergence, wherein the refractive element is located directly adjacent or on the electronic display.

Abstract: A co-layer surface-adhesive rule (SAR) that has a pre-defined cross-section profile. The co-layer surface-adhesive rule (SAR) has two or more layers, wherein at least one layer is made from flexible material and wherein at least two layers differ one from the other.

Abstract: A multi-tile processing system has a plurality of tiles each having an execution unit, and an interconnect operable to conduct communications between a group of the tiles according to a bulk synchronous parallel scheme. The execution unit is operable to execute instructions of an instruction set which has a synchronisation instruction for execution by each tile upon completion of its compute phase. The execution of the synchronisation instruction depends on the state of an exception enable flag. In one state, the synchronisation instruction causes the execution unit to send the synchronisation request to hardware logic in the interconnect. In another state of the exception enable flag the synchronisation instruction does not send the synchronisation request, but sets an exception events status to permit interrogation access to the tile. A corresponding method of controlling the debug states of the processing system is provided.

Abstract: The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

Abstract: One embodiment provides an apparatus for displaying an image comprising: a first optical substrate comprising at least one waveguide layer configured to propagate light in a first direction, wherein the at least one waveguide layer of the first optical substrate comprises at least one grating lamina configured to extract the light from the first substrate along the first direction; and a second optical substrate comprising at least one waveguide layer configured to propagate the light in a second direction, wherein the at least one waveguide layer of the second optical substrate comprises at least one grating lamina configured to extract light from the second substrate along the second direction; wherein the at least one grating lamina of at least one of the first and second optical substrates comprises an SBG in a passive mode.