Abstract: Provided are compositions and methods for selectively reducing the amount of antibiotic resistant and/or virulent bacteria in a mixed bacteria population, or for reducing any other type of unwanted bacteria in a mixed bacteria population. The compositions and methods involve targeting bacteria that are differentiated from other members of the population by at least one unique clustered regularly interspaced short palindromic repeats (CRISPR) targeted DNA sequence. The compositions and methods can be readily adapted to target any bacteria or any bacteria plasmid, or both.

Abstract: A device for linking separate members of a dowel cradle, comprising a bar; and at least two couplings, located on the bar. A dowel cradle comprising: at least one load transfer dowel; a basket having a pair of elongate members spaced apart from each other to support the load transfer dowel thereon; a device comprising: a bar located between the two elongate members of the basket; and at least two couplings located on the bar, each coupling being attached to a respective one of the elongate members of the basket.

Abstract: Systems, components, apparatuses, kits and methodologies of the present invention are directed to techniques that ensure that all deck-to-wall, roof-to-wall and other constructions properly protect the home from the environment, particularly along the wetter coastal regions by forming a layered, waterproof seal of metal, plastic and bitumen. A modularized system of components, that overlap each other either over and or under to create a system that meets the design criteria of critical flashing components, each with waterproofing capability either built-in or applied onsite in use, are employed to cover critical building areas prone to water infiltration and damage.

Abstract: Systems, apparatuses, and methods for performing a software override of a power estimation mechanism are disclosed. A computing system includes a plurality of tuned parameters for generating an estimate of power consumption. The tuned parameters are generated based on post-silicon characterization of the system. After deployment, the system executes a plurality of different applications. When launching a particular application, the system loads a corresponding set of override parameters which are used to replace the plurality of tuned parameters. The system generates an estimate of power consumption using the set of override parameters rather than the previously determined tuned parameters. Then while executing the particular application, the system makes adjustments to power and frequency values for the various system components based on the estimate of power consumption.

Abstract: Microfluidic devices, method for making and using same are disclosed. The microfluidic device can be made by applying a reagent in liquid form into a sample treatment site within a substrate base. The substrate base has hydrophilic properties bordering a flow channel, and has an application site, the sample treatment site and an analytical site. The flow channel is sized and configured so as to draw a sample applied into the application site to the analytical site through the sample treatment site by capillary action. The reagent is freeze-dried within the sample treatment site.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a MaTAR in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate breast cancer in an individual in need.

Abstract: There is disclosed a heat exchanger comprising at least one set of channels having a proximal end and a distal end, the set of channels comprising: a first channel defined by a first skin and a wall; and a second channel defined by a second skin and the wall, wherein the wall located between the first channel and the second channel comprises a first at least one aperture to allow fluid to pass through the wall from the first channel to the second channel.

Abstract: Embodiments described herein generally relate to apparatus having a canister with a sidewall, a top, and a bottom forming a canister volume. An inlet line and an outlet line is coupled to the top and is in fluid communication with the canister volume. A plate disposed within the canister volume forms a headspace volume below the plate. Each of the inlet line and the outlet line is in fluid communication with the headspace volume. The apparatus includes standoffs extending from a lower surface of the plate. The standoffs include a lower surface area substantially parallel with the plate.

Abstract: A fixed target sample holder for serial synchrotron crystallography comprising a goniometer compatible base, a carrier, a sample holding insert which can be placed into the carrier. The sample holding insert comprising fiducials and windows, wherein each of the windows are respectively configured to accept a sample. The windows can also have holes and texture within each window. Additionally, a sample loading workstation for loading crystals into the sample holder and the removal of excess liquid from the sample, comprising a humidity-controlled chamber, a sample support within the chamber, a capture to place the goniometer-compatible base, and a channel in communication with the chamber that allows for the flow of humidified air into the chamber.

Abstract: A method can include obtaining characteristic data for a wafer. The characteristic data can correspond to the wafer in a processed state and can include a set of stress values of the wafer. The wafer can include a front side, a back side opposite the front side, and a set of regions. The set of stress values can include a first stress value corresponding to a first region. In the processed state, one or more front-side processes can be completed on the front side of the wafer. The method can include determining that the first stress value exceeds a stress threshold and generating a compensation map. The compensation map can identify one or more regions for forming one or more trenches. The method can include initiating, based on the compensation map, a formation of a first trench on the back side of the wafer in the first region.

Abstract: In an example display system, a range of colors around a region may be identified and compared to a color of the region with respect to a perception threshold. In that example, a modification of the color within the region may be determined based on the range of colors around the region and a display may be caused to present the region in a modified color based on the range of colors around the region with respect to the perception threshold.

Abstract: A gripping assembly for gripping at least one conduit routed within a vertically adjustable medical boom head assembly includes a support, and a plurality of grip paddles pivotally mounted to the support and arranged around a central pathway for routing the at least one conduit, wherein the grip paddles are configured to pivot inwardly relative to the central pathway to grip the at least one conduit running through the central pathway.

Abstract: A computer-implemented device and corresponding method are provided for processing a multi-agent system input to form an at least partially optimised output indicative of an action policy. The method comprises receiving the multi-agent system input, the multi-agent system input comprising a definition of a multi-agent system and defining behaviour patterns of a plurality of agents based on system states; receiving an indication of an input system state; performing an iterative machine learning process to estimate a single aggregate function representing the behaviour patterns of the plurality of agents over a set of system states; and iteratively processing the single aggregate function for the input system state to estimate an at least partially optimised set of actions for each of the plurality of agents in the input system state. This may allow policies corresponding to the Nash equilibrium to be learned.

Abstract: Disclosed is system, method, and rack stand portion for the advantageous cooling of computer equipment. When multiple instances of computer equipment are managed from a central authority, cooling, heating, and/or cessation of either can be controlled in a way that enhances efficiency. Impediments that control access channels and interior access to computer equipment is toggled by the present invention.

Abstract: Techniques and mechanisms for metadata, which corresponds to cached data, to be selectively stored to a sequestered memory region. In an embodiment, integrated circuitry evaluates whether a line of a cache can accommodate a first representation of both the data and some corresponding metadata. Where the cache line can accommodate the first representation, said first representation is generated and stored to the line. Otherwise, a second representation of the data is generated and stored to a cache line, and the metadata is stored to a sequestered memory region that is external to the cache. The cache line include an indication as to whether the metadata is represented in the cache line, or is stored in the sequestered memory region. In another embodiment, a metric of utilization of the sequestered memory region is provided to software which determines whether a capacity of the sequestered memory region is to be modified.

Abstract: Provided herein are embodiments of golf club heads comprising a crown and a ribbed region. The ribbed region of the golf club head can be positioned on a portion of the crown and can further include a ribbed wall, wherein the ribbed wall comprises a ribbed wall interior surface, a ribbed wall exterior surface, and one or more external ribs. The one or more external ribs can protrude from the ribbed region to increase the strength of the crown and beneficially reduce crown thickness. Other embodiments and related methods are disclosed herein.

Abstract: Medical systems and methods for making and using medical systems are disclosed. Example medical systems may include an atherectomy system configured to engage and remove plaque from walls in vessels of a vascular system. The atherectomy system may include a drive shaft, a rotational tip coupled to an end of the drive shaft, a motor coupled to the drive shaft to rotate the rotational tip, and a controller configured to control a motor state of the motor. The controller may adjust a range of possible load outputs from the motor and/or a maximum load output from the motor to account for external loads acting on the drive shaft and/or rotational tip rotated by the motor and facilitate passing an occlusion in a vasculature of a patient.

Abstract: Disclosed herein are methods and compositions comprising a polymerase and a phosphorylated nucleoside, wherein the polymerase and the nucleoside are covalently linked by a cleavable linker at the terminal phosphate group. Further disclosed herein are enzymatic polynucleotide synthesis using polymerase and nucleotide conjugation strategies.

Abstract: Disclosed are systems and methods for reducing delays and obtaining rapid uplink access in 5G and 6G, by transmitting pre-grant messages on a random access channel. In one version, a user transmitting an SR (scheduling request) message at a pre-assigned time may transmit a second message on a random access channel synchronized with the SR message. For example, the second message may be a BSR (size) message, thereby avoiding additional delays. In another version, the user may transmit a series of messages on the random access channel without waiting for an uplink grant, thereby reducing delays further. The methods can generally be implemented by software upgrades, a cost-saving advantage. AI (artificial intelligence) may be used to determine which users may transmit messages pre-grant, and on which random access channels.

Abstract: A medical devices en-vivo positional determination system using a plurality of optical time of flight (TDF) transceivers along with gyroscopic angular and mechanical distance sensors for the determination of absolute linear and angular positional information of the tool bit tip for the purposes of more accurate hand-held drilling or cutting, on the workpiece using forward kinematic equations calculated on a microcomputer to provide a real-time display of the 3-linear position and 2-angular orientation of the tool bit (such as a drill, scalpel, or wire driver).