Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating actions for a supply chain network. One of the methods includes receiving a request to generate an action in a supply chain network for a particular product based on current state information; providing a request to an action model to generate a respective probability distribution for one or more actions for one or more products; receiving, from the action model, the respective probability distributions for the one or more products; determining, for each product, a binned action from the respective probability distribution; providing a request to a sequence model to generate a respective correction for the one or more binned actions; and receiving, from the sequence model, the respective correction for the respective binned action.

Abstract: An inverse design system combines a large language model (LLM) with a task-specific optimizer, which includes a search function, a forward model, and a comparator. The LLM adjusts parameters of the optimizer's components in response to a design scenario. Then the optimizer processes the design scenario to produce design candidates. Optionally, the LLM learns from the design candidates in an iterative process. A stochastic predictive modeling system combines an LLM with input distributions and a forward model. The LLM adjusts one or more of the input distributions and/or the forward model in response to a forecast scenario. Then the forward model processes a sampling of the input distributions to produce a forward distribution. Optionally, the LLM informs the sampling process. Optionally, the LLM learns from the forward distribution.

Abstract: The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies for the treatment of ErbB-2/ErbB-3 positive cells. More in particular it relates to treating of cells comprising an NRG1 fusion gene comprising at least a portion of the NRG1-gene fused to a sequence from a different chromosomal location.

Abstract: This specification is generally directed to techniques for generating interfacing source code between computing components based on natural language input. In various implementations, a natural language input that requests generation of interfacing source code to logically couple a first computing component with a second computing component may be processed to generate an interface request semantic embedding. The interface request semantic embedding may be processed based on one or more domain models associated with the first and second computing components to generate a pool(s) of candidate code snippets for logically coupling with first and second computing components. A plurality of candidate instances of interfacing source code may be generated between the first and second computing components. Each candidate software interface may include a different permutation of candidate code snippets from the pool(s) of candidate code snippets.

Abstract: Disclosed implementations relate to adding “bottleneck” models to machine learning pipelines that already apply domain models to translate and/or transfer representations of high-level semantic concepts between domains. In various implementations, an initial representation in a first domain of a transition from an initial state of an environment to a goal state of the environment may be processed based on a pre-trained first domain encoder to generate a first embedding that semantically represents the transition. The first embedding may be processed based on one or more bottleneck models to generate a second embedding with fewer dimensions than the first embedding. In various implementations, the second embedding may be processed in various ways to train one or more of the bottleneck model(s) based on various different auxiliary loss functions.

Abstract: The invention relates to methods of treating of subject that has breast cancer or is at risk of having said cancer, comprising administering to the subject in need thereof a combination of a therapeutically effective amount of an ErbB-2/ErbB-3 bispecific antibody and a therapeutically effective amount of an endocrine therapy drug, wherein the bispecific antibody has an antigen binding site that can bind an extra-cellular part of ErbB-2 and an antigen binding site that can bind an extra-cellular part of ErbB-3; and to means for said method.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for performing tasks. One of the methods includes obtaining a prompt, obtaining a set of documents, generating an input, providing the input to a plurality of language models, generating a distribution from intermediate answers from the language models; and generating an answer to the prompt by performing a probabilistic inference over the distribution.

Abstract: Disclosed implementations relate to preserving individuals' semantic privacy while facilitating automation of tasks across a population of individuals. In various implementations, data indicative of an observed set of interactions between a user and a computing device may be recorded and used to simulate multiple different synthetic sets of interactions between the user and the computing device. Each synthetic set may include a variation of the observed set of interactions at a different level of abstraction. User feedback may be obtained about each of the multiple different sets. Based on the user feedback, one of the multiple different synthetic sets of interactions may be selected and used to train a machine learning model.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating synthetic training data representing network disruptions. One of the methods includes obtaining data representing one or more first travel time distributions between at the at least two entities in the supply chain network. Synthetic network disruption data is generated including sampling from one or more second travel time distributions corresponding respectively to one or more simulated network disruptions. A second dataset having the synthetic network disruption data is generated, and a network policy agent is trained using the second dataset.

Abstract: Implementations are described herein for aggregating information responsive to a query from multiple different data feed services using machine learning. In various implementations, NLP may be performed on a natural language input comprising a query for information to generate a data feed-agnostic aggregator embedding (FAAE). A plurality of data feed services may be selected, each having its own data feed service action space that includes actions that are performable to access data via the data feed service. The FAAE may be processed based on domain-specific machine learning models corresponding to the selected data feed services. Each domain-specific machine learning model may translate between a respective data feed service action space and a data feed-agnostic semantic embedding space. Using these models, action(s) may be selected from the data feed service action spaces and performed to aggregate, from the plurality of data feed services, data that is responsive to the query.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating alternative networks. One of the methods includes receiving supply chain data representing a first supply chain network having nodes and links, receiving map data, providing the map data and the supply chain data as input to a generative process that is configured to generate one or more second supply chain networks, receiving, as output from the generative process, a second supply chain network, performing a supply chain simulation on the second supply chain network generated by the generative model, and computing a performance metric for the second supply chain network based on performing the simulation.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for using a large language model as a common interface between entities in a supply chain network. One of the methods includes receiving, by a supply chain analysis system, a plurality of messages from entities in a supply chain network having a plurality of entities. Each message is provided to a large language model that is configured to generate modified messages that are in a standardized format, wherein the standardized format includes one or more data elements representing a proposed exchange in the supply chain network. The standardized messages are provided to one or more of the entities in the supply chain network to effectuate a communications interface through the large language model for entities in the supply chain network.

Abstract: Disclosed implementations relate to automating semantically-similar computing tasks across multiple contexts. In various implementations, an initial natural language input and a first plurality of actions performed using a first computer application may be used to generate a first task embedding and a first action embedding in action embedding space. An association between the first task embedding and first action embedding may be stored. Later, subsequent natural language input may be used to generate a second task embedding that is then matched to the first task embedding. Based on the stored association, the first action embedding may be identified and processed using a selected domain model to select actions to be performed using a second computer application. The selected domain model may be trained to translate between an action space of the second computer application and the action embedding space.

Abstract: The present invention relates to a process for the production of hydrogen peroxide by the cyclic Auto-Oxydation-process comprising the two alternate steps of: hydrogenation of a working solution in the presence of a catalyst, wherein said working solution contains at least one quinone dissolved in at least one organic solvent, to obtain at least one corresponding hydroquinone; and oxidation of said at least one hydroquinone; characterized in that the organic solvent has the formula (I): wherein R1 is an aryl group comprising from 6 to 18 carbon atoms and R2 is an alkyl group comprising from 1 to 8 carbon atoms, when R2 is a methyl group, R1 is different from phenyl.

Abstract: Methods, systems, and apparatus for obtaining input features representative of a region of space, processing an input comprising the input features through the ML model to generate a prediction describing predicted features of the region of space, obtaining result features describing the region of space, determining a value of at least one evaluation metric that relates the predicted features and the result features, that at least one evaluation metric including one of a distance score, a pyramiding density error, and min-max intersection over union (IOU) score, and training the ML model responsive to the at least one evaluation metric. Other implementations of this aspect include corresponding systems, apparatus, and computer programs, configured to perform the actions of the methods, encoded on computer storage devices.

Abstract: The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies for the treatment of ErbB-2/ErbB-3 positive cells. More in particular it relates to treating of cells comprising an NRG1 fusion gene comprising at least a portion of the NRG1-gene fused to a sequence from a different chromosomal location.

Abstract: Implementations are described herein for aggregating information responsive to a query from multiple different data feed services using machine learning. In various implementations, NLP may be performed on a natural language input comprising a query for information to generate a data feed-agnostic aggregator embedding (FAAE). A plurality of data feed services may be selected, each having its own data feed service action space that includes actions that are performable to access data via the data feed service. The FAAE may be processed based on domain-specific machine learning models corresponding to the selected data feed services. Each domain-specific machine learning model may translate between a respective data feed service action space and a data feed-agnostic semantic embedding space. Using these models, action(s) may be selected from the data feed service action spaces and performed to aggregate, from the plurality of data feed services, data that is responsive to the query.

Abstract: The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies for the treatment of ErbB-2/ErbB-3 positive cells. More in particular it relates to treating of cells comprising an NRG1 fusion gene comprising at least a portion of the NRG1-gene fused to a sequence from a different chromosomal location.

Abstract: Disclosed implementations relate to automating semantically-similar computing tasks across multiple contexts. In various implementations, an initial natural language input and a first plurality of actions performed using a first computer application may be used to generate a first task embedding and a first action embedding in action embedding space. An association between the first task embedding and first action embedding may be stored. Later, subsequent natural language input may be used to generate a second task embedding that is then matched to the first task embedding. Based on the stored association, the first action embedding may be identified and processed using a selected domain model to select actions to be performed using a second computer application. The selected domain model may be trained to translate between an action space of the second computer application and the action embedding space.

Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for modeling agents in multi-agent systems as reinforcement learning (RL) agents and training control policies that cause the agents to cooperate towards a common goal. A method can include generating, for each of a group of simulated local agents in an agent network in which the simulated local agents share resources, information, or both, experience tuples having a state for the simulated local agent, an action taken by the simulated local agent, and a local result for the action taken, updating each local policy of each simulated local agent according to the respective local result, providing, to each of the simulated local agents, information representing a global state of the agent network, and updating each local policy of each simulated local agent according to the global state of the agent network.