Abstract: The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies for the treatment of ErbB-2/ErbB-3 positive tumor. More in particular it relates to treating tumors with a high ErbB-2/ErbB-3 cell-surface receptor ratio. Also encompassed are methods for treating patients not previously treated with an ErbB-2 specific therapy or with an ErbB-3 specific therapy.

Abstract: Autonomous control of a subject vehicle including a longitudinal motion control system includes determining states of parameters associated with a trajectory for the subject vehicle and parameters associated with a control reference determined for the subject vehicle. A range control routine is executed to determine a first parameter associated with a range control command based upon the states of the plurality of parameters, and a speed control routine is executed to determine a second parameter associated with a speed control command based upon the states of the plurality of parameters. An arbitration routine is executed to evaluate the range control command and the speed control command, and operation of the subject vehicle is controlled to achieve a desired longitudinal state, wherein the desired longitudinal state is associated with a minimum of the range control command and the speed control command.

Abstract: A method and apparatus that control lateral movement of the vehicle during backward motion are provided. The method includes loading a desired backward path of vehicle, the backward path comprising waypoints to be traveled along during a rearward motion of the vehicle, reflecting the waypoints along a reflection axis perpendicular to a longitudinal axis that runs from front to back of the vehicle such that the reflected waypoints define virtual forward path; and controlling lateral movement of the vehicle to follow the waypoints along the forward path while the vehicle is traveling in a backward direction.

Abstract: A process for the fluorination of a chlorinated C3 alkane or alkene compound having at least one chlorine atom into a fluorinated C3 alkane or alkene compound having at least one fluorine atom includes the following steps: a) contacting, in a reactor, the chlorinated compound with hydrogen fluoride in gas phase in the presence of a fluorination catalyst to produce a fluorinated compound, and b) regenerating the fluorination catalyst used in step a). The step (b) of regenerating the fluorination catalyst comprises (c) the treatment of said fluorination catalyst with an oxidizing agent-containing gas flow to form an oxidized fluorination catalyst, and (d) the treatment of the oxidized fluorination catalyst obtained in step (c) with a gaseous mixture comprising a reducing agent and an inert gas. The catalyst regenerated in step b) is reused in step a) and the reducing agent is selected from C1-C10 hydrohalocarbons.

Abstract: The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies, for the treatment of ErbB-2/ErbB-3 positive cells. More in particular it relates to treating of cells comprising an NRG1 fusion gene comprising at least a portion of the NRG1-gene fused to a sequence from a different chromosomal location.

Abstract: An automotive vehicle includes an actuator configured to control vehicle steering, acceleration, or shifting, a sensor configured to provide signals indicative of a lateral distance between a current vehicle location relative to a desired path, and a controller. The controller is configured to, in response to a determination that the lateral distance exceeds a threshold, automatically control the actuator according to an interstitial path. The interstitial path is automatically defined by the controller, and is based on a b-spline defined by a first position boundary condition at the current vehicle location, a second position boundary condition at a merge location relative to the desired vehicle path, a first curvature boundary condition based on a current vehicle yaw rate, and a second curvature boundary condition based on a curvature of the desired vehicle path at the merge location. The interstitial path is further optimized based on a cost function.

Abstract: The present invention relates to a method for fluorinating a chlorinated compound including the steps of (a) placing said chlorinated compound in contact with gaseous hydrogen fluoride within a reactor and in the presence of a fluorination catalyst to produce a fluorinated compound, and (b) regenerating the fluorination catalyst used in step a), the step of regenerating the fluorination catalyst including (c) treating said fluorination catalyst with an oxidizing agent to form an oxidized fluorination catalyst, and (d) treating the oxidized fluorination catalyst obtained in step (c) with a gas mixture including a reducing agent.

Abstract: An antenna having an inductor assembly including at least two conductors, which each define a conductor diameter Dc, and an electrically non-conductive carrier defining at least two lumens in which the at least two conductors are respectively located. The carrier maintains a conductor spacing S between the at least two conductors, and the inductor assembly defines at least one turn. The conductor spacing S and conductor diameter Dc together define a S/Dc ratio that ranges from about 0.5 to about 1.2.

Abstract: A machine includes a frame, an engine supported on the frame, ground-engaging elements supported on the frame and driven by the engine to propel the machine, a machine light structure supported on the frame, a multiple-axis accelerometer positioned to generate an acceleration signal relative to a base of the machine light structure, and a controller. The controller is programmed to receive the acceleration signal, partition the acceleration signal into overlapped window periods, transform the acceleration signal of each overlapped window period into a power spectral density, and pass the power spectral densities of each overlapped window period through a strain power spectral densities prediction model to generate predicted strain power spectral densities of the machine light structure. A health monitor receives the predicted strain power spectral densities and is configured to generate a notification responsive to the predicted strain power spectral densities.

Abstract: The invention relates to a method for cooling or heating a fluid or a body by means of a vapour compression circuit containing a heat transfer fluid, said circuit being at least partially contained in an enclosure, and the relative humidity of the air in the enclosure being less than or equal to a threshold value H1 which is less than 50%, the flammability of the heat transfer fluid at relative humidity H1 being less than the flammability of the heat transfer fluid at 50% relative humidity. The invention also relates to a cooling or heating installation suited to the implementation of this method. The invention also relates to a method of protection against the risks of fire or explosion in an enclosure containing at least partially a vapour compression circuit containing a heat transfer fluid, as well as a method for reducing the GWP of a transfer fluid. The invention also relates to heat transfer fluids suited to the implementation of the above methods.

Abstract: The present invention relates to a closure for a container, the closure having an asymmetrical protrusion. The invention further relates to a kit of parts for assembling such a closure.

Abstract: The present invention relates to a closure for a container, the closure comprising three positions. The invention further relates to a kit of parts for assembling such a closure. The present invention relates to a closure comprising an engine and a shroud, the closure adapted to attach to the opening of a container to define an interior and an outside; wherein the shroud and engine are adapted to engage; wherein the closure can take a first position, a second position and a third position, wherein: a. the shroud moves relative to the engine in a linear fashion and a different minimum force is required to move the closure from the first position to the second position than to move the closure from the second position to the first position; or b. the shroud moves relative to the engine in a linear fashion and a different minimum force is required to move the closure from the second position to the third position than to move the closure from the third position to the second position; or c. both a. and b.

Abstract: A faucet-mounted filter system includes a body forming a fluid chamber having a water inlet, a quick connect device positioned adjacent the water inlet for mounting the filter system to a water faucet, a filtered water flow path disposed within the body and in fluid communication with the water inlet, an unfiltered water flow path disposed within the body and in fluid communication with the water inlet, a diverter valve disposed within the fluid chamber and operable to open and close the filtered and unfiltered water flow paths, a seal, an actuator engaging the diverter valve to open and close the filtered and unfiltered water flow paths, a flow meter connected to the body and in fluid communication with the filter flow path, a filter housing connected to the body and having a reservoir, and a filter cartridge disposed within the reservoir.

Abstract: The invention relates to the separation of a mixture comprising 2-chloro-1,1-difluoroethane (R142) and trans-dichloroethylene (TDCE) by extractive distillation and more particularly to a separation process wherein the TDCE is removed selectively by extractive distillation, thus leading to purified 2-chloro-1,1-difluoroethane.

Abstract: The invention relates to a method for cooling or heating a fluid or a body by means of a vapour compression circuit containing a heat transfer fluid, said circuit being at least partially contained in an enclosure, and the relative humidity of the air in the enclosure being less than or equal to a threshold value H1 which is less than 50%, the flammability of the heat transfer fluid at relative humidity H1 being less than the flammability of the heat transfer fluid at 50% relative humidity. The invention also relates to a cooling or heating installation suited to the implementation of this method. The invention also relates to a method of protection against the risks of fire or explosion in an enclosure containing at least partially a vapour compression circuit containing a heat transfer fluid, as well as a method for reducing the GWP of a transfer fluid. The invention also relates to heat transfer fluids suited to the implementation of the above methods.

Abstract: The present invention relates to a method for fluorinating a chlorinated compound including the steps of (a) placing said chlorinated compound in contact with gaseous hydrogen fluoride within a reactor and in the presence of a fluorination catalyst to produce a fluorinated compound, and (b) regenerating the fluorination catalyst used in step a), the step of regenerating the fluorination catalyst including (c) treating said fluorination catalyst with an oxidizing agent to form an oxidized fluorination catalyst, and (d) treating the oxidized fluorination catalyst obtained in step (c) with a gas mixture including a reducing agent.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.

Abstract: Provided herein is a platform for prediction based on extraction of features and observations collected from a large number of disparate data sources that uses machine learning to reinforce quality of collection, prediction and action based on those predictions.

Abstract: A faucet-mounted filter system includes a body forming a fluid chamber having a water inlet, a quick connect device positioned adjacent the water inlet for mounting the filter system to a water faucet, a filtered water flow path disposed within the body and in fluid communication with the water inlet, an unfiltered water flow path disposed within the body and in fluid communication with the water inlet, a diverter valve disposed within the fluid chamber and operable to open and close the filtered and unfiltered water flow paths, a seal, an actuator engaging the diverter valve to open and close the filtered and unfiltered water flow paths, a flow meter connected to the body and in fluid communication with the filter flow path, a filter housing connected to the body and having a reservoir, and a filter cartridge disposed within the reservoir.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumor growth.