Abstract: The invention relates among others to antibodies comprising a first antigen-binding site that binds ErbB-2 and a second antigen-binding site that binds ErbB-3. The antibodies can typically reduce a ligand-induced receptor function of ErbB-3 on a ErbB-2 and ErbB-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an ErbB-2, ErbB-3 or ErbB-2/3 positive tumor.

Abstract: A process for the fluorination of a chlorinated C3 alkane or alkene compound having at least one chlorine atom into a fluorinated C3 alkane or alkene compound having at least one fluorine atom includes the following steps: a) contacting, in a reactor, the chlorinated compound with hydrogen fluoride in gas phase in the presence of a fluorination catalyst to produce a fluorinated compound, and b) regenerating the fluorination catalyst used in step a). The step (b) of regenerating the fluorination catalyst comprises (c) the treatment of said fluorination catalyst with an oxidizing agent-containing gas flow to form an oxidized fluorination catalyst, and (d) the treatment of the oxidized fluorination catalyst obtained in step (c) with a gaseous mixture comprising a reducing agent and an inert gas. The catalyst regenerated in step b) is reused in step a) and the reducing agent is selected from C1-C10 hydrohalocarbons.

Abstract: A method and apparatus that control lateral movement of the vehicle during backward motion are provided. The method includes loading a desired backward path of vehicle, the backward path comprising waypoints to be traveled along during a rearward motion of the vehicle, reflecting the waypoints along a reflection axis perpendicular to a longitudinal axis that runs from front to back of the vehicle such that the reflected waypoints define virtual forward path; and controlling lateral movement of the vehicle to follow the waypoints along the forward path while the vehicle is traveling in a backward direction.

Abstract: A method and apparatus that determine parking feasibility are provided. The method includes determining a charging pad location based on information received from sensors or the charging pad, generating a path function corresponding to a path from a vehicle position to the charging pad location, determining whether a vehicle is within a parking maneuver feasibility region by comparing values of the generated path function, a minimum turning radius of the vehicle, and a maximum steering angle rate of the vehicle, and moving the vehicle to the charging pad location if the vehicle is in the parking maneuver feasibility region.

Abstract: A method and apparatus that control lateral movement of a vehicle are provided. The method includes receiving vehicle information and path information of the vehicle, determining a center of vehicle rotation from the vehicle information, minimizing a path tracking error based on the path information of the vehicle, determining a road wheel angle command or a steering torque command using non-linear optimization based on the minimized path tracking error, and controlling an actuator according to the road wheel angle command or steering torque command.

Abstract: A method for providing low speed lateral steering control for an autonomously driven or semi-autonomously driven vehicle includes obtaining a desired final vehicle position relative to a current vehicle position, and calculating, by one or more data processors, a target vehicle position based on the current vehicle position and the desired final vehicle position. The method further includes calculating, by the one or more data processors, a road wheel angle command value based on the target vehicle position; determining, by the one or more data processors, a control signal based on the calculated road wheel command value; and providing the control signal to a steering controller.

Abstract: An automotive vehicle includes a vehicle-based charging unit including a receiving unit configured to receive power from a ground-based charging unit, the receiving unit including a multi-coil receiver, a first actuator operably coupled to the vehicle-based charging unit and configured to adjust a first position of the vehicle-based charging unit relative to the ground-based charging unit, and a controller configured to selectively actuate the first actuator.

Abstract: The invention relates to methods of treating of subject that has breast cancer or is at risk of having said cancer, comprising administering to the subject in need thereof a combination of a therapeutically effective amount of an ErbB-2/ErbB-3 bispecific antibody and a therapeutically effective amount of an endocrine therapy drug, wherein the bispecific antibody has an antigen binding site that can bind an extra-cellular part of ErbB-2 and an antigen binding site that can bind an extra-cellular part of ErbB-3; and to means for said method.

Abstract: Methods, systems, and apparatuses for improved fraud detection and reduction are described herein. A system may receive a number of analysis parameters for detecting and reducing fraud. Using the analysis parameters, the system may determine a set of training events for each of a number of selected event types for analysis. Each event type may include one or more attributes. The system may transform each of the attributes. The system may determine a predicted action for each event. The system may include a machine learning module. The predicted action for each event may be provided to the machine learning module to train a machine learning model(s) for fraud detection and prevention.

Abstract: Systems, methods and apparatuses for motion control for an autonomous vehicle by implementing an adaptive skeleton construct interface with models, including: a first model which uses constructs for lateral control from a set of a plurality of constructs; and a second model which uses constructs for longitudinal control from a set of a plurality of constructs; and a path reconciling module for reconciling a path based on vehicle data to validate a path for operation and for implementing one or more of a set of lateral or longitudinal controls without having to re-create another lateral control or longitudinal control set, by selecting one or more of an already created lateral or longitudinal control sets to implement one or more sets of the plurality of constructs for vehicle control.

Abstract: A machine includes a frame, an engine supported on the frame, ground-engaging elements supported on the frame and driven by the engine to propel the machine, a machine light structure supported on the frame, a multiple-axis accelerometer positioned to generate an acceleration signal relative to a base of the machine light structure, and a controller. The controller is programmed to receive the acceleration signal, partition the acceleration signal into overlapped window periods, transform the acceleration signal of each overlapped window period into a power spectral density, and pass the power spectral densities of each overlapped window period through a strain power spectral densities prediction model to generate predicted strain power spectral densities of the machine light structure. A health monitor receives the predicted strain power spectral densities and is configured to generate a notification responsive to the predicted strain power spectral densities.

Abstract: The present invention relates to a closure for a container, the closure comprising three positions. The invention further relates to a kit of parts for assembling such a closure. The present invention relates to a closure comprising an engine and a shroud, the closure adapted to attach to the opening of a container to define an interior and an outside; wherein the shroud and engine are adapted to engage; wherein the closure can take a first position, a second position and a third position, wherein: a. the shroud moves relative to the engine in a linear fashion and a different minimum force is required to move the closure from the first position to the second position than to move the closure from the second position to the first position; or b. the shroud moves relative to the engine in a linear fashion and a different minimum force is required to move the closure from the second position to the third position than to move the closure from the third position to the second position; or c. both a. and b.

Abstract: The present invention relates to a closure for a container, the closure having an asymmetrical protrusion. The invention further relates to a kit of parts for assembling such a closure.

Abstract: The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies for the treatment of ErbB-2/ErbB-3 positive tumor. More in particular it relates to treating tumors with a high ErbB-2/ErbB-3 cell-surface receptor ratio. Also encompassed are methods for treating patients not previously treated with an ErbB-2 specific therapy or with an ErbB-3 specific therapy.

Abstract: Autonomous control of a subject vehicle including a longitudinal motion control system includes determining states of parameters associated with a trajectory for the subject vehicle and parameters associated with a control reference determined for the subject vehicle. A range control routine is executed to determine a first parameter associated with a range control command based upon the states of the plurality of parameters, and a speed control routine is executed to determine a second parameter associated with a speed control command based upon the states of the plurality of parameters. An arbitration routine is executed to evaluate the range control command and the speed control command, and operation of the subject vehicle is controlled to achieve a desired longitudinal state, wherein the desired longitudinal state is associated with a minimum of the range control command and the speed control command.

Abstract: A method and apparatus that control lateral movement of the vehicle during backward motion are provided. The method includes loading a desired backward path of vehicle, the backward path comprising waypoints to be traveled along during a rearward motion of the vehicle, reflecting the waypoints along a reflection axis perpendicular to a longitudinal axis that runs from front to back of the vehicle such that the reflected waypoints define virtual forward path; and controlling lateral movement of the vehicle to follow the waypoints along the forward path while the vehicle is traveling in a backward direction.

Abstract: A process for the fluorination of a chlorinated C3 alkane or alkene compound having at least one chlorine atom into a fluorinated C3 alkane or alkene compound having at least one fluorine atom includes the following steps: a) contacting, in a reactor, the chlorinated compound with hydrogen fluoride in gas phase in the presence of a fluorination catalyst to produce a fluorinated compound, and b) regenerating the fluorination catalyst used in step a). The step (b) of regenerating the fluorination catalyst comprises (c) the treatment of said fluorination catalyst with an oxidizing agent-containing gas flow to form an oxidized fluorination catalyst, and (d) the treatment of the oxidized fluorination catalyst obtained in step (c) with a gaseous mixture comprising a reducing agent and an inert gas. The catalyst regenerated in step b) is reused in step a) and the reducing agent is selected from C1-C10 hydrohalocarbons.

Abstract: An automotive vehicle includes an actuator configured to control vehicle steering, acceleration, or shifting, a sensor configured to provide signals indicative of a lateral distance between a current vehicle location relative to a desired path, and a controller. The controller is configured to, in response to a determination that the lateral distance exceeds a threshold, automatically control the actuator according to an interstitial path. The interstitial path is automatically defined by the controller, and is based on a b-spline defined by a first position boundary condition at the current vehicle location, a second position boundary condition at a merge location relative to the desired vehicle path, a first curvature boundary condition based on a current vehicle yaw rate, and a second curvature boundary condition based on a curvature of the desired vehicle path at the merge location. The interstitial path is further optimized based on a cost function.

Abstract: The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies, for the treatment of ErbB-2/ErbB-3 positive cells. More in particular it relates to treating of cells comprising an NRG1 fusion gene comprising at least a portion of the NRG1-gene fused to a sequence from a different chromosomal location.

Abstract: The present invention relates to a method for fluorinating a chlorinated compound including the steps of (a) placing said chlorinated compound in contact with gaseous hydrogen fluoride within a reactor and in the presence of a fluorination catalyst to produce a fluorinated compound, and (b) regenerating the fluorination catalyst used in step a), the step of regenerating the fluorination catalyst including (c) treating said fluorination catalyst with an oxidizing agent to form an oxidized fluorination catalyst, and (d) treating the oxidized fluorination catalyst obtained in step (c) with a gas mixture including a reducing agent.