Abstract: A new, stable trimeric TNF? structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNF?/TNFR1 interaction. Membrane-bound TNF? is not affected in its ability to signal through TNFR2, and thus the new structure of TNF? may be used in therapies which do not significantly raise the risk of infection or malignancy.

Abstract: The invention relates to a liquid lens (1) with an adjustable optical power comprising at least the following components: a lens volume (VL) with a first transparent liquid (L1) arranged between a first transparent membrane (21) and a second transparent membrane (22) opposite the first membrane (21), wherein the first membrane (21) has a first side (21-1) facing outwards the lens volume (VL) and a second side (21-2) facing in the opposite direction particularly toward the lens volume (VL), wherein the second membrane (22) has a first side (22-1) facing toward the lens volume (VL) and a second side (22-2) facing in the opposite direction particularly outward the lens volume (VL), a lens shaping element (3) arranged on the first membrane (21), the lens shaping element (3) having a circumferential aperture (3a) defining a lens area (21a) of the first membrane (21) having an adjustable curvature, a rigid transparent window element (5) connected to the second membrane (22) covering a window portion (22a) of the

Abstract: Optical element (1) comprising a sealed volume (15), a first window (11), a second window (12) and a membrane (13), wherein the membrane (13) encloses the sealed volume (15) in lateral directions and the membrane (13) encloses the sealed volume (15) in directions perpendicular to lateral directions, or the first window (11) and the second window (12) enclose the sealed volume (15) in directions perpendicular to lateral directions, wherein the sealed volume (15) is deformable by tilting the first window (11) with respect to the second window (12), wherein the first window (11) and the second window (12) being spaced apart by a solid structure (14), and the solid structure (14) is arranged to guide a motion of the first window (11) with respect to the second window (12), so that a pressure in the sealed volume (15) is constant.

Abstract: Tunable optical device comprising an actuator, a transmission element, a mount and an optical component, wherein the optical component comprises a window member and a ring member, wherein an optical property of the optical component is adjustable by altering the position of the ring member with respect to the window member. The actuator is arranged to generate an actuation force along an axial direction, the transmission element is arranged to transmit the actuation force from the actuator to the optical component, the transmitted actuation force alters the position of the ring member with respect to the window member. The transmission element comprises a bridge portion and a meander portion, wherein the bridge portion couples the ring member to the actuator and the window member is attached to the mount, or the bridge portion couples the window member to the actuator and the ring member is attached to the mount.

Abstract: A network endpoint receiver controls packet flow from a transmitter. Packets are received via a network in packet traffic according to a push mode, where the transmitter controls pacing of transmitting the packets. Characteristics related to the packet traffic are monitored at the receiver. The monitored characteristics are compared to reception performance parameters, and based on the comparison, a decision is made to switch from the push mode to a pull mode for controlling the packet flow. The receiver transmits a pull mode request packet to the transmitter, where the pull mode request packet indicates a pacing of subsequent packets transmitted by the transmitter to the receiver in accordance with the pull mode. Pacing of further transmitted packets may be controlled by subsequent pull mode request packets sent over time to the transmitter by the receiver. Similarly, the receiver may control additional transmitters to transmit at equal or different rates.

Abstract: Techniques for adjusting radiotherapy treatment for a patient in real time are provided. The techniques include operations comprising: obtaining, during delivery of a radiotherapy treatment fraction to a patient, one or more images of the patient at a first rate; generating patient motion information at a second rate based on the one or more images obtained at the first rate; receiving, during delivery of the radiotherapy treatment fraction, radiotherapy treatment device settings at a third rate; computing, during delivery of the radiotherapy treatment fraction, dose delivered to the patient with a first level of accuracy based on the generated patient motion information and the radiotherapy treatment device settings; and determining, during delivery of the radiotherapy treatment fraction, a real-time measure of accumulated dose delivered to the patient with a second greater level of accuracy than the first level of accuracy using one or more prior dose computations.

Abstract: The present invention relates to an optical tuneable device comprising a volume and a polydimethylsiloxane (PDMS) membrane, wherein the membrane delimits the volume at least partially and the volume is filled with a silicone-based polymer of formula 1, with R1 being an alkyl moiety, —(CH2)-phenyl, phenyl, CF3 or alkyl-CN moiety, R2 to R8 being —H, an alkyl, (CH2)-phenyl or phenyl moiety. The polymer may optionally be substituted by —F. Furthermore, the present invention relates to the use of said polymer in an optical tuneable device.

Abstract: Tunable optical device comprising an optical element, an actuator and a transmission unit, wherein the transmission unit comprises a first fiber, the first fiber is arranged to transmit a tensile force from the actuator to the optical element, and the tensile force result in a change of an optical property of the optical element.

Abstract: A network endpoint receiver controls packet flow from a transmitter. Packets are received via a network in packet traffic according to a push mode, where the transmitter controls pacing of transmitting the packets. Characteristics related to the packet traffic are monitored at the receiver. The monitored characteristics are compared to reception performance parameters, and based on the comparison, a decision is made to switch from the push mode to a pull mode for controlling the packet flow. The receiver transmits a pull mode request packet to the transmitter, where the pull mode request packet indicates a pacing of subsequent packets transmitted by the transmitter to the receiver in accordance with the pull mode. Pacing of further transmitted packets may be controlled by subsequent pull mode request packets sent over time to the transmitter by the receiver. Similarly, the receiver may control additional transmitters to transmit at equal or different rates.

Abstract: Protection of a first software application to be executed on an execution platform by adding at least one check module to the software application, wherein the check module, when being executed, checks at least a part of the code of the protected software application loaded in the memory and carries out a predefined tamper response in case the check module detects that the checked code was changed or ensures that the protected software application continues to function correctly in case the check module detects that the checked code was not changed; selecting a first code region of the first software application, said first code region provides a first functionality when being executed; amending the selected first code region of the first software application such that an amended first code region is generated to provide the protected software application; wherein the amended first code region, when being executed, still provides the first functionality but carries out an access to at least a part of the code

Abstract: Tunable lens (1) comprising a fluidic volume (2), a flexible membrane (3) and a shaping element (4), wherein the membrane (3) delimits the fluidic volume (2) on one side, the shaping element (4) is attached to the membrane (3), the shaping element (4) surrounds an optically active region of the membrane, the shaping element (4) is arranged to alter optical properties of the tunable lens (1) by deflection, in top view the shaping element (4) has a non-circular contour (40), wherein the contour (40) extends within an imaginary circumcircle (10), and the amount of deflection of the shaping element (4) is proportional to a lateral distance of the contour (40) to the circumcircle (10).

Abstract: A system and method for implementing an acceleration structure are disclosed. The method includes: determining a position of an entity; mapping the position to a 3D (three-dimensional) voxel grid coordinate in the acceleration structure, which comprises a central grid structure and six additional grid structures each comprising a set of voxels; determining a first offset value corresponding to the 3D voxel grid coordinate that corresponds to either the central grid structure or one of the six additional grid structures; and determining a second offset value corresponding to the 3D voxel grid coordinate that corresponds to a particular voxel within either the central grid structure or one of the six additional grid structures corresponding to the first offset value, wherein data corresponding to the entity is stored in memory a location based on the first offset value and the second offset value.

Abstract: Techniques for adjusting radiotherapy treatment for a patient in real time are provided. The techniques include retrieving a reference plan that includes three-dimensional (3D) volume representation of information for the patient and a plurality of radiotherapy beam delivery segments; identifying a first portion of the 3D volume representation of information for a first beam delivery segment of the plurality of radiotherapy beam delivery segments that includes a volumetric portion of a target irradiated by the first beam delivery segment; accessing a deformation model representing patient deformation during a radiotherapy treatment fraction; deforming the first portion of the 3D volume representation of information based on the deformation model; and updating one or more parameters of a radiotherapy treatment device based on the deformed first portion of the 3D volume representation of information.

Abstract: The present invention relates to An optical device (1), particularly for an ophthalmic device, comprising: a container (2) enclosing an internal space (3) of the container (2), wherein the internal space (3) is filled with a transparent liquid (L), and wherein the container (2) comprises a transparent bottom (21) and a transparent and elastically deformable membrane (22) opposing said bottom (21) such that the liquid (L) is arranged between the membrane (22) and the bottom (21), a deformable annular lens shaping element (4) connected to the membrane (22) so that a circumferential edge (41) of the lens shaping element (4) defines a central area (23) of the membrane (22) so that light can pass through the container (2) via the central area (23) and the bottom (21), wherein in a non-deformed state said edge (41) lies in a plane, and an adjustable spherical power and an adjustable cylindrical power, wherein for adapting the cylindrical power of the optical device (1), the lens shaping element (4) is configured to

Abstract: The invention relates to a lens (1) having an adjustable focal length, comprising: a container (2) enclosing an internal space (3) of the container (2), wherein the internal space (3) is filled with a transparent liquid (L), and wherein the container (2) comprises a circumferential lateral wall (20) surrounding said internal space (3), wherein the lateral wall (20) is connected to a transparent cover element (21) and to a transparent and elastically deformable membrane (22) such that the liquid (L) is arranged between the membrane (22) and the cover element (21), an annular lens shaper (4) connected to the membrane (22) so that an inner circumferential edge (40) of the lens shaper (4) defines a central area (23) of the membrane (22) and light passing said area (23) is refracted depending on a curvature of said area (23), and an actuator configured to move the lens shaper (4) towards or away from the cover element (21) to adjust said curvature of said area (23) of the lens (1) and therewith the focal length of

Abstract: Described herein is a display unit (1) comprising a pixel-matrix (11) with multiple pixels (110) and at least one refractive optical element (12) having a refractive power, wherein the pixels (110) are arranged to emit light having a definable color and intensity, the light emitted by the pixel-matrix (11) passes through the refractive optical element (12), and the refractive power is tunable.

Abstract: The present invention relates to a camera comprising a sensor element, and an aperture, wherein the aperture comprises an opaque element having a plurality of through holes, a plurality of tunable lenses and an illumination device, wherein tunable lenses are assigned to the through holes respectively, and the illumination device is arranged on a side of the aperture, facing away from the sensor element.

Abstract: The corrective lens described herein comprises a carrier, a tuning element and an actuator. The corrective lens may be a contact lens which is arranged to be placed directly on the surface of the eyes. The corrective lens may be an intraocular lens, which is arranged to be implanted in the eye for example as part of a treatment for cataracts or myopia.

Abstract: A system and method for implementing an acceleration structure are disclosed. The method includes: determining a position of an entity; mapping the position to a 3D (three-dimensional) voxel grid coordinate in the acceleration structure, which comprises a central grid structure and six additional grid structures each comprising a set of voxels; determining a first offset value corresponding to the 3D voxel grid coordinate that corresponds to either the central grid structure or one of the six additional grid structures; and determining a second offset value corresponding to the 3D voxel grid coordinate that corresponds to a particular voxel within either the central grid structure or one of the six additional grid structures corresponding to the first offset value, wherein data corresponding to the entity is stored in memory a location based on the first offset value and the second offset value.

Abstract: The present invention relates to a lens (1), comprising: a first chamber (C1) filled with a first transparent liquid (L1) comprising a first mass density (?1) and a first refractive index (n1), a second chamber (C2) filled with a second transparent liquid (L2) comprising a second mass density (?2) and a second refractive index (n2), and a transparent and elastically deformable first membrane (12) that separates the two chambers (C1, C2) from one another and contacts the first liquid (L1) and the second liquid (L2), wherein said mass densities (?1, ?2) and said refractive indices (n1, n2) are selected such that a gravity-induced coma aberration of the lens (1) is reduced or prevented.