Abstract: The present invention relates to an IL-2 protein sequence of the formula Ala-SEQ A-Cys*-SEQ B (I), wherein SEQ A has at least 94% sequence identity to SEQ ID NO:1; SEQ B has at least 94% sequence identity to SEQ ID NO:2; Ala is an alanine residue; and Cys* is a cysteine residue; to conjugates thereof and their uses in the treatment of cancer.

Abstract: The present invention relates to an IL-2 protein sequence of the formula (Tag1)y - (Ala)x - SEQA - SEQ B - SEQ C -(Tag2)z (I), wherein SEQ A has at least 89% sequence identity with SEQ ID NO:1; SEQ B has at least 76% sequence identity to SEQ ID NO:2 and comprises at least one glycosylation motif; SEQ C has at least 91% sequence identity with SEQ ID NO:4; Tag 1 and Tag2 are independently a tag moiety; Ala is an alanine residue; x is 0 or 1; y is 0 or 1; and z is 0 or 1; to conjugates thereof and their uses in the treatment of cell-proliferation disorders.

Abstract: The present invention relates to an IL-2 protein sequence of the formula Ala-SEQ A-Cys*-SEQ B (I), wherein SEQ A has at least 94% sequence identity to SEQ ID NO:1; SEQ B has at least 94% sequence identity to SEQ ID NO:2; Ala is an alanine residue; and Cys* is a cysteine residue; to conjugates thereof and their uses in the treatment of cancer.

Abstract: The present invention relates to an IL-2 protein sequence of the formula Ala-SEQ A-Cys*-SEQ B (I), wherein SEQ A has at least 94% sequence identity to SEQ ID NO:1; SEQ B has at least 94% sequence identity to SEQ ID NO:2; Ala is an alanine residue; and Cys* is a cysteine residue; to conjugates thereof and their uses in the treatment of cancer.

Abstract: The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist (“PRRA”) for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA is administered by intra-tissue administration, and wherein the protein levels of at least one cytokine selected from the group consisting of IL-6, CCL2 and EL-10 in plasma has a more than 10-fold lower maximum protein level within 24 hours compared to an equivalent molar dose of the corresponding free PRRA upon intra/tissue administration; and to related aspects.

Abstract: The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist (“PRRA”) or its pharmaceutically acceptable salt or a pharmaceutical composition comprising such water-insoluble controlled-release PRRA or its pharmaceutical acceptable salt for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA, its pharmaceutically acceptable salt or the pharmaceutical composition is administered by intra-tissue administration, and wherein such intra-tissue administration results in local inflammation; and to related aspects.

Abstract: The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist (“PRRA”) or its pharmaceutically acceptable salt or a pharmaceutical composition comprising such water-insoluble controlled-release PRRA or its pharmaceutical acceptable salt for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA, its pharmaceutically acceptable salt or the pharmaceutical composition is administered by intra-tissue administration, and wherein at least 25% of the amount of PRRA remains local in such tissue 3 days after administration; and to related aspects.

Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

Abstract: A wireless access point with a centralized media access controller MAC (402) that enables multiple radios (404, 412, 408) to share MAC resources and implement load balancing and frequency control.

Abstract: The disclosed visual RRC-humanoid robot is a computer-based system that has been programmed to reach human-like levels of visualization Artificial Intelligence (AI). Behavioral-programming techniques are used to reach human-like levels of identification AI, recognition AI, visualization AI, and comprehension AI. The system is programmed to identify, recognize, visualize and comprehend the full array of sizes, distances, shapes, and colors of objects recorded in the FOV of the system. The following innovative features have been incorporated into the system: (i) incorporation of the RRC, (ii) incorporation of the Relational Correlation Sequencer (RCS): A proprietary RRC-module, (iii) a paradigm shift in the analytical-programming methodology employed in computer vision systems, (iv) incorporation of a central hub of intelligence, (v) design of a “self knowledge” capability and Internalization of all data, and (vi) design of an interface circuit compatible with human-like levels of visualization-AI.

Abstract: The disclosed visual RRC-humanoid robot is a computer-based system that has been programmed to reach human-like levels of visualization Artificial Intelligence (AI). Behavioral-programming techniques are used to reach human-like levels of identification AI, recognition AI, visualization AI, and comprehension AI. The system is programmed to identify, recognize, visualize and comprehend the full array of sizes, distances, shapes, and colors of objects recorded in the FOV of the system. The following innovative features have been incorporated into the system: (i) incorporation of the RRC, (ii) incorporation of the Relational Correlation Sequencer (RCS): A proprietary RRC-module, (iii) a paradigm shift in the analytical-programming methodology employed in computer vision systems, (iv) incorporation of a central hub of intelligence, (v) design of a “self knowledge” capability and Internalization of all data, and (vi) design of an interface circuit compatible with human-like levels of visualization-AI.

Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

Abstract: The disclosed Auditory RRC-Humanoid Robot equipped with a verbal-phoneme sound generator is a computer-based system programmed to reach high levels of human-like verbal-AI. Behavioral programming techniques are used to reach human-like levels of identification-AI, recognition-AI, and comprehension-AI of all the words and sentences presented to the robot as verbal input signals. An innovative behavioral speech processing methodology is used to recognize and repeat the acoustic sequential set of phoneme signals that comprise the verbally generated speech of human speakers. The recognized and repeated sequential set of phoneme signals are then mapped onto a unique phonetic structure such as all the words and clauses listed in a 50,000 word lexicon that may then make up the vocabulary of the RRC-Robot. The system is programmed to hear and understand verbal speech with its auditory sensors, and intelligently responds by verbally talking with its verbal-phoneme sound generator.

Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

Abstract: As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.

Abstract: A wireless access point with a centralized media access controller MAC (402) that enables multiple radios (404, 412, 408) to share MAC resources and implement load balancing and frequency control.

Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

Abstract: A system for managing parallel processing of network packets is also provided. A wireless access device that includes multiple transceivers and multiple processing units receives network packets. A media access controller determines which transceiver a received network packet is associated with. A tagging module determines whether the transceiver associated with the received network packet is bound to one of the processing units. In response to a determination that the transceiver is bound, a scheduler assigns the received packet to the processing unit the transceiver is bound to. In response to a determination that the transceiver is not bound, the tagging module binds the transceiver to a processing unit such that the processing unit processes network packets associated with the transceiver while the transceiver is bound to the processing unit, and the scheduler assigns the received network packet to the processing unit the transceiver is bound to.

Abstract: A wireless access point with a centralized media access controller MAC (402) that enables multiple radios (404, 412, 408) to share MAC resources and implement load balancing and frequency control.