Patents by Inventor David B. Rosen

David B. Rosen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170248604
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Application
    Filed: October 13, 2016
    Publication date: August 31, 2017
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
  • Publication number: 20170184597
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Application
    Filed: August 5, 2016
    Publication date: June 29, 2017
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, James R. Hackett, Michael Walker, Jing Shi
  • Patent number: 9622250
    Abstract: A wireless access point with a centralized media access controller MAC (402) that enables multiple radios (404, 412, 408) to share MAC resources and implement load balancing and frequency control.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: April 11, 2017
    Assignee: Xirrus, Inc.
    Inventors: Michael De La Garrigue, Shaun Clem, Michael R. Conley, David B. Rosen, Drew Bertagna
  • Patent number: 9573277
    Abstract: The disclosed visual RRC-humanoid robot is a computer-based system that has been programmed to reach human-like levels of visualization Artificial Intelligence (AI). Behavioral-programming techniques are used to reach human-like levels of identification AI, recognition AI, visualization AI, and comprehension AI. The system is programmed to identify, recognize, visualize and comprehend the full array of sizes, distances, shapes, and colors of objects recorded in the FOV of the system. The following innovative features have been incorporated into the system: (i) incorporation of the RRC, (ii) incorporation of the Relational Correlation Sequencer (RCS): A proprietary RRC-module, (iii) a paradigm shift in the analytical-programming methodology employed in computer vision systems, (iv) incorporation of a central hub of intelligence, (v) design of a “self knowledge” capability and Internalization of all data, and (vi) design of an interface circuit compatible with human-like levels of visualization-AI.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: February 21, 2017
    Inventors: Alan Rosen, David B. Rosen
  • Publication number: 20170008174
    Abstract: The disclosed visual RRC-humanoid robot is a computer-based system that has been programmed to reach human-like levels of visualization Artificial Intelligence (AI). Behavioral-programming techniques are used to reach human-like levels of identification AI, recognition AI, visualization AI, and comprehension AI. The system is programmed to identify, recognize, visualize and comprehend the full array of sizes, distances, shapes, and colors of objects recorded in the FOV of the system. The following innovative features have been incorporated into the system: (i) incorporation of the RRC, (ii) incorporation of the Relational Correlation Sequencer (RCS): A proprietary RRC-module, (iii) a paradigm shift in the analytical-programming methodology employed in computer vision systems, (iv) incorporation of a central hub of intelligence, (v) design of a “self knowledge” capability and Internalization of all data, and (vi) design of an interface circuit compatible with human-like levels of visualization-AI.
    Type: Application
    Filed: April 15, 2014
    Publication date: January 12, 2017
    Inventors: Alan Rosen, David B. Rosen
  • Patent number: 9500655
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: November 22, 2016
    Assignee: NODALITY, INC.
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
  • Patent number: 9302393
    Abstract: The disclosed Auditory RRC-Humanoid Robot equipped with a verbal-phoneme sound generator is a computer-based system programmed to reach high levels of human-like verbal-AI. Behavioral programming techniques are used to reach human-like levels of identification-AI, recognition-AI, and comprehension-AI of all the words and sentences presented to the robot as verbal input signals. An innovative behavioral speech processing methodology is used to recognize and repeat the acoustic sequential set of phoneme signals that comprise the verbally generated speech of human speakers. The recognized and repeated sequential set of phoneme signals are then mapped onto a unique phonetic structure such as all the words and clauses listed in a 50,000 word lexicon that may then make up the vocabulary of the RRC-Robot. The system is programmed to hear and understand verbal speech with its auditory sensors, and intelligently responds by verbally talking with its verbal-phoneme sound generator.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: April 5, 2016
    Inventors: Alan Rosen, David B. Rosen
  • Publication number: 20150276745
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Application
    Filed: December 16, 2014
    Publication date: October 1, 2015
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, James R. Hackett, Michael Walker, Jing Shi
  • Publication number: 20150119288
    Abstract: As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.
    Type: Application
    Filed: August 4, 2014
    Publication date: April 30, 2015
    Inventors: David M. Soper, David B. Rosen, Todd M. Covey, Ying-Wen Huang, Wendy J. Fantl, Ralph Lin
  • Publication number: 20150063153
    Abstract: A wireless access point with a centralized media access controller MAC (402) that enables multiple radios (404, 412, 408) to share MAC resources and implement load balancing and frequency control.
    Type: Application
    Filed: September 8, 2014
    Publication date: March 5, 2015
    Inventors: MICHAEL DELAGARRIGUE, SHAUN CLEM, MICHAEL R. CONLEY, DAVID B. ROSEN, DREW BERTAGNA
  • Publication number: 20150017119
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Application
    Filed: May 16, 2014
    Publication date: January 15, 2015
    Applicant: Nodality, Inc.
    Inventors: Wendy J. FANTL, David B. ROSEN, Alessandra CESANO, Santosh K. PUTTA, Garry NOLAN, Aileen COHEN, Erik EVENSEN
  • Patent number: 8831659
    Abstract: A wireless access point with a centralized media access controller MAC (402) that enables multiple radios (404, 412, 408) to share MAC resources and implement load balancing and frequency control.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: September 9, 2014
    Assignee: Xirrus, Inc.
    Inventors: Michael De La Garrigue, Shaun Clem, Michael R. Conley, David B. Rosen, Drew Bertagna
  • Patent number: 8830854
    Abstract: A system for managing parallel processing of network packets is also provided. A wireless access device that includes multiple transceivers and multiple processing units receives network packets. A media access controller determines which transceiver a received network packet is associated with. A tagging module determines whether the transceiver associated with the received network packet is bound to one of the processing units. In response to a determination that the transceiver is bound, a scheduler assigns the received packet to the processing unit the transceiver is bound to. In response to a determination that the transceiver is not bound, the tagging module binds the transceiver to a processing unit such that the processing unit processes network packets associated with the transceiver while the transceiver is bound to the processing unit, and the scheduler assigns the received network packet to the processing unit the transceiver is bound to.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: September 9, 2014
    Assignee: Xirrus, Inc.
    Inventor: David B. Rosen
  • Publication number: 20140199273
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell population.
    Type: Application
    Filed: November 21, 2013
    Publication date: July 17, 2014
    Inventors: Alessandra Cesano, David B. Rosen, Santosh K. Putta
  • Patent number: 8778620
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: July 15, 2014
    Assignee: Nodality, Inc.
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
  • Publication number: 20140147857
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Application
    Filed: October 9, 2013
    Publication date: May 29, 2014
    Applicant: Nodality, Inc.
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, James R. Hackett, Michael Walker, Jing Shi
  • Publication number: 20130130279
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Application
    Filed: May 17, 2012
    Publication date: May 23, 2013
    Applicant: Nodality, Inc.
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
  • Patent number: 8399206
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: March 19, 2013
    Assignee: Nodality, Inc.
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, James R. Hackett, Michael Walker, Jing Shi
  • Publication number: 20130034862
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
    Type: Application
    Filed: August 28, 2012
    Publication date: February 7, 2013
    Applicant: Nodality, Inc.
    Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, James R. Hackett, Michael Walker, Jing Shi
  • Publication number: 20130035253
    Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations.
    Type: Application
    Filed: August 3, 2012
    Publication date: February 7, 2013
    Applicant: Nodality, Inc. A Delaware Corporation
    Inventors: David B. Rosen, Santosh K. Putta, Brent Louie, Norman Purvis