Patents by Inventor David Baker

David Baker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220144895
    Abstract: Disclosed herein are polypeptides or polypeptide oligomers, including a buried hydrogen bond network that includes at least (1, 2, 3, 4, 5, 6, 7, 8, or 9) pH sensitive amino acids located (i) at an intra-chain interface between different: structural elements in one polypeptide, or (it) at an inter-chain interface between structural elements present in different chains of a polypeptide oligomer, wherein the polypeptide or polypeptide oligomer is stable above a given pH, and wherein the polypeptide or polypeptide oligomer undergoes a conformational transition when subjected to a pH at or below the given pH.
    Type: Application
    Filed: April 20, 2020
    Publication date: May 12, 2022
    Inventors: Scott BOYKEN, David BAKER, Zibo CHEN, Alfredo Quijano RUBIO, Neil P. KING, Jason C. KLIMA, Carl WALKEY
  • Publication number: 20220119467
    Abstract: Provided are molecular feedback circuits employing caged-degrons. Aspects of such circuits include the use of a caged-degron to modulate the output of a signaling pathway in a feedback-controlled manner. Also provided are nucleic acids encoding molecular circuits and cells containing such nucleic acids. Methods of using caged-degron-based molecular feedback circuits are also provided, including e.g., methods of modulating a signaling pathway of a cell that include genetically modifying the cell with a caged-degron-based molecular feedback circuit.
    Type: Application
    Filed: January 6, 2020
    Publication date: April 21, 2022
    Inventors: David Baker, Scott Boyken, Hana El-Samad, Marc Lajoie, Robert Langan, Andrew Ng
  • Publication number: 20220098250
    Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
    Type: Application
    Filed: October 15, 2021
    Publication date: March 31, 2022
    Inventors: Zibo CHEN, Scott BOYKEN, Sherry BERMEO, Robert A. LANGAN, David BAKER
  • Publication number: 20220095535
    Abstract: A lawn mower may include a blade housing configured to house at least a first blade and a second blade, a shaft disposed to rotate within the blade housing, a powerhead configured to selectively turn the shaft responsive to application of power from a power source, and a blade coupler configured to selectively couple the first blade and/or the second blade to the shaft to produce different cutting performance conditions based on which of the first blade and/or the second blade is operably coupled to the shaft.
    Type: Application
    Filed: October 30, 2019
    Publication date: March 31, 2022
    Inventors: Brad Graham, Samuel Lattimore, David Baker, Jonathan Funk
  • Publication number: 20220073565
    Abstract: Disclosed herein are non-naturally occurring cage polypeptides, kits and degron LOCKRs including the cage polypep-tides, and uses thereof, wherein the cage polypeptides include (a) a helical bundle, comprising between 2 and 7 alpha-helices, wherein the helical bundle includes: (i) a structural region; and (ii) a latch region, wherein the latch region composes a degron located within the latch region, wherein the structural region interacts with the latch region to prevent activity of the degron; and (b) amino acid linkers connecting each alpha helix
    Type: Application
    Filed: January 6, 2020
    Publication date: March 10, 2022
    Inventors: Robert LANGAN, Andrew NG, Scott BOYKEN, Marc LAJOIE, Hana EL-SAMAD, David BAKER
  • Publication number: 20220056095
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??cheterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: September 13, 2021
    Publication date: February 24, 2022
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, David Baker, Kenan Christopher Garcia, Jamie Spangler, Alfredo Quijano Rubio
  • Patent number: 11253490
    Abstract: The present invention relates generally method of treating or alleviating cognitive impairment by administering an abuse-deterrent formulation containing dextroamphetamine sulfate.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: February 22, 2022
    Assignee: Vallon Pharamaceuticals, Inc.
    Inventors: Ofir Levi, David Baker, Timothy Whitaker
  • Publication number: 20220025003
    Abstract: The present disclosure provides danoprevir/NS3a complex reader (DNCR) and grazoprevir/NS3a complex readers (GNCR) polypeptides, fusion proteins, and combinations and their use.
    Type: Application
    Filed: December 3, 2019
    Publication date: January 27, 2022
    Inventors: David BAKER, Daniel CUNNINGHAM-BRYANT, Emily DIETER, Glenna FOIGHT, Per GREISEN, Dustin MALY, Keunwan PARK, Zhizhi WANG, Cindy WEI
  • Publication number: 20220025356
    Abstract: The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks.
    Type: Application
    Filed: September 20, 2021
    Publication date: January 27, 2022
    Inventors: David BAKER, David YOUNGER, Eric KLAVINS
  • Publication number: 20220017588
    Abstract: Conditionally active receptor agonists that, when activated, bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor a subunit (IL˜13 R?) are disclosed, as are components of the conditionally active receptor agonists and methods for using the conditionally active receptor agonists.
    Type: Application
    Filed: November 19, 2019
    Publication date: January 20, 2022
    Inventors: Alfredo QUIJANO RUBIO, Daniel Adriano SILVA MANZANO, David BAKER, Umut ULGE, Marc Joseph LAJOIE
  • Publication number: 20220017579
    Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
    Type: Application
    Filed: September 23, 2021
    Publication date: January 20, 2022
    Inventors: Zibo CHEN, Scott BOYKEN, Sherry BERMEO, Robert A. LANGAN, David BAKER
  • Publication number: 20210403578
    Abstract: Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.
    Type: Application
    Filed: September 8, 2021
    Publication date: December 30, 2021
    Inventors: Kenan Christopher Garcia, David Baker, Claudia Yvonne Janda, Luke Dang, James Daniel Moody
  • Publication number: 20210380641
    Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using synthetic nanostructures are disclosed herein.
    Type: Application
    Filed: November 9, 2018
    Publication date: December 9, 2021
    Inventors: Gabriel BUTTERFIELD, Marc Joseph LAJOIE, Neil P. KING, David BAKER, Daniel ELLIS
  • Patent number: 11192926
    Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: December 7, 2021
    Assignees: University of Washington, Institute for Research in Biomedicine
    Inventors: Neil P. King, David Baker, Brooke Nickerson, Lance Joseph Stewart, Laurent Perez, Antonio Lanzavecchia, Jessica Marcandalli
  • Publication number: 20210363214
    Abstract: De novo designed multi-pass transmembrane polypeptides are described, that include 2 or more transmembrane domains that are each between 15 and 35 amino acids in length, include one or more polar residues, and include at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, or more hydrophobic amino acid residues.
    Type: Application
    Filed: February 28, 2019
    Publication date: November 25, 2021
    Inventors: Peilong LU, David BAKER, Scott BOYKEN, Zibo CHEN, Jorge FALLAS, George UEDA, William H. SHEFFLER
  • Publication number: 20210355175
    Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
    Type: Application
    Filed: November 4, 2019
    Publication date: November 18, 2021
    Inventors: Zibo CHEN, Scott BOYKEN, Sherry BERMEO, Robert A. LANGAN, David BAKER
  • Publication number: 20210340519
    Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.
    Type: Application
    Filed: June 2, 2021
    Publication date: November 4, 2021
    Inventors: Neil KING, Wesley SUNDQUIST, Joerg VOTTELER, Yang HSIA, David BAKER, Jacob BALE, Marc LAJOIE, Gabriel BUTTERFIELD, Elizabeth GRAY, Daniel STETSON
  • Publication number: 20210335064
    Abstract: Systems and methods cause a component of a vehicle to activate. The systems and methods receive audio data generated by a microphone of the vehicle, where the audio data represents sound of the component. Based on the audio data, a condition of the vehicle or the component may be determined, and based on the condition, the vehicle may be commissioned for use or decommissioned.
    Type: Application
    Filed: May 3, 2021
    Publication date: October 28, 2021
    Inventors: Nicholas Nakjoo Kim, Daniel David Baker
  • Publication number: 20210324011
    Abstract: Disclosed herein are polypeptides having the amino acid sequence that is at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the full length of the amino acid sequence selected from the group consisting of SEQ ID NO: 1-33 and 36, wherein the polypeptides include at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of the identified interface residues, and wherein the polypeptides are capable of end-to-end homo-polymerization, homo-polymers of the polypeptides, and related capping and anchor proteins to facilitate homo-polymer formation.
    Type: Application
    Filed: October 24, 2019
    Publication date: October 21, 2021
    Inventors: Hao SHEN, Jorge FALLAS, David BAKER
  • Patent number: D942966
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: February 8, 2022
    Assignee: Logitech Europe S.A.
    Inventors: Wenwei Wang, Ming-Hsiang Weng, Jeremy David Baker, Olivier Gregoire