Patents by Inventor David Baker

David Baker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210054365
    Abstract: The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks.
    Type: Application
    Filed: November 6, 2020
    Publication date: February 25, 2021
    Inventors: David BAKER, David YOUNGER, Eric KLAVINS
  • Publication number: 20210047373
    Abstract: Disclosed herein are de novo designed beta barrel polypeptides, methods for designing such polypeptides, and methods for their use.
    Type: Application
    Filed: April 4, 2019
    Publication date: February 18, 2021
    Inventors: Jiayi DOU, Anastassia VOROBIEVA, Jason C. KLIMA, David BAKER
  • Publication number: 20210030752
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Application
    Filed: October 8, 2020
    Publication date: February 4, 2021
    Inventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, Darren J. Baker, Jan M.A. van Deursen, Albert Davalos
  • Publication number: 20210015301
    Abstract: A cooking accessory insert for a cooking grill includes a heat distribution duct that, installed, extends from a burner proximate to the bottom of the grill's fire box generally to a cooking level near the top of the fire box. The heat distribution duct is defined by a plurality of side walls extending from a top end of the heat distribution duct to a bottom end, tapering inward, or narrowing, from top to bottom. A top surface substantially covers the top end of the heat distribution duct, while the bottom is open. A cover is provided to cover the top surface, defining a baking chamber between the cover and the top surface. A cooking surface element such as a pizza stone is removably disposed on the top surface, spaced apart from the top surface by a plurality of spacers.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 21, 2021
    Inventor: David BAKER
  • Publication number: 20210009936
    Abstract: A fluid pumping and bioreactor system including at least two cassettes, at least one storage reservoir, at least one bioreactor, at least one manifold including valve modules, and tubing to connect the cassettes to the storage reservoir and the bioreactor. The cassettes can include pumps, valves, and fluid conduits and can be communicatively connected to the at least one manifold. The bioreactor can include an adapter and fluid conduits extending through the adapter from the exterior of the bioreactor to the interior of the bioreactor. System and method for generating a tissue for transplant by decellularizing and recellularizing a supplied tissue.
    Type: Application
    Filed: September 22, 2020
    Publication date: January 14, 2021
    Inventors: Dean Kamen, Jason A. Demers, Frederick Morgan, Timothy D. Moreau, Brian D. Tracey, Matthew Ware, Dirk A. van der Merwe, Richard J. Lanigan, Michael A. Baker, David Blumberg, JR.
  • Publication number: 20210005277
    Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.
    Type: Application
    Filed: March 18, 2020
    Publication date: January 7, 2021
    Inventors: Jiye Shi, Terence Seward Baker, Alastair David Griffiths Lawson, Xiaofeng Liu
  • Publication number: 20210002629
    Abstract: The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks.
    Type: Application
    Filed: April 23, 2020
    Publication date: January 7, 2021
    Inventors: David BAKER, David YOUNGER, Eric KLAVINS
  • Publication number: 20210002154
    Abstract: A continuous flow granular/flocculent sludge wastewater process selects for granule biomass capable of nitrogen and phosphorus removal and controls granule size and concentration of granular and flocculent sludge for optimal nutrient, organic, and solids removal in a smaller footprint. A series of biological process zones lead to a secondary clarifier. Mixed liquor sludge, preferably from an aerobic zone, goes through a classifier or separator processing flow from the aerobic zone, to the secondary clarifier. In a sidestream process that can be included a portion of sludge preferably from an aerobic zone goes through a classifier or separator to selectively produce a granular-rich effluent, and the clarifier may also have a separator to further concentrate granular biomass, most of which is cycled back to an initial multi-stage anaerobic process zone. The anaerobic zone is structured and operated to encourage growth of granules in subsequent process zones.
    Type: Application
    Filed: September 21, 2020
    Publication date: January 7, 2021
    Inventors: Hiren Trivedi, John Vorwaller, Tyson Beaman, Sophia Baker, Sergio Pino-Jelcic, David Stensel
  • Patent number: 10874720
    Abstract: Disclosed herein are compositions and methods for treating celiac sprue.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: December 29, 2020
    Assignee: University of Washington
    Inventors: Justin Siegel, David Baker, Sydney Rin Anna Gordon, Ingrid Swanson Pultz, Elizabeth Joy Stanley, Sarah Jane Wolf
  • Publication number: 20200401986
    Abstract: Embodiments of the instrument inventory system create, record and enable access of data about collections of instruments and tools such as surgical instruments and dental instruments. The instrument inventory system includes at least one user interface, at least one instrument interface, an instrument processor and a database storing instrument records. The instrument inventory system includes a training function which enables the system to create a data record for new instruments when the system encounters new instruments.
    Type: Application
    Filed: September 4, 2020
    Publication date: December 24, 2020
    Inventors: Russell BAKER, Lawrence ZELNER, David BERK
  • Publication number: 20200397886
    Abstract: The present disclosure provides nanostructures and nanostructure-based vaccines. Some nanostructures of the present disclosure display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens. Some vaccines of the present disclosure are useful for preventing or decreasing the severity of infection with an infectious agent, including, for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus, flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means disclosed herein. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins, vaccine compositions, and methods of administration.
    Type: Application
    Filed: February 28, 2019
    Publication date: December 24, 2020
    Inventors: Neil KING, David BAKER, Lance STEWART, Brooke FIALA, Daniel ELLIS, Lauren CARTER, Rashmi RAVICHANDRAN, George UEDA, Jorge FALLAS, Una NATTERMAN
  • Publication number: 20200392187
    Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
    Type: Application
    Filed: April 3, 2018
    Publication date: December 17, 2020
    Inventors: Neil P. KING, David BAKER, Brooke NICKERSON, Lance Joseph STEWART, Laurent PEREZ, Antonio LANZAVECCHIA, Jessica MARCANDALLI
  • Publication number: 20200392768
    Abstract: A method of deactivating a secondary lock feature of a vehicle includes sensing a movement of an interior door handle, and determining a status of the secondary lock feature to ascertain whether the secondary lock feature is active. The method includes starting a timer to measure an elapsed time since sensing the movement of the interior door handle, sensing an environmental condition of an interior passenger compartment of the vehicle with a sensor, and setting an unlock delay time based on the environmental condition. When the secondary lock feature is disposed in an active state and the elapsed time period is greater than or equal to the unlock delay time, the method includes automatically generating a control signal to thereby deactivate the secondary lock feature.
    Type: Application
    Filed: June 17, 2019
    Publication date: December 17, 2020
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Jeffrey L. Konchan, George Baker, Besi Rrumbullaku, David T. Proefke, Tricia E. Morrow
  • Patent number: 10851135
    Abstract: Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: December 1, 2020
    Assignee: University of Washington
    Inventors: Robert A. Langan, Scott Boyken, David Baker, Walter Novak, Marc Joseph Lajoie, Alfredo Quijano Rubio
  • Publication number: 20200370084
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: May 4, 2020
    Publication date: November 26, 2020
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Publication number: 20200368072
    Abstract: An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site and a second surface opposite the first surface; wherein at least one of the interconnected polymeric stand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; a plurality of openings between adjacent interconnected polymeric strands; an adhesive layer in contact with the second surface of the interconnected polymeric strands; and a filler in contact with the adhesive layer, the adhesive layer in between the network of interconnected polymeric strands and the filler; wherein the article is a negative pressure wound therapy article.
    Type: Application
    Filed: December 12, 2018
    Publication date: November 26, 2020
    Inventors: Amy K. McNulty, Robert T. Fitzsimons, Kurt J. Halverson, Bryan A. Baker, Jana Ninkovic, Jie Liu, Minghua Dai, Wei Zhang, Kiu-Yuen Tse, David R. Holm, Graham M. Clarke, Federica Sgolastra
  • Patent number: 10845852
    Abstract: An internal component and external interface arrangement for a cylindrical compact computing system is described that includes at least a structural heat sink having triangular shape disposed within a cylindrical volume defined by a cylindrical housing. A computing engine having a generally triangular shape is described having internal components that include a graphics processing unit (GPU) board, a central processing unit (CPU) board, an input/output (I/O) interface board, an interconnect board, and a power supply unit (PSU).
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: November 24, 2020
    Assignee: Apple Inc.
    Inventors: Brett W. Degner, Caitlin Elizabeth Kalinowski, Richard D. Kosoglow, Joshua D. Banko, David H. Narajowski, Jonathan L. Berk, Michael E. Leclerc, Michael D. McBroom, Asif Iqbal, Paul S. Michelsen, Mark K. Sin, Paul A. Baker, Harold L. Sontag, Wai Ching Yuen, Matthew P. Casebolt, Kevin S. Fetterman, Alexander C. Calkins, Daniel L. McBroom
  • Patent number: 10844105
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: November 24, 2020
    Assignees: University of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
  • Publication number: 20200367199
    Abstract: A method is provided including receiving, by a user equipment, a signal either before or during a paging occasion comprising an indication indicating whether the user equipment is to skip decoding of at least one subsequent channel of a plurality of subsequent channels associated with a paging message. The plurality of subsequent channels include: a first channel carrying downlink control information for the paging message, and a second channel carrying the paging message. In response to the indication indicating that the user equipment is to skip decoding of the at least one subsequent channel, skipping decoding of the at least one subsequent channel.
    Type: Application
    Filed: November 17, 2017
    Publication date: November 19, 2020
    Inventors: David Bhatoolaul, Nitin Mangalvedhe, Matthew Baker, Rapeepat Ratasuk, Chunhai Yao
  • Patent number: D909435
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: February 2, 2021
    Assignee: Electrolux Home Products, Inc.
    Inventors: Luis Fernando Zeni Filho, Gabriel Lied, Charles David Baker, Brent Aaron Curtis, Benjamin Shrader, Josh Hanson, Cristhian Camacho, Swaminathan Iyer, Ola Lantz, Eunice Cheng