Patents by Inventor David Baker

David Baker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biologically relevant orthogonal cytokine/receptor pairs
    Patent number: 11439664
    Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: September 13, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, UNIVERSITY OF WASHINGTON
    Inventors: Kenan Christopher Garcia, Jonathan Sockolosky, David Baker, Chris King
  • Ultraspecific Cell Targeting Using De Novo Designed Co-Localization Dependent Protein Switches
    Publication number: 20220273711
    Abstract: Disclosed am protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called die key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co-localized when bound to their targets, components of such protein switches, and their use.
    Type: Application
    Filed: May 18, 2020
    Publication date: September 1, 2022
    Inventors: Scott BOYKEN, Marc Joseph LAJOIE, Robert A. LANGAN, David BAKER, Jilliane Ruth BRUFFEY
  • Riserless Offshore Production and Storage System and Related Methods
    Publication number: 20220243565
    Abstract: A method of conveying a production fluid from an offshore subsea well to an offshore vessel includes deploying an inflatable bladder from the offshore vessel, the inflatable bladder including a bladder valve, and fluidly connecting the inflatable bladder to an offloading port positioned at a seafloor, wherein the offloading port includes a port valve and is in fluid communication with one or more subterranean hydrocarbon-bearing formations. The method further includes opening the bladder and port valves to discharge the production fluid from the offloading port into the inflatable bladder, and thereby resulting in a substantially filled bladder, closing the bladder and port valves, and fluidly disconnecting the substantially filled bladder from the offloading port.
    Type: Application
    Filed: January 10, 2022
    Publication date: August 4, 2022
    Inventors: Deborah J. Davis, Sushil K. Mandot, David A. Baker, Zhen Li, Brian J. Fielding
  • De novo design of potent and selective interleukin mimetics
    Patent number: 11401313
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?cheterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: August 2, 2022
    Assignees: University of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20220235110
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: March 18, 2022
    Publication date: July 28, 2022
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl WALKEY
  • DE NOVO DESIGN OF PHOSPHORYLATION INDUCIBLE PROTEIN SWITCHES (PHOSPHO-SWITCHES)
    Publication number: 20220226485
    Abstract: The present disclosure provides a chimeric polypeptide comprising a helical bundle which comprises between about two and about seven alpha-helices and a bioactive peptide, wherein one or more of the alpha helices form one or more inter-helix hydrogen bonds and comprise at least one phosphorylation site and wherein the bioactive peptide is conformationally placed inside the helical bundle so that the bioactive peptide is not activated or exposed. The disclosure also provides a nucleotide sequence encoding the chimeric polypeptide, a vector comprising the nucleotide sequence, a cell comprising the nucleotide sequence, and method of making, using, or designing the chimeric polypeptide.
    Type: Application
    Filed: June 17, 2020
    Publication date: July 21, 2022
    Inventors: Nicholas WOODALL, Scott BOYKEN, Marc Joseph LAJOIE, Zibo CHEN, Robert A. LANGAN, David BAKER
  • LOCKR-MEDIATED RECRUITMENT OF CAR T CELLS
    Publication number: 20220218752
    Abstract: Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co/localized when bound to their targets, components of such protein switches, and their use.
    Type: Application
    Filed: May 18, 2020
    Publication date: July 14, 2022
    Inventors: David BAKER, Scott BOYKEN, Marc Joseph LAJOIE, Robert A. LANGAN, Stanley R. RIDDELL, Alexander SALTER
  • WORMS Scaffolds: Multi-scale protein complexes
    Publication number: 20220213153
    Abstract: The disclosure provides polypeptides as descried herein that including an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-46, oligomers of such polypeptides, methods for using such polypeptides and oligomers, and methods for designing such polypeptides and oligomers.
    Type: Application
    Filed: December 29, 2021
    Publication date: July 7, 2022
    Inventors: Yang HSIA, Rubul MOUT, Natasha EDMAN, Ivan VULOVIC, Una NATTERMANN, William H. SHEFFLER, TJ BRUNETTE, Young-Jun PARK, Asim BERA, Matthew BICK, Rachel REDLER, Damian EKIERT, Gira BHABHA, David VEESLER, David BAKER
  • AMANTADINE BINDING PROTEIN
    Publication number: 20220185853
    Abstract: Disclosed herein are amantadine binding polypeptides, fusion proteins thereof, and uses of such polypeptides and fusion proteins.
    Type: Application
    Filed: April 15, 2020
    Publication date: June 16, 2022
    Inventors: Jooyoung PARK, Scott BOYKEN, Kathy WEI, Gustav OBERDORFER, David BAKER
  • Precise Gene Activation Via Novel Designed Proteins Mediating Epigenetic Remodeling
    Publication number: 20220177862
    Abstract: Disclosed herein are compositions including an embryonic ectoderm development (BED) polypeptide binder (EB) domain and a CRISPR associated protein 9 (CAS9) domain linked to the EB domain, and uses thereof for gene activation in a biological cell.
    Type: Application
    Filed: March 11, 2020
    Publication date: June 9, 2022
    Inventors: Shiri LEVY, Hannele RUOHOLA-BAKER, David BAKER
  • FUEL CONDITIONER FOR GRILL
    Publication number: 20220170638
    Abstract: A cooking apparatus can include an enclosure defining a heating chamber configured to be heated and used for cooking food, a burn box proximate to the enclosure and which is configured to provide heat to the heating chamber, a hopper fluidly coupled to the burn box and configured to hold fuel, and a fuel conditioner disposed between the hopper and the burner to condition the fuel prior to burning in the burner. The fuel conditioner can be, for example, a wood chipper configured to reduce the size of the fuel.
    Type: Application
    Filed: February 4, 2021
    Publication date: June 2, 2022
    Inventors: David BAKER, Wang PING
  • Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use
    Publication number: 20220169681
    Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
    Type: Application
    Filed: November 10, 2021
    Publication date: June 2, 2022
    Inventors: Neil P. KING, David BAKER, Brooke NICKERSON, Lance Joseph STEWART, Laurent PEREZ, Antonio LANZAVECCHIA, Jessica MARCANDALLI
  • SELF-ASSEMBLING 2D ARRAYS WITH DE NOVO PROTEIN BUILDING BLOCKS
    Publication number: 20220162265
    Abstract: Disclosed herein are polypeptides that serve as building blocks that can be used, for example, to design 2D protein arrays, methods for designing such polypeptides, and methods for their use.
    Type: Application
    Filed: April 14, 2020
    Publication date: May 26, 2022
    Inventors: Zibo CHEN, David BAKER, Frank DIMAIO
  • DE NOVO DESIGN OF TUNABLE PH-DRIVEN CONFORMATIONAL SWITCHES
    Publication number: 20220144895
    Abstract: Disclosed herein are polypeptides or polypeptide oligomers, including a buried hydrogen bond network that includes at least (1, 2, 3, 4, 5, 6, 7, 8, or 9) pH sensitive amino acids located (i) at an intra-chain interface between different: structural elements in one polypeptide, or (it) at an inter-chain interface between structural elements present in different chains of a polypeptide oligomer, wherein the polypeptide or polypeptide oligomer is stable above a given pH, and wherein the polypeptide or polypeptide oligomer undergoes a conformational transition when subjected to a pH at or below the given pH.
    Type: Application
    Filed: April 20, 2020
    Publication date: May 12, 2022
    Inventors: Scott BOYKEN, David BAKER, Zibo CHEN, Alfredo Quijano RUBIO, Neil P. KING, Jason C. KLIMA, Carl WALKEY
  • CAGED-DEGRON-BASED MOLECULAR FEEDBACK CIRCUITS AND METHODS OF USING THE SAME
    Publication number: 20220119467
    Abstract: Provided are molecular feedback circuits employing caged-degrons. Aspects of such circuits include the use of a caged-degron to modulate the output of a signaling pathway in a feedback-controlled manner. Also provided are nucleic acids encoding molecular circuits and cells containing such nucleic acids. Methods of using caged-degron-based molecular feedback circuits are also provided, including e.g., methods of modulating a signaling pathway of a cell that include genetically modifying the cell with a caged-degron-based molecular feedback circuit.
    Type: Application
    Filed: January 6, 2020
    Publication date: April 21, 2022
    Inventors: David Baker, Scott Boyken, Hana El-Samad, Marc Lajoie, Robert Langan, Andrew Ng
  • Multi-Bladed Mower
    Publication number: 20220095535
    Abstract: A lawn mower may include a blade housing configured to house at least a first blade and a second blade, a shaft disposed to rotate within the blade housing, a powerhead configured to selectively turn the shaft responsive to application of power from a power source, and a blade coupler configured to selectively couple the first blade and/or the second blade to the shaft to produce different cutting performance conditions based on which of the first blade and/or the second blade is operably coupled to the shaft.
    Type: Application
    Filed: October 30, 2019
    Publication date: March 31, 2022
    Inventors: Brad Graham, Samuel Lattimore, David Baker, Jonathan Funk
  • ORTHOGONAL PROTEIN HETERODIMERS
    Publication number: 20220098250
    Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
    Type: Application
    Filed: October 15, 2021
    Publication date: March 31, 2022
    Inventors: Zibo CHEN, Scott BOYKEN, Sherry BERMEO, Robert A. LANGAN, David BAKER
  • DE NOVO DESIGN OF PROTEIN SWITCHES FOR TUNABLE CONTROL OF PROTEIN DEGRADATION
    Publication number: 20220073565
    Abstract: Disclosed herein are non-naturally occurring cage polypeptides, kits and degron LOCKRs including the cage polypep-tides, and uses thereof, wherein the cage polypeptides include (a) a helical bundle, comprising between 2 and 7 alpha-helices, wherein the helical bundle includes: (i) a structural region; and (ii) a latch region, wherein the latch region composes a degron located within the latch region, wherein the structural region interacts with the latch region to prevent activity of the degron; and (b) amino acid linkers connecting each alpha helix
    Type: Application
    Filed: January 6, 2020
    Publication date: March 10, 2022
    Inventors: Robert LANGAN, Andrew NG, Scott BOYKEN, Marc LAJOIE, Hana EL-SAMAD, David BAKER
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20220056095
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??cheterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: September 13, 2021
    Publication date: February 24, 2022
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, David Baker, Kenan Christopher Garcia, Jamie Spangler, Alfredo Quijano Rubio
  • Compositions and methods of treating cognitive impairment
    Patent number: 11253490
    Abstract: The present invention relates generally method of treating or alleviating cognitive impairment by administering an abuse-deterrent formulation containing dextroamphetamine sulfate.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: February 22, 2022
    Assignee: Vallon Pharamaceuticals, Inc.
    Inventors: Ofir Levi, David Baker, Timothy Whitaker