Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.

Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.

Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin-containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.

Abstract: The present invention relates to the treatment of diseases and conditions with an effective amount of a steroid having those formulas given in the specification, or a pharmacologically-acceptable salt or ester thereof. The disease or conditions treatable according to the invention include angiogenic diseases and conditions of the eye, angiogenic diseases and conditions of the brain, inflammatory diseases and conditions of the eye, inflammatory diseases and conditions of the brain and neurodegenerative diseases.

Abstract: The invention provides a method and kit for determining the quantity of certain proteins comprising post-translationally modified sulfhydryl groups. The invention also provides a method and kit for determining the quantity of a protein having no cysteines in its amino acid sequence.

Abstract: A method for use in a mobile communication system for estimating the location of a target mobile station (MS) which includes receiving signals from the target MS (N) at a plurality of receivers (MS1, MS2, MS3) in different locations and calculating the location of the target MS (N) from information obtained from the received signals, wherein at least one of the receivers (MS1) is a searching MS and wherein the calculation of location is carried out by the searching MS (MS1). The method may involve the target MS and the searching MS or MSs communicating by a direct mode of operation (DMO) link. The searching MSs may conveniently have GPS attachments. A mobile station which may be used as the target MS or as a searching MS and a system incorporating the same is also disclosed.

Abstract: The present invention provides methods of using compounds of formula I: and salts and prodrugs thereof, wherein n, R1 and R2 are defined herein. The invention also provides certain novel compounds of formula I and pharmaceutical compositions comprising them.

Abstract: The present invention provides methods of using compounds of formula I: and salts and prodrugs thereof, wherein n, R1 and R2 are defined herein.

Abstract: The present invention relates to an electrostatic capacity type encoder which includes a variable capacitance mechanism made on two dimensional planes, random time varying excitation generation system, interlaced fine & coarse cycles and digital signal processing unit. A variable capacitance mechanism which includes stationary and rotating disks facing each other and forming one or more variable capacitors. The transmit electrodes are split to two transmit phases and the receive electrodes to two receive phases, both can be implemented on two dimensional printed circuit boards without third dimension via interconnects. The combination of the 2 by 2 grid provides the four combinations required to detect both position and direction. Another configuration is made of electrostatic capacity type encoder which includes a first and second stationary disks and in between a third rotating disk, made either of a dielectric material with varying geometry or thickness or from a conductive patterns printed on a PCB.

Abstract: A method for setting up a group call within a dispatch radio communication system is disclosed. Additional stations which are not programmed to respond to a transmitted group identification code (GIC) are enabled to join the call. The method comprises steps carried out by a service provider of (a) providing first and second additional fields in a set-up message, the first additional field carrying a Group Call Access Permission (GCAP) value and the second additional field carrying a Help Request Level (HRL) value, (b) enabling a call initiator to select a GCAP value, according to a range of stations the call initiator wishes to reach, and a HRL value, according to an assigned call priority, for transmission alongside the GIC in the step (a) fields, and (c) enabling any station that receives a set-up message to determine whether to join the call based on the GCAP and HRL values.

Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin-containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.

Abstract: The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation.

Abstract: The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation.

Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.

Abstract: The invention provides therapeutic methods and products for the treatment of inflammation, inflammatory diseases and conditions, and proliferative diseases and conditions. The invention also provides methods and products for inhibiting inflammation in excised cells, tissues and organs. The invention further provides oral care methods and products for the treatment of the tissues of an animal's mouth. Finally, the invention provides personal care methods and products for the treatment of the skin of an animal. All of these methods and products utilize N-acyl-L-aspartic acid or an ester or pharmaceutically-acceptable salt thereof.

Abstract: A wireless communication system includes a system Infrastructure, a plurality of mobile stations and a control terminal operable to send to the mobile stations via the system infrastructure instruction signals by wireless communication relating to information the mobile stations are to store regarding wireless communications with other mobile stations in the system, wherein the information includes group membership information or data relating to communication groups of which the mobile stations are to be members and the instruction signals include an instruction relating to an order in which the group membership information or data in one or more lists of such information is to be stored by the mobile stations.

Abstract: A method for use in a mobile communication system for estimating the location of a target mobile station (MS) which includes receiving signals from the target MS (N) at a plurality of receivers (MS1, MS2, MS3) in different locations and calculating the location of the target MS (N) from information obtained from the received signals, wherein at least one of the receivers (MS1) is a searching MS and wherein the calculation of location is carried out by the searching MS (MS1). The method may involve the target MS and the searching MS or MSs communicating by a direct mode of operation (DMO) link. The searching MSs may conveniently have GPS attachments. A mobile station which may be used as the target MS or as a searching MS and a system incorporating the same is also disclosed.

Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.

Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.

Abstract: A method and system are disclosed for detecting a medical condition wherein a blood or plasma sample is combined with a metal such as cobalt and optically analyzed for an optical distinction that identifies the medical condition. The invention is useful for diagnosing medical conditions such as ischemia. Moreover, the diagnoses of patient samples according to the invention may be enhanced by developing a mathematical model based on signal processing techniques such as principal component analysis on the data obtained in patient studies.