Patents by Inventor David Bar-Or

David Bar-Or has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEASUREMENT AND USES OF OXIDATIVE STRESS
    Publication number: 20100267074
    Abstract: The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients who have suffered a trauma (such as a head injury), patients suspected of being critically-ill or who are critically ill, patients who have an infection, and patients suspected of having a myocardial infarction (MI) or who have had an MI. The method has also been found useful in monitoring and evaluating exercise performance in patients. In addition, the method has been found useful in monitoring and evaluating stored blood products and patients who will receive such a product.
    Type: Application
    Filed: November 24, 2009
    Publication date: October 21, 2010
    Applicant: INSTITUTE FOR MOLECULAR MEDICINE, INC.
    Inventors: David Bar-Or, Raphael Bar-Or
  • METAL-BINDING COMPOUNDS AND USES THEREFOR
    Publication number: 20100249016
    Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.
    Type: Application
    Filed: September 18, 2009
    Publication date: September 30, 2010
    Applicant: DMI BIOSCIENCES, INC.
    Inventors: David Bar-Or, C. Gerald Curtis, Edward Lau, Nagaraja K. R. Rao, James V. Winkler, Wannell M. Crook
  • TREATMENT OF T-CELL MEDIATED DISEASES
    Publication number: 20100190696
    Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
    Type: Application
    Filed: April 2, 2010
    Publication date: July 29, 2010
    Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz
  • TREATMENT OF T-CELL MEDIATED DISEASES
    Publication number: 20100144611
    Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
    Type: Application
    Filed: February 18, 2010
    Publication date: June 10, 2010
    Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz
  • METAL-BINDING COMPOUNDS AND USES THEREFOR
    Publication number: 20100144644
    Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.
    Type: Application
    Filed: November 2, 2009
    Publication date: June 10, 2010
    Applicant: DMI LIFE SCIENCES INC.
    Inventors: David Bar-Or, C. Gerald Curtis, Edward Lau, Nagaraja K.R. Rao, James V. Winkler, Wannell M. Crook
  • TREATMENT OF T-CELL MEDIATED DISEASES
    Publication number: 20100143338
    Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
    Type: Application
    Filed: February 18, 2010
    Publication date: June 10, 2010
    Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz
  • Treatment of T-cell mediated diseases
    Patent number: 7732403
    Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: June 8, 2010
    Assignee: DMI Biosciences, Inc.
    Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkovitz
  • DIAGNOSIS AND MONITORING OF DISEASES
    Publication number: 20100120056
    Abstract: The present invention relates to the diagnosis and monitoring of diseases and conditions by quantifying markers, including degradation products of disease-associated proteins, such as diketopiperazines composed of the two N-terminal amino acids or the two C-terminal amino acids of such proteins. The methods are useful for diagnosing or monitoring various diseases, including multiple sclerosis, Alzheimer's disease and ischemia. The invention further provides binding partners specific for the markers and compositions and kits for conducting the methods of the invention.
    Type: Application
    Filed: July 7, 2009
    Publication date: May 13, 2010
    Applicant: DMI LIFE SCIENCES, INC.
    Inventors: David Bar-Or, Raphael Bar-Or
  • Therapeutic Methods and Compounds
    Publication number: 20100105698
    Abstract: The invention provides diketopiperazines of formula I. The invention also provides pharmaceutical compositions comprising the diketopiperazines, or pharmaceutically-acceptable salts or prodrugs thereof, as the active ingredient. The invention further provides therapeutic treatments that utilize the diketopiperazines of formula I, including inhibition of a proliferative disease or condition, inhibition of angiogenesis, treatment of an angiogenic disease or condition, treatment of cancer and precancerous conditions, treatment of a fibrotic disorder, treatment of a viral infection, treatment of an Akt-mediated disease or condition, inhibition of the production, release or both of matrix metalloproteinase-9, and inhibition of Akt activation.
    Type: Application
    Filed: May 27, 2009
    Publication date: April 29, 2010
    Applicant: DMI LIFE SCIENCES, INC.
    Inventor: David Bar-Or
  • Metal-binding compounds and uses therefor
    Patent number: 7632803
    Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.
    Type: Grant
    Filed: July 19, 2004
    Date of Patent: December 15, 2009
    Assignee: DMI Life Sciences, Inc.
    Inventor: David Bar-Or
  • Methylphenidate Derivatives and Uses of Them
    Publication number: 20090275614
    Abstract: The present invention provides methods of using compounds of formula I: and salts and prodrugs thereof, wherein n, R1 and R2 are defined herein. The invention also provides certain novel compounds of formula I and pharmaceutical compositions comprising them.
    Type: Application
    Filed: October 29, 2008
    Publication date: November 5, 2009
    Inventors: David Bar-Or, Nagaraja R. K. Rao
  • Metal-binding compounds and uses therefor
    Patent number: 7592304
    Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: September 22, 2009
    Assignee: DMI Life Sciences, Inc.
    Inventor: David Bar-Or
  • SYSTEM AND METHOD OF TISSUE CLASSIFICATION
    Publication number: 20090234235
    Abstract: Provided a method of automated classifying a tissue and a system thereof.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 17, 2009
    Applicant: DUNE MEDICAL DEVICES LTD.
    Inventors: Dan HASHIMSHONY, Gil COHEN, Iddo GELTNER, David BAR-MOSHE
  • Diagnosis of multiple sclerosis with diketopiperazines
    Patent number: 7575929
    Abstract: The present invention relates to the diagnosis and monitoring of diseases and conditions by quantifying markers, including degradation products of disease-associated proteins, such as diketopiperazines composed of the two N-terminal amino acids or the two C-terminal amino acids of such proteins. The methods are useful for diagnosing or monitoring various diseases, including multiple sclerosis, Alzheimer's disease and ischemia. The invention further provides binding partners specific for the markers and compositions and kits for conducting the methods of the invention.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: August 18, 2009
    Assignee: DMI Life Sciences, Inc.
    Inventors: David Bar-Or, Raphael Bar-Or
  • Marker useful for detection and measurement of free radical damage and method
    Patent number: 7473558
    Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations affect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: January 6, 2009
    Assignee: Ischemia Technologies, Inc.
    Inventors: David Bar-Or, Edward Lau
  • Measurement and uses of oxidative stress
    Publication number: 20090004686
    Abstract: The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients who have suffered a trauma (such as a head injury), patients suspected of being critically-ill, patients who have a viral infection, and patients suspected of having a myocardial infarction. The method has also been found useful in monitoring and evaluating exercise performance in patients. In addition, the method has been found useful in monitoring and evaluating stored blood products and patients who will receive such a product.
    Type: Application
    Filed: May 16, 2008
    Publication date: January 1, 2009
    Applicant: Institute for Molecular Medicine, Inc.
    Inventors: David Bar-Or, Raphael Bar-Or
  • Tests for the rapid evaluation of ischemic states and kits
    Patent number: 7449338
    Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: November 11, 2008
    Assignee: Ischemia Technologies, Inc.
    Inventors: David Bar-Or, Edward Lau, James V. Winkler, Gary Fagan, Hollie Wayment
  • Treatment of Comorbid Premature Ejaculation and Erectile Dysfunction
    Publication number: 20080262094
    Abstract: The invention provides a method of treating comorbid premature ejaculation and erectile dysfunction. In particular, the method comprises administering an effective amount of a tramadol material and an effective amount of a phosphodiesterase inhibitor. The invention also provides a pharmaceutical composition comprising a pharmaceutically-acceptable carrier, a tramadol material and a phosphodiesterase inhibitor. The invention further provides a kit comprising a tramadol material and a phosphodiesterase inhibitor.
    Type: Application
    Filed: February 12, 2008
    Publication date: October 23, 2008
    Applicant: DMI BIOSCIENCES, INC.
    Inventors: James V. Winkler, Kevin Bilyard, David Bar-Or
  • Reducing Side Effects of Tramadol
    Publication number: 20080261991
    Abstract: The invention provides methods of reducing the side effects of tramadol. Accordingly, in one embodiment, the invention provides a method of reducing the incidence of newly-discovered side effects related to sexual function in human males taking a tramadol material. The method comprises administering a phosphodiesterase inhibitor to a male taking the tramadol material. The invention also provides pharmaceutical compositions. In one embodiment, the composition comprises a tramadol material and a phosphodiesterase inhibitor. The invention further provides kits. In one embodiment, the kit comprises a tramadol material and a phosphodiesterase inhibitor.
    Type: Application
    Filed: February 12, 2008
    Publication date: October 23, 2008
    Applicant: DMI BIOSCIENCES, INC.
    Inventors: David Bar-Or, Kevin Bilyard, James V. Winkler
  • Methods and products which utilize N-acyl-L-aspartic acid
    Publication number: 20080167376
    Abstract: The invention provides therapeutic methods and products for the treatment of inflammation, inflammatory diseases and conditions, and proliferative diseases and conditions. The invention also provides methods and products for inhibiting inflammation in excised cells, tissues and organs. The invention further provides oral care methods and products for the treatment of the tissues of an animal's mouth. Finally, the invention provides personal care methods and products for the treatment of the skin of an animal. All of these methods and products utilize N-acyl-L-aspartic acid or an ester or pharmaceutically-acceptable salt thereof.
    Type: Application
    Filed: December 28, 2007
    Publication date: July 10, 2008
    Applicant: DMI BIOSCIENCES, INC.
    Inventors: David Bar-Or, Leonard T. Rael