Patents by Inventor David Bar-Or

David Bar-Or has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of T-cell mediated diseases
    Patent number: 8969308
    Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: March 3, 2015
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz
  • Treatment of T-cell mediated diseases
    Patent number: 8962568
    Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: February 24, 2015
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz
  • METHOD OF USING DIKETOPIPERAZINES AND COMPOSITION CONTAINING THEM
    Publication number: 20150051223
    Abstract: The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula: wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: August 8, 2014
    Publication date: February 19, 2015
    Inventors: David Bar-Or, C. Gerald Curtis, Nagaraja K.R. Rao, Greg Thomas
  • THERAPEUTIC METHODS AND COMPOUNDS
    Publication number: 20150051224
    Abstract: The invention provides diketopiperazines of formula I. The invention also provides pharmaceutical compositions comprising the diketopiperazines, or pharmaceutically-acceptable salts or prodrugs thereof, as the active ingredient. The invention further provides therapeutic treatments that utilize the diketopiperazines of formula I, including inhibition of a proliferative disease or condition, inhibition of angiogenesis, treatment of an angiogenic disease or condition, treatment of cancer and precancerous conditions, treatment of a fibrotic disorder, treatment of a viral infection, treatment of an Akt-mediated disease or condition, inhibition of the production, release or both of matrix metalloproteinase-9, and inhibition of Akt activation.
    Type: Application
    Filed: August 27, 2014
    Publication date: February 19, 2015
    Inventor: David Bar-Or
  • ENHANCED PRIVACY FOR PROVISION OF COMPUTER VISION
    Publication number: 20150040242
    Abstract: Methods, apparatuses and storage medium associated with providing enhanced privacy during usage of computer vision are disclosed. In embodiments, an apparatus may include one or more privacy indicators to indicate one or more privacy conditions of the apparatus in association with provision of computer vision on the apparatus. The apparatus may further include a privacy engine coupled with the one or more privacy indicators, and configured to pre-process images from an image source of the apparatus associated with the provision of computer vision to the apparatus, to increase privacy for a user of the apparatus, and to control the one or more privacy indicators. In embodiments, the apparatus may include means for blanking out one or more pixels with depth values identified as greater than a threshold. Other embodiments may be described and claimed.
    Type: Application
    Filed: October 20, 2014
    Publication date: February 5, 2015
    Inventors: David Bar-On, Geoffrey Strongin
  • Method of using diketopiperazines and composition containing them
    Patent number: 8916568
    Abstract: The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula: wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: December 23, 2014
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, C. Gerald Curtis, Nagaraja K. R. Rao, Greg Thomas
  • Enhanced privacy for provision of computer vision
    Patent number: 8914894
    Abstract: Methods, apparatuses and storage medium associated with providing enhanced privacy during usage of computer vision are disclosed. In embodiments, an apparatus may include one or more privacy indicators to indicate one or more privacy conditions of the apparatus in association with provision of computer vision on the apparatus. The apparatus may further include a privacy engine coupled with the one or more privacy indicators, and configured to pre-process images from an image source of the apparatus associated with the provision of computer vision to the apparatus, to increase privacy for a user of the apparatus, and to control the one or more privacy indicators. In embodiments, the apparatus may include means for blanking out one or more pixels with depth values identified as greater than a threshold. Other embodiments may be described and claimed.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: December 16, 2014
    Assignee: Intel Corporation
    Inventors: David Bar-On, Geoffrey Strongin
  • Therapeutic methods and compounds
    Patent number: 8871772
    Abstract: The invention provides diketopiperazines of formula I. The invention also provides pharmaceutical compositions comprising the diketopiperazines, or pharmaceutically-acceptable salts or prodrugs thereof, as the active ingredient. The invention further provides therapeutic treatments that utilize the diketopiperazines of formula I, including inhibition of a proliferative disease or condition, inhibition of angiogenesis, treatment of an angiogenic disease or condition, treatment of cancer and precancerous conditions, treatment of a fibrotic disorder, treatment of a viral infection, treatment of an Akt-mediated disease or condition, inhibition of the production, release or both of matrix metalloproteinase-9, and inhibition of Akt activation.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: October 28, 2014
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventor: David Bar-Or
  • IMPLANTABLE MEDICAL DEVICES WITH INCREASED IMMUNE TOLERANCE, AND METHODS FOR MAKING AND IMPLANTING
    Publication number: 20140302114
    Abstract: The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).
    Type: Application
    Filed: October 10, 2012
    Publication date: October 9, 2014
    Inventor: David Bar-Or
  • TREATMENT OF RHINITIS
    Publication number: 20140294737
    Abstract: The invention provides a method of treating rhinitis. The method comprises administering an effective amount of a danazol compound or a pharmaceutically acceptable salt thereof. The invention also provides a pharmaceutical product formulated for nasal administration. The product comprises a danazol compound or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 5, 2012
    Publication date: October 2, 2014
    Inventor: David Bar-Or
  • TREATMENT OF RHINITIS
    Publication number: 20140294738
    Abstract: The invention provides a method of treating rhinitis. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP) formulated for nasal administration. The invention also provides a pharmaceutical product comprising a DA-DKP containing composition.
    Type: Application
    Filed: October 26, 2012
    Publication date: October 2, 2014
    Applicant: AMPIO PHARMACEUTICALS, INC.
    Inventor: David Bar-Or
  • Measurement and Uses of Oxidative Status
    Publication number: 20140291169
    Abstract: The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients who have suffered a trauma (such as a head injury), patients suspected of being critically-ill or who are critically ill, patients who have an infection, and patients suspected of having a myocardial infarction (MI) or who have had an MI. The method has also been found useful in monitoring and evaluating exercise performance in patients. In addition, the method has been found useful in monitoring and evaluating stored blood products and patients who will receive such a product.
    Type: Application
    Filed: March 21, 2014
    Publication date: October 2, 2014
    Applicant: Luoxis Diagnostics, Inc.
    Inventors: David Bar-Or, Raphael Bar-Or
  • COMPOSITIONS FOR THE MOBILIZATION, HOMING, EXPANSION AND DIFFERENTIATION OF STEM CELLS AND METHODS OF USING THE SAME
    Publication number: 20140286913
    Abstract: The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Applicant: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, Greg Thomas
  • Method of using diketopiperazines and composition containing them
    Patent number: 8841307
    Abstract: The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula: wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: September 23, 2014
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, C. Gerald Curtis, Nagaraja K. R. Rao, Greg Thomas
  • TREATMENT OF DEGENERATIVE JOINT DISEASE
    Publication number: 20140256642
    Abstract: The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP.
    Type: Application
    Filed: October 10, 2012
    Publication date: September 11, 2014
    Inventors: David Bar-Or, James V. Winkler
  • METHODS OF TREATMENT OF DISEASES
    Publication number: 20140227347
    Abstract: The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering a vascular-hyperpermeability-inhibiting amount of a danazol compound to the animal. The method comprises administering an effective amount of a danazol compound to the animal accounting for the body fat content of the animal. The invention also provides a method of modulating the cytoskeleton of an endothelial cell in an animal.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 14, 2014
    Applicant: AMPIO PHARMACEUTICALS, INC.
    Inventor: David Bar-Or
  • Methods and products for treatment of diseases
    Patent number: 8722651
    Abstract: The present invention relates to the treatment of diseases and conditions with an effective amount of a steroid having those formulas given in the specification, or a pharmacologically-acceptable salt or ester thereof. The disease or conditions treatable according to the invention include angiogenic diseases and conditions of the eye, angiogenic diseases and conditions of the brain, inflammatory diseases and conditions of the eye, inflammatory diseases and conditions of the brain and neurodegenerative diseases.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: May 13, 2014
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventor: David Bar-Or
  • METHODS AND SYSTEMS FOR MEASURING AND USING THE OXIDATION-REDUCTION POTENTIAL OF A BIOLOGICAL SAMPLE
    Publication number: 20140121158
    Abstract: Methods and systems for measuring and using the oxidation-reduction characteristics of a biological sample are provided. The system generally includes a test strip and a readout device. A fluid sample is placed in the test strip, and the test strip is in turn operatively connected to the readout device. The readout device provides a controlled current that is sent across the fluid in the sample chamber. In addition, the readout device identifies an inflection point or transition time at which the voltage between contacts of the test strip is changing at the highest rate. The oxidation-reduction capacity of the sample is taken as the integral of the current profile from the time at which current begins to be supplied to the sample to the identified transition time.
    Type: Application
    Filed: October 23, 2013
    Publication date: May 1, 2014
    Applicant: Luoxis Diagnostics, Inc.
    Inventors: Raphael Bar-Or, David Bar-Or, Leonard T. Rael
  • Measurement and uses of oxidative status
    Patent number: 8709709
    Abstract: The present invention provides a method of evaluating a patient in a hospital prior to discharge to determine if the patient is or is not at risk of early readmission if the patient were to be discharged from the hospital. The invention also provides a method of evaluating and monitoring the condition of a patient after discharge from a hospital. Both methods comprise measuring the oxidation-reduction potential (ORP) of a body fluid of the patient, a tissue of the patient of both.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: April 29, 2014
    Assignee: Luoxis Diagnostics, Inc.
    Inventors: David Bar-Or, Raphael Bar-Or
  • METHOD AND APPARATUS FOR MEASURING OXIDATION-REDUCTION POTENTIAL
    Publication number: 20140110257
    Abstract: Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.
    Type: Application
    Filed: December 30, 2013
    Publication date: April 24, 2014
    Applicant: Luoxis Diagnostics, Inc.
    Inventors: Raphael Bar-Or, David Bar-Or, Leonard T. Rael