Abstract: A method includes drilling a first bore into a formation to a first depth, the bore having a bore wall and a first diameter that is sufficient to receive a casing pipe. A casing pipe is driven into the drill bore, the casing pipe having a binder on an exterior surface of the casing pipe that is configured to secure the casing pipe to the bore wall, the casing pipe being secured to an anchoring nut at a proximal end. The anchoring nut includes a gripping feature. An anchoring clamp of a drill rig is engaged with the gripping feature of the anchoring nut to thereby anchor the drill rig to the formation. The anchoring clamp includes a plurality of jaws that are movable toward and away from a central axis.

Abstract: Disclosed herein is a system and method for managing financial information. According to an embodiment, electronic purchase data is received from an electronic payment source. The received electronic purchase data is generated into one or more visual representation formats using a transformation server. Once the visual representation has been generated, the visual representation format is rendered using a display device.

Abstract: Described are dominant-negative receptor mutants of V-Set and Immunoglobulin domain containing 3 (VSIG3) receptors and V-Set and Immunoglobulin domain containing 8 (VSIG8) receptors and methods of making the same for use in applications drawn to modulating the downstream signal transduction effects of VSIG3 and VSIG8 and their corresponding ligands. The invention is drawn to use of the use of the dnVSIG3 and/or dnVSIG8 receptor mutants to mitigate immunosuppressive effects associated with functional forms of VSIG3 and/or VSIG8 in the presence of their cognate ligands.

Abstract: The present disclosure provides novel and efficient methods and lentiviral vectors for manufacturing a population of immune cells engineered to express a Chimeric Antigen Receptor (CAR), an engineered T cell receptor (TCR), and/or a nucleic acid sequence encoding a polypeptide that enhances the immune cell function, or a functional derivative thereof in less than 72 hours; engineered cells generated by the methods, compositions comprising said cells and methods of treating a disease or condition using said cells.

Abstract: The disclosure relates to immune cells comprising one or more vectors comprising a nucleic acid sequence encoding a chimeric antigen receptor specific for CD19 and a nucleic acid sequence encoding an enhancer of T cell priming (e.g., IL-18), compositions comprising the T cells, and methods of generating and/or using the T cells to treat diseases associated with the expression of CD19.

Abstract: A method includes drilling a first bore into a formation to a first depth, the bore having a bore wall and a first diameter that is sufficient to receive a casing pipe. A casing pipe is driven into the drill bore, the casing pipe having a binder on an exterior surface of the casing pipe that is configured to secure the casing pipe to the bore wall, the casing pipe being secured to an anchoring nut at a proximal end. The anchoring nut includes a gripping feature. An anchoring clamp of a drill rig is engaged with the gripping feature of the anchoring nut to thereby anchor the drill rig to the formation. The anchoring clamp includes a plurality of jaws that are movable toward and away from a central axis.

Abstract: The present disclosure provides novel and efficient methods and lentiviral vectors for manufacturing a population of immune cells engineered to express a Chimeric Antigen Receptor (CAR), an engineered T cell receptor (TCR), and/or a nucleic acid sequence encoding a polypeptide that enhances the immune cell function, or a functional derivative thereof in less than 72 hours; engineered cells generated by the methods, compositions comprising said cells and methods of treating a disease or condition using said cells.

Abstract: The disclosure relates to immune cells comprising one or more vectors comprising a nucleic acid sequence encoding a chimeric antigen receptor specific for CD19 and a nucleic acid sequence encoding an enhancer of T cell priming (e.g., IL-18), compositions comprising the T cells, and methods of generating and/or using the T cells to treat diseases associated with the expression of CD19.

Abstract: The disclosure relates to chimeric antigen receptor (CAR) specific to CD19, vectors encoding the same, and recombinant T cells comprising the CD19 CAR. The disclosure also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD19 binding domain.

Abstract: Disclosed herein is a system and method for managing financial information. According to an embodiment, electronic purchase data is received from an electronic payment source. The received electronic purchase data is generated into one or more visual representation formats using a transformation server. Once the visual representation has been generated, the visual representation format is rendered using a display device.

Abstract: A drill rig having a longitudinal drilling axis, a front portion, and a rear portion can comprise a feedframe aligned with the longitudinal drilling axis, a first head assembly coupled to the feedframe and configured to rotate a drill string, and a rod holder proximate the front portion of the drill rig. A second head assembly can be movable on the feedframe along the longitudinal axis and can include a powered water swivel assembly comprising a spindle having an interior bore a drill rod connector at a first end of the spindle, a motor that is configured to rotate the spindle, a clutch configured to disengage the motor from the spindle, a gearbox that couples the motor to the spindle, and a water swivel that is configured to provide drilling fluid to the interior bore of the spindle.

Abstract: The present invention provides gene edited modified immune cells suitable for adoptive T cell therapy comprising a nucleic acid capable of downregulating CD3?, CD3?, CD3?, B2M, CIITA, TAP1, TAP2, TAPBP, NLRC5, HLA-DM, RFX5, RFXANK, RFXAP, and invariant chain; and further comprising an exogenous nucleic acid encoding a chimeric antigen receptor (CAR), an engineered T cell receptor (TCR), a Killer cell immunoglobulin-like receptor (KIR), dominant negative receptor and/or a switch receptor. Also provided are compositions and methods for generating the modified immune cell, and methods of using the modified immune cells for adoptive therapy and treating a disease or condition.

Abstract: This invention is an apparatus that can be intermittently bottom moored and moved with buoyancy as it uses its sensors to collect data in deep ocean water. In one embodiment of the invention, the apparatus includes one or more floats, buoyancy engines, payload sensors, depth sensors and electronics. The electronics provide the power and, among other things, control the transmission of data from and the reception of information by the apparatus. An anchor is used to moor the apparatus at desired locations. When not moored, the apparatus drifts with the currents at the depth at which the apparatus is then positioned, with the movement being directed by current flow of the water. The movement of the apparatus is guided with knowledge of the currents and tides (it is not random).

Abstract: The present disclosure is directed to chimeric antigen receptors binding to Glypican 2, nucleic acids encoding the same, and cells expressing the same, and methods of using such cells to treat cancers that express or overexpress the Glypican 2 antigen.

Abstract: A drill rig having a longitudinal drilling axis, a front portion, and a rear portion can comprise a feedframe aligned with the longitudinal drilling axis, a first head assembly coupled to the feedframe and configured to rotate a drill string, and a rod holder proximate the front portion of the drill rig. A second head assembly can be movable on the feedframe along the longitudinal axis and can include a powered water swivel assembly comprising a spindle having an interior bore a drill rod connector at a first end of the spindle, a motor that is configured to rotate the spindle, a clutch configured to disengage the motor from the spindle, a gearbox that couples the motor to the spindle, and a water swivel that is configured to provide drilling fluid to the interior bore of the spindle.

Abstract: A bi-directional egress hatch for a passenger aircraft may allow passengers to rapidly and safely exit an overhead cabin of the aircraft onto the main deck, while allowing cabin crew to safely ascend into the overhead cabin if need be. Hatch panels may blend in with overhead bin doors and ceiling panels of the main cabin; the inner portions of the hatch panels (facing the overhead cabin) may include anti-skid portions and graspable handles for descending passengers. The hatch may be easily activated by a passenger with a single motion (or remotely activated, or autodeployed). Once activated, the hatch panels may swing open and a telescoping ladder may deploy from the inner portion to the main deck, remaining rigid once reaching the floor. Similarly, any barriers protecting the ladder from passengers in the overhead cabin may be released, granting access to the telescoping ladder.

Abstract: The present disclosure provides improved compositions and methods for T-cell-based immunotherapy employing a modified T cells obtained from the lymphatic system of normal and cancer patient donors. These cells can then be used to treat patients for a variety of different blood and solid tumor cancers.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network having a plurality of network parameters and being configured to process an input data item to generate a feature representation comprising a values for each of a plurality of features of the input data item.

Abstract: Passenger rest compartments may be incorporated into remote areas of an aircraft, either in the overhead crown region or in lower lobe cargo decks. Each passenger rest compartment includes two-way audio communication with the flight deck and non-intrusive non-visual monitoring of the compartments and surrounding environment to determine passenger presence, absence, and general well-being as well as environmental safety. Rest compartments may be integrated into rest cabins in the overhead or lower lobe areas, the rest cabins accessible from the main passenger cabin via an entry vestibule providing dedicated enclosed paths to the overhead and lower cabins. Additional deployable egress hatches may allow passengers to rapidly return to the main deck from the overhead and lower lobe cabins in the event of an emergency. Selected passenger seats (e.g., partitioned or other premium seats) may include private access to passenger rest compartments.

Abstract: The field of the present invention relates, in general, to apparatus and methods of knitting a material into a tubular form, where the length of such tubular form is not dictated by conventional distances between the knitting areas and the catch basins of integrated machines. In short, this invention increases the distal relationship between the needle-equipped element, which performs the knitting function, and the basin that catches the resulting tubular form of the material. The basin rotates synchronized with the rotation of the resulting tubular form. The separation facilitates the continuous production of a length of the resulting tubular form of the material. The tubular form thus can be longer than such length where, as taught in the prior art, the catch basin is fixed—as part of integrated machines—in close proximity with the element that performs the knitting.