Abstract: The present invention relates to a multipurpose drill system, the multipurpose drill system comprising: a drilling rig adapted to drive a drilling assembly; and two or more power sources, wherein at least one of the two or more power sources is a high pressure power source, wherein the drilling assembly is adapted to be in communication with either or both of the two or more power sources.

Abstract: A method and system for activity classification. A pressure sensor receives input data resulting from physical activity of a subject performing an activity. The input data includes pressure data from at least one pressure sensor, and may include other data acquired through other types of sensors. A deep learning neural network is applied to the input data for identifying the activity. The neural network is trained with reference to training data from a training database. The training data may include empirical data from a database of previous data of corresponding activities, synthesized data prepared from the empirical data or simulated data. The training data may include data from physical activity of the subject being monitored by the system. Different aspects of the neural network may be trained with reference to the training data, and some aspects may be locked or opened depending on the application and the circumstances.

Abstract: The present invention relates to antibodies binding to IL13 and IL22. The invention provides novel multi-specific antibodies that bind to both IL13 and IL22 and compositions comprising an antibody that binds to IL13 and an antibody that binds to IL22. The invention further relates to therapeutic uses of the combination of anti-IL13 and anti-IL22 antibodies and multi-specific antibodies that bind to both IL13 and IL22.

Abstract: A suspended undercarriage assembly connectable to a multi-member frame assembly of a track system includes a beam having a leading portion and a trailing portion, at least one support wheel assembly connectable to the beam, at least one of a leading resilient bushing assembly and a trailing resilient bushing assembly including a bushing having an opening defined therein and being shaped and dimensioned for promoting deformation of the bushing in at least one of a vertical direction and a lateral direction. The bushing is resiliently deformable to permit movement of the beam relative to the multi-member frame assembly in the vertical direction and in the lateral direction, and to resiliently bias the beam towards a rest position with respect to the multi-member frame assembly. A track system having the suspended undercarriage assembly is also provided.

Abstract: Nodulisporic acids (NAs) comprise a group of indole diterpenes known for their potent insecticidal activities; however, biosynthesis of NAs by its natural producer, Hypoxylon pulicicidum (Nodulisporium sp.) is exceptionally difficult to achieve. The identification of genes responsible for NA production could enable biosynthetic pathway optimization to provide access to NAs for commercial applications. Obtaining useful quantities of NAs using published fermentations methods is challenging, making gene knockout studies an undesirable method to confirm gene function. Alternatively, heterologous gene expression of H. pulicicidum genes in a more robust host species like Penicillium paxilli provides a way to rapidly identify the function of genes that play a role in NA biosynthesis. In this work, we identified the function of four secondary-metabolic genes necessary for the biosynthesis of nodulisporic acid F (NAF) and reconstituted these genes in the genome of P.

Abstract: A suspended undercarriage assembly connectable to a multi-member frame assembly of a track system includes a beam having a leading portion and a trailing portion, at least one support wheel assembly connectable to the beam, at least one of a leading resilient bushing assembly and a trailing resilient bushing assembly including a bushing having an opening defined therein and being shaped and dimensioned for promoting deformation of the bushing in at least one of a vertical direction and a lateral direction. The bushing is resiliently deformable to permit movement of the beam relative to the multi-member frame assembly in the vertical direction and in the lateral direction, and to resiliently bias the beam towards a rest position with respect to the multi-member frame assembly. A track system having the suspended undercarriage assembly is also provided.

Abstract: A pivoting assembly for connecting a support wheel assembly to a frame of a track system is disclosed. The pivoting assembly includes first, intermediate and second clamping members, first and second resilient members and a shaft configured to connect to the support wheel assembly. The first resilient member has first and second engaging portions configured to, respectively, operationally engage with the first clamping member, and a first engaging side of the intermediate clamping member. The second resilient member has third and fourth engaging portions configured to, respectively, operationally engage with a second engaging side of the intermediate clamping member and the second clamping member. The intermediate clamping member is 216apivotable about a pivot axis. The first and intermediate clamping members apply a first clamping force to the first resilient member. The intermediate and second clamping members apply a second clamping force to the second resilient member.

Abstract: A computer implemented method includes receiving, by the computer, a request to display a process safety risk matrix associated with a process facility and displaying the process safety risk matrix. The process safety risk matrix includes a 2-dimensional representation of a plurality of risk matrix cells, each of the plurality of risk matrix cells associated with a combination of a likelihood level and a severity level. The computer implemented method includes displaying, by the computer, an indication of a hazardous process event scenario within a first cell within the process safety risk matrix, the cell location determined based on a Target Mitigated Event Likelihood (TMEL) and a Safety Severity. The computer implemented method includes displaying, by the computer, an indication of a second graphic indication on a second cell to identify a change in a hazardous scenario count associated with the second cell.

Abstract: The invention provides isolated achromosomal dynamic active systems (ADAS), including ADAS comprising secretion systems. These ADAS provided by the invention can be obtained by a variety of means. Various associated methods of making and using these ADAS are provided.

Abstract: Anti-viral compounds and methods of using antiviral compounds are described. The compounds can be used in methods of reducing infection rate of a virus and in methods of treating a viral infection in a subject in need thereof. The virus can be a coronavirus, such as SARS-CoV-2.

Abstract: An integrated circuit design method includes receiving an integrated circuit design, and determining a floor plan for the integrated circuit design. The floor plan includes an arrangement of a plurality of functional cells and a plurality of tap cells. Potential latchup locations in the floor plan are determined, and the arrangement of at least one of the functional cells or the tap cells is modified based on the determined potential latchup locations.

Abstract: The present disclosure relates to therapeutic agents and combinations thereof (e.g., pharmaceutical compositions) for the treatment of a viral infection in a subject, tissue or cell.

Abstract: An energy control system (ECS) for controlling an energy storage system (ESS's) that includes energy storage devices(s) or an energy storage combination (ESDC's) including?1 of the energy storage devices and ?1 of the energy storage combinations. A power conversion system is coupled to an output of the ESDC, and a transformer is coupled to an output of the power conversion system. The ECS includes an ECS server and an ESS adapter configured for providing an interface between ECS server and the ESS. The ECS server is configured for reading status data from the ESS and submitting schedules including selected charging and discharging times to the ESS, monitoring or displaying a variance between an expected performance of the ESS based on the schedules and an actual ESS performance, and responsive to the variance being determined to be above a predetermined threshold, sending an update of the schedules to the ESS.

Abstract: An integrated circuit design method includes receiving an integrated circuit design, and determining a floor plan for the integrated circuit design. The floor plan includes an arrangement of a plurality of functional cells and a plurality of tap cells. Potential latchup locations in the floor plan are determined, and the arrangement of at least one of the functional cells or the tap cells is modified based on the determined potential latchup locations.

Abstract: Techniques are disclosed for generating a search index for a hierarchical data set so that a search query of the hierarchical data may return results without searching or analyzing the hierarchical data set itself. The techniques generate a flattened index that includes selected indexed attributes and additional attributes to be displayed with the indexed attributes. The techniques also generate a hierarchy representation of the hierarchical data. Using these generated data structures, query results may be returned without directly traversing the hierarchical data itself while also providing data and hierarchical context for the query results by overlaying the query results with nodes of the hierarchical representation or otherwise concurrently displaying the query results with nodes of the hierarchical representation.

Abstract: A suspended undercarriage assembly connectable to a track system including a frame member has a resilient assembly. The resilient assembly includes a first arm connected to the frame member, a second arm pivotally connected to the first arm, a spacing defined between the first and second arms, and a resilient member disposed in the spacing and connected to the first and second arms. The resilient member is resiliently deformable to permit movement of the second arm relative to the first arm, and to resiliently bias the second arm towards a rest position with respect to the first arm. The suspended undercarriage assembly provides suspension to a support wheel assembly relative to the frame member when connected to the second arm.

Abstract: A surgical instrument for reducing a rod into a saddle of a fixation member includes a distal end for engaging the saddle and a proximal end. A reducing device is disposed between the distal end and the proximal end. The reducing device is operative to reduce the rod into the saddle. The reducing device defines a throughbore. The throughbore provides access there through by a first drive member to secure a plug to the saddle.

Abstract: A multi-member frame assembly for a track system includes a pivot pin defining a pivot axis, a leading frame member pivotally connected to the pivot pin for pivoting about the pivot axis, and a trailing frame member pivotally connected to the pivot pin for pivoting about the pivot axis, the trailing frame member pivoting independently from the leading frame member. A resilient member is pivotally connected to the leading frame member and to the trailing frame member. The resilient member extends generally vertically between the leading frame member and the trailing frame member. A track system having a multi-member frame assembly is also described.

Abstract: A suspended undercarriage assembly connectable to a multi-member frame assembly of a track system includes a beam having a leading portion and a trailing portion, at least one support wheel assembly connectable to the beam, at least one of a leading resilient bushing assembly and a trailing resilient bushing assembly including a bushing having an opening defined therein and being shaped and dimensioned for promoting deformation of the bushing in at least one of a vertical direction and a lateral direction. The bushing is resiliently deformable to permit movement of the beam relative to the multi-member frame assembly in the vertical direction and in the lateral direction, and to resiliently bias the beam towards a rest position with respect to the multi-member frame assembly. A track system having the suspended undercarriage assembly is also provided.

Abstract: Embolic coil implant systems and methods whereby coils are mechanically detachable are disclosed. The coils include a retention element that may be releasably retained within the distal end of an implant tool. The implant tool may include a fulcrum configured to engage a first filament and prevent the release of the coil when the first filament is engaged. Alternatively, an urging means and aperture may be disposed within the sidewall of the implant tool, and a first filament may, in conjunction with the aperture and sidewall, releasably retain the coil until the first filament is withdrawn. The implant tool may also include an alignment member for aligning the first filament.