Abstract: This disclosure relates generally to membrane-bound compositions, in particular exophers having a diameter between 1 and 20 microns induced from human cells, and uses thereof.

Abstract: An integrated circuit design method includes receiving an integrated circuit design, and determining a floor plan for the integrated circuit design. The floor plan includes an arrangement of a plurality of functional cells and a plurality of tap cells. Potential latchup locations in the floor plan are determined, and the arrangement of at least one of the functional cells or the tap cells is modified based on the determined potential latchup locations.

Abstract: A bone implant includes a proximal end, a distal end, a first portion extending between the proximal and distal ends having a maximum and minimum portion height, and a second portion extending between the proximal and distal ends having a maximum and minimum portion height. The second portion is connected to the first portion at the proximal end and the distal end and at least one of the first portion and the second portion is moveable relative to the other of the first portion and the second portion so as to transition the bone implant between a relaxed state wherein the first and second portions are separated by a first distance and a contracted state wherein the first and second portions are separated by a second distance different from the first distance. At least one of the proximal end and the distal end have the minimum portion height.

Abstract: A thromboembolic removal system for treating ischemic stroke, including a guide and occlusion catheter, a delivery and aspiration catheter, an aspiration pump, a thromboembolic receiver, and a thromboembolic separator.

Abstract: Systems and techniques to ensure reliable operation of devices, such as medical devices, that are configured to execute installed software are described. A secure software update process for the device utilizes multiple integrity checks in order to prove that software integrity has not been compromised before the device is allowed to be put into service with the software installed thereon. Also described is a computer architecture for an external defibrillator that isolates the execution of installed software applications by separately compiling the code for those applications and by executing the separately-compiled applications on different processors of the defibrillator. Among other things, this allows the defibrillator to be “brought online” faster, such as to deliver a shock to a patient.

Abstract: Techniques are disclosed for generating a search index for a hierarchical data set so that a search query of the hierarchical data may return results without searching or analyzing the hierarchical data set itself. The techniques generate a flattened index that includes selected indexed attributes and additional attributes to be displayed with the indexed attributes. The techniques also generate a hierarchy representation of the hierarchical data. Using these generated data structures, query results may be returned without directly traversing the hierarchical data itself while also providing data and hierarchical context for the query results by overlaying the query results with nodes of the hierarchical representation or otherwise concurrently displaying the query results with nodes of the hierarchical representation.

Abstract: An intra-osseous support structure can be used to fixate opposed portions of bone. In some examples, the intra-osseous support structure is positioned in openings formed in adjacent portions of bones. Fasteners are inserted through the bone portions to secure the intra-osseous support structure in the bones. Depending on the application, one or more external bone plates may also be applied to the bone portions. The external bone plate may be in compression while the intra-osseous support structure is in tension under load in situ.

Abstract: Nodulisporic acids (NAs) comprise a group of indole diterpenes known for their potent insecticidal activities; however, biosynthesis of NAs by its natural producer, Hypoxylon pulicicidum (Nodulisporium sp.) is exceptionally difficult to achieve. The identification of genes responsible for NA production could enable biosynthetic pathway optimization to provide access to NAs for commercial applications. Obtaining useful quantities of NAs using published fermentations methods is challenging, making gene knockout studies an undesirable method to confirm gene function. Alternatively, heterologous gene expression of H. pulicicidum genes in a more robust host species like Penicillium paxilli provides a way to rapidly identify the function of genes that play a role in NA biosynthesis. In this work, we identified the function of four secondary-metabolic genes necessary for the biosynthesis of nodulisporic acid F (NAF) and reconstituted these genes in the genome of P.

Abstract: A bone implant includes a proximal end, a distal end, a first portion extending between the proximal and distal ends having a maximum and minimum portion height, and a second portion extending between the proximal and distal ends having a maximum and minimum portion height. The second portion is connected to the first portion at the proximal end and the distal end and at least one of the first portion and the second portion is moveable relative to the other of the first portion and the second portion so as to transition the bone implant between a relaxed state wherein the first and second portions are separated by a first distance and a contracted state wherein the first and second portions are separated by a second distance different from the first distance. At least one of the proximal end and the distal end have the minimum portion height.

Abstract: A suspended undercarriage assembly connectable to a multi-member frame assembly of a track system includes a beam having a leading portion and a trailing portion, at least one support wheel assembly connectable to the beam, at least one of a leading resilient bushing assembly and a trailing resilient bushing assembly including a bushing having an opening defined therein and being shaped and dimensioned for promoting deformation of the bushing in at least one of a vertical direction and a lateral direction. The bushing is resiliently deformable to permit movement of the beam relative to the multi-member frame assembly in the vertical direction and in the lateral direction, and to resiliently bias the beam towards a rest position with respect to the multi-member frame assembly. A track system having the suspended undercarriage assembly is also provided.

Abstract: Nodulisporic acids (NAs) comprise a group of indole diterpenes known for their potent insecticidal activities; however, biosynthesis of NAs by its natural producer, Hypoxylon pulicicidum (Nodulisporium sp.) is exceptionally difficult to achieve. The identification of genes responsible for NA production could enable biosynthetic pathway optimization to provide access to NAs for commercial applications. Obtaining useful quantities of NAs using published fermentations methods is challenging, making gene knockout studies an undesirable method to confirm gene function. Alternatively, heterologous gene expression of H. pulicicidum genes in a more robust host species like Penicillium paxilli provides a way to rapidly identify the function of genes that play a role in NA biosynthesis. In this work, we identified the function of four secondary-metabolic genes necessary for the biosynthesis of nodulisporic acid F (NAF) and reconstituted these genes in the genome of P.

Abstract: A suspended undercarriage assembly connectable to a multi-member frame assembly of a track system includes a beam having a leading portion and a trailing portion, at least one support wheel assembly connectable to the beam, at least one of a leading resilient bushing assembly and a trailing resilient bushing assembly including a bushing having an opening defined therein and being shaped and dimensioned for promoting deformation of the bushing in at least one of a vertical direction and a lateral direction. The bushing is resiliently deformable to permit movement of the beam relative to the multi-member frame assembly in the vertical direction and in the lateral direction, and to resiliently bias the beam towards a rest position with respect to the multi-member frame assembly. A track system having the suspended undercarriage assembly is also provided.

Abstract: A pivoting assembly for connecting a support wheel assembly to a frame of a track system is disclosed. The pivoting assembly includes first, intermediate and second clamping members, first and second resilient members and a shaft configured to connect to the support wheel assembly. The first resilient member has first and second engaging portions configured to, respectively, operationally engage with the first clamping member, and a first engaging side of the intermediate clamping member. The second resilient member has third and fourth engaging portions configured to, respectively, operationally engage with a second engaging side of the intermediate clamping member and the second clamping member. The intermediate clamping member is 216apivotable about a pivot axis. The first and intermediate clamping members apply a first clamping force to the first resilient member. The intermediate and second clamping members apply a second clamping force to the second resilient member.

Abstract: A computer implemented method includes receiving, by the computer, a request to display a process safety risk matrix associated with a process facility and displaying the process safety risk matrix. The process safety risk matrix includes a 2-dimensional representation of a plurality of risk matrix cells, each of the plurality of risk matrix cells associated with a combination of a likelihood level and a severity level. The computer implemented method includes displaying, by the computer, an indication of a hazardous process event scenario within a first cell within the process safety risk matrix, the cell location determined based on a Target Mitigated Event Likelihood (TMEL) and a Safety Severity. The computer implemented method includes displaying, by the computer, an indication of a second graphic indication on a second cell to identify a change in a hazardous scenario count associated with the second cell.

Abstract: The invention provides isolated achromosomal dynamic active systems (ADAS), including ADAS comprising secretion systems. These ADAS provided by the invention can be obtained by a variety of means. Various associated methods of making and using these ADAS are provided.

Abstract: An integrated circuit design method includes receiving an integrated circuit design, and determining a floor plan for the integrated circuit design. The floor plan includes an arrangement of a plurality of functional cells and a plurality of tap cells. Potential latchup locations in the floor plan are determined, and the arrangement of at least one of the functional cells or the tap cells is modified based on the determined potential latchup locations.

Abstract: Anti-viral compounds and methods of using antiviral compounds are described. The compounds can be used in methods of reducing infection rate of a virus and in methods of treating a viral infection in a subject in need thereof. The virus can be a coronavirus, such as SARS-CoV-2.

Abstract: An energy control system (ECS) for controlling an energy storage system (ESS's) that includes energy storage devices(s) or an energy storage combination (ESDC's) including?1 of the energy storage devices and ?1 of the energy storage combinations. A power conversion system is coupled to an output of the ESDC, and a transformer is coupled to an output of the power conversion system. The ECS includes an ECS server and an ESS adapter configured for providing an interface between ECS server and the ESS. The ECS server is configured for reading status data from the ESS and submitting schedules including selected charging and discharging times to the ESS, monitoring or displaying a variance between an expected performance of the ESS based on the schedules and an actual ESS performance, and responsive to the variance being determined to be above a predetermined threshold, sending an update of the schedules to the ESS.

Abstract: The present disclosure relates to therapeutic agents and combinations thereof (e.g., pharmaceutical compositions) for the treatment of a viral infection in a subject, tissue or cell.

Abstract: An integrated circuit design method includes receiving an integrated circuit design, and determining a floor plan for the integrated circuit design. The floor plan includes an arrangement of a plurality of functional cells and a plurality of tap cells. Potential latchup locations in the floor plan are determined, and the arrangement of at least one of the functional cells or the tap cells is modified based on the determined potential latchup locations.