Abstract: The present invention relates to a catalyst, preferably for the selective catalytic reduction of NOx, for the oxidation of ammonia, for the oxidation of NO and for the oxidation of a hydrocarbon, the catalyst comprising a washcoat comprising one or more layers, the washcoat being disposed on a substrate, wherein the washcoat comprises a platinum group metal supported on a metal oxide support material, and one or more of an oxidic compound of V, an oxidic compound of W and a zeolitic material comprising one or more of Cu and Fe.

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines.

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines of Formula 2F, as shown below, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines, such methods comprising the preparation of a Compound of Formula 2F, as shown below and as further defined herein:

Abstract: An exercise machine including a vertical post and an adjustable pulley. The vertical post includes a plurality of engagement holes. The adjustable pulley is slideably connected to the vertical post. The adjustable pulley includes a pull pin and a lock. The pull pin is selectively engageable with one of the plurality of engagement holes. In response to the pull pin being engaged with an engagement hole, movement of the adjustable pulley relative to the vertical post is restricted. The lock is selectively engageable. In response to the lock being engaged with the pull pin, movement of the pull pin is restricted.

Abstract: The invention provides novel compounds, composition comprising said compounds and methods for inhibiting CK1 as well as methods of treating CK1 related disorders such as Alzheimer's disease comprising administering a therapeutically effective amount of a CK1 inhibitor to a patient in need thereof.

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycl fused gamma-carbolines.

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines of Formula 2J, as shown below, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines, such methods comprising the preparation of a Compound of Formula 2G, as shown below, and use of said compound to produce the fused gamma-carbolines of Formula 2J, as defined herein:

Abstract: The invention provides novel compounds, composition comprising said compounds and methods for inhibiting CK1 as well as methods of treating CK1 related disorders such as Alzheimer's disease comprising administering a therapeutically effective amount of a CK1 inhibitor to a patient in need thereof.

Abstract: A crank-driven exercise device (100). The crank-driven exercise device (100) includes a frame (102), a spindle (202) rotatably connected to the frame (102), a crank arm (104) connected to the spindle (202), and a user input (208) connected to the crank arm (104) configured to receive a force from a user. In some embodiments, the crank arm (104) includes a proximal section (204) and a distal section (206). The proximal section (204) may be connected to the spindle (202) at a spindle interface (302), the distal section (206) may be rotatably connected to the user input (208) at a user input interface (306), and the distal section (206) may be selectively fastenable and selectively rotatable relative to the proximal section (204) at a crank interface (304).

Abstract: The invention provides novel compounds, composition comprising said compounds and methods for inhibiting CK1 as well as methods of treating CK1 related disorders such as Alzheimer's disease comprising administering a therapeutically effective amount of a CK1 inhibitor to a patient in need thereof.

Abstract: A stationary exercise cycle. The stationary exercise cycle includes a frame, a crank rotatably connected to the frame, a driven wheel rotatably connected to the frame, and a frame stiffener. The frame includes a down tube and a fork. The crank and the driven wheel are in operative communication via a continuous flexible member. The frame stiffener is connected to the down tube and the fork and encircled by the continuous flexible member.

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycl fused gamma-carbolines.

Abstract: A cycle with tapered drivetrain connections. The cycle includes a frame, a crank rotatably connected to the frame, and a driven wheel rotatably connected to the frame. The crank includes a crank arm and a crank spindle rotatably connected to the frame and non-rotatably connected to the crank arm. The crank spindle includes a crank mating surface to interface with the crank arm. The diameter of the crank spindle continuously decreases along at least a portion of the crank mating surface in a lateral direction. The crank arm includes a crank bore to interface with the crank mating surface. At least a portion of the crank bore has a diameter that continuously decreases in lateral direction. At least a portion of the crank bore taper has a taper rate and diameter equal to a taper rate and diameter of at least a portion of the crank spindle taper.

Abstract: The present invention provides methods for the preparation of 4-(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido-[3?,4?:4,5]-pyrrolo[1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone in free form or a salt thereof.

Abstract: A dual treadle treadmill. The dual treadle treadmill includes a frame, a first treadle, a second treadle, and a generator. The first treadle and the second treadle are each pivotally coupled with the frame and each have a moving surface. The generator is operably associated with the first treadle such that the generator is driven in response to the first treadle pivoting relative to the frame. Other embodiments of dual treadle treadmills are also described.

Abstract: A crank-driven exercise device (100). The crank-driven exercise device (100) includes a frame (102), a spindle (202) rotatably connected to the frame (102), a crank arm (104) connected to the spindle (202), and a user input (208) connected to the crank arm (104) configured to receive a force from a user. In some embodiments, the crank arm (104) includes a proximal section (204) and a distal section (206). The proximal section (204) may be connected to the spindle (202) at a spindle interface (302), the distal section (206) may be rotatably connected to the user input (208) at a user input interface (306), and the distal section (206) may be selectively fastenable and selectively rotatable relative to the proximal section (204) at a crank interface (304).

Abstract: An exercise apparatus with a generator. The exercise apparatus includes a frame, a rotating component, a generator, and a battery. The rotating component is rotatably connected to the frame and the rotating component rotates in response to operation of the exercise apparatus. The generator is connected to the rotating component and the frame. The generator includes a rotor connected to the rotating component and a stator. The rotor rotates in response to rotation of the rotating component. The stator is connected to the frame. The stator interacts with the rotor to produce electric current at an output. In one embodiment, the battery is connected to the output wherein the battery is charged by electric current from the generator.

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines.

Abstract: A dual treadle treadmill. The dual treadle treadmill includes a frame, a first treadle, a second treadle, a clutch axle, and a tensioning mechanism. The first treadle and the second treadle are each pivotally coupled with the frame and each have a moving surface. The clutch axle includes an axle, a first driver, and a second driver. The axle is rotatably connected to the frame. The first driver is coupled to the axle by a first clutch. The first clutch transmits torque between the first driver and the axle in response to the first driver rotating in a first direction relative to the axle. The first treadle is connected to the first driver through a first link such that the first driver is rotated in a first direction in response to the first treadle being pivoted in the first direction. The tensioning mechanism maintains a tension on the first link.