Abstract: A dual treadle treadmill. The dual treadle treadmill includes a frame, a first treadle, a second treadle, and a generator. The first treadle and the second treadle are each pivotally coupled with the frame and each have a moving surface. The generator is operably associated with the first treadle such that the generator is driven in response to the first treadle pivoting relative to the frame. Other embodiments of dual treadle treadmills are also described.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: The present invention provides methods for the preparation of substituted 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole derivative useful as intermediates and methods for producing and using such intermediates.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines.

Abstract: A cycle with tapered drivetrain connections. The cycle includes a frame, a crank rotatably connected to the frame, and a driven wheel rotatably connected to the frame. The crank includes a crank arm and a crank spindle rotatably connected to the frame and non-rotatably connected to the crank arm. The crank spindle includes a crank mating surface to interface with the crank arm. The diameter of the crank spindle continuously decreases along at least a portion of the crank mating surface in a lateral direction. The crank arm includes a crank bore to interface with the crank mating surface. At least a portion of the crank bore has a diameter that continuously decreases in lateral direction. At least a portion of the crank bore taper has a taper rate and diameter equal to a taper rate and diameter of at least a portion of the crank spindle taper.

Abstract: An exercise apparatus with a generator. The exercise apparatus includes a frame, a rotating component, a generator, and a battery. The rotating component is rotatably connected to the frame and the rotating component rotates in response to operation of the exercise apparatus. The generator is connected to the rotating component and the frame. The generator includes a rotor connected to the rotating component and a stator. The rotor rotates in response to rotation of the rotating component. The stator is connected to the frame. The stator interacts with the rotor to produce electric current at an output. In one embodiment, the battery is connected to the output wherein the battery is charged by electric current from the generator.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

Abstract: A sensor for performing micro-conductivity measurements during well logging measurements in a borehole includes a magnetic core having a conductive insert wherein windings are driven with alternating current. Some embodiments include a sensor further having a conductive case. Various aspects of the sensor, such as dimensions and conductive properties of fabrication materials are selected to maximize performance of the sensor. Methods for using the sensor call for, among other things, placing the sensor in a well logging tool, and placing the tool in a well bore. A substantial focusing of the magnetic field on the wall of the borehole is achieved and provides for high quality data.

Abstract: A client processor including a communications receiver for receiving file fragments for the device, a micro-controller system including a microcontroller and a programmable non-volatile memory system, for building and storing application and data files from the fragments, and executing an application of the device by processing at least one application file and associated data identified by configuration instructions included in at least one of the fragments.