Patents by Inventor David Berge

David Berge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates for the preparation of 7-acyl-3-(substituted triazolylthiomethyl)cephalosporins
    Patent number: 4142046
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: February 27, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Intermediates for preparing 7-acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4140694
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 11, 1977
    Date of Patent: February 20, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Amino-3-(sulfonic acid and sulfamoyl substituted tetrazolythiomethyl)cephalosporin intermediates
    Patent number: 4139701
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 10, 1977
    Date of Patent: February 13, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Amino-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4138556
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: February 6, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamine-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins and pharmaceutical compositions containing them
    Patent number: 4130644
    Abstract: The compounds of this invention are cephalosporins having various acylamino substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: December 19, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Trifluoromethylthioacetamido-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomet hyl)-3-cephem-4-carboxylic acid
    Patent number: 4128722
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl group at position 3. Exemplary is 7-trifluoromethylthioacetamido-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiometh yl)-3-cephem-4-carboxylic acid.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: December 5, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(carboxyalkyl and carbamoylalkyl substituted oxadiazolylthiomethyl) cephalosporins and antibacterial compositions and methods employing them
    Patent number: 4126682
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a carboxyalkyl or carbamoylalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: March 18, 1977
    Date of Patent: November 21, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4118491
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: October 3, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins and pharmaceutical compositions containing them
    Patent number: 4118490
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds having antibacterial activity.
    Type: Grant
    Filed: May 11, 1977
    Date of Patent: October 3, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7.beta.-Acylamino-3-(phosphonoalkyl and esterified phosphonoalkyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4112086
    Abstract: The compounds of this invention are cephalosporins having various acylamino substituents at the 7-position and a phosphonoalkyl or esterified phosphonoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: September 5, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4112088
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: September 5, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 3-Sulfomethyl-1,2,4-triazole-5-thiol and its alkali metal salts
    Patent number: 4107173
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4- carboxylic acid disodium salt.
    Type: Grant
    Filed: December 1, 1977
    Date of Patent: August 15, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7.beta.-Acylamino-3-(alkanesulfonamidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4101656
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an alkanesulfonamidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: July 18, 1978
    Assignee: Smithkline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them, and methods of treating bacterial infections using them
    Patent number: 4096256
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: June 20, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Process for preparing triazolethiols
    Patent number: 4094881
    Abstract: 1,2,3-Triazole-4(5)-thiol is prepared by treating 1-benzyl-1,2,3-triazole with a strong base, treating the resulting anion with sulfur, removing the benzyl group by reductive means, and acidifying the resulting thiolate with strong acid.
    Type: Grant
    Filed: December 16, 1976
    Date of Patent: June 13, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins
    Patent number: 4093723
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus. The compounds have antibacterial activity.
    Type: Grant
    Filed: January 13, 1977
    Date of Patent: June 6, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7 -Acylamino-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4-carb oxylic acids
    Patent number: 4083975
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4- carboxylic acid disodium salt.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: April 11, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-(5-sulfomethyl-1,3,4-thiadiazol-2-y lthiomethyl)-3-cephem-4-carboxylic acids
    Patent number: 4079134
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl group at position 3. Exemplary is the anti-bacterially effective 7-D-mandelamido-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem -4-carboxylic acid disodium salt.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: March 14, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Intermediates for preparing 7-acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl)cephalosporins
    Patent number: 4067880
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: January 10, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Amino intermediates for preparing 7-acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)-cephalosporins
    Patent number: 4068073
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: January 10, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges