Patents by Inventor David Berge

David Berge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4066761
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have anti-bacterial activity.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: January 3, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Pharmaceutical compositions comprising 7-acyl-3-(substituted triazolyl thiomethyl)-cephalosporins and methods of treating bacterial infections
    Patent number: 4060610
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: November 29, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Ureidoalkyl substituted tetrazole thiol intermediates for preparing cephalosporins
    Patent number: 4059591
    Abstract: The uriedoalkyl substituted tetrazolethiol compounds of this invention are used for preparing 7-acyl-3-(uriedoalkyl substituted tetrazolythiomethyl)-cephalosporins.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: November 22, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-(.alpha.-Substituted phenylacetamido)-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-c ephem-4-carboxylic acids
    Patent number: 4057631
    Abstract: New semisynthetic cephalosporins characterized by having structures with a 1-carboxymethylthioethyltetrazolyl-5-thiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-ceph em-4-carboxylic acid disodium salt.
    Type: Grant
    Filed: September 2, 1976
    Date of Patent: November 8, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins
    Patent number: 4048311
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 19, 1976
    Date of Patent: September 13, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4041162
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: March 11, 1976
    Date of Patent: August 9, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(carboxyalkyl and carbamoylalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4034092
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a carboxyalkyl or carbamoylalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: July 5, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)-cephalosporins
    Patent number: 4025626
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 9, 1975
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • O-acyl-7-acylaminocephalosporadesic acids
    Patent number: 4007178
    Abstract: A method for O-acylating the 3-hydroxymethyl group of 7-acylaminocephalosporadesic acids by reaction with an azolide and new O-acyl-7-acylaminocephalosporadesic acids in which the O-acyl group is derived from an alkoxyalkanoic acid or an amino acid.
    Type: Grant
    Filed: May 15, 1975
    Date of Patent: February 8, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins
    Patent number: 3989694
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 27, 1974
    Date of Patent: November 2, 1976
    Assignee: SmithKline Corporation
    Inventor: David A. Berges