Abstract: The invention relates to a spindle drive device comprising a spindle provided with an external thread, a thread engagement element which is in threaded engagement with the external thread of the spindle, a drive assembly having a drive unit which is configured to drive the spindle or the thread engagement element, wherein the spindle or the thread engagement element is connected to at least one connection unit for connecting the spindle drive device to a superordinate assembly that is not part of the spindle drive device. According to the invention, it is provided that the spindle is a trapezoidal thread spindle made of carbon steel and is heat-treated by means of at least one thermochemical method.

Abstract: An attraction loading system is provided that includes a turntable configured to rotate about a vertical axis. A ride vehicle is configured to travel along a loading path disposed about a perimeter of the turntable. A first track switch of the system is disposed along the loading path to direct the ride vehicle to a main portion of the loading path from an attraction path, or to direct the ride vehicle to the main portion of the loading path from a secondary portion of the loading path. A second track switch of the system is disposed along the loading path to direct the ride vehicle from the main portion of the loading path to the attraction path, or to direct the ride vehicle from the main portion of the loading path to the secondary portion of the loading path.

Abstract: Methods and compositions for treating social function disorders are disclosed.

Abstract: A method or system for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system using closed loop programming is provided. For example, pulse generator feedback logic is executed by a processor to interface with control instructions of an implantable pulse generator by incorporating one or more machine learning engines to automatically generate a proposed set of stimulation parameter values that each affect a stimulation aspect of the implantable pulse generator, receive one or more clinical responses and automatically generate a revised set of values taking into account the received clinical responses, and repeating the automated receiving of a clinical response and adjusting the stimulation parameter values taking the clinical response into account, until or unless a stop condition is reach or the a therapeutic response is indicated within a designated tolerance.

Abstract: A method or system for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system using closed loop programming is provided. For example, pulse generator feedback logic is executed by a processor to interface with control instructions of an implantable pulse generator by incorporating one or more machine learning engines to automatically generate a proposed set of stimulation parameter values that each affect a stimulation aspect of the implantable pulse generator, receive one or more clinical responses and automatically generate a revised set of values taking into account the received clinical responses, and repeating the automated receiving of a clinical response and adjusting the stimulation parameter values taking the clinical response into account, until or unless a stop condition is reach or the a therapeutic response is indicated within a designated tolerance.

Abstract: An enhanced flexibility catheter is provided, such as for distal neurovascular access or aspiration. The catheter includes an elongate flexible body, having a proximal end, a distal end, and a side wall defining a central lumen. The side wall is formed from a plurality of adjacent tubular segments. At least one segment has a first end face inclined at a non normal angle to a longitudinal axis of the catheter. An adjacent segment has a second end face inclined at a complementary angle to form an inclined junction at the transition between the two segments. The transition serves to provide superior bending characteristics along the length of the catheter shaft.

Abstract: The invention relates to the identification of a new Tau species starting at residue Met11 (Met11-Tau) which is N-alpha-terminally acetylated form (N-alpha-acetyl-Met11-Tau species: Ac-Met11-Tau). Several monoclonal antibodies specific of this new Tau species have been developed. One of this antibody, 2H2/D11, was used in THY-Tau22 mouse model (that develops with age neurofibrillary degeneration (NFD) and memory deficits), and N-alpha-Ac-Met11-Tau species were clearly detected early in neurons displaying NFD on hippocampal brain sections while it is not reactive in hippocampus from elderly controls. Finally, by using ELISA sandwich specific of Ac-Met11-Tau species, Alzheimer Disease (AD) brain samples are clearly discriminated from human elderly control brains. Thus the invention relates to this new Tau species starting from the methionine residue at position 11 said methionine being N-alpha acetylated.

Abstract: An enhanced flexibility catheter is provided, such as for distal neurovascular access or aspiration. The catheter includes an elongate flexible body, having a proximal end, a distal end, and a side wall defining a central lumen. The side wall is formed from a plurality of adjacent tubular segments. At least one segment has a first end face inclined at a non normal angle to a longitudinal axis of the catheter. An adjacent segment has a second end face inclined at a complementary angle to form an inclined junction at the transition between the two segments. The transition serves to provide superior bending characteristics along the length of the catheter shaft.

Abstract: The invention relates to a method of treatment of Tauopathy disorder using antibody that specifically binds news Tau species, especially Tau species starting from the methionine residue at position (11), said methionine being N-alpha acetylated (AcMet11-Tau). The invention also relates to an antibody that specifically binds this new tau species. Inventors have discovered that AcMet11-Tau is a pathological Tau species that is involved in Tau pathology development. Inventors have demonstrated the causal link between AcMet11-Tau species and Tau pathology by showing that brain expression of AcMet11-Tau species potentiate Tau pathology development in Thy-Tau Transgenic mice and is involved in pathological process, at least by accelerating Tau pathology.

Abstract: A wearable camera systems according to examples of the present disclosure may include a camera and a mobile charging unit. The camera may include onboard power, memory and control for capturing and storing an image without being connected to the mobile charging unit and the camera body may have a width or a height that is smaller than the length of the camera body. The camera body may include a trigger for initiating image capture. The wearable camera may be attachable to an eyewear temple and the mobile charging unit is configured to recharge the wearable camera without being connected to an external power source.

Abstract: An enhanced flexibility catheter is provided, such as for distal neurovascular access or aspiration. The catheter includes an elongate flexible body, having a proximal end, a distal end, and a side wall defining a central lumen. The side wall is formed from a plurality of adjacent tubular segments. At least one segment has a first end face inclined at a non normal angle to a longitudinal axis of the catheter. An adjacent segment has a second end face inclined at a complementary angle to form an inclined junction at the transition between the two segments. The transition serves to provide superior bending characteristics along the length of the catheter shaft.

Abstract: Auxiliary units, in some instances implemented as a case for a wearable electronic device such as a wearable camera are described. The auxiliary units may include one or more electronic components typically included in the camera. By offloading an electronic component and the corresponding function (e.g., extended power capacity, memory capacity, wireless or other communication capabilities, etc.) to a removable auxiliary unit, the size of the wearable device can be advantageously further reduced.

Abstract: An ophthalmic device includes a lens and an electronic component embedded in the lens to enhance the functionality of the lens. The ophthalmic device includes a first coil to wirelessly receive energy from an external device, such as a wireless charger, and wirelessly transmits the received energy to a second coil coupled to the electronic component so as to power the electronic component. The first coil can function as part of a repeater to facilitate the wireless charging. The repeater can receive electrical energy wirelessly and works with various positions, sizes, and shapes of the electronic component. The wireless power efficiency can also be increased using the repeater to concentrate a magnetic flux within the second coil.

Abstract: An ophthalmic device includes a lens and an electronic component embedded in the lens to enhance the functionality of the lens. The ophthalmic device includes a first coil to wirelessly receive energy from an external device, such as a wireless charger, and wirelessly transmits the received energy to a second coil coupled to the electronic component so as to power the electronic component. The first coil can function as part of a repeater to facilitate the wireless charging. The repeater can receive electrical energy wirelessly and works with various positions, sizes, and shapes of the electronic component. The wireless power efficiency can also be increased using the repeater to concentrate a magnetic flux within the second coil.

Abstract: A hinge for a folding windshield is provided for vehicles such as all-terrain vehicles (ATVs) utility vehicles (UTVs), golf carts, and other vehicles. The hinge includes an integral stiffening member or brace to prevent the windshield from bowing due to wind pressure and vibration.

Abstract: Methods and systems for selecting electrical stimulation parameters for an electrical stimulation device implanted in a patient can use an iterative process for identifying electrodes for stimulation, as well as suitable stimulation parameters. The process begins with an initial set of electrode combinations to identify regions of the nerve or other tissue for stimulation. This leads to selection of other electrode combinations to test, followed by the selection of multiple electrode groups (which can include three or more electrodes) for stimulation.

Abstract: A system is provided comprising an optical filter. The optical filter comprises a Cu-porphyrin dye compound. The transmission spectrum of the system has an average transmission across the wavelength range of 460 nm-700 nm of at least 60%. The transmission spectrum of the system has an average transmission across the wavelength range 400 nm-460 nm that is less than 75%.

Abstract: Methods and compositions for treating social function disorders are disclosed.

Abstract: A method for generating a clinical effects map for electrical stimulation using an electrical stimulation lead includes receiving at least one clinical response for stimulation using each of multiple first sets of stimulation parameters where each clinical response is associated with at least one therapeutic effect or side effect. The method also includes determining, using the clinical responses and the first sets of stimulation parameters, a spatial relationship between the electrical stimulation lead and at least one effect region, where each effect region is associated with at least one of the therapeutic effects or side effects; estimating, based on the spatial relationship, at least one clinical response for each of multiple second sets of stimulation parameters; and generating and presenting a clinical effects map illustrating at least the estimated clinical response for one or more of the second sets of stimulation parameters.

Abstract: A method or system for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system using closed loop programming is provided. For example, pulse generator feedback logic is executed by a processor to interface with control instructions of an implantable pulse generator by incorporating one or more machine learning engines to automatically generate a proposed set of stimulation parameter values that each affect a stimulation aspect of the implantable pulse generator, receive one or more clinical responses and automatically generate a revised set of values taking into account the received clinical responses, and repeating the automated receiving of a clinical response and adjusting the stimulation parameter values taking the clinical response into account, until or unless a stop condition is reach or the a therapeutic response is indicated within a designated tolerance.