Abstract: The present invention relates to methods of reducing ischemic damage to a surgical incision in a tissue of subject, enhancing tissue viability and vascularity following an ischemic event, and preconditioning tissue to resist an ischemic insult, which comprises contacting the relevant tissue topically with an effective dose of a HIF-1 potentiating agent, thereby reducing ischemic damage to a surgical incision, enhancing tissue viability and vascularity following an ischemic event, and preconditioning tissue to resist an ischemic insult.

Abstract: Methods for fabricating semiconductor devices incorporating an activated p-(Al,In)GaN layer include exposing a p-(Al,In)GaN layer to a gaseous composition of H2 and/or NH3 under conditions that would otherwise passivate the p-(Al,In)GaN layer. The methods do not include subjecting the p-(Al,In)GaN layer to a separate activation step in a low hydrogen or hydrogen-free environment. The methods can be used to fabricate buried activated n/p-(Al,In)GaN tunnel junctions, which can be incorporated into electronic devices.

Abstract: Embodiments provided herein relate to methods, compositions and systems for rapid determination of the bioavailability of a therapeutic biologic in a sample from a subject.

Abstract: Vacuum cleaning devices include foldable wands to provide a storage configuration and/or facilitate use. A vacuum cleaning device includes a wand having a first end coupled to a vacuum unit and a second end coupled to a vacuum head or surface cleaning head. The wand defines an air passage allowing air to pass from the surface cleaning head to the vacuum unit and includes a flexible air passage along at least a portion of the wand. The wand also includes a plurality of segments pivotably connected together such that the wand is foldable about 180° in a forward direction until the vacuum unit is positioned proximate a top of the surface cleaning head, thereby providing a storage configuration.

Abstract: A method for monitoring glucose concentration in aqueous humor can include inserting an implantable device into an eye and determining glucose concentration as a function of glucose sensed at the implantable device. The method can optionally include optically detecting glucose concentration as a function of polarimetry and/or fluorescence. A system for monitoring glucose concentration can include devices described herein.

Abstract: A Global Navigation Satellite System (GNSS) receiver demodulates code shift keying (CSK) data utilizing a binary search. The GNSS receiver receives a signal including a pseudorandom noise (PRN) code modulated by code shift keying (CSK) to represent a symbol (i.e., CSK modulated symbol). The GNSS receiver maintains a plurality of receiver codes each representing a different shift in chips to the PRN code. The GNSS receiver performs a linear combination of portions of the receiver codes. In an embodiment, the GNSS receiver compares correlation power level value for respective portions of the receiver codes to demodulate the CSK data. In a further embodiment, the GNSS receiver compares the correlation power level values for portions of receiver codes with power detection threshold values to demodulate the CSK data. In a further embodiment, the GNSS receiver utilizes signs of the correlation power level values to demodulate the CSK data.

Abstract: This disclosure relates to a method and apparatus for energy production from at least one of electron-mediated nuclear reaction and single-element nuclear reaction, wherein a reactive nuclei fuel is loaded into a reactor. The fuel includes one or more reactive nuclei. To maintain a chain reaction, the fuel structure has a multiplication factor of energetic electrons larger than one. A chain reaction is initiated and/or periodically re-initiated in the fuel.

Abstract: Devices can be implanted in an eye to treat a dry eye condition. The devices include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. In some embodiments, the device is filterless. In some embodiments, a filter is included. The dry eye treatment devices provided herein prevent bacterial ingress, provide outflow resistance to retain a normal intraocular pressure, and provide moisture (e.g., aqueous humor) to an otherwise dry eye. Methods of treating a dry eye condition wherein the device is implanted in the sclera of an afflicted eye are also described.

Abstract: Described herein are methods of treating or preventing an ASK1 or DYRK1A associated disease, disorder, or condition comprising administering to a subject in need thereof a dual inhibitor of ASK1 and DYRK1A; including administering pharmaceutically acceptable salts and solvates thereof.

Abstract: A luminaire a small number of carefully designed extrusions is easily manufactured. The housing is formed by joining four pieces having a first extrusion profile. A second extrusion profile is used for the side and end covers. A third profile is used for access covers. The housing frames a lens, such as an acrylic sheet, and long lines of LEDs are positioned to shine directly into the side of the lens. A reflective layer on the lens directs all or some of the LED light out the luminaire's front, perhaps directing some light out the back. Strategically positioned diffusors ensure a pleasing lighting effect. The result is a very thin and light weight luminaire having a large surface area. The luminaire can be suspended by threaded nipples, by cables threaded through holes in the back, or by brackets screwed to threaded inserts.

Abstract: A computer-implemented method includes generating code for displaying a two-dimensional media programming schedule grid, receiving a command to compress the grid at a first location along a first dimension, and generating code for displaying the grid with visible graphical fold marks defining a fold area near the first location along the first dimension.

Abstract: The present disclosure comprises a lymphovascular bioreactor system and methods of making and using same.

Abstract: A surface cleaning head with a leading roller may be used to facilitate capturing of debris in the air flow into a suction conduit on the underside of the surface cleaning head. The leading roller is generally positioned adjacent to and in advance of the opening of the suction conduit. The surface cleaning head may have dual agitators—a leading roller and a rotating brush roll—with the leading roller being located in front of the brush roll. The leading roller may have a smaller diameter than the brush roll and may provide a softer cleaning element. The leading roller may also have a bottom portion exposed to the flow path to the suction conduit and at least a top half that is not exposed to that flow path. The leading roller may also float relative to the surface cleaning head and/or may be adjustable relative to the brush roll.

Abstract: Luminaire housings for architectural, industrial and warehouse applications have extrusions with parallel flat sides connected by a cross member. The wireway can be enclosed by the extrusion's roof or by cover segments clamped over an open top extrusion. Wireway openings provide access to the wireway. Nuts slid into T-channels in the roof or cover segments provide for mounting or suspension via wall brackets, cables, and housing brackets. Threaded nipples accessible through the roof or cover segments provide for pendant stem mounting. Continuous run brackets can join housings end to end. Optical elements slid into slots and channels in the housing can be retained by end caps. A housing cover over the wireway can be clamped in place by screws threaded into fixture brackets retained within the housing. The housing grooves in the cover segments can slidably engage the extrusion until the cover segments are clamped in place.

Abstract: Methods and systems for delivering a package to a customer employ an on-demand locker assembly having a plurality of lockers. A computer-implemented method of staging delivery of a package to a customer includes displaying a network link that is selectable by the customer on an electronic client device. In response to selection of the network link, the package is transferred to one of the lockers. An access code for the locker is sent to the electronic client device. Upon entry of the access code, the locker is opened to provide the customer with access to the package to retrieve the package from the locker.

Abstract: Methods and apparatuses including a patellar implant are disclosed. The patellar implant can include a member, an articulation component and a connection mechanism. The member can be configured to engage a osteotimized surface of a patella. The articulation component can have an articulation surface that can be configured to articulate with a femoral prosthesis along a patellar groove. The connection mechanism can connect the articulation component with the member and can be configured to allow for at least one of removal and translational movement of the articulation component relative to the member and patella.

Abstract: A Global Navigation Satellite System (GNSS) receiver demodulates code shift keying (CSK) data utilizing a binary search. The GNSS receiver receives a signal including a pseudorandom noise (PRN) code modulated by code shift keying (CSK) to represent a symbol (i.e., CSK modulated symbol). The GNSS receiver maintains a plurality of receiver codes each representing a different shift in chips to the PRN code. The GNSS receiver performs a linear combination of portions of the receiver codes. In an embodiment, the GNSS receiver compares correlation power level value for respective portions of the receiver codes to demodulate the CSK data. In a further embodiment, the GNSS receiver compares the correlation power level values for portions of receiver codes with power detection threshold values to demodulate the CSK data. In a further embodiment, the GNSS receiver utilizes signs of the correlation power level values to demodulate the CSK data.

Abstract: An electronic assembly, comprising a carrier wafer having a top wafer surface and a bottom wafer surface; an electronic integrated circuit being formed in the carrier wafer and comprising a wafer contact pad on the top wafer surface; said carrier wafer comprising a through-wafer cavity joining the top and bottom wafer surfaces; a component chip having a component chip top surface, a component chip bottom surface and component chip side surfaces, the component chip being held in said through-wafer cavity by direct contact of at least a side surface of said first component chip with an attachment metal that fills at least a portion of said through-wafer cavity; said component chip comprising at least one component contact pad on said component chip top surface; a first conductor connecting said wafer contact pad and said component contact pad.

Abstract: A method for monitoring glucose concentration in aqueous humor can include inserting an implantable device into an eye and determining glucose concentration as a function of glucose sensed at the implantable device. The method can optionally include optically detecting glucose concentration as a function of polarimetry and/or fluorescence. A system for monitoring glucose concentration can include devices described herein.

Abstract: Devices can be implanted in an eye to treat a dry eye condition. The devices include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. In some embodiments, the device is filterless. In some embodiments, a filter is included. The dry eye treatment devices provided herein prevent bacterial ingress, provide outflow resistance to retain a normal intraocular pressure, and provide moisture (e.g., aqueous humor) to an otherwise dry eye. Methods of treating a dry eye condition wherein the device is implanted in the sclera of an afflicted eye are also described.