Abstract: Described herein are kits, compositions, and combination therapies comprising sulindac for use in the treatment of fragile X syndrome (FXS).

Abstract: A system and method for assembling a plurality of components into an assembly is provided. The system includes an assembling robot and an adhesive dispensing robot. The assembling robot is configured to attach a first sub-assembly to a second sub-assembly. The first sub-assembly includes at least one of the plurality of components, and the second sub-assembly includes remaining ones of the plurality of components. The adhesive dispensing robot is configured to apply an adhesive between the first sub-assembly and the second sub-assembly, after the first sub-assembly is attached to the second sub-assembly, to bond the first sub-assembly to the second sub-assembly.

Abstract: Light emitting diode (LED) light tubes having rotatable end cap assemblies are described. The LED light tubes include a hollow tube and a circuit board with LED chips thereon. The end cap assemblies are provided on either end of the tube. Each end cap assembly includes a socket cap, a plug having a plug body and at least one connector, and an end cap body, one end of which engages one of the ends of the hollow tube. A cam locking mount that is positioned within the plug body and on the opposite side has projections to be positioned in the bore of the end cap body. A rotation cam is seated in the cam locking mount and provides for controlled rotation of the LED tube relative to the end caps. Methods of installing the LED light tubes in new installations and retrofit installations and for use in sign assemblies are also described.

Abstract: Described herein are kits, compositions, and combination therapies comprising sulindac for use in the treatment of fragile X syndrome (FXS).

Abstract: Embodiments of the present disclosure relate to traffic class management of NVMe (non-volatile memory express) traffic. One or more virtual controllers for at least one host adapter (HA) of a storage device are generated. Each virtual controller is assigned a unique controller identifier (ID) Additionally, one or more input/output (IO) queues for each virtual controller are established. Further, IO workloads are processed via each IO queue.

Abstract: A system according to one embodiment includes an access control device comprising a lock mechanism configured to secure access to a passageway, and a UWB accessory device configured to receive a credential of the mobile device via Bluetooth communication, determine, using UWB ranging of the UWB accessory device, a location of a mobile device relative to the passageway secured by the lock mechanism of the access control device, determine whether a user of the mobile device intends to access the passageway based on the determined location of the user relative to the passageway, and communicate an indication that the user intends to access the passageway to the electronic lock via Bluetooth communication, and wherein the access control device is configured to unlock the lock mechanism in response to the indication that the user intends to access the passageway.

Abstract: A gas turbine engine, includes: an engine core including a turbine, compressor, and shaft system connecting the turbine to the compressor, and forming a torque path therebetween. The shaft system is axially located by a thrust bearing located forward of the turbine, and the engine is configured, in the event of a shaft break which divides the shaft system into a front portion located by the thrust bearing and a rear portion unlocated by the thrust bearing, the rear portion is free to move axially rearwardly under a gas load. The engine further includes a shaft break detector having a forward speed sensor configured to measure a rotational speed of the front portion of the shaft system, and a rear microwave sensor configured to measure a rotational speed of the rear portion of the shaft system, wherein a shaft break can be detected based on differences in the measured speeds.

Abstract: Broadly speaking, embodiments of the present techniques provide methods for driving shape memory alloy (SMA) actuator wires in a more power-efficient manner.

Abstract: An electrochemical cell for a secondary battery, preferably for use in an electric vehicle, is provided. The cell includes a solid metallic anode, which is deposited over a suitable current collector substrate during the cell charging process. Several variations of compatible electrolyte are disclosed, along with suitable cathode materials for building the complete cell.

Abstract: A system for assembling a plurality of components into an assembly is provided. The system includes an installation table, a first transfer robot, a second transfer robot, and an adhesive dispensing robot. The first transfer robot is configured to assemble some of the plurality of components into a first sub-assembly and transfer the first sub-assembly to the installation table. The second transfer robot is configured to assemble remaining ones of the plurality of components into a second sub-assembly, transfer the second sub-assembly to the installation table, and attach the second sub-assembly to the first sub-assembly. The adhesive dispensing robot is configured to apply an adhesive between the first sub-assembly and the second sub-assembly, after the second sub-assembly is attached to the first sub-assembly, to bond the second sub-assembly to the first sub-assembly.

Abstract: An electrochemical cell is disclosed comprising a carbonate:nitrile type solvent mixture based electrolyte. The electrolyte may comprise an alkali salt and/or at least one polymer additive. The alkali salt cation may be a lithium cation and/or the alkali salt anion may comprise an oxalato-borate group. The electrolyte may further comprise one or more electrolyte additives, which may be an SEI improving additive. The anode may comprise carbon. The anode may be an alkali metal anode. The operating voltage and energy density performance of the disclosed invention is at the same level as the performance of presently market—leading battery cells, thereby these disclosed improvements do not come at the expense of battery performance.

Abstract: A treatment system and process includes a ribbon beam ion source that is configured to implant ions into a product to modify a portion of the product; multiple means of controlling the temperature of the product; the means including radiative conduction, gas conduction to a heatsink by means of a gas cushion, adjustment of the ion beam density at the product, adjustment of the ion beam intensity at the product and ion beam acceleration parameters, and adjustment of the ion dose to the product b; and a product movement system configured to move the product through the treatment system past the ribbon beam ion source. The treatment system further includes a system controller configured to control at least one the following: the gas cushion system, the ribbon beam ion source, the temperature control system, the heatsink, and the product movement system.

Abstract: A control unit is provided to improve positioning of transporting devices to thereby allow transporting devices to be driven at faster speeds and/or accelerations with minimal positional errors allowing for a reduction in the spacing between transporting devices. A control unit is arranged to control movement of at least one transporting device for containers stored in a facility having a plurality of pathways arranged in cells so as to form a grid-like structure above the stacks which extends in a first direction and in a second direction. The control unit includes a receiving unit arranged to receive information from a first sensor mounted on the at least one transporting device, and a calculating unit arranged to calculate a position of the at least one transporting device based on the received information.

Abstract: The present invention relates to compositions and kits comprising (i) ibudilast, or a pharmaceutically acceptable salt thereof; and (ii) Compound A, or a pharmaceutically acceptable salt thereof, Wherein Compound A is selected from: metformin, cannabidiol, sertraline, and quercetin. The compositions and kits are useful in the treatment of Fragile X syndrome.

Abstract: The present application is directed to antimicrobial compositions comprising chitosan polymers of at least two different average molecular weights (Mws), wherein the Mw of each different chitosan polymer is selected to target a different microorganism as well as method of making and using the compositions and product comprising the compositions.

Abstract: Provided herein are (alpha-substituted aralkylamino or heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases.

Abstract: Light emitting diode (LED) light tubes having rotatable end cap assemblies are described. The LED light tubes include a hollow tube and a circuit board with LED chips thereon. The end cap assemblies are provided on either end of the tube. Each end cap assembly includes a socket cap, a plug having a plug body and at least one connector, and an end cap body, one end of which engages one of the ends of the hollow tube. A cam locking mount that is positioned within the plug body and on the opposite side has projections to be positioned in the bore of the end cap body. A rotation cam is seated in the cam locking mount and provides for controlled rotation of the LED tube relative to the end caps. Methods of installing the LED light tubes in new installations and retrofit installations and for use in sign assemblies are also described.

Abstract: RPCVD apparatus for forming a film is disclosed including a showerhead having at least one gas chamber, one or more plasma inlets to deliver plasma from one or more plasma generators into a reaction chamber; and a plurality of gas inlets to deliver gas from at least one gas chamber into the reaction chamber. At least one of the plasma inlets is located at a position that is between a central region and an outer region of the showerhead and off-centre from an axis of rotation. The plasma generators generate plasma in line of sight of the susceptor and the plasma inlets have openings that are larger than openings of the gas inlets. The gas inlets are configured such that a combination of all of the spatial distributions of gas from the gas inlets provides a uniform distribution of gas density on the surface of a susceptor between a central region and an outer region of the susceptor, for a full rotation of the susceptor.

Abstract: Broadly speaking, embodiments of the present techniques provide methods for driving shape memory alloy (SMA) actuator wires in a more power-efficient manner.

Abstract: An engine health diagnostic apparatus is provided for analysing health of a reciprocating internal combustion engine. The apparatus comprises feature generation circuitry for processing vibration sensor data received from a vibration sensor detecting vibration at a component of the reciprocating internal combustion engine 4 and generating a feature vector indicating multiple features of the sensor data. Processing circuitry processes the feature vector using a trained classification model which is defined by model parameters characterising a decision boundary of healthy operation learnt from a training set of feature vectors captured during healthy operation of the engine. The model generates an engine health indication providing a quantitative indication of deviation of the feature vector from the decision boundary of healthy operation.