Abstract: The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.

Abstract: A method for secure detection of online fraud. The method includes generating an encrypted profile representing browser activity, sending the encrypted profile to a secure multiparty computation system, receiving a trust token from the secure multiparty computation system, based on a determination that the web browser is not engaged in online fraud, sending a request to redeem the trust token with the secure multiparty computation system, receiving an encrypted record of redemption from the secure multiparty computation system based on a determination that a web site associated with the web content is not blocked, and sending a request, containing the encrypted record of redemption, for third-party content, wherein the third-party content is associated with the web content.

Abstract: A method of attaching a flat flexible cable (FFC) to a plurality of terminals of an electrical connector includes a step of arranging a plurality of terminals within a connector housing, with each terminal defining a weld area adapted to be electrically connected to a conductor of the FFC. The FFC is then positioned proximate the connector housing such that the weld areas of each terminal are arranged directly adjacent a respective one of a plurality of exposed conductors of the FFC. At least the weld areas of the plurality of terminals are heated with an inductive heating source for electrically connecting the plurality of conductors of the FFC to the plurality of terminals.

Abstract: An improved solvent system for the formulation and application of N-alkyl thiophosphoric triamide urease inhibitors. These formulations provide safety and performance benefits relative to existing alternatives and enable storage, transport and subsequent coating or blending with urea based or organic based fertilizers. These formulations are comprised primarily of environmentally friendly aprotic and protic solvents (particularly dimethyl sulfoxide and alcohols/polyols) to stabilize the urease inhibitor.

Abstract: A neurostimulation device with ultrasound transducer elements is disclosed. The ultrasound transducer elements may be adapted for endoluminal delivery to a deployment site in a lumen of the substrate. The transducer elements may be used to focus acoustic energy, by controlling either the phase delay, time delay, or both, or the ultrasound signals. Further, the plurality of transducer elements may be arranged in a grid arrangement having at least two dimensions.

Abstract: Disclosed are one or more apparatuses, systems and methods that allow microwave communications signals to pass efficiently and reliably through high-loss obstructions, such as concrete structures. For example, a concrete-penetrating microwave apparatus includes a wireless microwave transceiver coupled to a multiple input multiple output (MIMO) antenna. The transceiver processes wireless microwave signals transmitted and received by the MIMO antenna through one or more obstructions. The MIMO antenna and transceiver are configured to compensate for path loss experienced by the microwave signals as they pass through the lossy obstruction so as to maintain the desired data rate of the wireless microwave signals. Concrete-penetrating microwave apparatuses may be paired together and aimed at each other, with one apparatus on either side of an obstruction, to allow high-speed networked microwave communication directly through the otherwise microwave-impenetrable obstruction.

Abstract: System and method of using voice nudge for hands free translation of robotic surgical microscope or exoscope. The system and method involve the use of voice control with no other physical inputs, e.g., foot pedal, to control movement of the arm of a robotic surgical microscope or exoscope. The voice control enables the robotic microscope to transition the field of view of the surgical microscope with incremental movements in multiple directions, e.g., left, right, up, and down, while maintaining the same field of view and the same magnification level.

Abstract: A system and method include generating a topological order of a DAG by creating residual series vectors, calculating normality statistic and MSE values for the residual series vectors, comparing the normality statistic values with a critical value, for each normality statistic value that is less than or equal to the critical value, adding a variable index to a temporary order list and the MSE value to an MSE list, counting a number of elements in the temporary order list, if the number of elements in the temporary order list is zero, updating an order list based on the normality statistic values or if the number of elements in the temporary order list is not zero, updating the order list based on at least one of the temporary order list or the MSE list, and outputting the order list as the topological order of the DAG.

Abstract: An apparatus, system, and method are disclosed for joining adjacent structural tubes together. The apparatus may include a tube retention body with a pair of substantially parallel retention bolts that are inserted in substantially parallel alignment within the end portions of the adjacent structural tubes. Additionally, an alignment lock plate may be pivotally affixed to the tube retention body and may be designed to retain and lock together a pair of adjacent structural tubes in a substantially parallel relation using a toolless connector. The disclosed system may include two adjacent tubular structures joined together by the disclosed apparatus via the disclosed method.

Abstract: A system includes one or more processing devices and at least one memory on which are stored instructions that, when executed by the one or more processing devices, enable the one or more processing devices to perform a method of facilitating delivery of an item from a source destination to a target destination. The method includes the steps of receiving a delivery-route assignment request from a first user device associated with a producer, transmitting the request to one or more vehicle drivers, receiving an acceptance of the request from a second user device associated with a vehicle driver, receiving a first signal indicating that the vehicle driver is a predetermined first distance from the source destination, receiving a second signal indicating that the vehicle driver is a predetermined distance from the target destination, and in response to receiving the second signal, authorizing a payment to the vehicle driver.

Abstract: A seal/damping component for use in an electrical connector, the seal/damping component providing sealing and vibration damping when the seal/damping component is positioned in the electrical connector. The seal/damping component may be made from one material or two or more materials.

Abstract: Instances of an identity and access management (IAM) system access resources through a cloud platform. An association module executed on control circuitry of a computing device is configured to determine a resident location of a base instance of the IAM system, obtain manager identity data for a manager instance of the IAM system associated with the resident location, and edit access settings for one or more containers within the base instance to provide access to the manager instance. The manager instance can access the one or more containers to service the resources within the one or more containers.

Abstract: A method for administering a dosage of Cagrisema to a patient for the treatment of obesity, the method comprising: administering a dosage of Cagrisema to the patient, wherein the dosage of Cagrisema is determined by: receiving patient data relating to a patient, wherein the patient data includes patient weight data; and processing the patient data including the patient weight data with a dosage calculator to determine the dosage of Cagrisema for administering to the patient wherein the dosage calculator is derived from a pharmacokinetic, PK, model.

Abstract: A charging health monitoring device for monitoring a health of a charging component for an electric vehicle includes a testing sensor held by a charging terminal and including a testing probe interfacing with a mating charging terminal. The charging health monitoring device includes a control circuit for controlling a charging operation and a testing operation. The control circuit measures a terminal voltage of the charging terminal and a sensor voltage of the testing sensor to determine resistance of the charging terminal and provide a test signal. The control circuit includes an electrically isolated switch receiving the test signal and generating a control signal based on the test signal for controlling a charging operation of the charging component. The control circuit performs the testing operation simultaneously with the charging operation.

Abstract: Disclosed is a robotic system including a telescoping transport conveyor with an automated unloader attached. The automated unloader includes a loading conveyor with at least two articulated robots attached to the first loading conveyor end. The automated unloader includes a control system with logic controlling the unloading of material to be handled from a transport container onto the telescoping transport conveyor, and thence to an automated palletizing system, where materials are loaded on pallets and supported by a pallet sleeve during storage or during transport to a stabilization system where pallet loads are stretch wrapped. Further disclosed are methods for controlling and operating the same to fully automate product unloading, handling, and distribution throughout a material handling facility.

Abstract: This disclosure relates to using probabilistic data structures to enable systems to detect fraud while preserving user privacy. In one aspect, a method includes obtaining a set of frequency filters. Each frequency filter defines a maximum event count for a specified event type over a specified time duration and corresponds to a respective content provider. A subset of the frequency filters are identified as triggered frequency filters for which an actual event count for the specified event type corresponding to the frequency filter exceeds the maximum event count defined by the frequency filter during a time period corresponding to a specified time duration for the frequency filter. A probabilistic data structure that represents at least a portion of the frequency filters in the subset of frequency filters is generated. A request for content is sent to multiple content providers. The request for content includes the probabilistic data structure.

Abstract: A seal includes a mating ring that rotates relative to a carbon primary ring at a seal interface. A buffer gas is provided into the seal and passes from the back of the primary ring to the seal interface though holes drilled in the primary ring. The seal can be used as a separation seal or in combination with another seal.

Abstract: The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.

Abstract: A point estimate value for an individual is computed using a Bayesian neural network model (BNN) by training a first BNN model that computes a weight mean value, a weight standard deviation value, a bias mean value, and a bias standard deviation value for each neuron of a plurality of neurons using observations. A plurality of BNN models is instantiated using the first BNN model. Instantiating each BNN model of the plurality of BNN models includes computing, for each neuron, a weight value using the weight mean value, the weight standard deviation value, and a weight random draw and a bias value using the bias mean value, the bias standard deviation value, and a bias random draw. Each instantiated BNN model is executed with the observations to compute a statistical parameter value for each observation vector of the observations. The point estimate value is computed from the statistical parameter value.

Abstract: Disclosed is a robotic system including a telescoping transport conveyor with an automated unloader attached. The automated unloader includes a loading conveyor with at least two articulated robots attached to the first loading conveyor end. The automated unloader includes a control system with logic controlling the unloading of material to be handled from a transport container onto the telescoping transport conveyor, and thence to an automated palletizing system, where materials are loaded on pallets and supported by a pallet sleeve during storage or during transport to a stabilization system where pallet loads are stretch wrapped. Further disclosed are methods for controlling and operating the same to fully automate product unloading, handling, and distribution throughout a material handling facility.