Abstract: A computing device selects new test configurations for testing software. (A) First test configurations are generated using a random seed value. (B) Software under test is executed with the first test configurations to generate a test result for each. (C) Second test configurations are generated from the first test configurations and the test results generated for each. (D) The software under test is executed with the second test configurations to generate the test result for each. (E) When a restart is triggered based on a distance metric value computed between the second test configurations, a next random seed value is selected as the random seed value and (A) through (E) are repeated. (F) When the restart is not triggered, (C) through (F) are repeated until a stop criterion is satisfied. (G) When the stop criterion is satisfied, the test result is output for each test configuration.

Abstract: An endoluminal neurostimulation device includes a plurality of ultrasound transducer elements forming a transducer array. The plurality of transducer elements are provided on or in a substrate layer that is adapted for endoluminal delivery to a deployment site in a lumen of a subject. The transducer elements are operable to focus acoustic energy emitted from the transducer array by controlling one or more of the phase delay and time delay of ultrasound signals emitted from the plurality of transducer elements such that acoustic energy emitted from the transducer array is maximised at a neuronal target near the deployment site to achieve stimulation thereof.

Abstract: Machine learning based methods for planning, execution, and reporting of clinical trials, incorporating a patient burden index are disclosed. In one aspect, there is a method for determining a patient burden index. The method includes parsing a protocol for a clinical trial. The method further includes providing factor data for each of a plurality of patients. The method further includes calculating a patient burden index for each of the plurality of patients based on the parsed protocol and the provided factor data for each of the plurality of patients.

Abstract: A nanopore based sequencing chip package is disclosed. The nanopore based sequencing chip package includes a reservoir defined by a plurality of surfaces. The chip package includes a nanopore cell array comprising a plurality of nanopore sensor cells enclosed by the reservoir. Each nanopore sensor cell has a working electrode. At least one surface of the reservoir is configured to be in contact with a conducting fluid when the conducting fluid is flowing through the reservoir. The chip package further includes a counter electrode disposed on the at least one surface of the reservoir.

Abstract: A grating coupled laser (GCL) includes an active section and a passive section. The passive section is butt coupled to the active section to form a butt joint with the active section. The active section includes an active waveguide. The passive section includes a passive waveguide, a transmit grating coupler, and a top cladding. The passive waveguide is optically coupled end to end with the active waveguide and includes a first portion and a second portion. The first portion of the passive waveguide is positioned between the second portion of the passive waveguide and the active waveguide. The transmit grating coupler is optically coupled to the passive waveguide and includes grating teeth that extend upward from the second portion of the passive waveguide. The top cladding is positioned directly above the first portion of the passive waveguide and is absent directly above at least some of the transmit grating coupler.

Abstract: A system (10) for convolving and adding frames of data comprises a first sensor-display device (14) and a second sensor display device (26). Each sensor display device (14, 26) comprises an array (80) of transmit-receive modules (82). Each transmit-receive module (82) comprises a light sensor element (86), a light transmitter element (84), and a memory bank (90). A radial modulator device (20) is positioned where transmission of light fields comprising frames of data are Fourier transformed. Filters implemented by modulator elements of the radial modulator device (20) convolve the fields of light comprising the frames of data, which are then sensed on a pixel-by-pixel basis by the light sensor elements (86), which accumulate charges, thus sum pixel values of sequential convolved frames of data.

Abstract: A method of evaluating rehabilitation potential in patients experiencing painful musculoskeletal or neuropathic conditions or both, by maximizing multidimensional rehabilitation outcomes by better identifying the specific needs of each patient; understanding the many obstacles to rehabilitation success falling into motivational, physical, and emotional categories; physical obstacles to rehabilitation including but not limited to incorrect diagnoses and deconditioning; emotional obstacles including fear avoidance, catastrophizing, generalized anxiety, depression, childhood adverse events, emotional awareness deficits; and motivational obstacles including factitious disorder, personality disorders, malingering and apathy. The resulting comprehensive pain rehabilitation program combines multiple treatment options. Medicinal treatments include anti-inflammatory medications; muscle relaxants; opioids and cannabinoids; injection therapies; neuropathic medications; and pain adjuvant medications.

Abstract: The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.

Abstract: The present invention relates to filters used to remove debris from water being sucked into a piping system. It has particular application use in nuclear power plants, which, after a loss of coolant accident, must pump cooling water back into the reactor core from a collection sump. This water may contain various types of debris that must be removed before the water is sent back into the reactor cooling system. There are restrictions on the allowable pressure drop across the strainer and the space available for installing this equipment. The finned strainer of the present invention addresses these issues while maximizing the quantity of debris filtered from the water.

Abstract: There is provided a winding system for use in an electrical, electronic or electromagnetic device or component including: one or more set of windings, each set of windings including an electrically-conductive element arranged in a winding pattern with multiple turns, at least one pair of adjacent turns of the multiple turns being spaced apart to provide at least one channel therebetween for coolant fluid to flow therethrough; and a housing for housing the set of windings, the housing including a fluid inlet and a fluid outlet each in fluid communication with the at least one channel, the housing facilitating coolant fluid to flow from the fluid inlet to the fluid outlet, via the at least one channel in direct contact with exposed surfaces of the set of windings, the exposed surfaces at least partially defining the at least one channel.

Abstract: A system includes one or more processing devices and at least one memory on which are stored instructions that, when executed by the one or more processing devices, enable the one or more processing devices to perform a method of facilitating delivery of an item from a source destination to a target destination. The method includes the steps of receiving a delivery-route assignment request from a first user device associated with a producer, transmitting the request to one or more vehicle drivers, receiving an acceptance of the request from a second user device associated with a vehicle driver, receiving a first signal indicating that the vehicle driver is a predetermined first distance from the source destination, receiving a second signal indicating that the vehicle driver is a predetermined distance from the target destination, and in response to receiving the second signal, authorizing a payment to the vehicle driver.

Abstract: An improved solvent system for the formulation and application of N-alkyl thiophosphoric triamide urease inhibitors. These formulations provide safety and performance benefits relative to existing alternatives and enable storage, transport and subsequent coating or blending with urea based or organic based fertilizers. These formulations are comprised primarily of environmentally friendly aprotic and protic solvents (particularly dimethyl sulfoxide and alcohols/polyols) to stabilize the urease inhibitor.

Abstract: The present invention relates to filters used to remove debris from water being sucked into a piping system. It has particular application use in nuclear power plants, which, after a loss of coolant accident, must pump cooling water back into the reactor core from a collection sump. This water may contain various types of debris that must be removed before the water is sent back into the reactor cooling system. There are restrictions on the allowable pressure drop across the strainer and the space available for installing this equipment. The finned strainer of the present invention addresses these issues while maximizing the quantity of debris filtered from the water.

Abstract: A treatment model that is a first neural network is trained to optimize a treatment loss function based on a treatment variable t using a plurality of observation vectors by regressing t on x(1),z. The trained treatment model is executed to compute an estimated treatment variable value {circumflex over (t)}i for each observation vector. An outcome model that is a second neural network is trained to optimize an outcome loss function by regressing y on x(2) and an estimated treatment variable t. The trained outcome model is executed to compute an estimated first unknown function value {circumflex over (?)}(xi(2)) and an estimated second unknown function value {circumflex over (?)}(xi(2)) for each observation vector. An influence function value is computed for a parameter of interest using {circumflex over (?)}(xi(2)) and {circumflex over (?)}(xi(2)). A value is computed for the predefined parameter of interest using the computed influence function value.

Abstract: The present disclosure provides in various embodiments a truss member connector including a first attachment section, a second attachment section, a connection section connecting the first attachment section to the second attachment section, and one or more guide pins. The present disclosure provides in various embodiments a reinforced truss and a method for reinforcing a truss member of a truss with the additional reinforcing member which includes attaching an additional reinforcing member to the truss member with a plurality of truss member connectors to enable rotation of the additional reinforcing member relative to the truss member such that the additional reinforcing member adds support and rigidity to the truss member and the entire truss.

Abstract: Machine learning based methods for planning, execution, and reporting of clinical trials, incorporating a patient burden index are disclosed. In one aspect, there is a method for determining a patient burden index. The method includes parsing a protocol for a clinical trial. The method further includes providing factor data for each of a plurality of patients. The method further includes calculating a patient burden index for each of the plurality of patients based on the parsed protocol and the provided factor data for each of the plurality of patients.

Abstract: A method for improving user interaction with a virtual environment includes measuring a first position of a user's gaze relative to the virtual environment, receiving a system engagement input, presenting a guidance cursor at the first position, receiving a target engagement input and decoupling the guidance cursor from the user's gaze, receiving a movement input, and translating the guidance cursor based on the movement input.

Abstract: An efficient search of a target string by a query string in homomorphically encrypted space. The target string may be encoded by reordering its characters into a plurality of target substrings, each encoding non-sequential characters of the target string separated by a periodic stride K and different target substrings having stride sequences offset relative to each other. The query string may be encoded into a plurality of query substrings, each defining a repeating sequence of a different respective character value in the query string. Each of the substrings may be homomorphically encrypted and hashed. The plurality of hashed encrypted target substrings and plurality of hashed encrypted query substrings may be compared to determine if there is a search result match. A rolling hash may iteratively update the plurality of hashed encrypted target substrings by one target string slot and the comparison may be repeated for each iterative update.

Abstract: Disclosed herein are novel compositions and methods for controlling the release of bile acid sequestrant to the stomach in order to treat or prevent upper GI tract disorders or disorders of the throat. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant dispersed in a polymeric matrix. The bile acid sequestrant composition may be administered alone or in combination with at least one proton pump inhibitor, and optionally one or more agents chosen from antacids, histamine H2-receptor antagonists, y-aminobutyric acid-I3 (GABA-B) agonists, prodrugs of GABA-B agonists, acid pump antagonists, protease inhibitors and GC-C agonists.

Abstract: A charging inlet assembly for an electric vehicle includes a housing having a power connector including AC terminals and DC terminals. An AC terminal assembly is coupled to the housing and includes AC bus bars electrically connected to corresponding AC terminals at a separable mating interface. A DC connector is mechanically and electrically connect to the DC contact of the DC connector at a separable mating interface.