Patents by Inventor David Burkhart

David Burkhart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccine adjuvants based on TLR receptor ligands
    Patent number: 11964014
    Abstract: Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmune disorders.
    Type: Grant
    Filed: August 8, 2023
    Date of Patent: April 23, 2024
    Assignee: THE UNIVERSITY OF MONTANA
    Inventors: Helene Bazin-Lee, David Burkhart, Jay Evans
  • Diaryl trehalose compounds and uses thereof
    Patent number: 11912736
    Abstract: Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: February 27, 2024
    Assignee: THE UNIVERSITY OF MONTANA
    Inventors: David Burkhart, George Ettenger, Jay Evans, Kendal T. Ryter, Alyson Smith
  • VACCINE ADJUVANTS BASED ON TLR RECEPTOR LIGANDS
    Publication number: 20240024469
    Abstract: Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmune disorders.
    Type: Application
    Filed: August 8, 2023
    Publication date: January 25, 2024
    Inventors: Helene Bazin-Lee, David Burkhart, Jay Evans
  • TLR7/8 AGONISTS TO ENHANCE IMMUNE RESPONSES IN OPIOID USING INDIVIDUALS
    Publication number: 20230310438
    Abstract: Provided herein are TLR7/8 agonists to enhance immune responses or for use as adjuvants in fentanyl vaccines in opioid-using individuals.
    Type: Application
    Filed: October 16, 2020
    Publication date: October 5, 2023
    Applicants: Children's Medical Center Corporation, the University of Montana, Regents of the University of Minnesota
    Inventors: David J. Dowling, Ofer Levy, Dheeraj Soni, Sharon Levy, Jay Evans, Marco Pravetoni, David Burkhart, Shannon Miller
  • DEVICES, SYSTEMS, AND METHODS FOR FREIGHT LOGISTICS AND ASSET MANAGEMENT
    Publication number: 20230297953
    Abstract: Devices, systems, and methods for unloading a tractor trailer that is loaded with assets are disclosed herein. An example method includes reading a unique identifier that is associated with each asset in the tractor trailer, the unique identifier including asset information. The method includes receiving indicia of the asset information, receiving a manual input of the asset information, and/or for choosing the asset information manually from a list of reference data displayed on the display device. The method includes performing a data comparison of the asset information with reference data stored on the storage to thereby identify the asset in an inventory associated with the reference data. The method includes modifying the inventory based on the data comparison when the asset has reached a destination.
    Type: Application
    Filed: February 13, 2023
    Publication date: September 21, 2023
    Inventors: Tim Plonski, David Burkhart
  • Immunogenic trehalose compounds and uses thereof
    Patent number: 11572381
    Abstract: Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: February 7, 2023
    Assignee: The University of Montana
    Inventors: David Burkhart, Jay Evans, Craig Johnson, Kendal T. Ryter, Alyson Smith, Walid Abdelwahab Marzouky Abdelwahab
  • Methods and compositions relating to adjuvants
    Patent number: 11464854
    Abstract: The methods and compositions described herein relate to methods of immunization or stimulating an immune response, e.g., using agonists of TLR7 and/or TLR8 as antigens. The methods and compositions described herein have particular relevance to use in infants.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: October 11, 2022
    Assignees: Children's Medical Center Corporation, University of Montana
    Inventors: Ofer Levy, David Dowling, Helene Bazin-Lee, David Burkhart, Jay Evans, Alyson Jessica Smith
  • VACCINE ADJUVANTS BASED ON TLR RECEPTOR LIGANDS
    Publication number: 20220241410
    Abstract: Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmnune disorders.
    Type: Application
    Filed: May 22, 2020
    Publication date: August 4, 2022
    Inventors: Helene Bazin-Lee, David Burkhart, Jay Evans
  • IMIDAZOQUINOLINE DERIVATIVES AND THEIR USE IN THERAPY
    Publication number: 20220144833
    Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.
    Type: Application
    Filed: January 24, 2022
    Publication date: May 12, 2022
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Helene G. BAZIN-LEE, Jay T. EVANS, David BURKHART, Michael COCHRAN, David A. JOHNSON
  • IMIDAZOQUINOLINE DERIVATIVES AND THEIR USE IN THERAPY
    Publication number: 20220144865
    Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.
    Type: Application
    Filed: January 24, 2022
    Publication date: May 12, 2022
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Helene G. BAZIN-LEE, Jay T. EVANS, David BURKHART, Michael COCHRAN, David A. JOHNSON
  • Imidazoquinoline derivatives and their use in therapy
    Patent number: 11274115
    Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: March 15, 2022
    Assignee: GLAXOSMITHKLINE BIOLOGICAL SA
    Inventors: Helene G. Bazin-Lee, Jay T. Evans, David Burkhart, Michael Cochran, David A. Johnson
  • Compositions and uses
    Patent number: 11207404
    Abstract: The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: December 28, 2021
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: David Burkhart, Michael Cochran, Christopher W Cluff, Daniel Larocque, Helene G. Bazin-Lee, Julien St-Jean
  • IMIDAZOQUINOLINE DERIVATIVES AND THEIR USE IN THERAPY
    Publication number: 20210277038
    Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.
    Type: Application
    Filed: September 5, 2016
    Publication date: September 9, 2021
    Applicant: GLAXOSMITHKLINE BIOLOGICALS, S.A.
    Inventors: Helene G. BAZIN-LEE, Jay T. EVANS, David BURKHART, Michael COCHRAN, David A. JOHNSON
  • DIARYL TREHALOSE COMPOUNDS AND USES THEREOF
    Publication number: 20210139521
    Abstract: Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Application
    Filed: February 21, 2019
    Publication date: May 13, 2021
    Inventors: David Burkhart, George Ettenger, Jay Evans, Kendal T. Ryter, Alyson Smith
  • Novel Immunogenic Peptides
    Publication number: 20200397911
    Abstract: The invention relates to isolated immunogenic peptides comprising a MHC class II T cell epitope, and immediately adjacent or separated from said epitope a H-X(0,2)-C-X(2)-[CST] or [CST]-X(2)-C-X(0,2)-H redox motif.
    Type: Application
    Filed: June 4, 2020
    Publication date: December 24, 2020
    Applicant: IMCYSE SA
    Inventors: Jean-Marie SAINT-REMY, Vincent Carlier, Luc Vander Elst, David Burkhart
  • IMMUNOGENIC TREHALOSE COMPOUNDS AND USES THEREOF
    Publication number: 20200369704
    Abstract: Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
    Type: Application
    Filed: March 1, 2019
    Publication date: November 26, 2020
    Inventors: David Burkhart, Jay Evans, Craig Johnson, Kendal T. Ryter, Alyson Smith, Walid Abdelwahab Marzouky Abdelwahab
  • COMPOSITIONS AND USES
    Publication number: 20200345841
    Abstract: The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.
    Type: Application
    Filed: April 15, 2020
    Publication date: November 5, 2020
    Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
    Inventors: David BURKHART, Michael COCHRAN, Christopher W. CLUFF, Daniel LAROCQUE, Helene G BAZIN-LEE, Julien ST JEAN
  • Compositions and uses
    Patent number: 10646566
    Abstract: The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: May 12, 2020
    Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: David Burkhart, Michael Cochran, Christopher W Cluff, Daniel Larocque, Helene G Bazin-Lee, Julien St Jean
  • METHODS AND COMPOSITIONS RELATING TO ADJUVANTS
    Publication number: 20200108139
    Abstract: The methods and compositions described herein relate to methods of immunization or stimulating an immune response, e.g., using agonists of TLR7 and/or TLR8 as antigens. The methods and compositions described herein have particular relevance to use in infants.
    Type: Application
    Filed: March 23, 2018
    Publication date: April 9, 2020
    Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION, UNIVERSITY OF MONTANA
    Inventors: Ofer LEVY, David DOWLING, Helene BAZIN-LEE, David BURKHART, Jay EVANS, Alyson Jessica SMITH
  • NOVEL ADJUVANT FORMULATIONS
    Publication number: 20180318415
    Abstract: The invention relates to a composition comprising solid lipid nanoparticles (SLNs), wherein the SLNs comprise an aminoalkyl glucosaminide phosphate (AGP).
    Type: Application
    Filed: December 6, 2016
    Publication date: November 8, 2018
    Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
    Inventors: David BURKHART, Jay T. Evans, Hardeep OBEROI, Yvonne M. YORGENSEN