Abstract: The invention relates to isolated immunogenic peptides comprising a MHC class II T cell epitope, and immediately adjacent or separated from said epitope a H-X(0,2)-C-X(2)-[CST] or [CST]-X(2)-C-X(0,2)-H redox motif.

Abstract: The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.

Abstract: There is provided a composition comprising an aminoalkyl glucosaminide phosphate compound or a pharmaceutically salt thereof and a buffer for use as an immunomodulator.

Abstract: A disc tossing game for a plurality of players: This game consists of players tossing discs onto a base target component that is physically connected by hinging/casing components to a backstop component to form a game system. The backstop can be locked into a relatively perpendicular relationship to the base target. The base target and backstop planar surface pieces can be folded flat to each other for transport and storage. A carrying handle is built-in. Participating players, in turn, each toss a disc at the base target of the game system. The player whose disc ends up on the base target closest to the backstop for that turn of play wins all other discs tossed by other participants. This is a competitive game that is safe and can be played either indoors or outdoors by young or old.

Abstract: A liposomal composition comprising a liposome and an aminoalkansulfonic buffer is described and claimed.

Abstract: There is provided a composition comprising an aminoalkyl glucosaminide phosphate compound or a pharmaceutically salt thereof and a buffer for use as an immunomodulator.

Abstract: The invention provides a prodrug platform technology for improving the therapeutic value of a variety of parent drug compounds by altering and improving drug characteristics such as aqueous solubility, hydrolytic stability, therapeutic index, toxicity profile, pharmacolcinetics and selectivity while allowing the potential for synthetic elaboration. The prodrug platform is particularly well suited for targeting therapeutic drugs, including anti-tumor drugs and antibiotics, to specific receptors on target cells (e.g., cancer cells and bacteria). The platform is a technology for providing an improved, preactivated form of a therapeutic drug, and for optionally targeting such drug to target cells or biological molecules. The invention is broadly applicable to many different therapeutic drugs, as well as to a variety of diseases and conditions, including a variety of forms of cancer and bacterial infections.

Abstract: The present invention provides methods and apparatuses for forming a mounting flange on a printing plate comprising first and second portions having an arcuate portion therebetween and defining a mounting flange angle. A bending device comprising a forming surface having a radius that is less than a desired radius for the arcuate portion can be used to form the arcuate portion in accordance with the present invention. This can be done by forming the arcuate portion to have a plurality of spaced apart bends that cooperatively define the arcuate portion.