Abstract: A system for interactive online instruction includes an instructional subscription website and video management system configured to process video recordings. The video recordings may include (i) student videos uploaded by a student and (ii) instructor videos providing feedback to said student videos. A method of interactive online instruction is also disclosed. The method includes the steps of providing prerecorded course materials on an instructional subscription website including video lessons accessible by subscribing students, and providing a video management system configured to process video recordings including (i) student videos submitted by a student and (ii) instructor videos providing feedback to said student videos.

Abstract: Disclosed herein are multifunctional polypeptides comprising a first domain comprising an anti-tau antigen binding domain and a second domain comprising a proteasome-targeting PEST motif, and methods for using these polypeptides in treatment of tauopathies.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).

Abstract: A commercial hopper grain bin shell can be assembled on a concrete pad using jacks to successively support previously coupled side-wall panel rings above the concrete pad. The assembled shell can be supported above the concrete pad with the jacks while coupling a horizontal support beam around a bottom of the assembled commercial hopper grain bin shell. An uppermost ring of vertical support legs can be coupled to the horizontal support beam. An uppermost ring of hopper panels can be coupled to the horizontal support beam. The assembled shell and the vertical support legs previously coupled to the horizontal support beam can be successively supported above the concrete pad with jacks while coupling an additional ring of vertical support legs to the bottom of the previously coupled vertical support legs. An additional ring of hopper panels can be successively coupled to the bottom of the previously coupled hopper panels.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

Abstract: The present disclosure concerns a bearing for a piston rod body for a drug delivery device. The bearing has an axis and comprises a first and a second surface which are spaced apart in the direction of the axis and a third surface, wherein the third surface connects the first and the second surface, wherein an opening is provided in each of the first and the third surface, and wherein the opening in the first surface is connected to the opening in the third surface. Further, the present disclosure concerns a piston rod body and a piston rod arrangement comprising said bearing and the piston rod body.

Abstract: The present invention concerns a drive mechanism for a drug delivery device comprising a housing having a longitudinal axis, a first feedback element which is movable along the longitudinal axis relative to the housing and a second feedback element, wherein the first feedback element and the second feedback element are adapted to interact with each other thereby providing at least one of tactile and audible feedback during at least one of a dose setting and dose dispensing operation of the drive mechanism. Moreover a drug delivery device incorporating such a drive mechanism is disclosed.

Abstract: The present disclosure concerns a bearing for a piston rod body for a drug delivery device. The bearing has an axis and comprises a first and a second surface which are spaced apart in the direction of the axis and a third surface, wherein the third surface connects the first and the second surface, wherein an opening is provided in each of the first and the third surface, and wherein the opening in the first surface is connected to the opening in the third surface. Further, the present disclosure concerns a piston rod body and a piston rod arrangement comprising said bearing and the piston rod body.

Abstract: A power semiconductor module including a housing within which lies at least one semiconductor switching element. The housing includes a vent aperture that is selectively openable and closeable by a cooperating vent cover. The vent cover is held in an open position during normal operation of the power semiconductor module to open the vent aperture and provide ventilation for the or each semiconductor switching element within the housing.

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).

Abstract: A pen-type drug injection device is disclosed which comprises a housing having a longitudinal axis, a threaded piston rod, a guide member for guiding the piston rod in a drug dispense operation, and a cartridge holder for receiving a cartridge, wherein the cartridge holder is detachable from the housing and wherein the guide member comprises an iris type aperture defined by a plurality of threaded pivotable segments. The drug delivery device is configured such that the aperture increases in diameter when the cartridge holder is being detached from the housing, such that the piston rod is free of the threaded engagement with the guide member and can be reset or pushed back to its initial position, and decreases in diameter when the cartridge holder is attached, such that the threads on segments reengage the piston rod.

Abstract: A utility sled is formed from a lightweight material and includes a handle flexibly attached to the front end thereof. The handle includes a hook that is seated within a small opening of the utility sled when not in use. A pair of retractable wheels is attached to an exterior of each sidewall of the utility sled. The sidewalls are biased outward when no load is present. When loaded, the sidewalls advantageously tend to straighten vertically. The formed bottom of the sled includes a plurality of ribs which both add strength to the sled as well as function as sled runners when the wheels are retracted. The ribs operate to reduce friction between the sled bottom and the underlying surface.

Abstract: The present disclosure relates to an operation aid for a medication delivery device, which is configured to alleviate the operation of an actuator of the medication delivery device. Furthermore, a system comprising a medication delivery device and an operation aid is disclosed.

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).

Abstract: An apparatus is provided that includes an optical noise generator and a noise combiner. The noise generator is configured to produce an optical signal having a noise channel. The noise combiner is configured to combine an optical data channel with the noise channel received at one or more add ports to produce an optical output signal. A controller is configured to operate the noise generator or the noise combiner to provide a variable bandwidth of added noise combined with the optical data channel.

Abstract: Disclosed herein are multifunctional polypeptides comprising a first domain comprising an anti-tau antigen binding domain and a second domain comprising a proteasome-targeting PEST motif, and methods for using these polypeptides in treatment of tauopathies.