Abstract: The present disclosure provides 4-pyrimidineamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.

Abstract: A method and system are disclosed for placing a computer in a safe and secure lock down state from a remote location using a remote command device such as a cellular telephone. The method and system includes optional security provisions before restarting the computer.

Abstract: A method and system for ensuring security-compliant creation and signing of endorsement keys of manufactured TPMs. The endorsement keys are generated for the TPM. The TPM vendor selects an N-byte secret and stores the N-byte secret in the TPM along with the endorsement keys. The secret number cannot be read outside of the TPM. The secret number is also provided to the OEM's credential server. During the endorsement key (EK) credential process, the TPM generates an endorsement key, which comprises both the public key and a hash of the secret and the public key. The credential server matches the hash within the endorsement key with a second hash of the received public key (from the endorsement key) and the vendor provided secret. The EK certificate is generated and inserted into the TPM only when a match is confirmed.

Abstract: A method computer usable medium and computer system circuitry are disclosed for starting or “booting up” a computer from a remote location using a remote command device such as a cellular telephone. The method and system includes a secure means for remotely storing and transmitting security passwords.

Abstract: A machinable austempered cast iron article has improved strength, machinability, fatigue performance, and resistance to environmental cracking. A method of making the machinable austempered cast iron article includes austenitizing an iron composition having a substantially pearlitic microstructure in an intercritical temperature range of between 1380° F. and 1500° F. This produces a ferritic plus austenitic microstructure. The ferritic plus austenitic microstructure is quenched into an austempering temperature range of between 575° F. and 750° F. within 3 minutes to prevent formation of pearlite. The ferritic plus austenitic microstructure is then austempered in the austempering temperature range of between 575° F. and 750° F. to produce a microstructure of a continuous matrix of equiaxed ferrite with islands of austenite. Finally, the microstructure of the continuous matrix of equiaxed ferrite with islands of austenite is cooled to ambient temperature to produce the machinable austempered cast iron article.

Abstract: The present disclosure provides methods for the inhibiting proliferation of tumor cells, and methods for treating solid tumor cancers in a subject by administration of 2,4-pyrimidinediamine compounds.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: Methods and arrangements are disclosed for secure single sign on to an operating system using only a power-on password. In many embodiments modified BIOS code prompts for, receives and verifies the power-on password. The power-on password is hashed and stored in a Platform Configuration Register of the Trusted Platform Module. In a setup mode, the trusted platform module encrypts the operating system password using the hashed power-on password. In a logon mode, the trusted platform module decrypts the operating system password using the hashed power-on password.

Abstract: The present disclosure provides 4-pyrimidineamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.

Abstract: The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

Abstract: To unlock a HDD when a computer is in the suspend state, at both BIOS and the HDD a secret is combined with a password to render a new one-time password. BIOS sends its new one-time password to the HDD which unlocks itself only if a match is found. The new one-time password is then saved as an “old” password for subsequent combination with the secret when coming out of subsequent suspend states. In this way, if a computer is stolen the thief cannot sniff the bus between BIOS and the HDD to obtain a password that is of any use once the computer ever re-enters the suspend state.

Abstract: A system, method, and program product is provided that executes a start sequence of an information handling system that includes a hardware based TPM. Multiple PCRs are stored in the TPM and are initialized to a predetermined state when the start sequence commences. During execution of the start sequence, software modules, including a hypervisor, are loaded the system's memory. PCR values resulting from the loading of the software modules are calculated. The resulting PCR values are compared with expected PCR values. If the PCR values match the expected PCR values, then a virtual environment is created under the hypervisor. The virtual environment includes a VM and a virtual trust platform module (vTPM) that is used by the virtual machine to satisfy the virtual machines TPM requests.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

Abstract: An apparatus, method, and system to seal a data repository to a trusted computing platform is described. The data repository may be sealed by encrypting the data on the repository and sealing a cryptographic key to a specific set of platform resources. With the data repository sealed to the platform, the system boot sequence will fail if the system configuration is compromised, for example by insertion of “snoopware” or a modified BIOS. Additionally, if the computer containing the data repository is lost or stolen, the encrypted data remains secure even if the repository is attached to a system modified to bypass normal safeguards.

Abstract: A system, method, and program product is provided that uses environments to control access to encryption keys. A request for an encryption key and an environment identifier is received. If the encryption key is not associated with the environment identifier, the request is denied. If they are associated, the system receives user-supplied environment authentication data items from a user. Examples of environment authentication data include passwords, user identifiers, user biometric data (e.g., fingerprint scan, etc.), smart cards, and the like. The system retrieves stored environment authentication data items from a secure (e.g., encrypted) storage location. The retrieved stored environment authentication data items correspond to the environment identifier that was received. The received environment authentication data items are authenticated using the retrieved stored environment authentication data items.