Abstract: A system, method, and program product is provided that has a virtualized environment provided by a hypervisor. In the virtualized environment, one or more guest operating systems operate simultaneously with a privileged operating system. One of the guest operating systems identifies a device software update, such as a device driver or firmware update, corresponding to a hardware device that is attached to the computer system. The hypervisor is used to notify the privileged operating system of the device software update. When the privileged operating system is notified of the update, the privileged operating system uses one or more techniques to deny the guest operating systems access to the device. The privileged operating system then updates the device software update. After the device software update has been applied, the privileged operating system resumes access between the guest operating systems and the hardware device.

Abstract: A system, method, and program product is provided that establishes a shared secret between a computer system and a peripheral device such as a removable nonvolatile storage device or a printer. After establishing the shared secret, the peripheral device is locked. After the peripheral device is locked, an unlock request is received and the shared secret is sent to the peripheral device. The peripheral device then attempts to verify the shared secret. If the shared secret is successfully verified, then the peripheral device is unlocked allowing use of the device by using an encryption key that is made available by the verified shared secret. On the other hand, if the shared secret is not verified, then the peripheral device remains locked and use of the device is prevented.

Abstract: A method of carrying out an autologous tissue implant in a subject in need thereof is carried out by: (a) forming an autologous tissue implant from autologous cells collected from a subject (e.g., by ink-jet printing, the autologous cells and the scaffold, separately or together), and then (b) implanting the autologous tissue implant in said subject.

Abstract: Sterilization methods and apparatus are effective to achieve a 6-log reduction in CFUs of industry standard bacteria and bacterial spores, i.e., B. stearothermophilus and B. subtilis spores, by subjecting sterilizable materials to a chemical additive-containing carbon dioxide sterilant fluid at or near its supercritical pressure and temperature conditions. Most preferably, the chemical additive-containing supercritical carbon dioxide sterilant fluid is agitated during sterilization, e.g., via mechanical agitation or via pressure cycling.

Abstract: A remote control system and method for the remote control operation of a locomotive in the performance of a car-kicking sequence comprises a portable control unit operable from a location off-board of the locomotive. The portable control unit includes an operator interface allowing an operator to initiate, with a single step, a predetermined sequence of locomotive operations for automatically performing a car-kicking procedure and generating a signal responsive to the single step for transmission to the locomotive. The system also includes a memory for storing a set of instructions corresponding to the predetermined sequence. An onboard slave control unit, interfaced with an operating system on the locomotive, receives the signal and automatically controls movement of the locomotive according to the set of instructions.

Abstract: When data changes in LBAs of a disk storage, the IDs of changed LBAs are written to a cache, with the LBAs being hashed to render a hash result. The hash result and contents of the cache are written to a file on the disk, the cache flushed, and the hash result written back to the cache for hashing together with subsequent changed LBAs. The process repeats. In this way, the hash result in the most current file on the disk can be compared with the hash result in cache, and if the two match, it indicates that the files on the disk contain an accurate record of changed LBAs.

Abstract: The present disclosure provides 4-pyrimidineamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.

Abstract: A method and system for ensuring security-compliant creation and signing of endorsement keys of manufactured TPMs. The endorsement keys are generated for the TPM. The TPM vendor selects an N-byte secret and stores the N-byte secret in the TPM along with the endorsement keys. The secret number cannot be read outside of the TPM. The secret number is also provided to the OEM's credential server. During the endorsement key (EK) credential process, the TPM generates an endorsement key, which comprises both the public key and a hash of the secret and the public key. The credential server matches the hash within the endorsement key with a second hash of the received public key (from the endorsement key) and the vendor provided secret. The EK certificate is generated and inserted into the TPM only when a match is confirmed.

Abstract: A method computer usable medium and computer system circuitry are disclosed for starting or “booting up” a computer from a remote location using a remote command device such as a cellular telephone. The method and system includes a secure means for remotely storing and transmitting security passwords.

Abstract: A method and system are disclosed for placing a computer in a safe and secure lock down state from a remote location using a remote command device such as a cellular telephone. The method and system includes optional security provisions before restarting the computer.

Abstract: A machinable austempered cast iron article has improved strength, machinability, fatigue performance, and resistance to environmental cracking. A method of making the machinable austempered cast iron article includes austenitizing an iron composition having a substantially pearlitic microstructure in an intercritical temperature range of between 1380° F. and 1500° F. This produces a ferritic plus austenitic microstructure. The ferritic plus austenitic microstructure is quenched into an austempering temperature range of between 575° F. and 750° F. within 3 minutes to prevent formation of pearlite. The ferritic plus austenitic microstructure is then austempered in the austempering temperature range of between 575° F. and 750° F. to produce a microstructure of a continuous matrix of equiaxed ferrite with islands of austenite. Finally, the microstructure of the continuous matrix of equiaxed ferrite with islands of austenite is cooled to ambient temperature to produce the machinable austempered cast iron article.

Abstract: The present disclosure provides methods for the inhibiting proliferation of tumor cells, and methods for treating solid tumor cancers in a subject by administration of 2,4-pyrimidinediamine compounds.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: Methods and arrangements are disclosed for secure single sign on to an operating system using only a power-on password. In many embodiments modified BIOS code prompts for, receives and verifies the power-on password. The power-on password is hashed and stored in a Platform Configuration Register of the Trusted Platform Module. In a setup mode, the trusted platform module encrypts the operating system password using the hashed power-on password. In a logon mode, the trusted platform module decrypts the operating system password using the hashed power-on password.

Abstract: The present disclosure provides 4-pyrimidineamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.

Abstract: The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

Abstract: The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

Abstract: The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.