Abstract: This invention relates to compounds that can be used to treat viral infections. The compounds are papain-like protease (PLpro) inhibitors.

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

Abstract: Processes for producing an oxazaborolidines and their use in animal feeds. One process reacts an amino alcohol with a boronic acid with azeotropic removal of water to provide a mixture of the starting materials and an oxazaborolidine end product; and purifying the oxazaborolidine end product. One purification step dissolves a bicarboxylic acid in water and mixes this solution with the end product to precipitate out the starting material as a salt and produce an oxazaborolidine product filtrate. An alternative process reacts amino alcohol with trihydridoboron (BH3) in an organic solvent; and immediately alkylates the unalkylated intermediate compound produced using Alkyl Lithium to provide the oxazaborolidine end product.

Abstract: A refrigerator includes a filter, a receiver, a manifold, and a cam. The filter has a handle extending therefrom. The receiver defines a cavity configured to receive the filter. The manifold is configured to engage an opposing end of the filter relative to the handle via axial rotation of the filter. The manifold is configured to pivot upward to transition the filter to an activated position. The manifold is configured to pivot downward to transition the filter to a deactivated position. The cam is configured to interfere with the handle in response to partial axial rotation of the filter to prevent the filter from pivoting upward to the activated position. The cam is configured to provide clearance for the handle in response to full axial rotation of the filter to facilitate the filter pivoting upward to the activated position.

Abstract: Examples of the present disclosure relate to the optical identification of telecommunications equipment. In examples, a user interacts with an application to capture image data relating to a device according to instructions presented to the user. The application may further generate metadata, such as user responses to one or more questions. The image data and/or metadata are evaluated using a machine learning model to generate an equipment classification for devices pictured therein. The data may also be used to generate an equipment configuration for the device, as well as an operational state (e.g., based on one or more indicators present on the device, log data, etc.). Accordingly, such information may be used to update a pre-existing inventory record for the device, or generate a new inventory record. In other examples, such information is used to generate one or more predicted issues and associated actions to troubleshoot the device.

Abstract: Systems and methods for determining whether and how to present digital animations in a user interface are disclosed. According to certain embodiments, the systems and methods may facilitate the identification of a set of products or services purchased by an individual, and the determination of a reward level associated with the set of products or services. The systems and methods may select a digital animation, from a set of digital animations that is predetermined based on a set of probabilities, corresponding to the reward level, and present the digital animation in a user interface.

Abstract: A system and method for monitoring the operating condition of a wheelset on a railcar comprising a sealed unit mounted on or near a wheelset of the railcar for collecting data from the wheelset and performing AI analyses on the collected data to determine the operational condition and predict failure modes for the wheelset. Results are communicated off-railcar wirelessly via one or more of several different methods.

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: Aspects of the present disclosure involve systems for providing multiple egress routes from a telecommunications network for a client of the network. In general, the system provides for a client of the network to receive intended packets of information through multiple connections to the network such that load balancing and failover services for traffic to the customer are provided. The process and system allow for telecommunications network to utilize a common next-hop value of announced border gateway protocol (BGP) routes to advertise multiple routes to reach a destination customer network or address. By utilizing a common next-hop value in the announced BGP information, the devices of the network may load balance communication packets to the destination customer or address among the multiple egress locations from the network, as well as providing fast failover to alternate routes when a failure at the network or customer occurs.

Abstract: A sportsbook odds optimization and parlay correlation analysis platform may be provided. The platform may be configured to assess the correlation value for proposition bet parlays. The platform may be employed by a sportsbooks or other betting event hosting establishment. The platform may be configured to establish parameters for processing at least one parlay offered to the establishment. The parameters may include, for example, but not be limited to, a correlation value and a payout type. Next, at least one parlay may be received for processing. A correlation value and a payout value associated with the at least one parlay may be calculated. The platform may be configured to determine whether to accept or decline the at least one parlay offering based on the parameters defined by the establishment. The at least one parlay may then be accepted or declined in accordance to the determination.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: A data item is searched for in first and/or second data sets of a data store. If it is found in the first data set and if it was updated in the first data set after the second data set became an overlay of the first data set, first data stored in association with the data item in the first data set is returned. If it is found in the first and second data sets and if the second data set became an overlay of the first data set after the data item was updated in the first data set, second data stored in association with the data item in the second data set is returned. The second data set is identified based on overlay metadata, indicative of the second data set being an overlay of the first data set.

Abstract: Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.

Abstract: Disclosed is a modular skid assembly. The modular skid assembly may include a receiving portion to receive a container. The container may be a receptacle for a portable toilet assembly. A portable toilet assembly may be assembled onto the modular skid assembly.

Abstract: Techniques for operating a kinematic structure by manual motion of a link coupled to the kinematic structure include a system comprising a first manipulating means and processing means. The processing means is for detecting whether a first means for accessing an internal worksite is mounted to the first manipulating means; detecting an input indicating the system is to be in a set-up mode; and inhibiting, in response to detecting that the first means is mounted to the first manipulating means, transition of the system to the set-up mode.

Abstract: Implementations described and claimed herein provide systems and methods for an optical domain controller for managing and maintaining a record of network component configuration and interconnections. The optical domain controller detects changes in a configuration of optical network elements in response to a requested service from the network, coordinates additional changes in configurations to optical network elements that may be affected by the detected change, communicates with the optical network elements to incorporate the changes to the configurations of the network element, and stores the configurations and states of the network elements. The use of the optical domain controller may thus replace or supplement a database storing network configuration information by automatically managing changes to the network as new services are instantiated directly on the optical network elements.

Abstract: Implementations described and claimed herein provide systems and methods for a configurable optical peering fabric to dynamically create a connection between participant sites without any physical site limitations or necessity of specialized client and network provider equipment being located within such a facility. Client sites to a network may connect to a configurable switching element to be interconnected to other client sites in response to a request to connect the first client site with a second site, also connected to network, via the switching element. A request may trigger verification of the requested and, upon validation, transmission of an instruction to the switching element to enable the cross connect within the switching element. The first site and the second site may thus be interconnected via the switching element in response to the request, without the need to co-locate equipment or to manually install a jumper between client equipment.

Abstract: A refrigerator includes a filter, a receiver, a manifold, and a cam. The filter has a handle extending therefrom. The receiver defines a cavity configured to receive the filter. The manifold is configured to engage an opposing end of the filter relative to the handle via axial rotation of the filter. The manifold is configured to pivot upward to transition the filter to an activated position. The manifold is configured to pivot downward to transition the filter to a deactivated position. The cam is configured to interfere with the handle in response to partial axial rotation of the filter to prevent the filter from pivoting upward to the activated position. The cam is configured to provide clearance for the handle in response to full axial rotation of the filter to facilitate the filter pivoting upward to the activated position.

Abstract: A computer system is provided. The computer system includes a memory and at least one processor coupled to the memory and configured to deploy public key enumeration code and private key enumeration code to a plurality of endpoint devices for execution on the endpoint devices. The at least one processor is further configured to collect public keys and associated public key metadata from the endpoint devices, and to collect private key metadata from the endpoint devices. The public keys and associated public key metadata are generated by the public key enumeration code and the private key metadata is generated by the private key enumeration code. The at least one processor is further configured to generate a graph illustrating trust relationships between user accounts on the endpoint devices. The graph is based on the collected public keys, the collected public key metadata, and the collected private key metadata.