Abstract: Aspects of the disclosure relate to compositions and methods for treating Fibrodysplasia ossificans progressiva (FOP). The disclosure is based, in part, on muscle-targeting, chemically-modified interfering nucleic acids (e.g., siRNAs) that bind to and inhibit an ACVR1R206H allele or an Inhba allele of a subject.

Abstract: A power swivel system for an articulated machine can include a core having a rotational axis and configured to permit electrical conduit passage. A first portion couples to and rotates with the cabin, including a first slip ring assembly for electrical power distribution and manifolds for hydraulic power coupling. A second portion rotatably disposed about the core rotates with the boom apparatus, can include a second slip ring assembly for electrical power and a first jug for hydraulic power distribution. A third portion remains stationary within the front chassis, providing both hydraulic and electrical power distribution. The first portion and the second portion rotate independently of each other and the third portion, enabling the cabin and boom apparatus to operate independently while maintaining continuous power transmission throughout the articulated machine.

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

Abstract: An object of the present invention is to provide immunogenic compositions for protection against S. pneumoniae, in particular against S. pneumoniae serogroup 18, while limiting the number of conjugates. The present invention therefore relates to new immunogenic compositions for use in pneumococcal vaccines and to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said immunogenic compositions.

Abstract: A tamper evident container comprises a base, a lid, a first hinge, a locking mechanism, a second hinge, and a tamper evidence feature. The base retains items for storage. The lid engages with and covers the base. The first hinge rotatably couples the base and the lid. The locking mechanism secures the lid to the base and includes a plug and a receptacle. The locking mechanism is engaged when the plug is within the receptacle. The second hinge rotatably couples the base and the plug. The tamper evidence feature provides evidence of the container being tampered with or opened and is positioned between the plug and the second hinge.

Abstract: A decking clip for attaching first and second adjacent decking boards to a decking support member. The decking clip includes a substantially planar base portion adapted to be attached to the decking support member. The base portion has a pair of opposing first and second clip members. Each clip member has a resiliently movable upright portion respectively extending from an upper surface of the base portion in a rest position. Each clip member has a protruding portion proximate its upper extremity which protrudes from the upright portion. In use, the protruding portion on the first clip member is adapted to engage with a side edge of the first decking board, and the protruding portion on the second clip member is adapted to engage with a side edge of the second decking board to retain the first and second decking boards on the decking support member.

Abstract: An articulated machine for moving an object includes a front chassis, a rear chassis, a power swivel system, a cabin, and a boom apparatus is provided. The rear chassis can be coupled to the front chassis by a rear chassis actuator for moving the rear chassis relative the front chassis. The power swivel system can be disposed partially within the front chassis and can have a rotational axis. The cabin can be rotatably coupled the power swivel system and can be disposed adjacent the boom swivel plate. The cabin can be independently rotatable about the rotational axis of the power swivel system. The boom apparatus can be rotatably mounted on the front chassis and can be coupled to the power swivel system. The boom swivel plate can permit independent rotation of the boom apparatus about the rotational axis of the power swivel system.

Abstract: An object of the present invention is to provide immunogenic compositions for protection against S. pneumoniae, in particular against S. pneumoniae serogroup 18, while limiting the number of conjugates. The present invention therefore relates to new immunogenic compositions for use in pneumococcal vaccines and to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said immunogenic compositions.

Abstract: A tamper evident container comprises a base, a lid, a first hinge, a locking mechanism, a second hinge, and a tamper evidence feature. The base retains items for storage. The lid engages with and covers the base. The first hinge rotatably couples the base and the lid. The locking mechanism secures the lid to the base and includes a plug and a receptacle. The locking mechanism is engaged when the plug is within the receptacle. The second hinge rotatably couples the base and the plug. The tamper evidence feature provides evidence of the container being tampered with or opened and is positioned between the plug and the second hinge.

Abstract: A filter assembly for a refrigerator includes a filter, a port, and a cam. The filter has a protrusion extending therefrom. The port is configured to engage the filter. The port is configured to move to transition the filter to an activated position. The port is configured to move to transition the filter to a deactivated position. The cam is configured to interfere with the protrusion in response to a partial connection between the filter and the port to prevent the filter from transitioning to the activated position. The cam is configured to provide clearance for the protrusion in response to a full connection between the filter and the port to facilitate the filter transitioning to the activated position.

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

Abstract: A refrigerator includes a filter, a receiver, a manifold, and a cam. The filter has a handle extending therefrom. The receiver defines a cavity configured to receive the filter. The manifold is configured to engage an opposing end of the filter relative to the handle via axial rotation of the filter. The manifold is configured to pivot upward to transition the filter to an activated position. The manifold is configured to pivot downward to transition the filter to a deactivated position. The cam is configured to interfere with the handle in response to partial axial rotation of the filter to prevent the filter from pivoting upward to the activated position. The cam is configured to provide clearance for the handle in response to full axial rotation of the filter to facilitate the filter pivoting upward to the activated position.

Abstract: A refrigerator includes a filter, a receiver, a manifold, and a cam. The filter has a handle extending therefrom. The receiver defines a cavity configured to receive the filter. The manifold is configured to engage an opposing end of the filter relative to the handle via axial rotation of the filter. The manifold is configured to pivot upward to transition the filter to an activated position. The manifold is configured to pivot downward to transition the filter to a deactivated position. The cam is configured to interfere with the handle in response to partial axial rotation of the filter to prevent the filter from pivoting upward to the activated position. The cam is configured to provide clearance for the handle in response to full axial rotation of the filter to facilitate the filter pivoting upward to the activated position.

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

Abstract: In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.

Abstract: This disclosure relates to novel modified oligonucleotides with increased stability and extended in vivo mRNA silencing activity.

Abstract: In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.

Abstract: An object of the present invention is to provide immunogenic compositions for protection against S. pneumoniae, in particular against S. pneumoniae serogroup 18, while limiting the number of conjugates. The present invention therefore relates to new immunogenic compositions for use in pneumococcal vaccines and to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said immunogenic compositions.

Abstract: A laser beam delivery apparatus for a microscope comprises first and second optical diffusers that are configured to move in a periodic manner with a respective different frequency. Each optical diffuser may comprise a spinning disk. The laser light is spatially randomized by the first spinning diffuser and its spatial pattern is further randomized by the second diffuser. The second diffuser prevents any spatial pattern from repeating after one revolution of the first diffuser, which prevents beating patterns from forming when the light is imaged through a spinning confocal disk and increases the uniformity in other cases.