Abstract: A system includes a processor circuit and a memory coupled to the processor circuit. The memory includes machine-readable instructions that, when executed by the processor circuit, cause the processor circuit to provide, by the processor circuit, a virtual environment in a metaverse. The virtual environment includes a virtual electronic gaming machine (EGM). The processor circuit is further caused to receive, via the processing circuit and from a gaming device that is in a physical world and that corresponds to a user, an identification of a modification to the virtual environment that is not possible in the physical world. The processor circuit further caused to provide, responsive to receiving the identification of the modification and via the processing circuit, the modification to the virtual environment.

Abstract: A graphical user interface (GUI) including a plurality of wagering game assets, such as game modules, math models, cosmetic game features, and other assets is provided to a user. Based on first user input received from the user via a GUI, a first virtual wagering game is generated using selected assets. The input may include selection from a plurality of The first virtual wagering game is provided to a plurality of players in a virtual gaming environment. A first revenue amount is received from wagers by the players in the first virtual wagering game. A first portion of the first revenue amount is awarded to the user.

Abstract: A primary wagering game is provided at a gaming device to a first player and a cryptographic token associated with the first player is determined. The cryptographic token includes a player identifier indicative of the player associated with the cryptographic token and a benefit identifier associated with a game benefit being provided to the first player associated with the cryptographic token. Based on the cryptographic token, a secondary game is provided at the gaming device, wherein play of the secondary game does not affect play of the primary wagering game, and wherein play of the secondary game appears to the first player to modify play of the primary wagering game.

Abstract: A cryptographic token associated with a player including a cryptographic hash associated with a blockchain, a player identifier indicative of a player associated with the cryptographic token, and a progress identifier indicative of a present progress value for a wagering game is determined, and a first progress value associated with a first play session of a first wagering game by a player is determined. Based on the first progress value, the progress identifier of the cryptographic token is modified to add the first progress value to the present progress value. Based on the present progress value, a first game benefit to the player is provided.

Abstract: The disclosure relates to compositions and methods for the production and therapeutic use of inhibitory double stranded RNAs.

Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.

Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.

Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.

Abstract: Systems and methods for authenticating a peripheral device prior to allowing the peripheral device access to components and data stored on user equipment. In some examples, the user equipment may include an authorization component that is configured to physically decouple a hardware interface from other components of the user equipment until the authorization component is able to authenticate the peripheral device. Both authorized peripheral devices and the user equipment may be provisioned with authorization data and/or credentials from a system outside the control of the individual users of the user equipment.

Abstract: Disclosed herein are compounds and methods for modulating C9orf72 transcript. Such compounds and methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof.

Abstract: Certain embodiments are directed to methods and compounds for increasing FXN. Such methods and compounds are useful for increasing expression of FXN in cells and animals.

Abstract: Systems and methods for encrypting and decrypting data sent to and received from a peripheral device physically coupled to a hardware interface of a user equipment. In some examples, the user equipment may include an encrypting/decryption component that is configured to physically between a hardware interface of the user equipment and the other components of the user equipment. The encrypting/decryption component may be configured to receive a plurality of encryption/decryption schemes from a remote system. The encrypting/decryption component may select and apply one or more of the plurality of encryption/decryption schemes to data being downloaded and/or uploaded to the peripheral device.

Abstract: Described herein are techniques for performing a trusted execution environment (TEE) detection of systemic malware in a computing system that hosts the TEE. As described, the techniques may include a TEE obtaining data from one or more subsystems of a computing system that hosts the TEE. The TEE is configured to execute components in isolation from the one or more subsystems of the computing system. Based on the data obtained, the TEE detects systemic malware on the one or more subsystems of the computing system. In response to the detected malware, the TEE reports the detection of malware on the one or more subsystems of the computing system.

Abstract: Systems and methods for authenticating a peripheral device prior to allowing the peripheral device access to components and data stored on user equipment. In some examples, the user equipment may include an authorization component that is configured to physically decouple a hardware interface from other components of the user equipment until the authorization component is able to authenticate the peripheral device. Both authorized peripheral devices and the user equipment may be provisioned with authorization data and/or credentials from a system outside the control of the individual users of the user equipment.

Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

Abstract: Disclosed herein are compounds and methods for modulating C9orf72 transcript. Such compounds and methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof.

Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.

Abstract: Technologies for using edge devices in a cellular network as compute nodes to participate in a blockchain network are described. A cellular network may provision one or more edge devices in communication with the cellular network to instantiate a virtual machine on the edge device to act as a compute node. The cellular network may submit a bid to solve a blockchain hash function using the compute nodes and may instruct the edge to solve the blockchain hash function.