Abstract: Technologies for using edge devices in a cellular network as compute nodes to participate in a blockchain network are described. A cellular network may provision one or more edge devices in communication with the cellular network to instantiate a virtual machine on the edge device to act as a compute node. The cellular network may submit a bid to solve a blockchain hash function using the compute nodes and may instruct the edge to solve the blockchain hash function.

Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Provided herein are a double-stranded oligonucleotides of 13 to 22 nucleobases in length targeting a GGGGCC expanded repeat region in an intron of C9orf72, comprises (a) 3-5 central mismatches (within bases 9-14) within a target sequence comprising the expanded repeat sequence, or (h) 3-5 mismatches outside of the seed sequence (bases 2-8 within the guide strand complementary to the expanded repeat sequence).

Abstract: Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules. In certain embodiments, compounds and methods useful for the modulation of ATXN-3 pre-mRNA are described. In certain embodiments, compounds and methods useful for the modulation of ATN-1 mRNA are described.

Abstract: A temporal identity vault used to authenticate an individual is described herein. User identifying input is received on a device, such as a cell phone. The identifying input is, in some examples, encrypted and stored as a temporal identity vault. The temporal identity vault is configured for a use. The use may be a time, location, or the like. A beacon is associated with the temporal identity vault. If the beacon is at a location relative to an object, the authentication process is started. The information stored in the temporal identity vault is authenticated at a central service. Upon authentication, the user is permitted to operate an object. The temporal identity vault may thereafter be deleted.

Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.

Abstract: Disclosed herein are compounds and methods for modulating C9orf72 transcript. Such compounds and methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof.

Abstract: Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules.

Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Provided herein are a double-stranded oligonucleotides of 13 to 22 nucleobases in length targeting a GGGGCC expanded repeat region in an intron of C9orf72, comprises (a) 3-5 central mismatches (within bases 9-14) within a target sequence comprising the expanded repeat sequence, or (h) 3-5 mismatches outside of the seed sequence (bases 2-8 within the guide strand complementary to the expanded repeat sequence).

Abstract: Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules. In certain embodiments, compounds and methods useful for the modulation of ATXN-3 pre-mRNA are described. In certain embodiments, compounds and methods useful for the modulation of ATN-1 mRNA are described.

Abstract: Provided herein are methods for single cell sequencing of miRNAs and other low abundance and/or or short cellular RNAs.

Abstract: Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules.

Abstract: Cup holder assemblies, methods of using cup holder assemblies and a high chair or tabletop with a cup holder assembly are disclosed. The cup holder assembly may include a mounting assembly configured to mount on a high chair or tabletop and a cup holder which is removably mounted on the mounting assembly so that the mounting assembly may remain on the high chair or tabletop when the cup holder is removed. The mounting assembly may be removable from the high chair or tabletop, and may remain on stackable high chairs during stacking thereof.

Abstract: The present invention is drawn to chemically-modified oligomers that are complementary to, and capable of hybridizing within the repeat region of CAG, CUG, or CCUG nucleotide repeat-containing RNAs (NRRs).

Abstract: An electronic card comprises a thin, flexible substrate having electrical circuitry embedded therein. An activation device is disposed in the substrate and is configured to complete a circuit in response to a stimulus, such as light or sound. An output device is disposed in the substrate and is configured to produce an output, such as music or vibration, wherein the output device is activated upon the completion of the circuit by the activation device. A cavity is formed in an outer surface of the substrate and has electrical contacts at an inner portion thereof in electrical communication with the electrical circuitry. The cavity further comprises retaining means for replaceably retaining a battery in the cavity to enable the battery to provide power to the electrical circuitry, the activation device, and the output device. The retaining means allows a battery to be removed from the cavity and replaced with another battery.

Abstract: An electronic card comprises a thin, flexible substrate having electrical circuitry embedded therein. An activation device is disposed in the substrate and is configured to complete a circuit in response to a stimulus, such as light or sound. An output device is disposed in the substrate and is configured to produce an output, such as music or vibration, wherein the output device is activated upon the completion of the circuit by the activation device. A cavity is formed in an outer surface of the substrate and has electrical contacts at an inner portion thereof in electrical communication with the electrical circuitry. The cavity further comprises retaining means for replaceably retaining a battery in the cavity to enable the battery to provide power to the electrical circuitry, the activation device, and the output device. The retaining means allows a battery to be removed from the cavity and replaced with another battery.

Abstract: Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.

Abstract: Transcription of a gene in a mammalian cell is methylase-independently inhibited by contacting the cell with a nucleic acid oligomer of 12-28 bases complementary for a partially single-stranded target genomic sequence of the gene.